BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0024.0171.p (417 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value SSO2727 [E] COG0160 4-aminobutyrate aminotransferase and related... 248 2e-65 PH1423 [E] COG0160 4-aminobutyrate aminotransferase and related ... 239 8e-63 APE0457 [E] COG0160 4-aminobutyrate aminotransferase and related... 238 1e-62 PAB0501 [E] COG0160 4-aminobutyrate aminotransferase and related... 237 4e-62 PAE1799 [E] COG0160 4-aminobutyrate aminotransferase and related... 235 1e-61 >SSO2727 [E] COG0160 4-aminobutyrate aminotransferase and related aminotransferases Sso Sulfolobus solfataricus Length = 440 Score = 248 bits (634), Expect = 2e-65, Method: Compositional matrix adjust. Identities = 147/395 (37%), Positives = 228/395 (57%), Gaps = 18/395 (4%) Query: 2 IEAELESLNFADAPKMVSSTYPGPKTAAALELSARTESMARGGGR-MPIAMDQAFGVTFK 60 +E L+S + +AP +++ T PG K+ L+ E+ A + IA+D+A G T Sbjct: 1 MEENLDS-SVLEAP-IINVTPPGSKSLKLLKDQEEYETSAINYPKYFKIAIDKAQGSTVT 58 Query: 61 DPDGNTFIDLSAGVGVSSVGRCNPRVVEAIRKQSESLMHSMEVNSSKRTELAAKISEIMP 120 D DGN +IDL G+ V ++G NP V + +++Q E + H++EV + R + K+ + Sbjct: 59 DVDGNVYIDLVTGISVVNLGHNNPFVRKRVQEQLEKVWHTLEVPTEIRVNFSKKLLSTL- 117 Query: 121 EGLRGDCITFFTQGGSDALEAAVKFAKRVTGRHQIIAFHGGYHGIWNASNALTTGTAYRK 180 G+R + FT G+DA+EAAVK A+ +TG+ IIAF G YHGI + LT +++ Sbjct: 118 -GMRAKLL--FTTTGADAVEAAVKIARFITGKKTIIAFEGSYHGITAGTLGLTGANRFKE 174 Query: 181 GFGPFMGG-VIHAPYPYAYRFPF-DTSNKSAEQIAGEYVDYLLNTPYTAADDVAAVIVEP 238 F PF V+ PYPY YR PF D N++ +DY ++ P DVA ++VEP Sbjct: 175 -FQPFFDDRVVKFPYPYPYRCPFKDCLNETLS-----LLDYAMSNPGYLGGDVAGILVEP 228 Query: 239 VQGEGGYVPPSPEFLQILRKACDRSGALLIVDEVQAGAGRTGKMWAVEHSGVKPDMLTFG 298 +QGEGGYV P FL+ L++ ++ LIVDEVQ G GRTGKMWA + ++PD++T Sbjct: 229 IQGEGGYVVPPKGFLKGLKELAEKYSVPLIVDEVQTGVGRTGKMWAYQWENIEPDIVTIS 288 Query: 299 KGIGGDMPMAGLVMRSDLAAKIPDGSQPNTFAANSISAAVALTNISILQDPRLDLVNRAH 358 K IG +P++ + R D K+P G T+ N + A L ++ ++ ++++R Sbjct: 289 KAIGEGIPVSMVAYREDF-DKLPTGFHLGTYRGNPLGLAAGLASLEFIESH--NILSRVE 345 Query: 359 ALGLEAQERIRSFNSHWVGEVRGRGLMIGIELVEN 393 LG +A E ++ + VG++RG G MIGIELV++ Sbjct: 346 RLGRKALELLKEVQNPHVGDIRGLGFMIGIELVKD 380 >PH1423 [E] COG0160 4-aminobutyrate aminotransferase and related aminotransferases Pho Pyrococcus horikoshii Length = 454 Score = 239 bits (610), Expect = 8e-63, Method: Compositional matrix adjust. Identities = 143/386 (37%), Positives = 219/386 (56%), Gaps = 16/386 (4%) Query: 23 PGPKTAAALELSAR-TESMARGGGRMPIAMDQAFGVTFKDPDGNTFIDLSAGVGVSSVGR 81 PGPK +E + + + +++A GV + D DGN +D S+G+GV +VG Sbjct: 11 PGPKARKVIEEHHKYMATTTNDPNEYFLVIERAEGVYWIDVDGNVLLDFSSGIGVMNVGL 70 Query: 82 CNPRVVEAIRKQSESLMHS--MEVNSSKRTELAAKISEIMPEGLRGDCITFFTQGGSDAL 139 NP+V+EAI+KQ + ++H+ + + + ELA K+ EI P + F + G++A Sbjct: 71 RNPKVIEAIKKQLDLVLHAAGTDYYNPYQVELAKKLVEIAPGDIERKV--FLSNSGTEAN 128 Query: 140 EAAVKFAKRVTGRHQIIAFHGGYHGIWNASNALT-TGTAYRKGFGPFMGGVIHAPYPYAY 198 EAA+K AK T R IAF G +HG + + +LT + R P M GV+H PYP Y Sbjct: 129 EAALKIAKWSTNRKMFIAFIGAFHGRTHGTMSLTASKPVQRSRMFPTMPGVVHVPYPNPY 188 Query: 199 RFPFDTSN-KSAEQIAGEYVDYL---LNTPYTAADDVAAVIVEPVQGEGGYVPPSPEFLQ 254 R P+ ++ +++ +DY+ L Y A++VA + EP+QGEGGYV P F + Sbjct: 189 RNPWGIDGYENPDELINRVIDYIEEYLFEHYVPAEEVAGIFFEPIQGEGGYVVPPKNFFK 248 Query: 255 ILRKACDRSGALLIVDEVQAGAGRTGKMWAVEHSGVKPDMLTFGKGIGGDMPMAGLVMRS 314 L+K D+ G LLI DEVQ G GRTG+MWA+EH + PD++T K +GG +P+ + R+ Sbjct: 249 ELKKLADKHGILLIDDEVQMGMGRTGRMWAIEHFDIVPDIVTVAKALGGGIPIGATIFRA 308 Query: 315 DLAAKIPDGSQPNTFAANSISAAVALTNISILQDPRLDLVNRAHALGLEAQERIRSFNSH 374 DL + G NTF N+++AA AL I LQ+ L+ A L +ER+ Sbjct: 309 DLDFGV-SGVHSNTFGGNTVAAAAALAVIEELQN---GLIENAQKLEPLFRERLEEMKEK 364 Query: 375 W--VGEVRGRGLMIGIELVENRETRD 398 + +G+VRG GL G+E V++R+T++ Sbjct: 365 YEIIGDVRGLGLAWGVEFVKDRKTKE 390 >APE0457 [E] COG0160 4-aminobutyrate aminotransferase and related aminotransferases Ape Aeropyrum pernix Length = 452 Score = 238 bits (608), Expect = 1e-62, Method: Compositional matrix adjust. Identities = 147/404 (36%), Positives = 225/404 (55%), Gaps = 20/404 (4%) Query: 13 DAPKMVSSTYPGPKTAAALELSART--ESMARGGGRMPIAMDQAFGVTFKDPDGNTFIDL 70 DAP++V PGP+ LE R +S R P+ + + +G +D DGN +ID Sbjct: 4 DAPRIVVEP-PGPRAREVLERDERVIMQSFTRW---YPLVVKRGYGAVVEDVDGNRYIDF 59 Query: 71 SAGVGVSSVGRCNPRVVEAIRKQSESLMHS--MEVNSSKRTELAAKISEIMPEGLRGDCI 128 +AG+ V +VG +PRVVEA+++Q E +H + + A +++ +P + G Sbjct: 60 NAGIAVLNVGHNHPRVVEAVKRQLERFLHYSLTDFYYEEAVSAAERLARSVP--ISGGAK 117 Query: 129 TFFTQGGSDALEAAVKFAKRVT--GRHQIIAFHGGYHG-IWNASNALTTGTAYRKGFGPF 185 TFFT G++++EA++K + R II+F GG+HG + A +A + +R F P Sbjct: 118 TFFTNSGAESIEASIKVVRAFFRGTRPYIISFLGGFHGRTYGAMSASASKPVHRARFYPL 177 Query: 186 MGGVIHAPYPYAYRFPFD-TSNKSAEQIAGEYVDYLLNTPYTAADDVAAVIVEPVQGEGG 244 + G IHAPYP YR PF ++ + A Y++ + + +VAA + EP+QGEGG Sbjct: 178 VPGFIHAPYPDPYRCPFPGLEGEACGEAAVSYIEDYIFSKLVDPGEVAAFLFEPIQGEGG 237 Query: 245 YVPPSPEFLQILRKACDRSGALLIVDEVQAGAGRTGKMWAVEHSGVKPDMLTFGKGIGGD 304 YV P FL L+K + G LLI DEVQ G RTG+M+AVEH GV+PD++ K +GG Sbjct: 238 YVVPPDSFLPSLQKLARKHGILLIADEVQTGFARTGRMFAVEHWGVEPDVMALAKAMGGG 297 Query: 305 MPMAGLVMRSDLAAKIPDGSQPNTFAANSISAAVALTNISILQDPRLDLVNRAHALGLEA 364 +P+ V RS++ + +P GS NTF N ++ A + +++ R L R+ LG +A Sbjct: 298 LPLGAAVGRSEVMS-LPRGSHANTFGGNPVALAAFNAVMDVIEGER--LWERSQRLGEKA 354 Query: 365 QERIRSFNSHW--VGEVRGRGLMIGIELVENRETRD-RSRARSW 405 + + VG VRG+GLMIG+ELV + TR+ A +W Sbjct: 355 LKILGEAAEELSIVGHVRGKGLMIGVELVRDENTREPHKEALAW 398 >PAB0501 [E] COG0160 4-aminobutyrate aminotransferase and related aminotransferases Pab Pyrococcus abyssi Length = 454 Score = 237 bits (605), Expect = 4e-62, Method: Compositional matrix adjust. Identities = 147/386 (38%), Positives = 217/386 (56%), Gaps = 16/386 (4%) Query: 23 PGPKTAAALELSAR-TESMARGGGRMPIAMDQAFGVTFKDPDGNTFIDLSAGVGVSSVGR 81 PGPK +E + + + +++A GV + D DGN +D S+G+GV +VG Sbjct: 11 PGPKARKVIEEHHKYMATTTNDPNEYFLVIEKAEGVYWIDVDGNVILDFSSGIGVMNVGL 70 Query: 82 CNPRVVEAIRKQSESLMHS--MEVNSSKRTELAAKISEIMPEGLRGDCITFFTQGGSDAL 139 NP+V+EAI+KQ + ++H+ + + + ELA K+ EI P + F + G++A Sbjct: 71 RNPKVIEAIKKQLDLVLHAAGTDYYNPYQVELAKKLIEIAPGDMERKV--FLSNSGTEAN 128 Query: 140 EAAVKFAKRVTGRHQIIAFHGGYHGIWNASNALT-TGTAYRKGFGPFMGGVIHAPYPYAY 198 EAA+K AK T R IAF G +HG + + +LT + +R P M GV H PYP Y Sbjct: 129 EAALKIAKWSTNRKMFIAFIGAFHGRTHGTMSLTASKPVHRSRMFPTMPGVEHVPYPNPY 188 Query: 199 RFPF--DTSNKSAEQI--AGEYVDYLLNTPYTAADDVAAVIVEPVQGEGGYVPPSPEFLQ 254 R P+ D E I EY++ L Y A++VA + EP+QGEGGYV P F + Sbjct: 189 RNPWGIDGYENPDELINRVIEYIEDYLFEHYVPAEEVAGIFFEPIQGEGGYVVPPKNFFK 248 Query: 255 ILRKACDRSGALLIVDEVQAGAGRTGKMWAVEHSGVKPDMLTFGKGIGGDMPMAGLVMRS 314 L+K D+ G LLI DEVQ G GRTG+MWA+EH V PD++T K +GG +P+ + R+ Sbjct: 249 ELKKLADKHGILLIDDEVQMGMGRTGRMWAIEHFDVVPDIITVAKALGGGIPIGATIFRA 308 Query: 315 DLAAKIPDGSQPNTFAANSISAAVALTNISILQDPRLDLVNRAHALGLEAQERIRSFNSH 374 DL + G NTF N+++AA AL I LQ+ L+ A L +ER+ Sbjct: 309 DLDFGV-SGVHSNTFGGNAVAAAAALAVIEELQN---GLIENAQKLEPLFRERLEEMKEK 364 Query: 375 W--VGEVRGRGLMIGIELVENRETRD 398 + +G+VRG GL G+E V++R+T++ Sbjct: 365 YEIIGDVRGLGLAWGVEFVKDRKTKE 390 >PAE1799 [E] COG0160 4-aminobutyrate aminotransferase and related aminotransferases Pya Pyrobaculum aerophilum Length = 448 Score = 235 bits (600), Expect = 1e-61, Method: Compositional matrix adjust. Identities = 146/394 (37%), Positives = 226/394 (57%), Gaps = 24/394 (6%) Query: 13 DAPKMVSSTYPGPKTAAALELSARTES--MARGGGRMPIAMDQAFGVTFKDPDGNTFIDL 70 D PK+V PGPK ALE+ R E M P+ + + +G +D DGN ++D Sbjct: 12 DVPKIVVEP-PGPK---ALEIVKRDEELIMQSFARWYPLVIARGYGPVVEDVDGNLYVDF 67 Query: 71 SAGVGVSSVGRCNPRVVEAIRKQSESLMHS--MEVNSSKRTELAAKISEIMPEGLRGDCI 128 ++G+ V++VG +P+VVEAI++Q+E +H + +LA ++ I P + G Sbjct: 68 NSGIAVTNVGHAHPKVVEAIKRQAELFLHYSLTDFYYEIAVKLAERLVSIAP--ISGRKK 125 Query: 129 TFFTQGGSDALEAAVKFAKRVTG--RHQIIAFHGGYHGIWNASNALT-TGTAYRKGFGPF 185 FFT G++++E +K A+ R +IAF G +HG S +LT + +R+ F P Sbjct: 126 VFFTNSGTESVEGVLKIARGYFKGQRPYVIAFLGAFHGRTYGSMSLTASKPVHRRHFSPL 185 Query: 186 MGGVIHAPYPYAYRFPFDTSN-KSAEQIAGEYVDYLLNTPYTAADDVAAVIVEPVQGEGG 244 + VIHAPYP+ R PF S+ + + A +++ + +V+ VI+EP+QGEGG Sbjct: 186 VPNVIHAPYPHPVRCPFKASDPEECGEYALAFIEDWIFKRLVDPSEVSLVIIEPIQGEGG 245 Query: 245 YVPPSPEFLQILRKACDRSGALLIVDEVQAGAGRTGKMWAVEHSGVKPDMLTFGKGIGGD 304 YV P F+Q LRK + G L VDEVQ G GRTGK +AVEH GV+PD++ K I Sbjct: 246 YVVPPKNFIQGLRKLTQKHGILFAVDEVQTGFGRTGKWFAVEHFGVEPDLIATAKAIAAG 305 Query: 305 MPMAGLVMRSDLAAKIPDGSQPNTFAANSISAAVALTNISILQDPRLDLVNRAHALGLEA 364 +P+ ++ R+++ + +P G+ NTF N ++AA AL +I ++++ L++ A LG Sbjct: 306 LPLGAIIGRAEVMS-LPRGAHANTFGGNPVAAAAALASIEVIEEE--GLLHHAQTLG--- 359 Query: 365 QERIRSFNSHWVGE---VRGRGLMIGIELVENRE 395 E ++ F VGE VRG GLMIGIEL++ R+ Sbjct: 360 -EELKKFFKDEVGEKHDVRGLGLMIGIELLDERK 392