BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0024.0151.p (1036 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSp0312 [V] COG0841 Cation/multidrug efflux pump Rso Ralstonia s... 1495 0.0 RSc0010 [V] COG0841 Cation/multidrug efflux pump Rso Ralstonia s... 1185 0.0 SMc02867 [V] COG0841 Cation/multidrug efflux pump Sme Sinorhizob... 1173 0.0 AGl3217 [V] COG0841 Cation/multidrug efflux pump Atu Agrobacteri... 1162 0.0 PA4598 [V] COG0841 Cation/multidrug efflux pump Pae Pseudomonas ... 1139 0.0 >RSp0312 [V] COG0841 Cation/multidrug efflux pump Rso Ralstonia solanacearum Length = 1049 Score = 1495 bits (3870), Expect = 0.0, Method: Compositional matrix adjust. Identities = 763/1011 (75%), Positives = 879/1011 (86%) Query: 1 MPRFFIDRPIFAWVVALFIVLFGVIAMSQLPIARYPSVAPPSVTINATYPGATPQTMNDG 60 MP+FFI RP+FAWV+ALFI+L G IA+ +LPIARYPSVAPP+V ++ATYPGATPQTMNDG Sbjct: 1 MPQFFIRRPVFAWVIALFIILLGAIAIPKLPIARYPSVAPPTVNLSATYPGATPQTMNDG 60 Query: 61 VISLIERELSGVKNLLYFESSADTSGSAQITVTFKPGTDPELAQVDVQNKLKAIEARLPQ 120 VISLIERELS VKNLLYFESS+DTSGSA I TFKPGTDP +AQVDVQNKLKAIE RLPQ Sbjct: 61 VISLIERELSSVKNLLYFESSSDTSGSASIVATFKPGTDPAMAQVDVQNKLKAIEPRLPQ 120 Query: 121 TVRQNGVTVESAASGFLLMVSLTSVDGRHDEIRLNDYLARNIVEELRRVDGVGRVQLFGA 180 VRQNG+TVESA+SGFL+++ L S DGR DE L+DY+ARN+VEELRR++GVGRVQLFGA Sbjct: 121 VVRQNGLTVESASSGFLMIIGLQSDDGRFDETALSDYMARNVVEELRRIEGVGRVQLFGA 180 Query: 181 EQAMRIWIDPFKLNAFGLSVTDISTAISQQNAQIAPGRLGDTPTVPGQQIAVPLTVQGQL 240 EQAMRIW+DP KL A+GLS+ D+S AISQQNAQIAPG +G +P +P Q++ VPLTVQGQL Sbjct: 181 EQAMRIWVDPAKLIAYGLSMNDLSAAISQQNAQIAPGSVGASPALPAQRVTVPLTVQGQL 240 Query: 241 QSPDQFASIVLKAKADGSRVLLGDVARVELGAQSYAFANREDGKPAGVAAVQLSPGANAV 300 +P+QFA+IVL+A A+GS+V++GDVARVELGAQSY F NRE+GK A AAVQL+PGANAV Sbjct: 241 TTPEQFAAIVLRANANGSKVVMGDVARVELGAQSYGFINRENGKAATAAAVQLAPGANAV 300 Query: 301 RTAAAIQARMEELRPSLPQGMQFSLPYNTAPFVKISIQKVVQTLIEAMVLVFLVMYLFLQ 360 RTA +QARM EL ++P GM +S+P+NTAPFVKISI+KV+QTLIEAMVLVFLVMYLFLQ Sbjct: 301 RTAEGVQARMAELSRTMPAGMSYSIPFNTAPFVKISIEKVIQTLIEAMVLVFLVMYLFLQ 360 Query: 361 NVRYTVIPAIVAPIALLGTLAVMLVAGYSVNVLTMFGMVLAIGIIVDDAIVVVENVERIM 420 NVRYT+IPAIVAPIALLGT +ML +G+S+NVLTMFGMVLAIGIIVDDAIVVVENVER+M Sbjct: 361 NVRYTLIPAIVAPIALLGTFTIMLASGFSINVLTMFGMVLAIGIIVDDAIVVVENVERLM 420 Query: 421 AEEGLGPREATIKAMGEITGAIIGITLVLTAVFIPMALAGGSVGVIYRQFSLAMAVSILF 480 A+EGL PR+ATIKAM EITGA+IGITLVLTAVFIPMALA GSVGVIY+QF+L+MAVSI+F Sbjct: 421 AQEGLSPRDATIKAMKEITGAVIGITLVLTAVFIPMALASGSVGVIYQQFTLSMAVSIVF 480 Query: 481 SAFLALSLTPALCATLLKPVAPGHHEKRGFFGAFNRAFARLTRRYESLLGRLIARGLRMM 540 SAFLAL+LTPALCATLLKPV P HHEKRG FG FNR F R+T+ Y + +G+L+ R R+M Sbjct: 481 SAFLALTLTPALCATLLKPVDPAHHEKRGVFGWFNRRFDRITQGYAARVGKLVTRTGRVM 540 Query: 541 LLYGALSLLLVLGLRALPSAFLPEEDQGYFMTSFQLPADATTERTARAVDQFERYLKTRE 600 L++GA++ +L L R LPS+FLPEEDQGYFMT+FQLPADAT ERT V FER++ +R Sbjct: 541 LVFGAIAAVLALAFRQLPSSFLPEEDQGYFMTTFQLPADATAERTLDVVKAFERHVASRA 600 Query: 601 DIGANLSVLGFGFSGSGPNAAMAFTELKDWKERKGSTAAIEAQHAQAAMENGVDGMVMSL 660 I +N+S++GFGFSGSG NAAMAFT LKDW R G+TA E + AQ AM +G VMSL Sbjct: 601 SIQSNMSIVGFGFSGSGSNAAMAFTMLKDWDARNGATAQNEMRLAQQAMAGATEGTVMSL 660 Query: 661 LPPAIEELGNSSGFAMRLQDRANQGHAALKAAEAQLLALAAHSPKLAGVYADGLPPGASL 720 LPPAI+ELG SSGF +RLQDRANQG AALKAAE +LL LAA S ++GVY DGLP G S+ Sbjct: 661 LPPAIDELGTSSGFTLRLQDRANQGDAALKAAETKLLELAAQSRIVSGVYPDGLPAGTSI 720 Query: 721 QLNVDRHKAAALGVSFASISDTLSAAMGSFYVNDFPNAGRMQQVIIQAQAQSRMQIEDLM 780 +L++DR KA ALGV+F SIS+TLS A+GS YVNDFPNAGRMQQVIIQA A +RMQI+D++ Sbjct: 721 RLDIDRQKAEALGVAFTSISETLSTAIGSLYVNDFPNAGRMQQVIIQADAPARMQIDDVL 780 Query: 781 KLYVRNQNGGMVPLSEMVQAQWQVVPTQLQRYQGFPAVRISGSAAPGVASGDAMAEMESL 840 KLYVRN GGMVPLSE+V+ W P QL R+QGFPA RISG+AAPG +SG AMAEME L Sbjct: 781 KLYVRNAGGGMVPLSEVVRPVWSETPLQLVRFQGFPAARISGNAAPGASSGAAMAEMERL 840 Query: 841 AKQLPPGFAVAWTGQSLQERLSAAQAPMLMALSMLVVFLVLAALYESWRIPLSVMLVVPL 900 A QLPPGFA+AWTGQSLQER SAAQAPMLMALSMLVVFLVLAALYESW IPLSVMLVVPL Sbjct: 841 AAQLPPGFAIAWTGQSLQERQSAAQAPMLMALSMLVVFLVLAALYESWAIPLSVMLVVPL 900 Query: 901 GLIGAVAAVMLRDMPNDVFFKVGMITVIGLSAKNAILIVEFARQLRAEGAGLVEAAIKAA 960 GL+GAV AV+LR MPNDVFFKVGMITVIGLSAKNAILIVEFA+QLR +G GLVE+A+ AA Sbjct: 901 GLLGAVLAVLLRGMPNDVFFKVGMITVIGLSAKNAILIVEFAKQLREQGKGLVESAVTAA 960 Query: 961 VLRLRPILMTSLAFALGVVPLMLASGASAETQRAIGTGVFGGMVSATVLAV 1011 LRLRPILMTSLAF LGVVPLM+A GASAETQ AIGTGVFGGMVSATVLA+ Sbjct: 961 RLRLRPILMTSLAFGLGVVPLMIAMGASAETQHAIGTGVFGGMVSATVLAI 1011 >RSc0010 [V] COG0841 Cation/multidrug efflux pump Rso Ralstonia solanacearum Length = 1049 Score = 1185 bits (3065), Expect = 0.0, Method: Compositional matrix adjust. Identities = 589/1014 (58%), Positives = 751/1014 (74%), Gaps = 4/1014 (0%) Query: 1 MPRFFIDRPIFAWVVALFIVLFGVIAMSQLPIARYPSVAPPSVTINATYPGATPQTMNDG 60 M +FFIDRP+FAWV+ALFI++ G I+++QLPIA+YP++APPS+ I ATYPGA+ +T++D Sbjct: 1 MAKFFIDRPVFAWVLALFIIVAGAISITQLPIAQYPTIAPPSIIITATYPGASAKTLDDA 60 Query: 61 VISLIERELSGVKNLLYFES-SADTSGSAQITVTFKPGTDPELAQVDVQNKLKAIEARLP 119 V S+IE+E++G LLY ES S +G A ITVTFKPGTDP LAQVDVQN+LK +EARLP Sbjct: 61 VTSIIEQEMNGADGLLYIESVSQAGNGQATITVTFKPGTDPALAQVDVQNRLKRVEARLP 120 Query: 120 QTVRQNGVTVESAASGFLLMVSLTSVDGRHDEIRLNDYLARNIVEELRRVDGVGRVQLFG 179 +V Q GV V+ S FLL +L S DG+ D + L DY++RN++ E++RV GVG+ LFG Sbjct: 121 SSVTQQGVQVDKTRSNFLLFATLISKDGKMDPVALGDYISRNVLNEVKRVPGVGQAVLFG 180 Query: 180 AEQAMRIWIDPFKLNAFGLSVTDISTAISQQNAQIAPGRLGDTPTVPGQQIAVPLTVQGQ 239 E+AMRIWIDP KL + L+ TD+ AI QNA ++ G LGD P+ Q IA + V+GQ Sbjct: 181 TERAMRIWIDPAKLVGYKLTPTDVYNAIRNQNALVSAGTLGDLPSTSDQPIAATVVVEGQ 240 Query: 240 LQSPDQFASIVLKAKADGSRVLLGDVARVELGAQSYAFANREDGKPAGVAAVQLSPGANA 299 + + +QF +IVL +K DGS+V + DVAR+ELG Q+YA + R +G+P VQLSP NA Sbjct: 241 MTTTEQFGNIVLVSKPDGSQVRIKDVARLELGGQTYATSARINGQPISAIGVQLSPTGNA 300 Query: 300 VRTAAAIQARMEELRPSLPQGMQFSLPYNTAPFVKISIQKVVQTLIEAMVLVFLVMYLFL 359 + TA A++A+++EL P G+++ +PY+T+ FV+ISI++VV+TL EAM LVFLVM +FL Sbjct: 301 LGTAKAVKAKLDELSKYFPAGVEYKIPYDTSKFVQISIEEVVKTLFEAMALVFLVMLVFL 360 Query: 360 QNVRYTVIPAIVAPIALLGTLAVMLVAGYSVNVLTMFGMVLAIGIIVDDAIVVVENVERI 419 QN+RYT+IP+IV PI+LLG A M G+S+NVLTMFG+VLAIGI+VDDAIVVVENVERI Sbjct: 361 QNIRYTLIPSIVVPISLLGAFATMNALGFSINVLTMFGLVLAIGILVDDAIVVVENVERI 420 Query: 420 MAEEGLGPREATIKAMGEITGAIIGITLVLTAVFIPMALAGGSVGVIYRQFSLAMAVSIL 479 M++EGL PREAT KAMG+ITGAIIGITLVL AVFIPMA GSVG IYRQFSL+M SI Sbjct: 421 MSQEGLPPREATRKAMGQITGAIIGITLVLMAVFIPMAFFSGSVGAIYRQFSLSMVASIF 480 Query: 480 FSAFLALSLTPALCATLLKPVAPG-HHEKRGFFGAFNRAFARLTRRYESLLGRLIARGLR 538 FSA +AL+LTPALC+TLLKP+ G HHEK+GFFG FNR F T RY+SL+ R++ + R Sbjct: 481 FSALMALTLTPALCSTLLKPIEKGSHHEKKGFFGWFNRMFTSTTDRYQSLVERVLKKTFR 540 Query: 539 MMLLYGALSLLLVLGLRALPSAFLPEEDQGYFMTSFQLPADATTERTARAVDQFERYLKT 598 M++YGAL +V LPS+FLP EDQGY +T+ QLP A+ RT + E Y + Sbjct: 541 YMVIYGALIAAVVFLFMRLPSSFLPNEDQGYIITNIQLPPAASANRTLEVIKHVENYYQH 600 Query: 599 REDIGANLSVLGFGFSGSGPNAAMAFTELKDWKERKGSTAAIE-AQHAQAAMENGV-DGM 656 + + ++V GF FSG+GPNAA+ FT LKDW R +A A A A+ G+ D + Sbjct: 601 EKAVENIVAVQGFSFSGNGPNAALVFTTLKDWSSRGADQSADAVAGRAFGALFGGIRDAI 660 Query: 657 VMSLLPPAIEELGNSSGFAMRLQDRANQGHAALKAAEAQLLALAAHSPKLAGVYADGLPP 716 V L PP I ELGN++GF RLQDR GH AL AA QLL +A S L V DGL Sbjct: 661 VFPLNPPPIPELGNATGFTFRLQDRGGLGHDALMAARNQLLGMAGQSKVLKNVRPDGLED 720 Query: 717 GASLQLNVDRHKAAALGVSFASISDTLSAAMGSFYVNDFPNAGRMQQVIIQAQAQSRMQI 776 Q+++DR KA ALGV+FA I++ LS A+GS Y NDFPN GR Q+VI+QA +RMQ Sbjct: 721 SPQYQVDIDREKANALGVAFADINNVLSTALGSAYANDFPNYGRQQRVIVQADRINRMQP 780 Query: 777 EDLMKLYVRNQNGGMVPLSEMVQAQWQVVPTQLQRYQGFPAVRISGSAAPGVASGDAMAE 836 ED+M LYVRN G MVP+S + W V P QL RY G+P+VRISG AA G ++GDAM E Sbjct: 781 EDIMNLYVRNTQGSMVPMSAFAKGHWVVGPVQLVRYNGYPSVRISGDAATGASTGDAMDE 840 Query: 837 MESLAKQLPPGFAVAWTGQSLQERLSAAQAPMLMALSMLVVFLVLAALYESWRIPLSVML 896 ME LA +LP G WTGQSLQE+ S +QAP L ALS+L VFLVLAALYESW IP +V+L Sbjct: 841 MEHLASRLPAGIGFEWTGQSLQEKSSGSQAPALYALSLLAVFLVLAALYESWSIPAAVIL 900 Query: 897 VVPLGLIGAVAAVMLRDMPNDVFFKVGMITVIGLSAKNAILIVEFARQLRAEGAGLVEAA 956 VVPLG++GA+ V LR MP+DV+FKVG+I V+GLSAKNAILI+EFA+ L+A+G GL+EA Sbjct: 901 VVPLGVLGALLGVTLRFMPDDVYFKVGLIAVVGLSAKNAILIIEFAKDLQAQGKGLIEAT 960 Query: 957 IKAAVLRLRPILMTSLAFALGVVPLMLASGASAETQRAIGTGVFGGMVSATVLA 1010 ++A LR RPI+MTS AF LGV+PL +A+GAS+ +QRAIGTGV GGM++ATVLA Sbjct: 961 LEAVHLRFRPIIMTSFAFILGVLPLAIATGASSASQRAIGTGVMGGMITATVLA 1014 >SMc02867 [V] COG0841 Cation/multidrug efflux pump Sme Sinorhizobium meliloti Length = 1048 Score = 1173 bits (3035), Expect = 0.0, Method: Compositional matrix adjust. Identities = 594/1013 (58%), Positives = 749/1013 (73%), Gaps = 2/1013 (0%) Query: 1 MPRFFIDRPIFAWVVALFIVLFGVIAMSQLPIARYPSVAPPSVTINATYPGATPQTMNDG 60 MP FFIDRPIFAWVVA+FI++ G+IA+ LP+++YP VAPP ++IN YPGA+ Q Sbjct: 1 MPSFFIDRPIFAWVVAIFIMIAGIIAIPLLPVSQYPDVAPPQISINTNYPGASSQDTYQS 60 Query: 61 VISLIERELSGVKNLLYFESSADTSGSAQITVTFKPGTDPELAQVDVQNKLKAIEARLPQ 120 V LIE EL+GV+ LLYFESS +SGS I TF+PGTDP A VD+QN+++ +E RLP Sbjct: 61 VTRLIEDELNGVEGLLYFESSTSSSGSVSIDATFQPGTDPSQASVDIQNRVQRVEPRLPD 120 Query: 121 TVRQNGVTVESAASGFLLMVSLTSVDGRHDEIRLNDYLARNIVEELRRVDGVGRVQLFGA 180 VRQ GV V+ A +GFLL++SLTS DG D I L DYL+RN++ E++RV GVGR QLF Sbjct: 121 PVRQQGVQVDEAGAGFLLIISLTSTDGSMDAIGLGDYLSRNVLSEIQRVPGVGRAQLFAT 180 Query: 181 EQAMRIWIDPFKLNAFGLSVTDISTAISQQNAQIAPGRLGDTPTVPGQQIAVPLTVQGQL 240 E++MR+W+DP K+ L+ D++ AI QNAQIA G +G P QQ+ P+ ++GQL Sbjct: 181 ERSMRVWLDPDKMLGLNLTAADVTAAIQAQNAQIASGSIGAQPNPITQQVTAPVVIKGQL 240 Query: 241 QSPDQFASIVLKAKADGSRVLLGDVARVELGAQSYAFANREDGKPAGVAAVQLSPGANAV 300 SP++F +IVL+A ADGS V L DVAR+E+G +SY F+ R +G P+ AVQLSP NA+ Sbjct: 241 SSPEEFGAIVLRANADGSAVRLRDVARLEIGGESYTFSTRLNGSPSAAIAVQLSPSGNAM 300 Query: 301 RTAAAIQARMEELRPSLPQGMQFSLPYNTAPFVKISIQKVVQTLIEAMVLVFLVMYLFLQ 360 T+AAI+ARM+EL P+G+++S+PY+T+PFV +SI+KV+ TL+EA+ LVFLVM+LFLQ Sbjct: 301 STSAAIKARMDELAEFFPEGLEYSIPYDTSPFVAVSIEKVLHTLVEAVGLVFLVMFLFLQ 360 Query: 361 NVRYTVIPAIVAPIALLGTLAVMLVAGYSVNVLTMFGMVLAIGIIVDDAIVVVENVERIM 420 NVRYT+IP IV P+ALLGT AVML G+S+NVLTMFGMVLAIGI+VDDAI+VVENVERIM Sbjct: 361 NVRYTIIPTIVVPVALLGTCAVMLAMGFSINVLTMFGMVLAIGILVDDAIIVVENVERIM 420 Query: 421 AEEGLGPREATIKAMGEITGAIIGITLVLTAVFIPMALAGGSVGVIYRQFSLAMAVSILF 480 +EEGL P++AT KAM +ITGA+IGITLVL +VFIPMA G+VGVIYRQFSL M VSILF Sbjct: 421 SEEGLTPKDATRKAMKQITGAVIGITLVLASVFIPMAFFPGAVGVIYRQFSLTMVVSILF 480 Query: 481 SAFLALSLTPALCATLLKPVAPGHHE-KRGFFGAFNRAFARLTRRYESLLGRLIARGLRM 539 SA LALSLTPALCA+ LK V GHH KRGFFG FNR F R + Y +G ++ R R Sbjct: 481 SALLALSLTPALCASFLKQVPKGHHHAKRGFFGWFNRGFDRTSHGYTRAVGGIVRRTGRF 540 Query: 540 MLLYGALSLLLVLGLRALPSAFLPEEDQGYFMTSFQLPADATTERTARAVDQFERYLKTR 599 M++Y AL L LPS+FLP+EDQG+ + QLP++AT RT ++Q E Sbjct: 541 MVIYLALLAGLGWAFLQLPSSFLPDEDQGFVIVMMQLPSEATANRTTEVIEQTETIFGQE 600 Query: 600 EDIGANLSVLGFGFSGSGPNAAMAFTELKDWKERKGSTAAIE-AQHAQAAMENGVDGMVM 658 + + +++ GF F GSG NA +AF LKDW ER +A A A AM D + Sbjct: 601 KAVDTIVAINGFSFFGSGQNAGLAFVTLKDWSERDADNSAQSIAGRATMAMSQIKDAISF 660 Query: 659 SLLPPAIEELGNSSGFAMRLQDRANQGHAALKAAEAQLLALAAHSPKLAGVYADGLPPGA 718 +L PPAI+ LG + GF+ RLQDRA G AAL A QLL LA+ S L GV +G+P A Sbjct: 661 ALSPPAIQGLGTTGGFSFRLQDRAGLGQAALAEARDQLLDLASQSKVLTGVRFEGMPDAA 720 Query: 719 SLQLNVDRHKAAALGVSFASISDTLSAAMGSFYVNDFPNAGRMQQVIIQAQAQSRMQIED 778 + +N+DR KA GV+FA I+ T+S +GS YVNDFPNAGRMQ+V +QA RMQ D Sbjct: 721 QVSVNIDREKANTFGVTFADINSTISTNLGSSYVNDFPNAGRMQRVTVQADETKRMQTAD 780 Query: 779 LMKLYVRNQNGGMVPLSEMVQAQWQVVPTQLQRYQGFPAVRISGSAAPGVASGDAMAEME 838 L+ L VRN NGGMVPLS +W PTQ Y G+PAVRISG AAPG +SGDA+AEME Sbjct: 781 LLNLNVRNSNGGMVPLSAFADVEWVKAPTQTVGYNGYPAVRISGEAAPGYSSGDAIAEME 840 Query: 839 SLAKQLPPGFAVAWTGQSLQERLSAAQAPMLMALSMLVVFLVLAALYESWRIPLSVMLVV 898 L +LP GF WTGQSLQE S +QAP+L+ALS L+VFL LAALYESW IP+SV++VV Sbjct: 841 RLVAELPAGFGYEWTGQSLQEIQSGSQAPLLIALSCLLVFLCLAALYESWSIPVSVIMVV 900 Query: 899 PLGLIGAVAAVMLRDMPNDVFFKVGMITVIGLSAKNAILIVEFARQLRAEGAGLVEAAIK 958 PLG+IGAV AV +RDMPNDV+FKVG+I +IGLSAKNAILI+EFA++LR +G L+++ ++ Sbjct: 901 PLGVIGAVLAVTMRDMPNDVYFKVGLIAIIGLSAKNAILIIEFAKELREQGKSLIDSTLE 960 Query: 959 AAVLRLRPILMTSLAFALGVVPLMLASGASAETQRAIGTGVFGGMVSATVLAV 1011 AA LR RPILMTSLAF LGV+PL +A+GAS+ +QRAIGTGV GGM+SATVLA+ Sbjct: 961 AAHLRFRPILMTSLAFTLGVLPLAIATGASSGSQRAIGTGVMGGMISATVLAI 1013 >AGl3217 [V] COG0841 Cation/multidrug efflux pump Atu Agrobacterium tumefaciens strain C58 (Cereon) Length = 1044 Score = 1162 bits (3005), Expect = 0.0, Method: Compositional matrix adjust. Identities = 599/1013 (59%), Positives = 765/1013 (75%), Gaps = 3/1013 (0%) Query: 1 MPRFFIDRPIFAWVVALFIVLFGVIAMSQLPIARYPSVAPPSVTINATYPGATPQTMNDG 60 M RFFIDRPIFAWVVA+FI+L G++A+ LPIA+YP+VAPP ++I YPGA+P+ + Sbjct: 1 MARFFIDRPIFAWVVAIFIMLAGLLAIPMLPIAQYPNVAPPQISIGTNYPGASPEDIYQS 60 Query: 61 VISLIERELSGVKNLLYFESSADTSGSAQITVTFKPGTDPELAQVDVQNKLKAIEARLPQ 120 V IE EL+GV L+YFES++++SG I VTF+PGT+ AQV+VQN++ +E RLP+ Sbjct: 61 VTRPIEEELNGVPGLIYFESTSESSGRISINVTFEPGTNIGEAQVEVQNRIARVEPRLPR 120 Query: 121 TVRQNGVTVESAASGFLLMVSLTSVDGRHDEIRLNDYLARNIVEELRRVDGVGRVQLFGA 180 +V Q G+ VE A + FL+MV+LTSVDG D I L DYL+RN++ ELRRV GVG QLF Sbjct: 121 SVTQQGLRVEQAGTSFLMMVALTSVDGNTDAIGLGDYLSRNVLGELRRVPGVGSAQLFAT 180 Query: 181 EQAMRIWIDPFKLNAFGLSVTDISTAISQQNAQIAPGRLGDTPTVPGQQIAVPLTVQGQL 240 +++MRIW+DP K+ L+ D+ AI QN+Q+A GR+G +P GQQI+ + VQGQL Sbjct: 181 QRSMRIWMDPDKMLGLSLTSDDVINAIQAQNSQVAAGRIGASPNPVGQQISATVNVQGQL 240 Query: 241 QSPDQFASIVLKAKADGSRVLLGDVARVELGAQSYAFANREDGKPAGVAAVQLSPGANAV 300 SP++F SIVL+A DGS V L DVARVE+G +SY F++R +GKP+ VQLSP ANA+ Sbjct: 241 TSPEEFGSIVLRANPDGSSVRLRDVARVEVGGESYNFSSRLNGKPSAAIGVQLSPTANAM 300 Query: 301 RTAAAIQARMEELRPSLPQGMQFSLPYNTAPFVKISIQKVVQTLIEAMVLVFLVMYLFLQ 360 +T+ ++A MEEL PQG+++ +PY+T+PFVKISI+KV+ TLIEAM+LVF+VM++FLQ Sbjct: 301 QTSEGVRATMEELSRYFPQGIEYEIPYDTSPFVKISIEKVIHTLIEAMILVFVVMFVFLQ 360 Query: 361 NVRYTVIPAIVAPIALLGTLAVMLVAGYSVNVLTMFGMVLAIGIIVDDAIVVVENVERIM 420 N+RYT+IP +V P+ALLGT AVM V+G+S+NVLTMF MVLAIGI+VDDAIVVVENVERIM Sbjct: 361 NIRYTIIPTLVVPVALLGTCAVMYVSGFSINVLTMFAMVLAIGILVDDAIVVVENVERIM 420 Query: 421 AEEGLGPREATIKAMGEITGAIIGITLVLTAVFIPMALAGGSVGVIYRQFSLAMAVSILF 480 AEE L P+EAT KAMG+I+GAIIGITLVLTAVF+PMA G+VG+IY+QFSL M VSILF Sbjct: 421 AEEHLSPKEATRKAMGQISGAIIGITLVLTAVFVPMAFFPGAVGIIYQQFSLTMVVSILF 480 Query: 481 SAFLALSLTPALCATLLKPVAPGHHEKRGFFGAFNRAFARLTRRYESLLGRLIARGLRMM 540 S FLALSLTPALCA+ LKP+ GHHEK+GFFG FNR F + + +Y S +G +I R R M Sbjct: 481 SGFLALSLTPALCASFLKPIKAGHHEKKGFFGWFNRNFDKASHKYSSSVGGIIKRSGRFM 540 Query: 541 LLYGALSLLLVLGLRALPSAFLPEEDQGYFMTSFQLPADATTERTARAVDQFERYLKTRE 600 ++Y AL L LPS+FLP EDQGY + Q PA+A+TERT +++ Q E+ Sbjct: 541 IIYAALLAGLGWAYMQLPSSFLPNEDQGYLIVDIQAPAEASTERTLQSIQQIEKIFMEEP 600 Query: 601 DIGANLSVLGFGFSGSGPNAAMAFTELKDWKER--KGSTAAIEAQHAQAAMENGVDGMVM 658 + +++ GF FSGSG NA +AF LKDW ER + S AAI A+ + D M Sbjct: 601 AVERVIAISGFSFSGSGQNAGLAFATLKDWSERGPEDSAAAISAR-INGKLWGLPDAMSF 659 Query: 659 SLLPPAIEELGNSSGFAMRLQDRANQGHAALKAAEAQLLALAAHSPKLAGVYADGLPPGA 718 +L PP I+ LGNSSGF RLQDR+ G AL AA AQL+A A SP LAG+ +G+P A Sbjct: 660 ALSPPPIQGLGNSSGFTFRLQDRSGAGQTALSAAGAQLMAAARQSPVLAGLRIEGMPDAA 719 Query: 719 SLQLNVDRHKAAALGVSFASISDTLSAAMGSFYVNDFPNAGRMQQVIIQAQAQSRMQIED 778 + L +DR KA GV+F+ I+ T+SA MGS YVNDFPNAGRMQ+V +QA+ RM+ ED Sbjct: 720 QVNLIIDREKANTFGVTFSDINATISANMGSSYVNDFPNAGRMQRVTVQAEQGQRMKTED 779 Query: 779 LMKLYVRNQNGGMVPLSEMVQAQWQVVPTQLQRYQGFPAVRISGSAAPGVASGDAMAEME 838 L+ L VRN NGGMVP+S +W P+Q+ Y G+PA+R+SG +APG +SGDA+AEME Sbjct: 780 LLNLNVRNANGGMVPVSSFATVEWVRGPSQVVGYNGYPAIRVSGQSAPGYSSGDAIAEME 839 Query: 839 SLAKQLPPGFAVAWTGQSLQERLSAAQAPMLMALSMLVVFLVLAALYESWRIPLSVMLVV 898 LA++LP GF WTGQSLQE S +QAP L+ LS+L VFL+LAALYESW IPLSVMLVV Sbjct: 840 RLARELPGGFGFEWTGQSLQEIQSGSQAPALIGLSVLFVFLLLAALYESWSIPLSVMLVV 899 Query: 899 PLGLIGAVAAVMLRDMPNDVFFKVGMITVIGLSAKNAILIVEFARQLRAEGAGLVEAAIK 958 PLG+IG+VAAVMLR MPNDV+F VG++ +IGLSAKNAILI+EFA+ LRAEG +A ++ Sbjct: 900 PLGVIGSVAAVMLRGMPNDVYFLVGLVAIIGLSAKNAILIIEFAKDLRAEGKSTYDATVE 959 Query: 959 AAVLRLRPILMTSLAFALGVVPLMLASGASAETQRAIGTGVFGGMVSATVLAV 1011 AA LR RPILMTSLAF+LGV+P+ +ASGASA +Q AIGTGV GGM+SAT+LA+ Sbjct: 960 AAHLRFRPILMTSLAFSLGVLPMAIASGASAASQNAIGTGVLGGMISATILAI 1012 >PA4598 [V] COG0841 Cation/multidrug efflux pump Pae Pseudomonas aeruginosa Length = 1043 Score = 1139 bits (2946), Expect = 0.0, Method: Compositional matrix adjust. Identities = 594/1035 (57%), Positives = 754/1035 (72%), Gaps = 7/1035 (0%) Query: 1 MPRFFIDRPIFAWVVALFIVLFGVIAMSQLPIARYPSVAPPSVTINATYPGATPQTMNDG 60 M FFI RP FAWVVALFI L G++ +S+LP+A+YP+VAPP +TI ATYPGA+ + + D Sbjct: 1 MSEFFIKRPNFAWVVALFISLAGLLVISKLPVAQYPNVAPPQITITATYPGASAKVLVDS 60 Query: 61 VISLIERELSGVKNLLYFESSADTSGSAQITVTFKPGTDPELAQVDVQNKLKAIEARLPQ 120 V S++E L+G K LLYFES+ +++G+A+I VTF+PGTDP+LAQVDVQN+LK EAR+PQ Sbjct: 61 VTSVLEESLNGAKGLLYFESTNNSNGTAEIVVTFEPGTDPDLAQVDVQNRLKKAEARMPQ 120 Query: 121 TVRQNGVTVESAASGFLLMVSLTSVDG--RHDEIRLNDYLARNIVEELRRVDGVGRVQLF 178 V G+ VE ++GFLL+ +L+ +G R D L DY ARNI ELRR+ GVG++Q F Sbjct: 121 AVLTQGLQVEQTSAGFLLIYALSYKEGAQRSDTTALGDYAARNINNELRRLPGVGKLQFF 180 Query: 179 GAEQAMRIWIDPFKLNAFGLSVTDISTAISQQNAQIAPGRLGDTPTVPGQQIAVPLTVQG 238 +E AMR+WIDP KL FGLS+ D+S AI QN Q+ G G P Q++ L V+G Sbjct: 181 SSEAAMRVWIDPQKLVGFGLSIDDVSNAIRGQNVQVPAGAFGSAPGSSAQELTATLAVKG 240 Query: 239 QLQSPDQFASIVLKAKADGSRVLLGDVARVELGAQSYAFANREDGKPAGVAAVQLSPGAN 298 L P +F +VL+A DGS V L DVAR+ELG +SY ++R +G P A+QLSPGAN Sbjct: 241 TLDDPQEFGQVVLRANEDGSLVRLADVARLELGKESYNISSRLNGTPTVGGAIQLSPGAN 300 Query: 299 AVRTAAAIQARMEELRPSLPQGMQFSLPYNTAPFVKISIQKVVQTLIEAMVLVFLVMYLF 358 A++TA ++ R+ EL P+ MQ+S+PY+T+ FV ++I+KV+ TLIEAMVLVFLVM+LF Sbjct: 301 AIQTATLVKQRLAELSAFFPEDMQYSVPYDTSRFVDVAIEKVIHTLIEAMVLVFLVMFLF 360 Query: 359 LQNVRYTVIPAIVAPIALLGTLAVMLVAGYSVNVLTMFGMVLAIGIIVDDAIVVVENVER 418 LQNVRYT+IP+IV P+ LLGTL VM + G+SVN++TMFGMVLAIGI+VDDAIVVVENVER Sbjct: 361 LQNVRYTLIPSIVVPVCLLGTLMVMYLLGFSVNMMTMFGMVLAIGILVDDAIVVVENVER 420 Query: 419 IMAEEGLGPREATIKAMGEITGAIIGITLVLTAVFIPMALAGGSVGVIYRQFSLAMAVSI 478 IMAEEG+ P EAT+KAM +++GAI+GITLVL+AVF+P+A GSVGVIY+QFS+++AVSI Sbjct: 421 IMAEEGISPAEATVKAMKQVSGAIVGITLVLSAVFLPLAFMAGSVGVIYQQFSVSLAVSI 480 Query: 479 LFSAFLALSLTPALCATLLKPVAPGHHEKRGFFGAFNRAFARLTRRYESLLGRLIARGLR 538 LFS FLAL+ TPALCATLLKP+ GHHEKRGFFGAFNR FAR+T RY L +L+AR R Sbjct: 481 LFSGFLALTFTPALCATLLKPIPEGHHEKRGFFGAFNRGFARVTERYSLLNSKLVARAGR 540 Query: 539 MMLLYGALSLLLVLGLRALPSAFLPEEDQGYFMTSFQLPADATTERTARAVDQFERYLKT 598 ML+Y L +L LP AF+P ED GY + QLP A+ RT ++ ER+LK+ Sbjct: 541 FMLVYAGLVAMLGYFYLRLPEAFVPAEDLGYMVVDVQLPPGASRVRTDATGEELERFLKS 600 Query: 599 REDIGANLSVLGFGFSGSGPNAAMAFTELKDWKER---KGSTAAIEAQHAQAAMENGVDG 655 RE + + + GF FSG G NAA+AF KDW ER + + A I A + A+ + DG Sbjct: 601 REAVASVFLISGFSFSGQGDNAALAFPTFKDWSERGAEQSAAAEIAALNEHFALPD--DG 658 Query: 656 MVMSLLPPAIEELGNSSGFAMRLQDRANQGHAALKAAEAQLLALAAHSPKLAGVYADGLP 715 VM++ PP I LGNS GFA+RL DR+ G AL A LL +PK +GL Sbjct: 659 TVMAVSPPPINGLGNSGGFALRLMDRSGVGREALLQARDTLLGEIQTNPKFLYAMMEGLA 718 Query: 716 PGASLQLNVDRHKAAALGVSFASISDTLSAAMGSFYVNDFPNAGRMQQVIIQAQAQSRMQ 775 L+L +DR KA ALGVSF +IS TLSAA GS +NDF NAGR Q+V+IQA+ +RM Sbjct: 719 EAPQLRLLIDREKARALGVSFETISGTLSAAFGSEVINDFTNAGRQQRVVIQAEQGNRMT 778 Query: 776 IEDLMKLYVRNQNGGMVPLSEMVQAQWQVVPTQLQRYQGFPAVRISGSAAPGVASGDAMA 835 E +++LYV N G +VPLS V +W+ P QL RY G+P++RI G AAPG ++G+AMA Sbjct: 779 PESVLELYVPNAAGNLVPLSAFVSVKWEEGPVQLVRYNGYPSIRIVGDAAPGFSTGEAMA 838 Query: 836 EMESLAKQLPPGFAVAWTGQSLQERLSAAQAPMLMALSMLVVFLVLAALYESWRIPLSVM 895 EME LA QLP G WTG S QE++SA QA L AL++LVVFL+L ALYESW IPLSVM Sbjct: 839 EMERLASQLPAGIGYEWTGLSYQEKVSAGQATSLFALAILVVFLLLVALYESWSIPLSVM 898 Query: 896 LVVPLGLIGAVAAVMLRDMPNDVFFKVGMITVIGLSAKNAILIVEFARQLRAEGAGLVEA 955 L+VP+G IGAV AVM+ M NDV+FKVG+IT+IGLSAKNAILIVEFA++L +G L +A Sbjct: 899 LIVPIGAIGAVLAVMVSGMSNDVYFKVGLITIIGLSAKNAILIVEFAKELWEQGHSLRDA 958 Query: 956 AIKAAVLRLRPILMTSLAFALGVVPLMLASGASAETQRAIGTGVFGGMVSATVLAVLFVP 1015 AI+AA LR RPI+MTS+AF LGV+PL LASGA A +QRAIGTGV GGM+SAT L VLFVP Sbjct: 959 AIEAARLRFRPIIMTSMAFILGVIPLALASGAGAASQRAIGTGVIGGMLSATFLGVLFVP 1018 Query: 1016 LFFVLVLGAGRRRSA 1030 + FV +L R + A Sbjct: 1019 ICFVWLLSLLRSKPA 1033