BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0024.0128.p (541 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value PA5015 [C] COG2609 Pyruvate dehydrogenase complex, dehydrogenase... 567 e-161 RSc1600 [C] COG2609 Pyruvate dehydrogenase complex, dehydrogenas... 553 e-157 NMB1341 [C] COG2609 Pyruvate dehydrogenase complex, dehydrogenas... 553 e-157 XF0669 [C] COG2609 Pyruvate dehydrogenase complex, dehydrogenase... 552 e-157 NMA1554 [C] COG2609 Pyruvate dehydrogenase complex, dehydrogenas... 551 e-156 >PA5015 [C] COG2609 Pyruvate dehydrogenase complex, dehydrogenase (E1) component Pae Pseudomonas aeruginosa Length = 882 Score = 567 bits (1461), Expect = e-161, Method: Compositional matrix adjust. Identities = 293/540 (54%), Positives = 366/540 (67%), Gaps = 12/540 (2%) Query: 6 LCAIGATLTDEEINRLRRGGHDMKKIFSAYQAAASHRGQPTVILAQTKKGYGMGAAGEGK 65 L + L+DEEI +L RGGHD K+++AY A +H+GQPTVILA+T KGYG G+ GE K Sbjct: 339 LLEMVKDLSDEEIWKLNRGGHDPYKVYAAYHQAVNHKGQPTVILAKTIKGYGTGS-GEAK 397 Query: 66 MTTHQQKKLDEESLLQFRDRFKLPLTDEQCRELAFYKPADDSPEMKHLHARRAALGGYLP 125 H KK+D +SL FRD+F +P+ D +L FYKP + S E K+L RRAALGG++P Sbjct: 398 NIAHNVKKVDVDSLRAFRDKFDIPVKDADLEKLPFYKPEEGSAEAKYLAERRAALGGFMP 457 Query: 126 RRHAGDARRTVPPLEAHSKFALEADGKEMSSTMALVRQLGNLLKDKDFGQYVVPIVADEA 185 R VPPLE + +E+S+TMA VR + L+KDK+ G +VPIV DEA Sbjct: 458 VRRQKSMSVPVPPLETLKAMLDGSGDREISTTMAFVRIISQLVKDKELGPRIVPIVPDEA 517 Query: 186 RTFGMANLFRQVGIYSSQGQLYEPEDIGSILYYREAKDGQILEEGITEAGAISSWTAAAT 245 RTFGM +FRQ+GIYSS GQLYEP D +++YRE K GQILEEGI EAGA+SSW AA T Sbjct: 518 RTFGMEGMFRQLGIYSSVGQLYEPVDKDQVMFYREDKKGQILEEGINEAGAMSSWIAAGT 577 Query: 246 AYSVHGTPMLPFYIYYSMFGFQRIGDLIWAAADQRARGFLIGATSGRTTLGGEGLQHQDG 305 +YS H PMLPFYI+YSMFGFQRIGDL WAA D RA GFLIG T+GRTTL GEGLQH+DG Sbjct: 578 SYSTHNQPMLPFYIFYSMFGFQRIGDLAWAAGDSRAHGFLIGGTAGRTTLNGEGLQHEDG 637 Query: 306 NSLVTAASIPNCVSYDPAYAYELAVILDEGMRRMMERGDDVFYYITVTNENEAQPSLPEG 365 +S + A++IPNC +YDP YAYELAVI+ EG R+M+E D+FYYITV NEN QP++P+G Sbjct: 638 HSHLLASTIPNCRTYDPTYAYELAVIIREGSRQMIEEQQDIFYYITVMNENYVQPAMPKG 697 Query: 366 VQDGILRGMYCL---GRKPGAQVRLLGSGPILKEAVAAAALLQQHWQIDAEVWSVTSYTE 422 ++GI++GMY L ++ V+LLGSG IL+E AA LL+ + I A+VWSV S+ E Sbjct: 698 AEEGIIKGMYLLEEDKKEAAHHVQLLGSGTILREVEEAAKLLRNDFGIGADVWSVPSFNE 757 Query: 423 LARDGVAAQRAQRL--SGSVGQPYVTAQLQDSAAPVIAVSDYIRTLPESIRAFVPAP-YV 479 L RDG+A +R RL Q YV L PVIA +DY++ E IR +VP+ Y Sbjct: 758 LRRDGLAVERWNRLHPGQKPKQSYVEECLGGRRGPVIASTDYMKLYAEQIRQWVPSKEYK 817 Query: 480 TLGTDGFGRSDTRVNLRDFFEIDARWTAYTALCEVWGD----ERARLQEAARTLGIDTNK 535 LGTDGFGRSD+R LR+FFE+D W AL E D E + EA GID K Sbjct: 818 VLGTDGFGRSDSRKKLRNFFEVDRHWVVLAAL-EALADRGDIEPKVVAEAIAKYGIDPEK 876 >RSc1600 [C] COG2609 Pyruvate dehydrogenase complex, dehydrogenase (E1) component Rso Ralstonia solanacearum Length = 896 Score = 553 bits (1426), Expect = e-157, Method: Compositional matrix adjust. Identities = 277/548 (50%), Positives = 374/548 (68%), Gaps = 14/548 (2%) Query: 6 LCAIGATLTDEEINRLRRGGHDMKKIFSAYQAAASHRGQPTVILAQTKKGYGMGAAGEGK 65 L A+ A +D++I L RGGHD KIF+A+++A H+GQPTVILA+T KGYGMG AGE Sbjct: 351 LKAMVADWSDDDIWALNRGGHDPHKIFAAFKSATEHKGQPTVILAKTIKGYGMGEAGEAM 410 Query: 66 MTTHQQKKLDEESLLQFRDRFKLPLTDEQCRELAFYKPADDSPEMKHLHARRAALGGYLP 125 HQQKK+ +++ + RDRF +P+ D+Q + + K + S E++++ R LGGYLP Sbjct: 411 NIAHQQKKMPVDAIRKLRDRFNIPVADDQLEHVPYVKFEEGSKELEYMRRARMDLGGYLP 470 Query: 126 -RRHAGDARRTVPPLEAHSKF-ALEADGKEMSSTMALVRQLGNLLKDKDFGQYVVPIVAD 183 RR DA + VP L A +G+E+S+TMA VR L LLKDK+ G++VVPIV D Sbjct: 471 ARRQKADALQ-VPALAAFDALLKATGEGREVSTTMAFVRILNILLKDKNVGKHVVPIVPD 529 Query: 184 EARTFGMANLFRQVGIYSSQGQLYEPEDIGSILYYREAKDGQILEEGITEAGAISSWTAA 243 E+RTFGM LFRQVGI++ +GQ Y P+D +++Y+E++ GQ+L+EGI EAGA+ W AA Sbjct: 530 ESRTFGMEGLFRQVGIWNQEGQKYVPQDHDQLMFYKESQTGQVLQEGINEAGAMCDWIAA 589 Query: 244 ATAYSVHGTPMLPFYIYYSMFGFQRIGDLIWAAADQRARGFLIGATSGRTTLGGEGLQHQ 303 AT+YS HG M+PFYIYYSMFG QRIGDL WAA D R+RGFL+G T+GRTTL GEGLQH+ Sbjct: 590 ATSYSTHGVAMIPFYIYYSMFGIQRIGDLCWAAGDMRSRGFLLGGTAGRTTLNGEGLQHE 649 Query: 304 DGNSLVTAASIPNCVSYDPAYAYELAVILDEGMRRMMERGDDVFYYITVTNENEAQPSLP 363 DG+S V A+IPNC+SYDP + YELAV++ +G+RRM +DV+YY+TV NEN P +P Sbjct: 650 DGHSHVYHAAIPNCISYDPTFQYELAVVMQDGLRRMYVEQEDVYYYLTVMNENYEHPEMP 709 Query: 364 EGVQDGILRGMYCLGR----KPGAQVRLLGSGPILKEAVAAAALLQQHWQIDAEVWSVTS 419 G + I++GMY + +V+LLGSG I +E +AAA LL++ W +++++W S Sbjct: 710 AGAEADIIKGMYLFKKGVENSNAPRVQLLGSGTIFREVIAAAELLKKDWGVESDLWGCPS 769 Query: 420 YTELARDGVAAQRAQRL--SGSVGQPYVTAQLQDSAAPVIAVSDYIRTLPESIRAFVPAP 477 +TELAR+G AA R L + + + +V L+ PVIA +DY+RT E IRAFVP Sbjct: 770 FTELAREGNAAARWNLLHPTDAPRESHVEKMLKGVRGPVIASTDYVRTFAEQIRAFVPRR 829 Query: 478 YVTLGTDGFGRSDTRVNLRDFFEIDARWTAYTALCEVWGDE----RARLQEAARTLGIDT 533 YV LGTDGFGRSDTR LR FFE+D W +L + DE R ++ EA + +D Sbjct: 830 YVVLGTDGFGRSDTREKLRHFFEVDRYWVTVASLKAL-ADEGVLPREKVAEALKKYNLDP 888 Query: 534 NKPLSSSV 541 NKP +V Sbjct: 889 NKPNPMTV 896 >NMB1341 [C] COG2609 Pyruvate dehydrogenase complex, dehydrogenase (E1) component Nme Neisseria meningitidis MC58 Length = 887 Score = 553 bits (1425), Expect = e-157, Method: Compositional matrix adjust. Identities = 275/504 (54%), Positives = 356/504 (70%), Gaps = 7/504 (1%) Query: 6 LCAIGATLTDEEINRLRRGGHDMKKIFSAYQAAASH-RGQPTVILAQTKKGYGMGAAGEG 64 L A+ A +TDE++ L RGGHD +K+++AY AA+H G+PTVILA+T KGYGMGA+GEG Sbjct: 342 LKALVADMTDEQLWALNRGGHDPQKVYNAYDRAANHADGKPTVILAKTIKGYGMGASGEG 401 Query: 65 KMTTHQQKKLDEESLLQFRDRFKLPLTDEQCR--ELAFYKPADDSPEMKHLHARRAALGG 122 + HQ KK+D+ SL QFRDRF +P+TDEQ +L + A D+ E K+LHARR ALGG Sbjct: 402 QNVAHQAKKMDKASLKQFRDRFDIPVTDEQIESGDLPYLTFAPDTEEYKYLHARRDALGG 461 Query: 123 YLPRRHAGDARRTVPPLEAHSKFALEADGKEMSSTMALVRQLGNLLKDKDFGQYVVPIVA 182 YLP+R VP L A + +E S+TMA VR L LLKDK G+ VVPIV Sbjct: 462 YLPQRKPTQEVLEVPELSAFDAQLKSSGEREFSTTMAFVRILSTLLKDKKIGKRVVPIVP 521 Query: 183 DEARTFGMANLFRQVGIYSSQGQLYEPEDIGSILYYREAKDGQILEEGITEAGAISSWTA 242 DE+RTFGM +FRQ GI++ +GQ Y P+D +++Y+E+ DGQIL+EGI E GA++ W A Sbjct: 522 DESRTFGMEGMFRQYGIWNPKGQQYTPQDKDQLMFYKESVDGQILQEGINEPGAMADWIA 581 Query: 243 AATAYSVHGTPMLPFYIYYSMFGFQRIGDLIWAAADQRARGFLIGATSGRTTLGGEGLQH 302 AAT+Y+ M+PFYIYYSMFGFQRIGDL WAA D ARGFL+G T+GRTTL GEGLQH Sbjct: 582 AATSYANSNFAMIPFYIYYSMFGFQRIGDLAWAAGDMHARGFLLGGTAGRTTLNGEGLQH 641 Query: 303 QDGNSLVTAASIPNCVSYDPAYAYELAVILDEGMRRMMERGDDVFYYITVTNENEAQPSL 362 +DG+S + A IPNCVSYDP + YE+AVI+ +G+RRM +DVFYYIT+ NEN P + Sbjct: 642 EDGHSHIQADLIPNCVSYDPTFQYEVAVIVQDGLRRMYANNEDVFYYITLMNENYTHPDM 701 Query: 363 PEGVQDGILRGMYCL--GRKPGAQVRLLGSGPILKEAVAAAALLQQHWQIDAEVWSVTSY 420 PEG + IL+GMY L G K +V+L+GSG IL+E +A A LL+ + ++A++WS S+ Sbjct: 702 PEGAEQDILKGMYLLKAGGKGDKKVQLMGSGTILQEVIAGAELLKADFGVEADIWSCPSF 761 Query: 421 TELARDGVAAQRAQRLSGSVGQ--PYVTAQLQDSAAPVIAVSDYIRTLPESIRAFVPAPY 478 L RD V +R RL + P+VT+QLQ PVIA +DYIR+ + IRA++P Y Sbjct: 762 NLLHRDAVEVERFNRLHPLEAEKVPFVTSQLQGHDGPVIAATDYIRSYADRIRAYIPNDY 821 Query: 479 VTLGTDGFGRSDTRVNLRDFFEID 502 LGTDGFGRSD+R NLR FFE+D Sbjct: 822 HVLGTDGFGRSDSRANLRRFFEVD 845 >XF0669 [C] COG2609 Pyruvate dehydrogenase complex, dehydrogenase (E1) component Xfa Xylella fastidiosa 9a5c Length = 985 Score = 552 bits (1422), Expect = e-157, Method: Compositional matrix adjust. Identities = 272/507 (53%), Positives = 352/507 (69%), Gaps = 11/507 (2%) Query: 7 CAIGATLTDEEINRLRRGGHDMKKIFSAYQAAASHRGQPTVILAQTKKGYGMGAAGEGKM 66 A+ A L+D +I RL RGGHD KI++AY A + +G PTVILA+T KGYGMG AGE Sbjct: 437 AAMVAHLSDNDIWRLNRGGHDPHKIYAAYHRAVNTQGMPTVILAKTVKGYGMGTAGESLN 496 Query: 67 TTHQQKKLDEESLLQFRDRFKLPLTDEQ---CRELAFYKPADDSPEMKHLHARRAALGGY 123 THQ KKLD +++ FRDRF +P++D+Q + FY P DSPE+K++ ARR ALGG+ Sbjct: 497 PTHQTKKLDHDAIKHFRDRFNIPISDQQLDAADHIPFYHPGPDSPEIKYMLARREALGGF 556 Query: 124 LPRRHAGDARR-TVPPLEAHSKFALEADGKEMSSTMALVRQLGNLLKDKDFGQYVVPIVA 182 LP+R ++ VP L+ + + + + S+TMA V+ L L+DK G ++VPIVA Sbjct: 557 LPQRRTKSSKSFIVPGLDKYERLLTSSGERTYSTTMAFVQSLNITLRDKALGPHIVPIVA 616 Query: 183 DEARTFGMANLFRQVGIYSSQGQLYEPEDIGSILYYREAKDGQILEEGITEAGAISSWTA 242 DEARTFGM LFRQ+GIY+ GQ Y+P D ++YYRE + GQ+L++GITE GAI+SW A Sbjct: 617 DEARTFGMEGLFRQIGIYAPFGQKYKPVDADQLMYYREDESGQVLQQGITEPGAIASWMA 676 Query: 243 AATAYSVHGTPMLPFYIYYSMFGFQRIGDLIWAAADQRARGFLIGATSGRTTLGGEGLQH 302 A T+YSV PMLPFYIYYSMFGFQRIGD+ W AAD R RGFL+G T+GRTTL GEGLQH Sbjct: 677 AGTSYSVSDVPMLPFYIYYSMFGFQRIGDIAWQAADMRTRGFLLGGTAGRTTLNGEGLQH 736 Query: 303 QDGNSLVTAASIPNCVSYDPAYAYELAVILDEGMRRMMERGDDVFYYITVTNENEAQPSL 362 +DG+S + A +IPN SYDP + YE+ VIL GM+ MM+ D +YY+T+ NEN A P + Sbjct: 737 EDGHSHLMAGAIPNVRSYDPTFGYEVTVILQHGMKAMMQDQIDEYYYLTLMNENYAHPDM 796 Query: 363 PEGVQDGILRGMYCLG-----RKPGAQVRLLGSGPILKEAVAAAALLQQHWQIDAEVWSV 417 P G + GI++GMY L +K +V+LLGSG IL+EA+AAA LL Q + I A++WS Sbjct: 797 PAGAEQGIIKGMYLLKDAGKPKKGELRVQLLGSGAILREAIAAAELLHQDFGITADLWSC 856 Query: 418 TSYTELARDGVAAQRAQRL--SGSVGQPYVTAQLQDSAAPVIAVSDYIRTLPESIRAFVP 475 S++EL +DG +R RL PYVT QL++ P IA +DY+R + IRAFVP Sbjct: 857 PSFSELRKDGFDTERWNRLHPDSEPRTPYVTQQLENRQGPAIAATDYVRLFADQIRAFVP 916 Query: 476 APYVTLGTDGFGRSDTRVNLRDFFEID 502 Y LGTDGFGRSDTR NLR FFE+D Sbjct: 917 MHYTVLGTDGFGRSDTRSNLRRFFEVD 943 >NMA1554 [C] COG2609 Pyruvate dehydrogenase complex, dehydrogenase (E1) component NmA Neisseria meningitidis Z2491 Length = 887 Score = 551 bits (1420), Expect = e-156, Method: Compositional matrix adjust. Identities = 273/504 (54%), Positives = 355/504 (70%), Gaps = 7/504 (1%) Query: 6 LCAIGATLTDEEINRLRRGGHDMKKIFSAYQAAASH-RGQPTVILAQTKKGYGMGAAGEG 64 L + A +TDE++ L RGGHD +K+++AY AA+H G+PTVILA+T KGYGMGA+GEG Sbjct: 342 LKTLVADMTDEQLWALNRGGHDPQKVYNAYDRAANHADGKPTVILAKTIKGYGMGASGEG 401 Query: 65 KMTTHQQKKLDEESLLQFRDRFKLPLTDEQCR--ELAFYKPADDSPEMKHLHARRAALGG 122 + HQ KK+D+ SL QFRDRF +P+TDEQ +L + A D+ E K+LHARR ALGG Sbjct: 402 QNVAHQAKKMDKASLKQFRDRFDIPVTDEQIESGDLPYLTFAPDTEEYKYLHARRDALGG 461 Query: 123 YLPRRHAGDARRTVPPLEAHSKFALEADGKEMSSTMALVRQLGNLLKDKDFGQYVVPIVA 182 YLP+R VP L A + +E S+TMA VR L LLKDK G+ VVPIV Sbjct: 462 YLPQRKPTQEVLEVPELSAFDAQLKSSGEREFSTTMAFVRILSTLLKDKKIGKRVVPIVP 521 Query: 183 DEARTFGMANLFRQVGIYSSQGQLYEPEDIGSILYYREAKDGQILEEGITEAGAISSWTA 242 DE+RTFGM +FRQ GI++ +GQ Y P+D +++Y+E+ DGQIL+EGI E GA++ W A Sbjct: 522 DESRTFGMEGMFRQYGIWNPKGQQYTPQDKDQLMFYKESVDGQILQEGINEPGAMADWIA 581 Query: 243 AATAYSVHGTPMLPFYIYYSMFGFQRIGDLIWAAADQRARGFLIGATSGRTTLGGEGLQH 302 AAT+Y+ M+PFYIYYSMFGFQR+GDL WAA D ARGFL+G T+GRTTL GEGLQH Sbjct: 582 AATSYANSNFAMIPFYIYYSMFGFQRVGDLAWAAGDMHARGFLLGGTAGRTTLNGEGLQH 641 Query: 303 QDGNSLVTAASIPNCVSYDPAYAYELAVILDEGMRRMMERGDDVFYYITVTNENEAQPSL 362 +DG+S + A IPNCVSYDP + YE+AVI+ +G+RRM +DVFYYIT+ NEN P + Sbjct: 642 EDGHSHIQADLIPNCVSYDPTFQYEVAVIVQDGLRRMYANNEDVFYYITLMNENYTHPDM 701 Query: 363 PEGVQDGILRGMYCL--GRKPGAQVRLLGSGPILKEAVAAAALLQQHWQIDAEVWSVTSY 420 PEG + IL+GMY L G K +V+L+GSG IL+E +A A LL+ + ++A++WS S+ Sbjct: 702 PEGAEQDILKGMYLLKAGGKGDKKVQLMGSGTILQEVIAGAELLKADFGVEADIWSCPSF 761 Query: 421 TELARDGVAAQRAQRLSGSVGQ--PYVTAQLQDSAAPVIAVSDYIRTLPESIRAFVPAPY 478 L RD V +R RL + P+VT+QLQ PVIA +DYIR+ + IRA++P Y Sbjct: 762 NLLHRDAVEVERFNRLHPLEAEKVPFVTSQLQGHDGPVIAATDYIRSYADRIRAYIPNDY 821 Query: 479 VTLGTDGFGRSDTRVNLRDFFEID 502 LGTDGFGRSD+R NLR FFE+D Sbjct: 822 HVLGTDGFGRSDSRANLRRFFEVD 845