BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0023.0013.p (339 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSc2989 [H] COG0113 Delta-aminolevulinic acid dehydratase Rso Ra... 530 e-150 PA5243 [H] COG0113 Delta-aminolevulinic acid dehydratase Pae Pse... 457 e-128 NMA1011 [H] COG0113 Delta-aminolevulinic acid dehydratase NmA Ne... 454 e-127 NMB0801 [H] COG0113 Delta-aminolevulinic acid dehydratase Nme Ne... 453 e-127 PM1692 [H] COG0113 Delta-aminolevulinic acid dehydratase Pmu Pas... 446 e-125 >RSc2989 [H] COG0113 Delta-aminolevulinic acid dehydratase Rso Ralstonia solanacearum Length = 331 Score = 530 bits (1364), Expect = e-150, Method: Compositional matrix adjust. Identities = 251/328 (76%), Positives = 290/328 (88%) Query: 10 AGYPALRMRRMRRDAFSRALMAENVITSADLIYPVFVQEGQNLRTPVASLPGVERLSLDT 69 A +P R RRMRRD FSR +M E+ +T+ DLIYPVF+ EG N+R V S+PGVER+S+D Sbjct: 3 ASFPDHRPRRMRRDDFSRRMMRESRLTADDLIYPVFILEGTNVRQAVPSMPGVERVSVDV 62 Query: 70 LLPVAEECVKLGVPVLALFPVIDPALKTPDGIEATNPDGLVPRVVRALKDRFPELGVLCD 129 LL VAE+CV+LG+PVLALFPVI+P+LKTPDGIEATN DGL+PR V+ALK RFPELG+L D Sbjct: 63 LLGVAEQCVQLGIPVLALFPVIEPSLKTPDGIEATNADGLIPRAVKALKARFPELGILTD 122 Query: 130 VALDPYTSHGQDGVLDETGYILNDETIALLVKQAQTQADAGVDVVAPSDMMDGRIAAIRA 189 VALDPYTSHGQDGVLD+ GY+LN+ET+ +L +QA QA+AGVD+VAPSDMMDGRI AIR Sbjct: 123 VALDPYTSHGQDGVLDDAGYVLNEETVEILTRQALVQAEAGVDIVAPSDMMDGRIGAIRL 182 Query: 190 MLEAQGHIYTRIMAYSAKYASAFYGPFRDAVGSAANLGKGSKATYQMDPANSDEALREVA 249 LE HIYTRIMAY+AKYASAFYGPFRDAVGSAANLGKG+K TYQMDPANSDEALREVA Sbjct: 183 ALENDDHIYTRIMAYAAKYASAFYGPFRDAVGSAANLGKGNKMTYQMDPANSDEALREVA 242 Query: 250 LDLQEGADMVMVKPGMPYLDIVRRVKDEFRVPTFAYQVSGEYAMIKAAAQNGWLDHDKTM 309 LD+ EGADMVMVKPGMPYLDIVRRVKDEFR PT+ YQVSGEYAM+KAAAQNGWLDHDK + Sbjct: 243 LDIAEGADMVMVKPGMPYLDIVRRVKDEFRFPTYVYQVSGEYAMLKAAAQNGWLDHDKVV 302 Query: 310 MEAMMAFKRAGADGVLTYFALDIARKLK 337 +E+++AFKRAGA+G+LTYFALD AR L+ Sbjct: 303 LESLLAFKRAGANGILTYFALDAARLLR 330 >PA5243 [H] COG0113 Delta-aminolevulinic acid dehydratase Pae Pseudomonas aeruginosa Length = 337 Score = 457 bits (1176), Expect = e-128, Method: Compositional matrix adjust. Identities = 227/339 (66%), Positives = 266/339 (78%), Gaps = 3/339 (0%) Query: 1 MSLTDFSSNAGYPALRMRRMRRDAFSRALMAENVITSADLIYPVFVQEGQNLRTPVASLP 60 MS T +N YP R+RR RRD FSR L+ ENV+T DLI PVFV +G N R + S+P Sbjct: 1 MSFT--PANRAYPYTRLRRNRRDDFSRRLVRENVLTVDDLILPVFVLDGVNQRESIPSMP 58 Query: 61 GVERLSLDTLLPVAEECVKLGVPVLALFPVIDPALKTPDGIEATNPDGLVPRVVRALKDR 120 GVERLS+D LL AEE V LG+P LALFPV K+ D EA NP+G+ R RAL++R Sbjct: 59 GVERLSIDQLLIEAEEWVALGIPALALFPVTPVEKKSLDAAEAYNPEGIAQRATRALRER 118 Query: 121 FPELGVLCDVALDPYTSHGQDGVLDETGYILNDETIALLVKQAQTQADAGVDVVAPSDMM 180 FPELG++ DVALDP+T+HGQDG+LD+ GY+LND +I +LV+QA + A+AG VVAPSDMM Sbjct: 119 FPELGIITDVALDPFTTHGQDGILDDDGYVLNDVSIDVLVRQALSHAEAGAQVVAPSDMM 178 Query: 181 DGRIAAIRAMLEAQGHIYTRIMAYSAKYASAFYGPFRDAVGSAANLGKGSKATYQMDPAN 240 DGRI AIR LE+ GH RIMAYSAKYASA+YGPFRDAVGSA+NLGKG+KATYQMDPAN Sbjct: 179 DGRIGAIREALESAGHTNVRIMAYSAKYASAYYGPFRDAVGSASNLGKGNKATYQMDPAN 238 Query: 241 SDEALREVALDLQEGADMVMVKPGMPYLDIVRRVKDEFRVPTFAYQVSGEYAMIKAAAQN 300 SDEAL EVA DL EGADMVMVKPGMPYLDIVRRVKDEFR PTF YQVSGEYAM A QN Sbjct: 239 SDEALHEVAADLAEGADMVMVKPGMPYLDIVRRVKDEFRAPTFVYQVSGEYAMHMGAIQN 298 Query: 301 GWLDHDKTMMEAMMAFKRAGADGVLTYFALDIARKLKQG 339 GWL + ++E++ AFKRAGADG+LTYFA A +L++G Sbjct: 299 GWL-AESVILESLTAFKRAGADGILTYFAKQAAEQLRRG 336 >NMA1011 [H] COG0113 Delta-aminolevulinic acid dehydratase NmA Neisseria meningitidis Z2491 Length = 338 Score = 454 bits (1167), Expect = e-127, Method: Compositional matrix adjust. Identities = 220/314 (70%), Positives = 259/314 (82%), Gaps = 1/314 (0%) Query: 25 FSRALMAENVITSADLIYPVFVQEGQNLRTPVASLPGVERLSLDTLLPVAEECVKLGVPV 84 FSR LM E+ +T+ DLIYPVFV EG V S+PGV+R SLD LL AEE VKLG+P+ Sbjct: 26 FSRRLMREHTLTADDLIYPVFVLEGSAREEDVPSMPGVKRQSLDRLLFTAEEAVKLGIPM 85 Query: 85 LALFPVIDPALKTPDGIEATNPDGLVPRVVRALKDRFPELGVLCDVALDPYTSHGQDGVL 144 LALFPV+ A KT EA NP+GLVP VRAL++RFPELG++ DVALDPYT HGQDG+ Sbjct: 86 LALFPVVT-ANKTERAQEAYNPEGLVPSTVRALRERFPELGIMTDVALDPYTVHGQDGLT 144 Query: 145 DETGYILNDETIALLVKQAQTQADAGVDVVAPSDMMDGRIAAIRAMLEAQGHIYTRIMAY 204 DE GY++NDET+ +LVKQA A+AG VVAPSDMMDGRI AIR LE GHI+TRIMAY Sbjct: 145 DENGYVMNDETVEVLVKQALCHAEAGAQVVAPSDMMDGRIGAIREALEDAGHIHTRIMAY 204 Query: 205 SAKYASAFYGPFRDAVGSAANLGKGSKATYQMDPANSDEALREVALDLQEGADMVMVKPG 264 SAKYASAFYGPFRDAVGS+ NLGK K TYQMDPAN+DEAL EVALD+QEGADMVMVKPG Sbjct: 205 SAKYASAFYGPFRDAVGSSGNLGKADKKTYQMDPANTDEALHEVALDIQEGADMVMVKPG 264 Query: 265 MPYLDIVRRVKDEFRVPTFAYQVSGEYAMIKAAAQNGWLDHDKTMMEAMMAFKRAGADGV 324 +PYLD+VRRVKDEF VPT+AYQVSGEYAM++AA NGWLD K ++E+++AFKRAGADG+ Sbjct: 265 LPYLDVVRRVKDEFGVPTYAYQVSGEYAMLQAAVANGWLDGGKVVLESLLAFKRAGADGI 324 Query: 325 LTYFALDIARKLKQ 338 LTY+A++ A+ LK+ Sbjct: 325 LTYYAIEAAKMLKR 338 >NMB0801 [H] COG0113 Delta-aminolevulinic acid dehydratase Nme Neisseria meningitidis MC58 Length = 333 Score = 453 bits (1166), Expect = e-127, Method: Compositional matrix adjust. Identities = 220/314 (70%), Positives = 259/314 (82%), Gaps = 1/314 (0%) Query: 25 FSRALMAENVITSADLIYPVFVQEGQNLRTPVASLPGVERLSLDTLLPVAEECVKLGVPV 84 FSR LM E+ +T+ DLIYPVFV EG V S+PGV+R SLD LL AEE VKLG+P+ Sbjct: 21 FSRRLMREHTLTADDLIYPVFVLEGSAREEDVPSMPGVKRQSLDRLLFTAEEAVKLGIPM 80 Query: 85 LALFPVIDPALKTPDGIEATNPDGLVPRVVRALKDRFPELGVLCDVALDPYTSHGQDGVL 144 LALFPV+ A KT EA NP+GLVP VRAL++RFPELG++ DVALDPYT HGQDG+ Sbjct: 81 LALFPVVT-ANKTERAQEAYNPEGLVPSTVRALRERFPELGIMTDVALDPYTVHGQDGLT 139 Query: 145 DETGYILNDETIALLVKQAQTQADAGVDVVAPSDMMDGRIAAIRAMLEAQGHIYTRIMAY 204 DE GY++NDET+ +LVKQA A+AG VVAPSDMMDGRI AIR LE GHI+TRIMAY Sbjct: 140 DENGYVMNDETVEVLVKQALCHAEAGAQVVAPSDMMDGRIGAIREALEDAGHIHTRIMAY 199 Query: 205 SAKYASAFYGPFRDAVGSAANLGKGSKATYQMDPANSDEALREVALDLQEGADMVMVKPG 264 SAKYASAFYGPFRDAVGS+ NLGK K TYQMDPAN+DEAL EVALD+QEGADMVMVKPG Sbjct: 200 SAKYASAFYGPFRDAVGSSGNLGKADKKTYQMDPANTDEALHEVALDIQEGADMVMVKPG 259 Query: 265 MPYLDIVRRVKDEFRVPTFAYQVSGEYAMIKAAAQNGWLDHDKTMMEAMMAFKRAGADGV 324 +PYLD+VRRVKDEF VPT+AYQVSGEYAM++AA NGWLD K ++E+++AFKRAGADG+ Sbjct: 260 LPYLDVVRRVKDEFGVPTYAYQVSGEYAMLQAAIANGWLDGGKVVLESLLAFKRAGADGI 319 Query: 325 LTYFALDIARKLKQ 338 LTY+A++ A+ LK+ Sbjct: 320 LTYYAIEAAKMLKR 333 >PM1692 [H] COG0113 Delta-aminolevulinic acid dehydratase Pmu Pasteurella multocida Length = 341 Score = 446 bits (1148), Expect = e-125, Method: Compositional matrix adjust. Identities = 219/328 (66%), Positives = 258/328 (78%), Gaps = 1/328 (0%) Query: 10 AGYPALRMRRMRRDAFSRALMAENVITSADLIYPVFVQEGQNLRTPVASLPGVERLSLDT 69 A +P R+RRMR+ AFSR LMAEN ++ DLIYPVF+ EG+ R PV S+PGVERL++D Sbjct: 7 ANFPQRRLRRMRKQAFSRRLMAENKLSVEDLIYPVFIIEGEKQREPVPSMPGVERLTIDE 66 Query: 70 LLPVAEECVKLGVPVLALFPVIDPALKTPDGIEATNPDGLVPRVVRALKDRFP-ELGVLC 128 LL AE VK GVPV+ALFPVI K+ EA +PDGLV R V+ALKD+FP ELG+L Sbjct: 67 LLIEAELLVKYGVPVIALFPVIAQEKKSLMAEEAYHPDGLVQRAVKALKDKFPTELGILT 126 Query: 129 DVALDPYTSHGQDGVLDETGYILNDETIALLVKQAQTQADAGVDVVAPSDMMDGRIAAIR 188 D+ALDPYT+HGQDG++D+ GY+LND T +LVKQA + A AG D+VAPSDMMDGRI IR Sbjct: 127 DIALDPYTTHGQDGIIDQHGYVLNDVTSDILVKQALSHAKAGADIVAPSDMMDGRIGKIR 186 Query: 189 AMLEAQGHIYTRIMAYSAKYASAFYGPFRDAVGSAANLGKGSKATYQMDPANSDEALREV 248 LE +G I T IMAYSAKYAS +YGPFRDAVGSA NL G K TYQ+DPANSDE L+EV Sbjct: 187 HALEEKGFINTLIMAYSAKYASHYYGPFRDAVGSATNLKGGDKKTYQLDPANSDEGLQEV 246 Query: 249 ALDLQEGADMVMVKPGMPYLDIVRRVKDEFRVPTFAYQVSGEYAMIKAAAQNGWLDHDKT 308 ALDLQEGADMVMVKPGMPYLD+V RVK F VPTFAYQVSGEYAM +AA QNGWL + Sbjct: 247 ALDLQEGADMVMVKPGMPYLDLVYRVKTHFGVPTFAYQVSGEYAMHQAAIQNGWLKEKEC 306 Query: 309 MMEAMMAFKRAGADGVLTYFALDIARKL 336 +ME+++ FKRAGADG+LTY+A +A L Sbjct: 307 IMESLLCFKRAGADGILTYYAKQVAEWL 334