BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0022.0289.p (281 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value mlr7896 [GER] COG0697 Permeases of the drug/metabolite transport... 217 2e-56 mll3062 [GER] COG0697 Permeases of the drug/metabolite transport... 189 4e-48 BMEI1244 [GER] COG0697 Permeases of the drug/metabolite transpor... 189 5e-48 SMc01807 [GER] COG0697 Permeases of the drug/metabolite transpor... 167 2e-41 STM3796A [GER] COG0697 Permeases of the drug/metabolite transpor... 160 2e-39 >mlr7896 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Mlo Mesorhizobium loti Length = 278 Score = 217 bits (553), Expect = 2e-56, Method: Compositional matrix adjust. Identities = 131/281 (46%), Positives = 168/281 (59%), Gaps = 3/281 (1%) Query: 1 MTLSVIALVLAAALLHASWNALLKSSHDRLASLSLMTLGAGLGAIPLVLWRPWPQAESWF 60 M+ VI L L AA+LHASWNA L++ DRL ++++M+ AIPL ++ +P +W Sbjct: 1 MSPLVIGLALFAAILHASWNAFLRTGADRLWTVTVMSFSDTALAIPLAIFNGFPATSAWP 60 Query: 61 YILLSGLLHTGYNLFLIRAYRIGDFGQSYPIARGSSPLLVALGAAVFAGEQLGIYTVIGI 120 Y+ LS L GY++FL+ AYR G+ GQ YPI RGS PLLV LG + AG+QL TV Sbjct: 61 YVGLSACLQVGYSVFLVAAYRYGELGQVYPIVRGSVPLLVTLGGFLLAGQQL---TVPET 117 Query: 121 ALVSLGIVSLANLRAMRRREHLSGPLAALATGAFIAAYTITDGIGARLAGDAIAYAGWLF 180 V L + L R R + L ALATGA IA Y D IG R AG+ AY W+ Sbjct: 118 VGVVLVGGGIMGLSLGRGRAATTSILYALATGAIIAVYATVDAIGVRAAGNVGAYTAWVL 177 Query: 181 VADSIPLALLYQYKHGRSPVVLSHKDTWIGLAGGVMSLLAYGIVIWAVTLAPMGMVSALR 240 +A L + GR PV +TW L GG+ +LLAYG+V+ A L P G ++A+R Sbjct: 178 LAYGALLPATFVACRGRLPVDPRAPETWKALGGGLFALLAYGVVVAAFALGPAGPITAIR 237 Query: 241 ETSVLFALLIGTLFLGEKLTLRRVLSCAVIAAGAIVLGTHH 281 ETSV+FA IG LFLGE LT RRV +CAV+A GAI LG Sbjct: 238 ETSVVFAAFIGRLFLGETLTPRRVGACAVVALGAICLGYQS 278 >mll3062 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Mlo Mesorhizobium loti Length = 281 Score = 189 bits (481), Expect = 4e-48, Method: Compositional matrix adjust. Identities = 122/262 (46%), Positives = 165/262 (62%), Gaps = 5/262 (1%) Query: 19 WNALLKSSHDRLASLSLMTLGAGLGAIPLVLWRPWPQAESWFYILLSGLLHTGYNLFLIR 78 WNAL+K DR S++LMTLG G A+ ++ + +P+AE W +IL S + H GY FLI Sbjct: 19 WNALVKVHLDRFLSITLMTLGMGFAALFVLPFVEFPKAEVWPFILASVVFHMGYRTFLIG 78 Query: 79 AYRIGDFGQSYPIARGSSPLLVALGAAVFAGEQLGIYTVIGIALVSLGIVSLANLR--AM 136 AYR GDF Q+YP+ARG++PLL ALG V E + ++GI L+S G + + + R A Sbjct: 79 AYRAGDFAQTYPLARGTAPLLAALGGIVVVQEVPAPFAILGILLLSAGTLVM-SFRGGAH 137 Query: 137 RRREHLSGPLAALATGAFIAAYTITDGIGARLAGDAIAYAGWLFVADSI-PLALLYQYKH 195 R +L AL T FIA+YT++DG GARLA A +YA WLFV D+ L L ++ Sbjct: 138 LERLNLRAVGFALGTSIFIASYTLSDGSGARLAATAQSYAAWLFVCDATWALVLCVVFRG 197 Query: 196 GRSPVVLSHKDTWIGLAGGVMSLLAYGIVIWAVTLAPMGMVSALRETSVLFALLIGTLFL 255 +S VL+ +D GL GV+S AY IV+WA+T AP+ V++LRETS+LFA+LI L Sbjct: 198 PQSLPVLA-RDWKAGLFTGVLSGAAYWIVMWAMTKAPIASVASLRETSILFAMLISVYAL 256 Query: 256 GEKLTLRRVLSCAVIAAGAIVL 277 GEK+T R + I AG I L Sbjct: 257 GEKMTGWRGAAALSIVAGVIAL 278 >BMEI1244 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Bme Brucella melitensis Length = 281 Score = 189 bits (480), Expect = 5e-48, Method: Compositional matrix adjust. Identities = 118/280 (42%), Positives = 175/280 (62%), Gaps = 5/280 (1%) Query: 1 MTLSVIALVLAAALLHASWNALLKSSHDRLASLSLMTLGAGLGAIPLVLWRPWPQAESWF 60 M+ V+ +VL A LH SWNA++K S D+ + +T AGL A+ LV + P P A SW Sbjct: 1 MSGGVLLIVLFGAFLHTSWNAIVKGSGDKFFGAASVTGAAGLIALFLVPFLPLPTAASWI 60 Query: 61 YILLSGLLHTGYNLFLIRAYRIGDFGQSYPIARGSSPLLVALGAAVFAGEQLGIYTVIGI 120 Y+LLS + T Y + AY+ GD ++YPI RG+ PLLVAL + GE +G + +GI Sbjct: 61 YMLLSTITQTFYMSLVAAAYKSGDMSEAYPIMRGTPPLLVALVSGPLVGEIMGWQSWLGI 120 Query: 121 ALVSLGIVSLANLRAMRRREHLSGP--LAALATGAFIAAYTITDGIGARLAGDAIAYAGW 178 L+ G++++A L A RR S L ALA FIA+YT+ DG+G R++G+ ++Y W Sbjct: 121 VLICSGVLAMA-LDARRRNRGASSRTVLLALANAGFIASYTLIDGLGVRVSGEPLSYTLW 179 Query: 179 LFVADSIPLALLYQYKHGRSPVVLSHKDTW-IGLAGGVMSLLAYGIVIWAVTLAPMGMVS 237 LF+ +++PLA Y+ S + ++ W L GGV +L +YG+ +WA+T+AP+ +V+ Sbjct: 180 LFLLNAVPLAGWALYRE-PSRFINYIRNRWRPALIGGVGTLGSYGLALWAMTMAPIAVVA 238 Query: 238 ALRETSVLFALLIGTLFLGEKLTLRRVLSCAVIAAGAIVL 277 ALRET++LF +LI L L EK+ L R ++ I AGAI L Sbjct: 239 ALRETAILFGMLISALILKEKVGLPRFVAAGFIVAGAIAL 278 >SMc01807 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Sme Sinorhizobium meliloti Length = 278 Score = 167 bits (424), Expect = 2e-41, Method: Compositional matrix adjust. Identities = 106/274 (38%), Positives = 167/274 (60%), Gaps = 10/274 (3%) Query: 1 MTLSVIALVLAAALLHASWNALLKSSHDRLASLSLMTLGAGLGAIPLVLWRPWPQAESWF 60 M VIALVL ALLHA+WNAL+K+ ++ ++++LG + A+P + + P P +E+ Sbjct: 1 MPPDVIALVLLGALLHATWNALVKAGTEKSLDAAMVSLGGAVVALPFLPFLPMPGSEAVP 60 Query: 61 YILLSGLLHTGYNLFLIRAYRIGDFGQSYPIARGSSPLLVALGAAVFAGEQLGIYTVIGI 120 YIL+S L Y + AYR GD G YP+ RG +PL+VA +++ GE+L + GI Sbjct: 61 YILVSALFQFAYFQLVAAAYRAGDIGLVYPLMRGVAPLIVAATSSLVIGEKLTGGAMAGI 120 Query: 121 ALVSLGIVSLANLRAMRRREHLSGPLAALATGAFIAAYTITDGIGARLAGDAIAYAGWLF 180 +S G+++LA R+ + AL IA+YT DGIGAR++G+AI+Y W+ Sbjct: 121 MTISAGVLTLAF---ESRKGGRHAIVLALLNACVIASYTYVDGIGARISGNAISYTLWMA 177 Query: 181 VADSIPLALLYQYKHGRSPV--VLSH--KDTWIGLAGGVMSLLAYGIVIWAVTLAPMGMV 236 + +P LL+ + R V V H + W GL GG S+ +YG+ +WA+T AP+ V Sbjct: 178 L---LPPVLLFGWAFARRGVKPVARHVSRHWWRGLIGGAGSIGSYGLALWAMTKAPVATV 234 Query: 237 SALRETSVLFALLIGTLFLGEKLTLRRVLSCAVI 270 +ALRET++LFA++I +FL E+++ R+++ +I Sbjct: 235 AALRETAILFAVVISVVFLKERVSAWRIIAAFII 268 >STM3796A [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Sty Salmonella typhimurium LT2 Length = 286 Score = 160 bits (406), Expect = 2e-39, Method: Compositional matrix adjust. Identities = 105/281 (37%), Positives = 167/281 (59%), Gaps = 11/281 (3%) Query: 1 MTLSVIALVLAAALLHASWNALLKSSHDRLASLSLMTLGAGLGAIPLVLWRPWPQAESWF 60 MTLSV ++L AALLHASWNA++K+ +D+L + ++ A + A+ L+ + P P S Sbjct: 10 MTLSVFCILLFAALLHASWNAIVKAGNDKLYAAIGVSGSAAVMALILLPFSPQPAHASIP 69 Query: 61 YILLSGLLHTGYNLFLIRAYRIGDFGQSYPIARGSSPLLVALGAAVFAGEQLGIYTVIGI 120 ++ S L Y + + + Y++ D Q+YP+ RG++PLLVAL + +F G+ L +GI Sbjct: 70 FLAASTALQVVYTVLVAKTYQVSDMSQTYPLMRGTAPLLVALISVLFLGDSLSSLAWVGI 129 Query: 121 ALVSLGIVSLA-NLRAMRRREHLSGPLAALATGAFIAAYTITDGIGARLAGDAIAYAGWL 179 A++ + I+ +A N RA +R G + AL FIA YT+ DG G RL+ A+ Y W Sbjct: 130 AVICMAILGMACNGRASSQR----GVVLALTNACFIAGYTLVDGTGVRLSETALGYTLWS 185 Query: 180 FVADSIPL---ALLYQYKHGRSPVVLSHKDTWIGLAGGVMSLLAYGIVIWAVTLAPMGMV 236 F + L A++ + + + K G+ GG+ ++ +YG+ +WA+T AP+ +V Sbjct: 186 FFLNGACLLTWAMIARRREASRYLAQQWKK---GIFGGIGTMGSYGLALWAMTQAPLAVV 242 Query: 237 SALRETSVLFALLIGTLFLGEKLTLRRVLSCAVIAAGAIVL 277 +ALRETS+LF LI L L EK+ R+++ IA GAI+L Sbjct: 243 AALRETSILFGALIAWLLLKEKVAGLRLVAAGGIALGAILL 283