BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0022.0253.p (430 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value NMB0360 [GEPR] COG0477 Permeases of the major facilitator superf... 437 e-122 NMA2127 [GEPR] COG0477 Permeases of the major facilitator superf... 429 e-120 PM0285 [GEPR] COG0477 Permeases of the major facilitator superfa... 426 e-119 HI0350 [GEPR] COG0477 Permeases of the major facilitator superfa... 361 2e-99 YPO3162 [GEPR] COG0477 Permeases of the major facilitator superf... 295 1e-79 >NMB0360 [GEPR] COG0477 Permeases of the major facilitator superfamily Nme Neisseria meningitidis MC58 Length = 427 Score = 437 bits (1124), Expect = e-122, Method: Compositional matrix adjust. Identities = 226/414 (54%), Positives = 305/414 (73%), Gaps = 8/414 (1%) Query: 20 QYLNRRMLICVFLGFTSGLPLFILLSLLQAWLAKSGLNVKTLGLFALVMFPYTWKFVWSP 79 Q +R ML+C+F GFTSGLPL+ L++L+ AWL +++K++GL AL+ P+TWKF+WSP Sbjct: 11 QIFSRNMLVCIFTGFTSGLPLYFLINLIPAWLRSEQVDLKSIGLMALIGLPFTWKFLWSP 70 Query: 80 LMDRFHFGRIGRRRGWMVFTQLLLFLAIGGMGMLDPLTDVSTIAFMASVVAFLSASQDIA 139 LMD +GRRRGWM+ TQ L A+ L+P + IA ++ +VAF SASQDI Sbjct: 71 LMDAVRLPVLGRRRGWMLLTQAGLLAALAVYAFLNPRNHLPLIAGLSVLVAFFSASQDIV 130 Query: 140 IDAYRREILPEAELGLGSAIHVNAYKLSGMVPGALSLVLADQMPWPTVFWITAAFMLPGL 199 +DA+RREIL + ELGLG+++HVNAY+++ ++PG+LSLVLAD+MPW VF IT+ FMLPGL Sbjct: 131 LDAFRREILSDEELGLGNSVHVNAYRIAALIPGSLSLVLADRMPWLEVFVITSLFMLPGL 190 Query: 200 LCSL-VVKEPKVYGTPPKSLTEAVVLPFREFIARGGWGNALWVLGFIFLYKLGDSMATAL 258 L +L + +EP + PK+L + VV PF+EF R G +A+ VL FIFLYKLGDSMATAL Sbjct: 191 LMTLFLAREPVLPPAVPKTLKQTVVEPFKEFFTRKGIASAVCVLLFIFLYKLGDSMATAL 250 Query: 259 ATKFYIDLGFSMTEIGVVSKTTSLWASVAGGIIGGIWMVRLGINRGLWVFGVLQAVPILG 318 AT FY+D+GFS T+IG+++K LW +VA GI+GG+WM+++G+N+ LW+FG +QAV +LG Sbjct: 251 ATPFYLDMGFSKTDIGLIAKNAGLWPAVAAGILGGVWMLKIGVNKALWLFGAVQAVTVLG 310 Query: 319 FAWLAHVG-------ASLPVLAVVIGLEAFGVGLGTTAFVAYIMRETDPRYTATQFALFT 371 F WLA G +LA VIG EA GVGLGT AFV+Y+ RET+P +TATQ ALFT Sbjct: 311 FVWLAGFGPFDTVGTGERLMLAAVIGAEAVGVGLGTAAFVSYMARETNPAFTATQLALFT 370 Query: 372 SLMAVPRTFVNSSVGYIVADTGWLNFFLICFVLALPGMLMLPRIAPWNEKPVES 425 SL AVPRT +NS GY++ G++ FF +CF LALPGML+L ++APWN + + Sbjct: 371 SLSAVPRTVINSFAGYLIEWLGYVPFFQLCFALALPGMLLLLKVAPWNGEKTQD 424 >NMA2127 [GEPR] COG0477 Permeases of the major facilitator superfamily NmA Neisseria meningitidis Z2491 Length = 427 Score = 429 bits (1102), Expect = e-120, Method: Compositional matrix adjust. Identities = 228/414 (55%), Positives = 306/414 (73%), Gaps = 8/414 (1%) Query: 20 QYLNRRMLICVFLGFTSGLPLFILLSLLQAWLAKSGLNVKTLGLFALVMFPYTWKFVWSP 79 Q +R ML+C+F GFTSGLPL+ L++L+ AWL +++K++GL AL+ P+TWKF+WSP Sbjct: 11 QIFSRNMLVCIFTGFTSGLPLYFLINLIPAWLRSEQVDLKSIGLMALIGLPFTWKFLWSP 70 Query: 80 LMDRFHFGRIGRRRGWMVFTQLLLFLAIGGMGMLDPLTDVSTIAFMASVVAFLSASQDIA 139 LMD +GRRRGWM+ TQ L A+ L+P + IA ++ +VAF SASQDI Sbjct: 71 LMDAVRLPVLGRRRGWMLLTQAGLLAALAAYAFLNPRNHLPLIAGLSVLVAFFSASQDIV 130 Query: 140 IDAYRREILPEAELGLGSAIHVNAYKLSGMVPGALSLVLADQMPWPTVFWITAAFMLPGL 199 +DA+RREIL + ELGLG+++HVNAY+++ ++PG+LSLVLAD+MPW VF IT+ FMLPGL Sbjct: 131 LDAFRREILSDEELGLGNSVHVNAYRVAALIPGSLSLVLADRMPWSEVFVITSLFMLPGL 190 Query: 200 LCSL-VVKEPKVYGTPPKSLTEAVVLPFREFIARGGWGNALWVLGFIFLYKLGDSMATAL 258 L +L + +EP + PK+L + VV PF+EF R G +A+ VL FIFLYKLGDSMATAL Sbjct: 191 LMTLFLAREPVLPPAVPKTLKQTVVEPFKEFFTRKGIASAVCVLLFIFLYKLGDSMATAL 250 Query: 259 ATKFYIDLGFSMTEIGVVSKTTSLWASVAGGIIGGIWMVRLGINRGLWVFGVLQAVPILG 318 AT FY+D+GFS T+IG+++K LW +VA GI+GG+WM+++G+N+ LW+FG +QAV +LG Sbjct: 251 ATPFYLDMGFSKTDIGLIAKNAGLWPAVAAGILGGVWMLKIGVNKALWLFGAVQAVTVLG 310 Query: 319 FAWLAHVGASLPV-------LAVVIGLEAFGVGLGTTAFVAYIMRETDPRYTATQFALFT 371 F WLA G V LA VIG EA GVGLGT AFV+Y+ RET+P +TATQ ALFT Sbjct: 311 FVWLAGFGHFDTVGTGERLMLAAVIGAEAVGVGLGTAAFVSYMARETNPAFTATQLALFT 370 Query: 372 SLMAVPRTFVNSSVGYIVADTGWLNFFLICFVLALPGMLMLPRIAPWNEKPVES 425 SL AVPRT +NS GY++ G++ FF +CFVLALPGML+L ++APWN + + Sbjct: 371 SLSAVPRTVINSFAGYLIEWLGYVPFFQLCFVLALPGMLLLLKVAPWNGEKTQD 424 >PM0285 [GEPR] COG0477 Permeases of the major facilitator superfamily Pmu Pasteurella multocida Length = 425 Score = 426 bits (1094), Expect = e-119, Method: Compositional matrix adjust. Identities = 215/412 (52%), Positives = 290/412 (70%), Gaps = 11/412 (2%) Query: 19 QQYLNRRMLICVFLGFTSGLPLFILLSLLQAWLAKSGLNVKTLGLFALVMFPYTWKFVWS 78 Q +R ML+C+F GF+SGLPL++L ++ AWL+ S ++VKT+G F L+ FPYTWKF+ S Sbjct: 10 SQIFSRNMLLCIFTGFSSGLPLYVLFQMVPAWLSSSNVDVKTIGFFTLIGFPYTWKFIIS 69 Query: 79 PLMDRFHFGRIGRRRGWMVFTQLLLFLAIGGMGMLDPLTDVSTIAFMASVVAFLSASQDI 138 PL+DR++ +GRRR WM TQ+ L + +G DP+ +++ +A +++ +A SA QDI Sbjct: 70 PLLDRYYPNFLGRRRSWMFMTQVALLALLALLGQYDPVANITIVAVISTSIAVFSAVQDI 129 Query: 139 AIDAYRREILPEAELGLGSAIHVNAYKLSGMVPGALSLVLADQMPWPTVFWITAAFMLPG 198 IDAYRREIL + ELGLG++IHVNAY++SG++PG LSL+LAD +PW VF TA FM+PG Sbjct: 130 VIDAYRREILTDEELGLGNSIHVNAYRISGLIPGGLSLILADSLPWDVVFIFTALFMIPG 189 Query: 199 LLCSLVV-KEPKVYGTPPKSL--TEAVVLPFREFIARGGWGNALWVLGFIFLYKLGDSMA 255 L+ SL + KEP V +SL LPF+EF +R G +AL ++ FIFLYK GDS+A Sbjct: 190 LILSLFLSKEPDV-PQIDRSLPFYHTFALPFKEFFSRKGVASALGLIFFIFLYKFGDSLA 248 Query: 256 TALATKFYIDLGFSMTEIGVVSKTTSLWASVAGGIIGGIWMVRLGINRGLWVFGVLQAVP 315 T+L TKF +D+GFS T+IG V K SLWAS+ G++GGI M+R+GINR LW+FG +Q + Sbjct: 249 TSLQTKFILDMGFSKTDIGTVVKLNSLWASIISGMLGGILMLRIGINRSLWLFGFVQLIT 308 Query: 316 ILGFAWLAHVGA-------SLPVLAVVIGLEAFGVGLGTTAFVAYIMRETDPRYTATQFA 368 ILGF W+A G VL VI E GVGLGT AFVA++ RET+P YTATQ A Sbjct: 309 ILGFVWMASYGKFNTIGSFEFFVLTTVIIGEYIGVGLGTAAFVAFMARETNPLYTATQLA 368 Query: 369 LFTSLMAVPRTFVNSSVGYIVADTGWLNFFLICFVLALPGMLMLPRIAPWNE 420 +FTSL A+P ++ G +VAD G+ FF ICF A+PGMLML ++APW+ Sbjct: 369 IFTSLSAIPSKIFSAFSGVLVADYGYYTFFWICFFAAIPGMLMLFKVAPWHS 420 >HI0350 [GEPR] COG0477 Permeases of the major facilitator superfamily Hin Haemophilus influenzae Length = 425 Score = 361 bits (926), Expect = 2e-99, Method: Compositional matrix adjust. Identities = 198/418 (47%), Positives = 272/418 (65%), Gaps = 9/418 (2%) Query: 19 QQYLNRRMLICVFLGFTSGLPLFILLSLLQAWLAKSGLNVKTLGLFALVMFPYTWKFVWS 78 Q R+MLIC F GF SGLPLF+L +L WL L+++ +G VM PY KF+W+ Sbjct: 7 SQIFTRKMLICAFTGFNSGLPLFVLSQMLPVWLTDKHLSIELIGAVTGVMLPYGLKFLWA 66 Query: 79 PLMDRFHFGRIGRRRGWMVFTQLLLFLAIGGMGMLDPLTDVSTIAFMASVVAFLSASQDI 138 PL+DR+ +GRRR WM+ +Q+ L + + + + DPLT + T+A +A ++AF SA+QDI Sbjct: 67 PLLDRYFPSFLGRRRSWMLLSQVALLILLYIISLFDPLTQLGTVANIALLIAFFSATQDI 126 Query: 139 AIDAYRREILPEAELGLGSAIHVNAYKLSGMVPGALSLVLADQMPWPTVFWITAAFMLPG 198 +DAYRREIL + ELGLG+ IH+NAY+++G++PG LSL LA PW TVF TA ML G Sbjct: 127 VLDAYRREILSDHELGLGNTIHINAYRIAGLIPGGLSLYLAAIYPWETVFLWTALCMLAG 186 Query: 199 LLCSL-VVKEPKV-YGTPPKSLTEAVVLPFREFIARGGWGNALWVLGFIFLYKLGDSMAT 256 + +L + KEPK+ + +A +P +EF R G A+ L F+FLYK GDS AT Sbjct: 187 IFMTLFLAKEPKIDMQQTNQPFYQAFWIPLQEFFQRKGVIQAIGFLLFLFLYKFGDSFAT 246 Query: 257 ALATKFYIDLGFSMTEIGVVSKTTSLWASVAGGIIGGIWMVRLGINRGLWVFGVLQAVPI 316 L TKF D+GFS +I +V K+T+LW+S+ G+ GG+ M++LGINR LW+FG++Q V I Sbjct: 247 TLQTKFIYDMGFSKEDIAIVVKSTALWSSILSGLAGGMIMLKLGINRALWLFGLVQMVTI 306 Query: 317 LGFAWLAHVG-------ASLPVLAVVIGLEAFGVGLGTTAFVAYIMRETDPRYTATQFAL 369 GF WLA G A L L VVI E GVGLGT AFVA++ RE++P YTATQ AL Sbjct: 307 GGFIWLAAFGHFDVITSAELWKLGVVIAAEYIGVGLGTAAFVAFMARESNPLYTATQLAL 366 Query: 370 FTSLMAVPRTFVNSSVGYIVADTGWLNFFLICFVLALPGMLMLPRIAPWNEKPVESQT 427 FTSL A+P + GY+V G+ +F C LA+PGML L +AP ++ ++ + Sbjct: 367 FTSLSALPSKVLGILSGYVVGAVGYYQYFWFCLFLAIPGMLCLFWVAPLKQENNKTSS 424 >YPO3162 [GEPR] COG0477 Permeases of the major facilitator superfamily Ype Yersinia pestis Length = 492 Score = 295 bits (755), Expect = 1e-79, Method: Compositional matrix adjust. Identities = 168/411 (40%), Positives = 251/411 (61%), Gaps = 10/411 (2%) Query: 21 YLNRRMLICVFLGFTSGLPLFILLSLLQAWLAKSGLNVKTLGLFALVMFPYTWKFVWSPL 80 + R +I + LGF SGLPL + LQAW+ +N+KT+G+F+LV Y +KF+WSPL Sbjct: 9 FTQRNSIILLLLGFASGLPLALTSGTLQAWMTVENVNLKTIGIFSLVGQAYVFKFLWSPL 68 Query: 81 MDRFHFGRIGRRRGWMVFTQLLLFLAIGGMGMLDPLTDVSTIAFMASVVAFLSASQDIAI 140 MDR+ +GRRRGW++ +QLLL +AI MG ++P + +A +A +VAF SASQDI Sbjct: 69 MDRYTPSFLGRRRGWLLVSQLLLIIAIIAMGFMEPAKHLWWLAAVAVLVAFCSASQDIVF 128 Query: 141 DAYRREILPEAELGLGSAIHVNAYKLSGMVPGALSLVLADQ-MPWPTVFWITAAFMLPGL 199 DAY+ ++L E G G+A+ V Y+L+ +V G L+L +AD+ + W + +W+ A ML G+ Sbjct: 129 DAYKTDLLTTEERGTGAAVSVLGYRLAMLVSGGLALWIADRYLGWQSTYWLMAGLMLIGV 188 Query: 200 LCSLVVKEPKVYGTPPKSLTEAVVLPFREFIARGGWGNALWVLGFIFLYKLGDSMATALA 259 +L+ EP + PPK+L +A+V P R+F R NA +L I YK+GD+ A +L+ Sbjct: 189 FATLLAPEPDIRIAPPKTLEQAIVAPLRDFFGR---NNAWLILLLIVFYKMGDAFAASLS 245 Query: 260 TKFYID-LGFSMTEIGVVSKTTSLWASVAGGIIGGIWMVRLGINRGLWVFGVLQAVPILG 318 T F I +GF E+G+V+KT L A++ G + GG+ M RL + R L +FG+LQAV +G Sbjct: 246 TTFLIRGVGFDAGEVGLVNKTLGLIATIIGALYGGLLMQRLSLFRALMIFGILQAVSNMG 305 Query: 319 FAWLAHVGASLPVLAVVIGLEAFGVGLGTTAFVAYIMRETDPRYTATQFALFTSLMAVPR 378 + LA ++ + I LE G+GT AFVA +M + ++ATQFAL ++L AV R Sbjct: 306 YWLLAITDKNIFSMGSAIFLENLCGGMGTAAFVALLMTLCNKSFSATQFALLSALSAVGR 365 Query: 379 TFVNSSVGYIVADTGWLNFFLICFVLALPGMLMLPRIAPWNEKPVESQTQK 429 +V G+ V GW F+L A+PG+L+L + + TQK Sbjct: 366 VYVGPIAGWFVEAHGWPLFYLFSIAAAIPGLLLL-----YVCRQTLDHTQK 411