BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0022.0184.p (843 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSc2843 [M] COG0773 UDP-N-acetylmuramate-alanine ligase Rso Rals... 692 0.0 NMA2061 [M] COG0773 UDP-N-acetylmuramate-alanine ligase NmA Neis... 571 e-162 NMB0423 [M] COG0773 UDP-N-acetylmuramate-alanine ligase Nme Neis... 553 e-157 PA4411 [M] COG0773 UDP-N-acetylmuramate-alanine ligase Pae Pseud... 519 e-147 XF0798 [M] COG0773 UDP-N-acetylmuramate-alanine ligase Xfa Xylel... 495 e-139 >RSc2843 [M] COG0773 UDP-N-acetylmuramate-alanine ligase Rso Ralstonia solanacearum Length = 483 Score = 692 bits (1786), Expect = 0.0, Method: Compositional matrix adjust. Identities = 355/474 (74%), Positives = 406/474 (85%), Gaps = 13/474 (2%) Query: 364 MKHRVKNIHFVGIGGSGMSGIAEVLLNLGYGVSGSDLGSNAATQRLAQLGASIRYGHAAE 423 MKH VKNIHFVGIGG+GMSGIAEVLLNLGY V+GSDLG +AATQRL LGA++ GHA E Sbjct: 1 MKHIVKNIHFVGIGGAGMSGIAEVLLNLGYRVTGSDLGQSAATQRLTALGATVMQGHAPE 60 Query: 424 NIEGADAIVTSTAVKGDNPEVLAARKKHIPIVPRAVMLGELMRLKKGIAIAGTHGKTTTT 483 ++ GA+A+V STAV+GDNPEVLAAR K IPIVPRAVML ELMRLK+GIAIAGTHGKTTTT Sbjct: 61 HVVGANAVVVSTAVRGDNPEVLAARAKRIPIVPRAVMLAELMRLKQGIAIAGTHGKTTTT 120 Query: 484 SLVASVLAQGGLDPTFVIGGPQGDCGLTSAGANAKLGTGEFIVAEADESDASFLNLTPVI 543 SLVASVLA+GGLDPTFVIGG L SAGANA+LGTG+FIVAEADESDASFLNL PVI Sbjct: 121 SLVASVLAEGGLDPTFVIGGR-----LNSAGANARLGTGDFIVAEADESDASFLNLFPVI 175 Query: 544 EVITNIDADHMETYNHDFARLKQAFVEFTQRLPFYGVAVLCLDDPHVREIMPMVSKPILT 603 EVITNIDADHM+TY HDFARLKQAF+EFT RLPFYG+AVLC+DDP+VREI+P VSKP++ Sbjct: 176 EVITNIDADHMDTYGHDFARLKQAFIEFTHRLPFYGIAVLCVDDPNVREILPFVSKPVVR 235 Query: 604 YGFHEDADVRAIDAKAVDGKMEFTVIQ--DGYA--PMQVSLNQPGMHNVQNACAAIAIAR 659 YGF EDA VRA++A+AVDG+MEFTVI+ +G+A P+ ++LN PGMHNVQNA AAIAIA Sbjct: 236 YGFAEDAQVRAVNARAVDGRMEFTVIRQLNGHAEPPLSITLNLPGMHNVQNALAAIAIAT 295 Query: 660 ELDVDDAATQKALTEFNGVGRRFTRYGEVPITDAQGNPAGHFTLVDDYGHHPVETAATIA 719 EL+V D A KAL EFNGVGRRF RYGEVP D Q G FTL+DDYGHHPVE AAT+A Sbjct: 296 ELEVPDEAIVKALAEFNGVGRRFQRYGEVPTADGQ----GRFTLIDDYGHHPVEMAATLA 351 Query: 720 AARGAYPGRRLVLAFQPHRYTRTRDLFEDFVKVLSSPDVLVLGEVYSAGEAPIVAADGRS 779 AARGA+PGRRLVLAFQPHR+TRTRD FEDF+KVL + D L+L EVY+AGE PIVAADGR+ Sbjct: 352 AARGAFPGRRLVLAFQPHRFTRTRDCFEDFIKVLGTVDALLLAEVYAAGEPPIVAADGRA 411 Query: 780 LAHALRAAGKVEPVFVDDIGDMPETIRNVVRDGDVVMTMGAGSISAVPGRLVAQ 833 L ALR AGK+EPVFV+ I DMP+ I + +D DVV+TMGAGSI VPG++VA+ Sbjct: 412 LTRALRVAGKIEPVFVEQIEDMPQAILDAAQDNDVVITMGAGSIGQVPGQVVAR 465 >NMA2061 [M] COG0773 UDP-N-acetylmuramate-alanine ligase NmA Neisseria meningitidis Z2491 Length = 506 Score = 571 bits (1472), Expect = e-162, Method: Compositional matrix adjust. Identities = 286/472 (60%), Positives = 353/472 (74%), Gaps = 14/472 (2%) Query: 364 MKHRVKNIHFVGIGGSGMSGIAEVLLNLGYGVSGSDLGSNAATQRLAQLGASIRYGHAAE 423 MK+RV NIHFVGIGG GMSGIAEVL NLG+ VSGSD NAAT+ L LG + GH AE Sbjct: 39 MKNRVTNIHFVGIGGVGMSGIAEVLHNLGFKVSGSDQARNAATEHLGSLGIQVYPGHTAE 98 Query: 424 NIEGADAIVTSTAVKGDNPEVLAARKKHIPIVPRAVMLGELMRLKKGIAIAGTHGKTTTT 483 ++ GAD +VTSTAVK +NPEV+AA ++ IP++PRA+ML ELMR + GIAIAGTHGKTTTT Sbjct: 99 HVNGADVVVTSTAVKKENPEVVAALEQQIPVIPRALMLAELMRFRDGIAIAGTHGKTTTT 158 Query: 484 SLVASVLAQGGLDPTFVIGGPQGDCGLTSAGANAKLGTGEFIVAEADESDASFLNLTPVI 543 SL AS+L GLDPTFVIGG L +AG NA+LG GE+IVAEADESDASFL+LTP++ Sbjct: 159 SLTASILGAAGLDPTFVIGGK-----LNAAGTNARLGKGEYIVAEADESDASFLHLTPIM 213 Query: 544 EVITNIDADHMETYNHDFARLKQAFVEFTQRLPFYGVAVLCLDDPHVREIMPMVSKPILT 603 V+TNID DHM+TY H +L QAF++F R+PFYG A LC+D HVR I+P VSKP T Sbjct: 214 SVVTNIDEDHMDTYGHSVEKLHQAFIDFIHRMPFYGKAFLCIDSEHVRAILPKVSKPYAT 273 Query: 604 YGFHEDADVRAIDAKAVDGKMEFTV-IQ-DGY--APMQVSLNQPGMHNVQNACAAIAIAR 659 YG + AD+ A D + V +M+FTV +Q G+ +V LN PG HNV NA AAI +A Sbjct: 274 YGLDDTADIYATDIENVGAQMKFTVHVQMKGHEQGSFEVVLNMPGRHNVLNALAAIGVAL 333 Query: 660 ELDVDDAATQKALTEFNGVGRRFTRYGEVPITDAQGNPAGHFTLVDDYGHHPVETAATIA 719 E+ A QK L F GVGRRF +YG++ + + G LVDDYGHHPVE AAT++ Sbjct: 334 EVGASVEAIQKGLLGFEGVGRRFQKYGDIKLPN-----GGTALLVDDYGHHPVEMAATLS 388 Query: 720 AARGAYPGRRLVLAFQPHRYTRTRDLFEDFVKVLSSPDVLVLGEVYSAGEAPIVAADGRS 779 AARGAYP +RLVLAFQPHRYTRTRDLFEDF KVL++ D LVL EVY+AGE PI AAD R+ Sbjct: 389 AARGAYPEKRLVLAFQPHRYTRTRDLFEDFTKVLNTVDALVLTEVYAAGEEPIAAADSRA 448 Query: 780 LAHALRAAGKVEPVFVDDIGDMPETIRNVVRDGDVVMTMGAGSISAVPGRLV 831 LA A+R GK+EP++ +++ D+PE + NV++DGD+V+ MGAGSI+ VP L+ Sbjct: 449 LARAIRVLGKLEPIYCENVADLPEMLLNVLQDGDIVLNMGAGSINRVPAALL 500 >NMB0423 [M] COG0773 UDP-N-acetylmuramate-alanine ligase Nme Neisseria meningitidis MC58 Length = 469 Score = 553 bits (1424), Expect = e-157, Method: Compositional matrix adjust. Identities = 287/473 (60%), Positives = 353/473 (74%), Gaps = 14/473 (2%) Query: 364 MKHRVKNIHFVGIGGSGMSGIAEVLLNLGYGVSGSDLGSNAATQRLAQLGASIRYGHAAE 423 MK+RV NIHFVGIGG GMSGIAEVL NLG+ VSGSD NAAT+ L LG + GH AE Sbjct: 2 MKNRVTNIHFVGIGGVGMSGIAEVLHNLGFKVSGSDQARNAATEHLGSLGIQVYPGHTAE 61 Query: 424 NIEGADAIVTSTAVKGDNPEVLAARKKHIPIVPRAVMLGELMRLKKGIAIAGTHGKTTTT 483 ++ GAD +VTSTAVK +NPEV+AA ++ IP++PRA+ML ELMR + GIAIAGTHGKTTTT Sbjct: 62 HVNGADVVVTSTAVKKENPEVVAALEQQIPVIPRALMLAELMRFRDGIAIAGTHGKTTTT 121 Query: 484 SLVASVLAQGGLDPTFVIGGPQGDCGLTSAGANAKLGTGEFIVAEADESDASFLNLTPVI 543 SL AS+L GLDPTFVIGG L +AG NA+LG GE+IVAEADESDASFL+LTP++ Sbjct: 122 SLTASILGAAGLDPTFVIGGK-----LNAAGTNARLGKGEYIVAEADESDASFLHLTPIM 176 Query: 544 EVITNIDADHMETYNHDFARLKQAFVEFTQRLPFYGVAVLCLDDPHVREIMPMVSKPILT 603 V+TNID DHM+TY H +L QAF++F R+PFYG A LC+D HVR I+P VSKP T Sbjct: 177 SVVTNIDEDHMDTYGHSVEKLHQAFIDFIHRMPFYGKAFLCIDSEHVRAILPKVSKPYAT 236 Query: 604 YGFHEDADVRAIDAKAVDGKMEFTV-IQ-DGY--APMQVSLNQPGMHNVQNACAAIAIAR 659 YG + AD+ A D + V +M+FTV +Q G+ +V LN PG HNV NA AAI +A Sbjct: 237 YGLDDTADIYATDIENVGAQMKFTVHVQMKGHEQGSFEVVLNMPGRHNVLNALAAIGVAL 296 Query: 660 ELDVDDAATQKALTEFNGVGRRFTRYGEVPITDAQGNPAGHFTLVDDYGHHPVETAATIA 719 E+ A QK L F GVGRRF +YG++ + + G LVDDYGHHPVE AAT+A Sbjct: 297 EVGASVEAIQKGLLGFEGVGRRFQKYGDIKLPN-----GGTALLVDDYGHHPVEMAATLA 351 Query: 720 AARGAYPGRRLVLAFQPHRYTRTRDLFEDFVKVLSSPDVLVLGEVYSAGEAPIVAADGRS 779 AARGAY +RLVLAFQPHRYTRTRDLFEDF KVL++ D LVL EVY+AGE PI AAD R+ Sbjct: 352 AARGAYLEKRLVLAFQPHRYTRTRDLFEDFTKVLNTVDALVLTEVYAAGEEPIAAADSRA 411 Query: 780 LAHALRAAGKVEPVFVDDIGDMPETIRNVVRDGDVVMTMGAGSISAVPGRLVA 832 LA A+R GK+EP++ +++ D+PE + NV++DGD+V+ MGAGSI+ VP L+A Sbjct: 412 LARAIRVLGKLEPIYCENVADLPEMLLNVLQDGDIVLNMGAGSINRVPAALLA 464 >PA4411 [M] COG0773 UDP-N-acetylmuramate-alanine ligase Pae Pseudomonas aeruginosa Length = 480 Score = 519 bits (1337), Expect = e-147, Method: Compositional matrix adjust. Identities = 259/473 (54%), Positives = 336/473 (71%), Gaps = 13/473 (2%) Query: 372 HFVGIGGSGMSGIAEVLLNLGYGVSGSDLGSNAATQRLAQLGASIRYGHAAENIEGADAI 431 HFVGIGG+GM GIAEVLLNLGY VSGSDL ++A T+RL + GA I GH AEN +GAD + Sbjct: 19 HFVGIGGAGMCGIAEVLLNLGYEVSGSDLKASAVTERLEKFGAQIFIGHQAENADGADVL 78 Query: 432 VTSTAVKGDNPEVLAARKKHIPIVPRAVMLGELMRLKKGIAIAGTHGKTTTTSLVASVLA 491 V S+A+ NPEV +A ++ IP+VPRA ML ELMR + GIA+AGTHGKTTTTSL+ASV A Sbjct: 79 VVSSAINRANPEVASALERRIPVVPRAEMLAELMRYRHGIAVAGTHGKTTTTSLIASVFA 138 Query: 492 QGGLDPTFVIGGPQGDCGLTSAGANAKLGTGEFIVAEADESDASFLNLTPVIEVITNIDA 551 GGLDPTFVIGG L +AG NA+LG ++VAEADESDASFL+L P++ V+TNIDA Sbjct: 139 AGGLDPTFVIGGR-----LNAAGTNAQLGASRYLVAEADESDASFLHLQPMVAVVTNIDA 193 Query: 552 DHMETYNHDFARLKQAFVEFTQRLPFYGVAVLCLDDPHVREIMPMVSKPILTYGFHEDAD 611 DHM TY DF +LK+ FVEF LPFYG+AV+C+DDP VREI+P +++P +TYG EDAD Sbjct: 194 DHMATYGGDFNKLKKTFVEFLHNLPFYGLAVMCVDDPVVREILPQIARPTVTYGLSEDAD 253 Query: 612 VRAIDAKAVDGKMEFTVIQDGYAPMQVSLNQPGMHNVQNACAAIAIARELDVDDAATQKA 671 VRAI+ + + FTV++ P+ VS+N PG+HNV N+ A I IA + + D A + Sbjct: 254 VRAINIRQEGMRTWFTVLRPEREPLDVSVNMPGLHNVLNSLATIVIATDEGISDEAIVQG 313 Query: 672 LTEFNGVGRRFTRYGEVPITDAQGNPAGHFTLVDDYGHHPVETAATIAAARGAYPGRRLV 731 L+ F GVGRRF YGE+ + G LVDDYGHHP E AA I A RG +P RRLV Sbjct: 314 LSGFQGVGRRFQVYGELQVE------GGSVMLVDDYGHHPREVAAVIKAIRGGWPERRLV 367 Query: 732 LAFQPHRYTRTRDLFEDFVKVLSSPDVLVLGEVYSAGEAPIVAADGRSLAHALRAAGKVE 791 + +QPHRYTRTRDL+EDFV+VL +VL+L EVY AGE PI AD R L H++R G+++ Sbjct: 368 MVYQPHRYTRTRDLYEDFVQVLGEANVLLLMEVYPAGEEPIPGADSRQLCHSIRQRGQLD 427 Query: 792 PVFVDDIGDMPETIRNVVRDGDVVMTMGAGSISAVPGRLVAQA--GGKNEQGA 842 P++ + D+ ++ ++R GD+++ GAG + + +L+ GK +GA Sbjct: 428 PIYFERDADLAPLVKPLLRAGDILLCQGAGDVGGLAPQLIKNPLFAGKGGKGA 480 >XF0798 [M] COG0773 UDP-N-acetylmuramate-alanine ligase Xfa Xylella fastidiosa 9a5c Length = 477 Score = 495 bits (1274), Expect = e-139, Method: Compositional matrix adjust. Identities = 254/460 (55%), Positives = 325/460 (70%), Gaps = 10/460 (2%) Query: 371 IHFVGIGGSGMSGIAEVLLNLGYGVSGSDLGSNAATQRLAQLGASIRYGHAAENIEGADA 430 +HFVGIGG+GM+GIAEV+L LGY VSGSD NAAT+RLA LGA + GH+A N+ G D Sbjct: 18 VHFVGIGGAGMTGIAEVMLTLGYEVSGSDNADNAATRRLATLGARVMRGHSAANVLGTDC 77 Query: 431 IVTSTAVKGDNPEVLAARKKHIPIVPRAVMLGELMRLKKGIAIAGTHGKTTTTSLVASVL 490 +V S+A++ DNPE++ AR + IPI+PRA ML ELMR + GIA+AGTHGKTTTTSL+A+VL Sbjct: 78 VVVSSAIREDNPELMEARSQRIPIMPRAAMLAELMRFRHGIAVAGTHGKTTTTSLIAAVL 137 Query: 491 AQGGLDPTFVIGGPQGDCGLTSAGANAKLGTGEFIVAEADESDASFLNLTPVIEVITNID 550 ++GGLDPTFVIGG L +AGANAKLG G+++V EADESD SFL L P++ V+TNID Sbjct: 138 SEGGLDPTFVIGGQ-----LLAAGANAKLGAGQWLVVEADESDGSFLRLNPLVAVVTNID 192 Query: 551 ADHMETYNHDFARLKQAFVEFTQRLPFYGVAVLCLDDPHVREIMPMVSKPILTYGFHEDA 610 ADH+E Y +DF+R+K AF EF QRLPFYG+A+LCLDDP V E+ + ++TYG A Sbjct: 193 ADHLENYGNDFSRIKDAFTEFLQRLPFYGLALLCLDDPEVAELAGKARRHVMTYGIDAAA 252 Query: 611 DVRAIDAKAVDGKMEFTVIQDGYAPMQVSLNQPGMHNVQNACAAIAIARELDVDDAATQK 670 DVRA D +M FT+ + V+L PG HNV NA AA A+ +L V + Sbjct: 253 DVRAEDVVQDGARMCFTLCLPEGKVIPVTLALPGRHNVLNALAASAVGWQLGVPPEVIGR 312 Query: 671 ALTEFNGVGRRFTRYGEVPITDAQGNPAGHFTLVDDYGHHPVETAATIAAARGAYPGRRL 730 AL F G+GRRF G+V I GN A L+DDYGHHP E A AA RG +P +RL Sbjct: 313 ALKSFVGIGRRFNDLGDVAI----GNGAC-VRLIDDYGHHPRELEAVFAAVRGGWPDKRL 367 Query: 731 VLAFQPHRYTRTRDLFEDFVKVLSSPDVLVLGEVYSAGEAPIVAADGRSLAHALRAAGKV 790 V+AFQPHRY+RTRD F+ F VLSS D LVL EVY AGE PI AD ++LA A+RA G+ Sbjct: 368 VVAFQPHRYSRTRDQFDAFAAVLSSVDALVLSEVYPAGEVPIPGADAKALARAIRARGRS 427 Query: 791 EPVFVDDIGDMPETIRNVVRDGDVVMTMGAGSISAVPGRL 830 EPV V + + E + +V+++GD+++ MGAG I ++ R+ Sbjct: 428 EPVVVGQVASLIEVLPDVLQEGDLLLMMGAGDIGSIAQRI 467