BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0022.0157.p (1071 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSp1113 [V] COG0841 Cation/multidrug efflux pump Rso Ralstonia s... 1533 0.0 SMc01095 [V] COG0841 Cation/multidrug efflux pump Sme Sinorhizob... 1416 0.0 AGc4508 [V] COG0841 Cation/multidrug efflux pump Atu Agrobacteri... 1355 0.0 PA2494 [V] COG0841 Cation/multidrug efflux pump Pae Pseudomonas ... 1310 0.0 STM0351 [V] COG0841 Cation/multidrug efflux pump Sty Salmonella ... 1208 0.0 >RSp1113 [V] COG0841 Cation/multidrug efflux pump Rso Ralstonia solanacearum Length = 1069 Score = 1533 bits (3969), Expect = 0.0, Method: Compositional matrix adjust. Identities = 817/1042 (78%), Positives = 922/1042 (88%) Query: 1 MNISKFFIDRPIFAGVLSVLLLLGGVLAMLQLPISEYPEVVPPSVVVRAQYPGANPKVIA 60 MN SKFF+DRPIFAGVLS L+LL G++++ +LPISEYPEVVPPSVVVRAQ+PGANPKVIA Sbjct: 1 MNFSKFFVDRPIFAGVLSTLILLIGIISIWRLPISEYPEVVPPSVVVRAQFPGANPKVIA 60 Query: 61 ETVASPLEEQINGVENMLYMQSQANSDGNLTITVNFRLGVDPDKAQQLVQNRVSQALPRL 120 ETVASPLEEQINGVENMLYMQSQANSDGNLT+TV F+LG DPDKAQQLVQNRVSQA+PRL Sbjct: 61 ETVASPLEEQINGVENMLYMQSQANSDGNLTVTVTFKLGTDPDKAQQLVQNRVSQAMPRL 120 Query: 121 PEDVQRLGVTTLKSSPTLTMVVHLTSPDNRYDTTYLRNYAVLNVKDRLARIQGVGEVGLF 180 P+ VQRLGVTT+KSSP LTMVVHL SP++RYD TYLRNYAVLNVKDRLARI GVG+V LF Sbjct: 121 PDVVQRLGVTTIKSSPDLTMVVHLLSPNDRYDMTYLRNYAVLNVKDRLARINGVGQVQLF 180 Query: 181 GSGNYAMRVWLDPNKVAQRGLTASDVVRAIREQNVQVAAGVIGASPSSPETPLQLSVNAQ 240 GSG+Y+MRVWLDPNKVA+RGLTA++VVRAIR+QNVQVAAGVIG SPS P T LQLSVNAQ Sbjct: 181 GSGDYSMRVWLDPNKVAERGLTANEVVRAIRDQNVQVAAGVIGGSPSLPGTDLQLSVNAQ 240 Query: 241 GRLKTEGEFRDIILKASPDGATTRLGDVARVELAASEYGLRSLLDNKPAVAIPIFQAPGA 300 GRLKTE EF DIILK+SP+GA T L DVAR+ELAASEYGLRSLLDNK AVAIPIFQAPG+ Sbjct: 241 GRLKTEQEFGDIILKSSPNGAVTTLRDVARIELAASEYGLRSLLDNKQAVAIPIFQAPGS 300 Query: 301 NALDVSTQVRAAMKELSADFPSSVSYSIVYDPTQFVRASIEAVVHTLLEAIALVVIVVII 360 NAL +S VR M EL DFP V Y IVYDPTQFVR+SIEAV HTLLEA+ALVV+VVI+ Sbjct: 301 NALQISDDVRKTMAELKEDFPEGVDYRIVYDPTQFVRSSIEAVTHTLLEAVALVVLVVIL 360 Query: 361 FLQTWRASIIPLLAVPVSIIGTFSLMLGFGYTINALSLFGMVLAIGIVVDDAIVVVENVE 420 FLQTWRAS+IPLLAVPVSIIGTF LML FG++INALSLFG+VLAIGIVVDDAIVVVENVE Sbjct: 361 FLQTWRASVIPLLAVPVSIIGTFGLMLMFGFSINALSLFGLVLAIGIVVDDAIVVVENVE 420 Query: 421 RNIGAGLSPRDATYRAMQEVSGPIIAIALTLVAVFVPLAFMTGLTGQFYKQFAMTIAIST 480 RNI GLSPR+ATY+AM+EVSGPIIAIALTL+AVFVPLAFMTGLTGQFYKQFA+TI+IST Sbjct: 421 RNIADGLSPREATYKAMREVSGPIIAIALTLIAVFVPLAFMTGLTGQFYKQFALTISIST 480 Query: 481 VISAFNSLTLSPALAALLLKGHGDKPDWLTRQMDRFLGGFFIRFNRFFNRASDNYGHGVT 540 VISAFNSLTLSPALAALLLK H D L R M+R LG F FNR F AS++YG + Sbjct: 481 VISAFNSLTLSPALAALLLKSHDAPKDLLARVMERGLGWIFRPFNRVFGAASESYGRSTS 540 Query: 541 GVIKRKGATMGVYVVLLAATLGVSYIVPGGFVPGQDKQYLVAFAQLPNGASIDRSEEVMR 600 VI RK +G+Y+ L+ T + VPGGFVP QDKQYLV+FAQLP+GAS+DR+E+V+R Sbjct: 541 RVIGRKAVMLGIYLALIGLTALLFNRVPGGFVPMQDKQYLVSFAQLPDGASLDRTEDVIR 600 Query: 601 KMSDIMLKEPGVASAIAFPGLSINGFTNSSSAGIVFVGLKPFEERKSKELSGNAIAASLN 660 +MSDI LK PGV SA+AFPGLSINGFTNS SAGIVFV LKPF++RK+ LSG AIA LN Sbjct: 601 RMSDIALKHPGVESAVAFPGLSINGFTNSPSAGIVFVTLKPFDQRKTPNLSGGAIAGQLN 660 Query: 661 KKFGGIKEAFTAVFPPPPVMGLGTLGGFKMQIEDRDALGYAELDKAAQAFMKAAAKEPAL 720 +++G IK+AF AVFPPPPV GLGT+GGFKMQ+EDR ++GY +L A+QAFM+ A + P L Sbjct: 661 QQYGAIKDAFIAVFPPPPVQGLGTVGGFKMQLEDRGSVGYEQLFAASQAFMQKARQTPEL 720 Query: 721 GPMFSSYQINVPQLDVELDRVKAKQLGIPVTDVFNTMQIYLGSLYVNDFNRFGRVYQVRA 780 GP FSSYQINVPQL+ +LDRVKAKQLG+PVTDVF+TMQIYLGSLYVNDFNRFGR YQV+ Sbjct: 721 GPSFSSYQINVPQLNADLDRVKAKQLGVPVTDVFDTMQIYLGSLYVNDFNRFGRTYQVKV 780 Query: 781 QADAPFRAKAEDIAQLKTRNDAGEMVPLSSVVKVKQTFGPEMVVRYNGYTAADINGGPAP 840 QADAPFRA AEDI QLKTRN G+MVPLSS+++V Q FGP+MVVRYNGYTAADINGGPAP Sbjct: 781 QADAPFRAHAEDILQLKTRNTDGDMVPLSSLLRVSQGFGPDMVVRYNGYTAADINGGPAP 840 Query: 841 GYSSDQAQAAAERVAAATLPRGIKFEWTDLTYQKILAGNAGVWVFPISVLLVFLVLAALY 900 GYSS QAQAAAER+A LP+G++FEWTDLTYQ+ILAGN+ VW+FP+ VLLVFLVLAA Y Sbjct: 841 GYSSGQAQAAAERIAREVLPKGVRFEWTDLTYQQILAGNSAVWIFPLCVLLVFLVLAAQY 900 Query: 901 ESLTLPLAVILIVPMSILAALTGVWLTRGDNNIFTQIGLMVLVGLSAKNAILIVEFAREL 960 ESLTLPLAVILIVPMS+ AA+ GVW++ GDNNIFTQIGL+VLVGL+ KNAILIVEFAREL Sbjct: 901 ESLTLPLAVILIVPMSLFAAMLGVWISHGDNNIFTQIGLVVLVGLACKNAILIVEFAREL 960 Query: 961 EMQGRTAVQAAIEASRLRLRPILMTSIAFIMGVVPLVTSSGAGSEMRHAMGIAVFFGMLG 1020 E+QGR+ V+AAIEA RLRLRPILMTSIAFIMGVVPLV S+GAG+EMRHAMG+AVF GMLG Sbjct: 961 ELQGRSIVEAAIEACRLRLRPILMTSIAFIMGVVPLVMSTGAGAEMRHAMGVAVFAGMLG 1020 Query: 1021 VTLFGLFLTPVFYVLLRTIDRR 1042 VTLFGLFLTPVFYV+LRT+ R Sbjct: 1021 VTLFGLFLTPVFYVVLRTLASR 1042 >SMc01095 [V] COG0841 Cation/multidrug efflux pump Sme Sinorhizobium meliloti Length = 1061 Score = 1416 bits (3665), Expect = 0.0, Method: Compositional matrix adjust. Identities = 752/1068 (70%), Positives = 880/1068 (82%), Gaps = 10/1068 (0%) Query: 1 MNISKFFIDRPIFAGVLSVLLLLGGVLAMLQLPISEYPEVVPPSVVVRAQYPGANPKVIA 60 MN S+FF+DRP+FAGVLSV++ + G++ M LPISEYPEVVPP +VVRAQYPGANP VIA Sbjct: 1 MNFSRFFVDRPVFAGVLSVIIFVAGLIGMTGLPISEYPEVVPPQIVVRAQYPGANPAVIA 60 Query: 61 ETVASPLEEQINGVENMLYMQSQANSDGNLTITVNFRLGVDPDKAQQLVQNRVSQALPRL 120 ETVA+PLEEQINGVE MLYMQSQA +DG +T+TV F LG DPD+AQQLVQNRVSQ PRL Sbjct: 61 ETVATPLEEQINGVEGMLYMQSQATADGLMTLTVTFELGTDPDQAQQLVQNRVSQGEPRL 120 Query: 121 PEDVQRLGVTTLKSSPTLTMVVHLTSPDNRYDTTYLRNYAVLNVKDRLARIQGVGEVGLF 180 PE+V+RLGVTT+KSSP LT+VVHL SP+ +YD YLRNY VLNVKDRLAR+ GVG+V +F Sbjct: 121 PEEVRRLGVTTVKSSPDLTLVVHLISPNGQYDINYLRNYGVLNVKDRLARVDGVGQVQIF 180 Query: 181 GSGNYAMRVWLDPNKVAQRGLTASDVVRAIREQNVQVAAGVIGASPSSPETPLQLSVNAQ 240 G G+Y+MRVW+DP K A+RGL ASD+ A+R QNVQ AAGVIGASPS P LQLSVNAQ Sbjct: 181 GGGDYSMRVWIDPEKAAERGLAASDIANAVRGQNVQAAAGVIGASPSVPGLDLQLSVNAQ 240 Query: 241 GRLKTEGEFRDIILKASPDGATTRLGDVARVELAASEYGLRSLLDNKPAVAIPIFQAPGA 300 GRLKT +F DI++K+ G TRLGDVARVE+ A++Y LRSLLDNK AV + +FQAPG+ Sbjct: 241 GRLKTPEDFADIVVKSGESGEITRLGDVARVEMGAADYSLRSLLDNKAAVGMGVFQAPGS 300 Query: 301 NALDVSTQVRAAMKELSADFPSSVSYSIVYDPTQFVRASIEAVVHTLLEAIALVVIVVII 360 NA+ +S V M EL P V Y IVYD TQFVRASIE+V+HTLLEAIALVV+VVI+ Sbjct: 301 NAIQISENVHKVMAELKQTMPDGVDYEIVYDTTQFVRASIESVIHTLLEAIALVVVVVIV 360 Query: 361 FLQTWRASIIPLLAVPVSIIGTFSLMLGFGYTINALSLFGMVLAIGIVVDDAIVVVENVE 420 FLQTWRASIIPL+AVPVSI+GTF++M FG++INALSLFG+VLAIGIVVDDAIVVVENVE Sbjct: 361 FLQTWRASIIPLVAVPVSIVGTFAVMYVFGFSINALSLFGLVLAIGIVVDDAIVVVENVE 420 Query: 421 RNIGAGLSPRDATYRAMQEVSGPIIAIALTLVAVFVPLAFMTGLTGQFYKQFAMTIAIST 480 RNI GLSP ATYRAMQEVSGPIIAIAL LVAVFVPLAF+TGLTGQFY+QFA+TIAIST Sbjct: 421 RNISQGLSPVQATYRAMQEVSGPIIAIALVLVAVFVPLAFITGLTGQFYRQFALTIAIST 480 Query: 481 VISAFNSLTLSPALAALLLKGHGDKPDWLTRQMDRFLGGFFIRFNRFFNRASDNYGHGVT 540 VISA NSLTLSPALAALLLK H D LTR MD G FF FNRFF +S+ YG GV Sbjct: 481 VISALNSLTLSPALAALLLKDHHAPKDRLTRVMDGLFGWFFRGFNRFFGASSEAYGRGVG 540 Query: 541 GVIKRKGATMGVYVVLLAATLGVSYIVPGGFVPGQDKQYLVAFAQLPNGASIDRSEEVMR 600 G++ RK MGVYVVLL T + VPGGFVP QDKQYL+ FAQLP+ A++DRSE+V+R Sbjct: 541 GILTRKSLVMGVYVVLLGVTFVLFRAVPGGFVPAQDKQYLIGFAQLPDAATLDRSEDVIR 600 Query: 601 KMSDIMLKEPGVASAIAFPGLSINGFTNSSSAGIVFVGLKPFEERKSKELSGNAIAASLN 660 +MS+I LK PGV AIAFPGLSINGFTNSS++GIVFV LKPFEER + ELSG AIA LN Sbjct: 601 RMSEIALKHPGVEHAIAFPGLSINGFTNSSNSGIVFVSLKPFEERTTPELSGGAIAMQLN 660 Query: 661 KKFGGIKEAFTAVFPPPPVMGLGTLGGFKMQIEDRDALGYAELDKAAQAFMKAAAKEPAL 720 ++FG I++AF A+FPPPPV GLGT GGFK+QIEDR+ LGY LD A +A + A P L Sbjct: 661 QEFGAIQDAFIAMFPPPPVQGLGTTGGFKLQIEDRNGLGYRTLDDATKAVLAKAMAAPEL 720 Query: 721 GPMFSSYQINVPQLDVELDRVKAKQLGIPVTDVFNTMQIYLGSLYVNDFNRFGRVYQVRA 780 ++SS+QINVPQL +LDR KA+QLG+ VTDVF T+QIYLGSLYVNDFN FGR Y VR Sbjct: 721 AGLYSSFQINVPQLYADLDRTKARQLGVAVTDVFETLQIYLGSLYVNDFNAFGRTYSVRI 780 Query: 781 QADAPFRAKAEDIAQLKTRNDAGEMVPLSSVVKVKQTFGPEMVVRYNGYTAADINGGPAP 840 QADA +R+ A+DI +LK R+ GEM+PLS+++ V+QT G E +RYNG+ AADINGGPAP Sbjct: 781 QADASYRSHADDIGKLKVRSQTGEMIPLSALLNVEQTVGAERAIRYNGFLAADINGGPAP 840 Query: 841 GYSSDQAQAAAERVAAATLPRGIKFEWTDLTYQKILAGNAGVWVFPISVLLVFLVLAALY 900 G+SS QAQAA ER+AA TLP GI +EWTDLTYQ+ILAGN+G+ VFP+++LLV+LVLAA Y Sbjct: 841 GFSSGQAQAAIERIAAETLPPGISYEWTDLTYQQILAGNSGILVFPLALLLVYLVLAAQY 900 Query: 901 ESLTLPLAVILIVPMSILAALTGVWLTRGDNNIFTQIGLMVLVGLSAKNAILIVEFAREL 960 ESL LP+A+ILIVPM I+AALTGVWLT GDNN+FTQIGL+VLVGLSAKNAILIVEFAREL Sbjct: 901 ESLLLPIAIILIVPMGIMAALTGVWLTGGDNNVFTQIGLIVLVGLSAKNAILIVEFAREL 960 Query: 961 EMQGRTAVQAAIEASRLRLRPILMTSIAFIMGVVPLVTSSGAGSEMRHAMGIAVFFGMLG 1020 E+ G AV AAIEASRLRLRPILMTS+AFIMGVVPLVTS+GAG+EMR AMG+AVF GM+G Sbjct: 961 ELSGSNAVSAAIEASRLRLRPILMTSMAFIMGVVPLVTSTGAGAEMRSAMGVAVFAGMIG 1020 Query: 1021 VTLFGLFLTPVFYVLLRTI--DRRALHSASHHEAPMTAGTHIAHAAPG 1066 VT FG+F+TPVFYVL+R + ++ H+ +H EAP H APG Sbjct: 1021 VTAFGIFMTPVFYVLIRKLSGEKPLKHTGAHIEAP--------HLAPG 1060 >AGc4508 [V] COG0841 Cation/multidrug efflux pump Atu Agrobacterium tumefaciens strain C58 (Cereon) Length = 1064 Score = 1355 bits (3507), Expect = 0.0, Method: Compositional matrix adjust. Identities = 726/1039 (69%), Positives = 863/1039 (83%) Query: 1 MNISKFFIDRPIFAGVLSVLLLLGGVLAMLQLPISEYPEVVPPSVVVRAQYPGANPKVIA 60 MNIS+FF+DRP+FAGVLS+L+++ G+L M LPISEYPEVVPPSVVVRA YPGANP VIA Sbjct: 1 MNISRFFVDRPVFAGVLSILIVVAGLLGMRALPISEYPEVVPPSVVVRATYPGANPTVIA 60 Query: 61 ETVASPLEEQINGVENMLYMQSQANSDGNLTITVNFRLGVDPDKAQQLVQNRVSQALPRL 120 ETVA+PLEEQINGVE+MLYM SQA SDG LT+TV F+LG DPDKAQQLVQNRVSQA PRL Sbjct: 61 ETVATPLEEQINGVEDMLYMGSQATSDGVLTLTVTFKLGTDPDKAQQLVQNRVSQAEPRL 120 Query: 121 PEDVQRLGVTTLKSSPTLTMVVHLTSPDNRYDTTYLRNYAVLNVKDRLARIQGVGEVGLF 180 P +V+ LG+TT+KSSP MVV+L S + YD TYLRNYA LNVKDRLARI+GVG+V +F Sbjct: 121 PAEVRALGITTVKSSPDFIMVVNLVSKTDAYDITYLRNYATLNVKDRLARIEGVGQVQVF 180 Query: 181 GSGNYAMRVWLDPNKVAQRGLTASDVVRAIREQNVQVAAGVIGASPSSPETPLQLSVNAQ 240 G+G+Y+MRVWLDP KVA+ L A+DV AIR+QNVQ AAGVIGASPS LQL+VNAQ Sbjct: 181 GAGDYSMRVWLDPQKVAEHDLAAADVSDAIRQQNVQAAAGVIGASPSPNGVDLQLNVNAQ 240 Query: 241 GRLKTEGEFRDIILKASPDGATTRLGDVARVELAASEYGLRSLLDNKPAVAIPIFQAPGA 300 GRL T EF +II+K+ +G TRL DVAR+EL A++Y LRSLLD +PAVA+ + QAPG+ Sbjct: 241 GRLTTPEEFGNIIVKSGANGEITRLRDVARIELGAADYTLRSLLDGEPAVAVAVLQAPGS 300 Query: 301 NALDVSTQVRAAMKELSADFPSSVSYSIVYDPTQFVRASIEAVVHTLLEAIALVVIVVII 360 NA++++ VRA M L P V Y IVYD T+FVR+SIE VV TLLEA+ LVV+VVI+ Sbjct: 301 NAIEIADNVRATMDNLQLAMPDGVKYEIVYDTTKFVRSSIEKVVDTLLEAVGLVVLVVIL 360 Query: 361 FLQTWRASIIPLLAVPVSIIGTFSLMLGFGYTINALSLFGMVLAIGIVVDDAIVVVENVE 420 FLQTWRASIIPL+AVPVSIIGTF++M FG++INAL+LFG+VLAIGIVVDDAIVVVENVE Sbjct: 361 FLQTWRASIIPLIAVPVSIIGTFAVMYAFGFSINALTLFGLVLAIGIVVDDAIVVVENVE 420 Query: 421 RNIGAGLSPRDATYRAMQEVSGPIIAIALTLVAVFVPLAFMTGLTGQFYKQFAMTIAIST 480 RNI GLSPRDATY+AM+EVSGPIIAIAL LVAVFVPLAF++GL+GQFY+QFA+TIAIST Sbjct: 421 RNIENGLSPRDATYKAMREVSGPIIAIALVLVAVFVPLAFISGLSGQFYRQFALTIAIST 480 Query: 481 VISAFNSLTLSPALAALLLKGHGDKPDWLTRQMDRFLGGFFIRFNRFFNRASDNYGHGVT 540 VISA NSLTLSPALAALLLK HG DWLTR MD+ LG FF FNR F AS+ YG V Sbjct: 481 VISAINSLTLSPALAALLLKEHGAPKDWLTRFMDKILGWFFRGFNRAFGAASNGYGKTVG 540 Query: 541 GVIKRKGATMGVYVVLLAATLGVSYIVPGGFVPGQDKQYLVAFAQLPNGASIDRSEEVMR 600 G++ RK M VY+ L+AAT G+ VP GFVP QDKQYL+ FAQLP+GA++DR+E V++ Sbjct: 541 GLVTRKSLVMIVYMALVAATYGMFTTVPSGFVPAQDKQYLIGFAQLPDGATLDRTESVIK 600 Query: 601 KMSDIMLKEPGVASAIAFPGLSINGFTNSSSAGIVFVGLKPFEERKSKELSGNAIAASLN 660 +MS I ++ PGV+ AIAFPGLSINGFT S++GIVF L FE+RK+ ELSG AIA LN Sbjct: 601 RMSAIAMETPGVSHAIAFPGLSINGFTIGSNSGIVFAVLDDFEKRKTPELSGGAIAMQLN 660 Query: 661 KKFGGIKEAFTAVFPPPPVMGLGTLGGFKMQIEDRDALGYAELDKAAQAFMKAAAKEPAL 720 +KF GI++AF A+FPPPPV GLG GGFK+QIEDR GY LD+AA+A + A + P L Sbjct: 661 QKFAGIQDAFIAMFPPPPVNGLGQTGGFKLQIEDRAGYGYQTLDEAAKAVIAKAYQTPEL 720 Query: 721 GPMFSSYQINVPQLDVELDRVKAKQLGIPVTDVFNTMQIYLGSLYVNDFNRFGRVYQVRA 780 +FSS+QINVPQL +LDR KA+QLG+ V+DVF T+QIYLGSLYVNDFN FGR Y VR Sbjct: 721 AGIFSSFQINVPQLFADLDRAKAEQLGVSVSDVFQTLQIYLGSLYVNDFNAFGRTYSVRV 780 Query: 781 QADAPFRAKAEDIAQLKTRNDAGEMVPLSSVVKVKQTFGPEMVVRYNGYTAADINGGPAP 840 QAD+ FRA AEDI +LK R+ G+M+PLS+++KV T GPE RYNG+ AADINGGPAP Sbjct: 781 QADSQFRAHAEDIGRLKVRSATGQMIPLSTLLKVDATTGPERTNRYNGFLAADINGGPAP 840 Query: 841 GYSSDQAQAAAERVAAATLPRGIKFEWTDLTYQKILAGNAGVWVFPISVLLVFLVLAALY 900 G+SS QAQAA E++ A LP GI +EWTDLTYQ+ILAGN+ + VFP+++LLV+LVLAA Y Sbjct: 841 GFSSGQAQAAMEKILAENLPAGIDYEWTDLTYQQILAGNSSIVVFPLALLLVYLVLAAQY 900 Query: 901 ESLTLPLAVILIVPMSILAALTGVWLTRGDNNIFTQIGLMVLVGLSAKNAILIVEFAREL 960 ESLTLP+A+ILIVP+ +LAALTGVWLT GDNNIFTQIGL+VLVGLSAKNAILIVEFAREL Sbjct: 901 ESLTLPIAIILIVPLGVLAALTGVWLTGGDNNIFTQIGLVVLVGLSAKNAILIVEFAREL 960 Query: 961 EMQGRTAVQAAIEASRLRLRPILMTSIAFIMGVVPLVTSSGAGSEMRHAMGIAVFFGMLG 1020 E +GRT +QAA+EASRLRLRPILMTS+AFIMGVVPLV S+GAG+EMR AMG+AVF GM+G Sbjct: 961 EFEGRTPLQAAVEASRLRLRPILMTSLAFIMGVVPLVVSTGAGAEMRAAMGVAVFSGMIG 1020 Query: 1021 VTLFGLFLTPVFYVLLRTI 1039 VT FG+F+TPVFYVL+R + Sbjct: 1021 VTFFGIFMTPVFYVLVRKL 1039 >PA2494 [V] COG0841 Cation/multidrug efflux pump Pae Pseudomonas aeruginosa Length = 1062 Score = 1310 bits (3391), Expect = 0.0, Method: Compositional matrix adjust. Identities = 687/1058 (64%), Positives = 833/1058 (78%), Gaps = 5/1058 (0%) Query: 1 MNISKFFIDRPIFAGVLSVLLLLGGVLAMLQLPISEYPEVVPPSVVVRAQYPGANPKVIA 60 MN S+FFI RPIFA VLS+L+L+GG +++ QLPISEYPEVVPP+VVVRA +PGANPKVI Sbjct: 1 MNFSQFFIQRPIFAAVLSLLILIGGAISLFQLPISEYPEVVPPTVVVRANFPGANPKVIG 60 Query: 61 ETVASPLEEQINGVENMLYMQSQANSDGNLTITVNFRLGVDPDKAQQLVQNRVSQALPRL 120 ETVASPLE+ I GVENMLYM SQ+ SDG LT+T+ F LG D D AQ VQNRV++ P+L Sbjct: 61 ETVASPLEQAITGVENMLYMSSQSTSDGKLTLTITFALGTDLDNAQVQVQNRVTRTEPKL 120 Query: 121 PEDVQRLGVTTLKSSPTLTMVVHLTSPDNRYDTTYLRNYAVLNVKDRLARIQGVGEVGLF 180 PE+V RLG+T K+SP LTMVVHLTSPDNRYD YL NYAVLNVKD LAR+ GVG+V LF Sbjct: 121 PEEVTRLGITVDKASPDLTMVVHLTSPDNRYDMLYLSNYAVLNVKDELARLDGVGDVQLF 180 Query: 181 GSGNYAMRVWLDPNKVAQRGLTASDVVRAIREQNVQVAAGVIGASPSSPETPLQLSVNAQ 240 G G+Y++RVWLDPNKVA R LTA+DVV AIREQN QVAAG +GA P+ +T QLS+N Q Sbjct: 181 GLGDYSLRVWLDPNKVASRNLTATDVVNAIREQNRQVAAGTLGAPPAPSDTSFQLSINTQ 240 Query: 241 GRLKTEGEFRDIILKASPDGATTRLGDVARVELAASEYGLRSLLDNKPAVAIPIFQAPGA 300 GRL TE EF +II++A +G TRL D+ARVEL +++Y LRSLL+NKPAVAIPIFQ PG+ Sbjct: 241 GRLVTEEEFENIIIRAGANGEITRLRDIARVELGSNQYALRSLLNNKPAVAIPIFQRPGS 300 Query: 301 NALDVSTQVRAAMKELSADFPSSVSYSIVYDPTQFVRASIEAVVHTLLEAIALVVIVVII 360 NA+++S VR M EL FP + YSIVYDPT FVR SIEAVVHTL EA+ LVV+VVI+ Sbjct: 301 NAIEISNLVREKMAELKHSFPQGMDYSIVYDPTIFVRGSIEAVVHTLFEALVLVVLVVIL 360 Query: 361 FLQTWRASIIPLLAVPVSIIGTFSLMLGFGYTINALSLFGMVLAIGIVVDDAIVVVENVE 420 FLQTWRASIIPL AVPVS+IGTF++M G+++NALSLFG+VLAIGIVVDDAIVVVENVE Sbjct: 361 FLQTWRASIIPLAAVPVSLIGTFAVMHMLGFSLNALSLFGLVLAIGIVVDDAIVVVENVE 420 Query: 421 RNIGAGLSPRDATYRAMQEVSGPIIAIALTLVAVFVPLAFMTGLTGQFYKQFAMTIAIST 480 RNIG GL P +AT RAM+EV+GPIIA AL L AVF+P AF++GLTGQFY+QFA+TIAIST Sbjct: 421 RNIGLGLKPVEATKRAMREVTGPIIATALVLCAVFIPTAFISGLTGQFYRQFALTIAIST 480 Query: 481 VISAFNSLTLSPALAALLLKGHGDKPDWLTRQMDRFLGGFFIR-FNRFFNRASDNYGHGV 539 VISAFNSLTLSPALAA+LLKGH + D + +D+ LG + R FNRFF+RAS Y V Sbjct: 481 VISAFNSLTLSPALAAVLLKGHHEPKDRFSVFLDKLLGSWLFRPFNRFFDRASHGYVGTV 540 Query: 540 TGVIKRKGATMGVYVVLLAATLGVSYIVPGGFVPGQDKQYLVAFAQLPNGASIDRSEEVM 599 V++ + VY L+ T P GFVP QDKQYLVAFAQLP+ AS+DR+E V+ Sbjct: 541 NRVLRGSSIALLVYGGLMVLTYFGFSSTPTGFVPQQDKQYLVAFAQLPDAASLDRTEAVI 600 Query: 600 RKMSDIMLKEPGVASAIAFPGLSINGFTNSSSAGIVFVGLKPFEERKSKELSGNAIAASL 659 ++MS+I L +PGVA ++AFPGLSINGFTNS ++GIVF LKPF+ERK S AIAA+L Sbjct: 601 KQMSEIALAQPGVADSVAFPGLSINGFTNSPNSGIVFTPLKPFDERKDPSQSAGAIAAAL 660 Query: 660 NKKFGGIKEAFTAVFPPPPVMGLGTLGGFKMQIEDRDALGYAELDKAAQAFMKAAAKEPA 719 N K+ I++A+ A+FPPPPV GLGT+GGF++QIEDR GY EL K Q + A P Sbjct: 661 NAKYADIQDAYIAIFPPPPVQGLGTIGGFRLQIEDRGNQGYEELFKQTQNIITKARALPE 720 Query: 720 LGP--MFSSYQINVPQLDVELDRVKAKQLGIPVTDVFNTMQIYLGSLYVNDFNRFGRVYQ 777 L P +FSSYQ+NVPQ+D ++DR KAK G+ ++D+F+T+Q+YLGSLY NDFNRFGR YQ Sbjct: 721 LEPSSVFSSYQVNVPQIDADIDREKAKTHGVAISDIFDTLQVYLGSLYANDFNRFGRTYQ 780 Query: 778 VRAQADAPFRAKAEDIAQLKTRNDAGEMVPLSSVVKVKQTFGPEMVVRYNGYTAADINGG 837 V QA+ FR + E I QLK RN+ GEMVPL+S +KV T GP+ V+ YNG+ A++NG Sbjct: 781 VNVQAEQQFRLEPEQIGQLKVRNNLGEMVPLASFIKVSDTSGPDRVMHYNGFITAELNGA 840 Query: 838 PAPGYSSDQAQAAAERVAAATLPRGIKFEWTDLTYQKILAGNAGVWVFPISVLLVFLVLA 897 PA GYSS QAQAA E++ LP G+ +EWT+LTYQ+ILAGN ++VFP+ VLL FLVLA Sbjct: 841 PAAGYSSGQAQAAIEKLLKEELPNGMTYEWTELTYQQILAGNTALFVFPLCVLLAFLVLA 900 Query: 898 ALYESLTLPLAVILIVPMSILAALTGVWLTRGDNNIFTQIGLMVLVGLSAKNAILIVEFA 957 A YES +LPLAVILIVPM++L+A+TGV L DNNIFTQIGL+VLVGL+ KNAILIVEFA Sbjct: 901 AQYESWSLPLAVILIVPMTLLSAITGVILAGSDNNIFTQIGLIVLVGLACKNAILIVEFA 960 Query: 958 RELEMQGRTAVQAAIEASRLRLRPILMTSIAFIMGVVPLVTSSGAGSEMRHAMGIAVFFG 1017 ++ + +G V A +EA RLRLRPILMTSIAFIMGVVPLV S+GAG+EMRHAMG+AVF G Sbjct: 961 KDKQEEGMDRVAAVLEACRLRLRPILMTSIAFIMGVVPLVISTGAGAEMRHAMGVAVFSG 1020 Query: 1018 MLGVTLFGLFLTPVFYVLLRTI--DRRALHSASHHEAP 1053 M+GVT FGL LTPVFYVL+R +R A +A+ P Sbjct: 1021 MIGVTFFGLLLTPVFYVLIRRFVENREARRAANDKGLP 1058 >STM0351 [V] COG0841 Cation/multidrug efflux pump Sty Salmonella typhimurium LT2 Length = 1055 Score = 1208 bits (3125), Expect = 0.0, Method: Compositional matrix adjust. Identities = 621/1053 (58%), Positives = 782/1053 (74%), Gaps = 3/1053 (0%) Query: 1 MNISKFFIDRPIFAGVLSVLLLLGGVLAMLQLPISEYPEVVPPSVVVRAQYPGANPKVIA 60 M + FFI RPIFA VLS+L+LL G +A L+LP+SEYP V PP+V V A YPGANP+VIA Sbjct: 1 MKFTHFFIARPIFAIVLSLLMLLAGAIAFLKLPLSEYPAVTPPTVQVSASYPGANPQVIA 60 Query: 61 ETVASPLEEQINGVENMLYMQSQANSDGNLTITVNFRLGVDPDKAQQLVQNRVSQALPRL 120 +TVA+PLE+ INGV+ MLYM +Q DG + I++ F G DPD AQ VQNRVS+ALPRL Sbjct: 61 DTVAAPLEQVINGVDGMLYMNTQMAIDGRMVISIAFEQGTDPDMAQIQVQNRVSRALPRL 120 Query: 121 PEDVQRLGVTTLKSSPTLTMVVHLTSPDNRYDTTYLRNYAVLNVKDRLARIQGVGEVGLF 180 PE+VQR+GV T K+SP + MVVHL SP RYD+ YL N+A+ V+D LAR+ GVG+V ++ Sbjct: 121 PEEVQRIGVVTEKTSPDMLMVVHLVSPQKRYDSLYLSNFAIRQVRDELARLPGVGDVLVW 180 Query: 181 GSGNYAMRVWLDPNKVAQRGLTASDVVRAIREQNVQVAAGVIGASPSSPETPLQLSVNAQ 240 G+G YAMRVWLDP K+A RGLTASD+V A+REQNVQVAAG +G P + Q++VN Sbjct: 181 GAGEYAMRVWLDPAKIANRGLTASDIVTALREQNVQVAAGSVGQQPEA-SAAFQMTVNTL 239 Query: 241 GRLKTEGEFRDIILKASPDGATTRLGDVARVELAASEYGLRSLLDNKPAVAIPIFQAPGA 300 GRL +E +F +I++K DG TRL DVARV L A Y LRSLL+ + A A+ I Q+PGA Sbjct: 240 GRLTSEEQFGEIVVKIGADGEVTRLRDVARVTLGADAYTLRSLLNGEAAPALQIIQSPGA 299 Query: 301 NALDVSTQVRAAMKELSADFPSSVSYSIVYDPTQFVRASIEAVVHTLLEAIALVVIVVII 360 NA+DVS +R M EL +FP + Y I YDPT FVRAS+++V TLLEA+ LVV+VV++ Sbjct: 300 NAIDVSNAIRGKMDELQQNFPQDIEYRIAYDPTVFVRASLQSVAITLLEALVLVVLVVVM 359 Query: 361 FLQTWRASIIPLLAVPVSIIGTFSLMLGFGYTINALSLFGMVLAIGIVVDDAIVVVENVE 420 FLQTWRASIIPL+AVPVS++GTF+LM FG+++N LSLFG+VL+IGIVVDDAIVVVENVE Sbjct: 360 FLQTWRASIIPLVAVPVSLVGTFALMHLFGFSLNTLSLFGLVLSIGIVVDDAIVVVENVE 419 Query: 421 RNIGAGLSPRDATYRAMQEVSGPIIAIALTLVAVFVPLAFMTGLTGQFYKQFAMTIAIST 480 R+I G SP +A +AM EV+GPI++I L AVF+P AF+ GL G+FY+QFA+TIAIST Sbjct: 420 RHISQGKSPGEAAKKAMDEVTGPILSITSVLTAVFIPSAFLAGLQGEFYRQFALTIAIST 479 Query: 481 VISAFNSLTLSPALAALLLKGHGD--KPDWLTRQMDRFLGGFFIRFNRFFNRASDNYGHG 538 ++SA NSLTLSPALAA+LL+ H D K DWLTR M GGFF RFNRFF+ AS+ Y Sbjct: 480 ILSAINSLTLSPALAAILLRPHHDTAKADWLTRLMGTVTGGFFHRFNRFFDSASNRYVSA 539 Query: 539 VTGVIKRKGATMGVYVVLLAATLGVSYIVPGGFVPGQDKQYLVAFAQLPNGASIDRSEEV 598 V ++ M +Y + T + VP GFVP QDK YLV AQLP+GAS+DR+E V Sbjct: 540 VRRAVRGSVIVMVLYAGFVGLTWLGFHQVPNGFVPAQDKYYLVGIAQLPSGASLDRTEAV 599 Query: 599 MRKMSDIMLKEPGVASAIAFPGLSINGFTNSSSAGIVFVGLKPFEERKSKELSGNAIAAS 658 +++MS I L EPGV S + FPGLS+NG N ++ ++F LKPF+ER+ LS NAIA Sbjct: 600 VKQMSAIALAEPGVESVVVFPGLSVNGPVNVPNSALMFAMLKPFDEREDPSLSANAIAGK 659 Query: 659 LNKKFGGIKEAFTAVFPPPPVMGLGTLGGFKMQIEDRDALGYAELDKAAQAFMKAAAKEP 718 L KF I + F +FPPPPV GLG GGFK+QIEDR LG+ + K M A + P Sbjct: 660 LMHKFSHIPDGFIGIFPPPPVPGLGATGGFKLQIEDRAELGFEAMTKVQSEIMSKAMQTP 719 Query: 719 ALGPMFSSYQINVPQLDVELDRVKAKQLGIPVTDVFNTMQIYLGSLYVNDFNRFGRVYQV 778 L M +S+Q N PQL V++DRVKAK +G+ +TD+F T+QI LGSLYVNDFNRFGR ++V Sbjct: 720 ELANMLASFQTNAPQLQVDIDRVKAKSMGVSLTDIFETLQINLGSLYVNDFNRFGRAWRV 779 Query: 779 RAQADAPFRAKAEDIAQLKTRNDAGEMVPLSSVVKVKQTFGPEMVVRYNGYTAADINGGP 838 AQADAPFR + EDI LK RN GEM+PLS+ V + + GP+ ++ YNG+ + DI+GGP Sbjct: 780 MAQADAPFRMQQEDIGLLKVRNAKGEMIPLSAFVTIMRQSGPDRIIHYNGFPSVDISGGP 839 Query: 839 APGYSSDQAQAAAERVAAATLPRGIKFEWTDLTYQKILAGNAGVWVFPISVLLVFLVLAA 898 APG+SS QA A E++ TLP G+ FEWTDL YQ+ AGN+ + +F ++VLL FL+LAA Sbjct: 840 APGFSSGQATDAIEKIVRETLPEGMVFEWTDLVYQEKQAGNSALAIFALAVLLAFLILAA 899 Query: 899 LYESLTLPLAVILIVPMSILAALTGVWLTRGDNNIFTQIGLMVLVGLSAKNAILIVEFAR 958 Y S +LP AV+LI PMS+L+A+ GVW++ GDNNIFTQIG +VLVGL+AKNAILIVEFAR Sbjct: 900 QYNSWSLPFAVLLIAPMSLLSAIVGVWVSGGDNNIFTQIGFVVLVGLAAKNAILIVEFAR 959 Query: 959 ELEMQGRTAVQAAIEASRLRLRPILMTSIAFIMGVVPLVTSSGAGSEMRHAMGIAVFFGM 1018 E G + A +EASRLRLRPILMTS AFI GVVPLV ++GAG+EMRHAMGIAVF GM Sbjct: 960 AKEHDGADPLTAVLEASRLRLRPILMTSFAFIAGVVPLVLATGAGAEMRHAMGIAVFAGM 1019 Query: 1019 LGVTLFGLFLTPVFYVLLRTIDRRALHSASHHE 1051 LGVTLFGL LTPVFYV++R + + + H+ Sbjct: 1020 LGVTLFGLLLTPVFYVVVRRMALKRENRVDSHD 1052