BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0022.0137.p (482 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value SMc04362 [GEPR] COG0477 Permeases of the major facilitator super... 588 e-167 Cgl2919 [GEPR] COG0477 Permeases of the major facilitator superf... 152 2e-36 PA3467 [GEPR] COG0477 Permeases of the major facilitator superfa... 142 2e-33 RSp0052 [GEPR] COG0477 Permeases of the major facilitator superf... 132 2e-30 AGpA571 [GEPR] COG0477 Permeases of the major facilitator superf... 131 4e-30 >SMc04362 [GEPR] COG0477 Permeases of the major facilitator superfamily Sme Sinorhizobium meliloti Length = 482 Score = 588 bits (1515), Expect = e-167, Method: Compositional matrix adjust. Identities = 288/467 (61%), Positives = 367/467 (78%), Gaps = 4/467 (0%) Query: 9 PDLPHSPRVAELDGALDKIGVTRSHHTIIFLILIGCLFDAFEQNAIGLVGPLLKQQWGLT 68 P SP + +L+ A KIGVT +H I+ L+LIGCLFD+FEQN IG+ GP+LK+ WGLT Sbjct: 3 PTGGSSPVIRQLESAFTKIGVTGAHKQILALVLIGCLFDSFEQNTIGVAGPILKEHWGLT 62 Query: 69 ATDIGLLNTVTFASAAIGRIVSGLVADRYGRRVMLSLDLLLFTLGAGICALAPDLTVMAV 128 TDIG LNT+TF SAAIGR++SG++ DRYGRRVML+++LLLFT+G+ CA+AP+ T++ Sbjct: 63 GTDIGFLNTITFGSAAIGRLLSGILGDRYGRRVMLTINLLLFTIGSAACAMAPNFTMLCF 122 Query: 129 GRAIVGFGLGGEIAIAVTMLAEFCSSKFRGTAVGLVNVGAGGMGNFLAPAFGLLVFTLFP 188 RAIVGFG+GGEI+ AVTML+EFCS KFRGTA GLVNVGAGG GNFLAPAFGLL+FTLFP Sbjct: 123 ARAIVGFGVGGEISTAVTMLSEFCSPKFRGTAAGLVNVGAGGFGNFLAPAFGLLIFTLFP 182 Query: 189 GENSWRWLFFCLMLPALLGAFYRRYIPETPRFLLSRNKIAEANQVLARLASGKLSGPAPQ 248 GENSWRWLF L LPALL FYRR++PETPRFL S+NKI EAN+VL+ LASG L Sbjct: 183 GENSWRWLFASLALPALLVVFYRRFVPETPRFLASKNKIGEANKVLSILASGSLKPRNLV 242 Query: 249 GRDWISDDGSRQQTAPAKVRSMEIFQGALARRTLPLCIAIWMTYGAQISVLTLMPTILVS 308 ++++ D + AP K E+F+ RT+P+ IAI M+YGAQ+SVLTLMP I VS Sbjct: 243 VHEYLTTDHMTDE-APEKSDWRELFRAPFIGRTIPVAIAILMSYGAQLSVLTLMPVIFVS 301 Query: 309 LGYTISKSLLFTMVMQSGSLLGAIAASVFGFHLPRKRVLTAGAICACLAALAIGFLAKSI 368 +GYT+S SLL++M++QSGS+LGAIAAS+FG++LPRK+VLT GA ACLAA++I L +I Sbjct: 302 MGYTLSGSLLYSMIIQSGSVLGAIAASMFGYYLPRKKVLTVGAALACLAAVSIVTLGTNI 361 Query: 369 VLILAAGAVFQFFVLLLNTTIWIFAPELYPTRVRAFGTAFILATGTAAGALMPLVAGRLF 428 L+L GA+FQFFVLLLNT+IWI+APEL+PTR+RAFG A ILATG+AAG+ +P ++G LF Sbjct: 362 YLVLLFGAIFQFFVLLLNTSIWIYAPELFPTRIRAFGVALILATGSAAGSFVPTISGMLF 421 Query: 429 DAFGLAGVFGMIAAMYGIFTVAIRTVPETYGKSPD---APLEETEPE 472 D++G+ GVFG+ A MY +F I+ PETYG+S + P E +P+ Sbjct: 422 DSYGMVGVFGLAAGMYAVFAFCIQLGPETYGRSMEDLSQPAEADQPK 468 >Cgl2919 [GEPR] COG0477 Permeases of the major facilitator superfamily Cgl Corynebacterium glutamicum Length = 439 Score = 152 bits (384), Expect = 2e-36, Method: Compositional matrix adjust. Identities = 123/407 (30%), Positives = 192/407 (47%), Gaps = 24/407 (5%) Query: 24 LDKIGVTRSHHTIIFLILIGCLFDAFEQNAIGLVGPLLKQQWGLTATDIGLLNTVTFASA 83 LD++ VT H I+ IG DA + I V L WGL+ T+ LL ++ F Sbjct: 9 LDRLPVTSKHKKILGGSGIGWALDAMDVGLISFVMAALATHWGLSPTETSLLGSIGFVGM 68 Query: 84 AIGRIVSGLVADRYGRRVMLSLDLLLFTLGAGICALAPDLTVMAVGRAIVGFGLGGEIAI 143 AIG + GL+AD+ GRR + +L LL++ + G AL+ L ++ R +VG GLG E+ + Sbjct: 69 AIGASLGGLLADKLGRRQVFALSLLVYGVATGASALSVSLAMLMALRFVVGLGLGAELPV 128 Query: 144 AVTMLAEFCSSKFRGTAVGLVNVGAGGMGNFLAPAFGLLVFTLFPGENSWRWLFFCLMLP 203 A T+++EF K RG V ++ +G +A G F + +N WRW +P Sbjct: 129 ASTLISEFSPRKVRGRMVVILE-AFWALGWIMAAIVG--TFVVAGSDNGWRWALALGCVP 185 Query: 204 ALLGAFYRRYIPETPRFLLSRNKIAEANQVLARLASGKLSGPAPQGRDW--ISDDGSRQQ 261 A+ + R +PE+ RFL + + EA ++ + + D+ + Sbjct: 186 AIYAVYVRLGLPESVRFLEKKGRHDEAEAIVVSFEEAAAAEGKAADATTAVVHDNAAEG- 244 Query: 262 TAPAKVRSMEIFQGALARRTLPLCIAIWMT-----YGAQISVLTLMPTILVSLGYTISKS 316 S+ I+ AL +RT+ L I +W YGA I + P++LV+ G+T+ KS Sbjct: 245 -------SVSIWSAALRKRTVALWI-VWFCINLSYYGAFIWI----PSLLVADGFTLVKS 292 Query: 317 LLFTMVMQSGSLLGAIAASVFGFHLPRKRVLTAGAICACLAALAIGFLAKSIVLILAAGA 376 FT+++ L G A+ R+ L + + ++A G LA IL AG Sbjct: 293 FQFTLIITLAQLPGYAVAAWLIEKWGRRSTLATFLVGSAISAALYG-LANVEWQILVAGC 351 Query: 377 VFQFFVLLLNTTIWIFAPELYPTRVRAFGTAFILATGTAAGALMPLV 423 + FF L ++ PELYPT VR GT G A + PL+ Sbjct: 352 LLSFFNLGAWGALYAIGPELYPTNVRGTGTGAAAGFGRIASIIAPLI 398 >PA3467 [GEPR] COG0477 Permeases of the major facilitator superfamily Pae Pseudomonas aeruginosa Length = 455 Score = 142 bits (357), Expect = 2e-33, Method: Compositional matrix adjust. Identities = 127/480 (26%), Positives = 224/480 (46%), Gaps = 49/480 (10%) Query: 9 PDLPHSPRVAELDGALDKIGVTRSHHTIIFLILIGCLFDAFEQNAIGLVGPLLKQQWGLT 68 PD P S AE L+++ ++ H + +I + FD+ + + + +K ++GL Sbjct: 2 PDAPAS--AAE---RLERLPLSPYHRLVFVIIALAFFFDSMDLAMMTFLLGSIKAEFGLD 56 Query: 69 ATDIGLLNTVTFASAAIGRIVSGLVADRYGRRVMLSLDLLLFTLGAGICALAPDLTVMAV 128 + GLL + +F IG +SG++ADR+GR+ + ++L+ L + +C+ A DL + Sbjct: 57 SAQAGLLASSSFFGMVIGAALSGMLADRFGRKPVFQASIVLWGLASYLCSTAGDLDSLTF 116 Query: 129 GRAIVGFGLGGEIAIAVTMLAEFCSSKFRGTAVGLVN-------VGAGGMGNFLAPAFGL 181 R ++G G+G E IA ++L+E + RG + L++ V AG + FL P G Sbjct: 117 YRVLLGIGMGMEFPIAQSLLSEMIPASRRGKYIALMDGFWPLGFVAAGCLSYFLLPLTG- 175 Query: 182 LVFTLFPGENSWRWLFFCLMLPALLGAFYRRYIPETPRFLLSRNKIAEANQVLARLAS-- 239 WR +F L LPA+ R IPE+PR+L + +A++VL + + Sbjct: 176 -----------WRSIFLVLALPAVFVLAIRFLIPESPRWLEQAGRREQADRVLRDIEARV 224 Query: 240 ----GKLSGPAPQGRDWISDDGSRQQTAPAKVRSM-EIFQGALARRTLPLCIAIWMTYGA 294 G P P + R+++ P + E++ A RRTL + + Sbjct: 225 MRSLGLTELPPPLRQP------QRERSRPGFFSAFAELWSPAYRRRTLTVWGLWFFALLG 278 Query: 295 QISVLTLMPTILVSLGYTISKSLLFTMVMQSGSLLGAIAASVFGFHLPRK-----RVLTA 349 + + + +L G+ +++S+ +T+++ + G + A+ RK +L Sbjct: 279 FYGLTSWLSALLQQSGFAVTQSVYYTVLISLAGIPGFLCAAWLVESWGRKPSCVLMLLGG 338 Query: 350 GAICACLAALAIGFLAKSIVLILAAGAVFQFFVLLLNTTIWIFAPELYPTRVRAFGTAFI 409 GA+ A+ S+ L++ G QFF+ + ++ + PELYPT RA G+ F Sbjct: 339 GAMAYAYGQTAV--FGGSLALLIGFGLAMQFFLFGMWAVLYTYTPELYPTSARATGSGFA 396 Query: 410 LATGTAAGALMPLVAGRLFDAFGLAGVFGMIAAMYGIFTVAIRTVP-ETYGKSPDAPLEE 468 A G L PLV G + G GVF + A +G+ + + ET G++ LEE Sbjct: 397 SAVGRIGSLLGPLVTGLVLPLTGQGGVFTLGALCFGVAALVVWAFGIETRGRT----LEE 452 >RSp0052 [GEPR] COG0477 Permeases of the major facilitator superfamily Rso Ralstonia solanacearum Length = 476 Score = 132 bits (331), Expect = 2e-30, Method: Compositional matrix adjust. Identities = 111/430 (25%), Positives = 204/430 (47%), Gaps = 35/430 (8%) Query: 24 LDKIGVTRSHHTIIFLILIGCLFDAFEQNAIGLVGPLLKQQWGLTATDIGLLNTVTFASA 83 L+++ + H I +I I FD+ + + V +K+++GL+ GL+ + +F Sbjct: 17 LERLPFSGYHKRIFIIIAIAFFFDSVDLATMTFVLGSIKKEFGLSTATAGLVASSSFFGM 76 Query: 84 AIGRIVSGLVADRYGRRVMLSLDLLLFTLGAGICALAPDLTVMAVGRAIVGFGLGGEIAI 143 IG V+GL+ADR+GRR + ++L+ + + +C+ A + + R ++G G+G E + Sbjct: 77 VIGAAVAGLLADRFGRRPVFQWSMVLWGVASYLCSTAQSVEALIAWRILLGIGMGMEFPV 136 Query: 144 AVTMLAEFCSSKFRGTAVGLVN-------VGAGGMGNFLAPAFGLLVFTLFPGENSWRWL 196 A T+L+EF + RG + L++ + AG + F+ P FG WR + Sbjct: 137 AQTLLSEFVPTANRGRLIALMDGFWPLGFITAGIVSYFVLPQFG------------WRAV 184 Query: 197 FFCLMLPALLGAFYRRYIPETPRFLLSRNKIAEANQVLARLASGKLSGPAPQGRDWISDD 256 F L +PA+ RR +PE+PR+L + A+A+ V+ + + + + + + Sbjct: 185 FALLAVPAIFVLIVRRAVPESPRWLEHAGRNAQADTVMRGIEAKVM-----RSLNTTTLP 239 Query: 257 GSRQQTAPAKVRSM----EIFQGALARRTLPLCIAIWMTYGAQISVLTLMPTILVSLGYT 312 Q +AP VR EI+ A RRT + + + + + + +L G+ Sbjct: 240 PIVQHSAPQPVRRHSALREIWSAAYRRRTTMVWLLWFFALLGFYGLTSWLGALLQQAGFA 299 Query: 313 ISKSLLFTMVMQSGSLLGAIAASVFGFHLPRK-----RVLTAGAICACLAALAIGFLAKS 367 +++S+ +T+++ G + G + A+ RK +L GA+ A+ S Sbjct: 300 VTQSVYYTVLISLGGVPGFLCAAWLVERWGRKPTCIASLLGGGAMAYLYGQSAL--YGGS 357 Query: 368 IVLILAAGAVFQFFVLLLNTTIWIFAPELYPTRVRAFGTAFILATGTAAGALMPLVAGRL 427 + L++ G QFF+ + ++ + PE Y T RA G+ F A G + P V G + Sbjct: 358 VTLLICTGLAMQFFLFGMWAVLYTYTPEQYGTGARATGSGFASAIGRVGSLIGPYVVGVV 417 Query: 428 FDAFGLAGVF 437 FG GVF Sbjct: 418 LPVFGQGGVF 427 >AGpA571 [GEPR] COG0477 Permeases of the major facilitator superfamily Atu Agrobacterium tumefaciens strain C58 (Cereon) Length = 461 Score = 131 bits (329), Expect = 4e-30, Method: Compositional matrix adjust. Identities = 134/476 (28%), Positives = 223/476 (46%), Gaps = 55/476 (11%) Query: 18 AELDGALDKIGVTRSHHTIIFLILIGCLFDAFEQNAIGLVGPLLKQQWGLTATDIGLLNT 77 A++ L+++ +TR ++ FD + AI P+L ++WGLT + G++ + Sbjct: 19 ADISARLERLPITREVFWARNIVGAATFFDGYTVIAIAYAMPVLVREWGLTPSQTGMILS 78 Query: 78 VTFASAAIGRIVSGLVADRYGRRVMLSLDLLLFTLGAGICALAPDLTVMAVGRAIVGFGL 137 + + IG I+ G +A+R GR +L +LLF C A +M R + G G Sbjct: 79 MGYLGQLIGAILFGWLAERIGRLKVLLFTILLFVSMDVACLFAAGAGMMMAFRFVQGIGT 138 Query: 138 GGEIAIAVTMLAEFCSSKFRGTAVGLVN-------VGAGGMGNFLAPAFGLLVFTLFPGE 190 GGE+ +A + E SK RG L VGAG +G F+ P +G Sbjct: 139 GGEVPVASAYINELIGSKGRGRFFLLYEVMFLLGLVGAGLIGYFMVPLYG---------- 188 Query: 191 NSWRWLFFCLMLPALLGAFYRRYIPETPRFLLSRNKIAEANQVLARL-ASGKLSGPA-PQ 248 W+ +F ++PA+L R ++ E+PR+L + + EAN ++ R+ S + +G A P+ Sbjct: 189 --WKAMFIVGLVPAMLMIPLRWFLKESPRWLAATGRYDEANVIVKRMEESARAAGKALPE 246 Query: 249 GRDWISDDGSRQQTAPAKVRS--MEIFQGALARRTLPLCIAIWMTYGAQISVLTLMPTIL 306 R PAK S E+FQG +RTL + + Y +T +PT+ Sbjct: 247 ---------PRIIATPAKRVSDWRELFQGIYLKRTLSIWAMWFCAYMVANGTITWLPTLY 297 Query: 307 -VSLGYTISKSLLFTMVMQSGSLLGAIAASVFGFHLPRKRVLTAGAICACLAALAI---- 361 + + S+L+ + + ++ A+ ++ + RKR AGA+ LAI Sbjct: 298 RQTFNLPLETSILYGFMTSAAGVVAAVICALLIDKVGRKR-WYAGALLLAPVPLAILAWL 356 Query: 362 GFLAKSIVLILA--AGAVFQFFVLLLNTTIWIFAPELYPTRVRAFGT---AFILATGTAA 416 G + VLI A A A+ Q + ++++++ E+YPTR+RA GT + L G++A Sbjct: 357 GATSPMQVLIFAGLAYAIVQ----TVTFSLYLYSAEIYPTRMRAIGTGAGSAWLRLGSSA 412 Query: 417 GALMPLVAGRLFDAFGLAGVFGMIAAMYGI-FTVAIRTVPETYGKSPDAPLEETEP 471 G P++ G + + G+ VF A + I V + ET GK LEE P Sbjct: 413 G---PMLVGFVMSSMGIQYVFATFAFILIIGAVVTMLFAVETKGKV----LEELSP 461