BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0022.0038.p (429 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value ZarsB [P] COG1055 Na+/H+ antiporter NhaD and related arsenite pe... 593 e-169 ECs4374 [P] COG1055 Na+/H+ antiporter NhaD and related arsenite ... 593 e-169 arsB [P] COG1055 Na+/H+ antiporter NhaD and related arsenite per... 592 e-169 PA2278 [P] COG1055 Na+/H+ antiporter NhaD and related arsenite p... 581 e-165 YPO3347 [P] COG1055 Na+/H+ antiporter NhaD and related arsenite ... 566 e-161 >ZarsB [P] COG1055 Na+/H+ antiporter NhaD and related arsenite permeases EcZ Escherichia coli O157:H7 EDL933 Length = 429 Score = 593 bits (1529), Expect = e-169, Method: Compositional matrix adjust. Identities = 309/419 (73%), Positives = 359/419 (85%) Query: 7 IFLLTLTLVIWQPKGLGIGWSACGGAALALACGVIHLADIPVVWHIVWNATGTFVAIIII 66 IF+LT+ LVIWQPKGLGIGWSA GA LAL GV+H DIPVVW+IVWNAT F+A+III Sbjct: 7 IFVLTIVLVIWQPKGLGIGWSATLGAVLALVTGVVHPGDIPVVWNIVWNATAAFIAVIII 66 Query: 67 SLLLDKAGFFEWAALHVARWGGGRGRMLFVLLILLGAAVSALFANDGAALILTPIVISML 126 SLLLD++GFFEWAALHV+RWG GRGR+LF ++LLGAAV+ALFANDGAALILTPIVI+ML Sbjct: 67 SLLLDESGFFEWAALHVSRWGNGRGRLLFTWIVLLGAAVAALFANDGAALILTPIVIAML 126 Query: 127 LALRFSPAATLAFVMAAGFIADTASLPLVVSNLVNIVSADFFNIGFAQYASVMVPVNLVS 186 LAL FS TLAFVMAAGFIADTASLPL+VSNLVNIVSADFF +GF +YASVMVPV++ + Sbjct: 127 LALGFSKGTTLAFVMAAGFIADTASLPLIVSNLVNIVSADFFGLGFREYASVMVPVDIAA 186 Query: 187 VAATLLVLLIHFRRDLPERYDLAQLRSPASAIRDRATFIAGGWVLALLLAGFFWLEGKGL 246 + ATL++L ++FR+D+P+ YD+A L+SPA AI+D ATF G VL LLL GFF LE G+ Sbjct: 187 IVATLVMLHLYFRKDIPQNYDMALLKSPAEAIKDPATFKTGWVVLLLLLVGFFVLEPLGI 246 Query: 247 PISVVAAVGALILLLVAGRGRVISTRAVIKGAPWQVVFFSLGMYLVVYGLRNAGLTNALT 306 P+S +AAVGALIL +VA RG I+T V++GAPWQ+V FSLGMYLVVYGLRNAGLT L+ Sbjct: 247 PVSAIAAVGALILFVVAKRGHAINTGKVLRGAPWQIVIFSLGMYLVVYGLRNAGLTEYLS 306 Query: 307 GVLNEFATHGVWGAALGTGVLTALLSSIMNNMPTVLVGALSIDATSAQGVVKEAMVYANI 366 GVLN A +G+W A LGTG LTA LSSIMNNMPTVLVGALSID ++A GV+KEAMVYAN+ Sbjct: 307 GVLNVLADNGLWAATLGTGFLTAFLSSIMNNMPTVLVGALSIDGSTASGVIKEAMVYANV 366 Query: 367 IGCDLGPKITPIGSLATLLWLHVLDSKNIHISWGAYFRTGALLTLPVLLVTLSALALRL 425 IGCDLGPKITPIGSLATLLWLHVL KN+ ISWG YFRTG ++TLPVL VTL+ALALRL Sbjct: 367 IGCDLGPKITPIGSLATLLWLHVLSQKNMTISWGYYFRTGIIMTLPVLFVTLAALALRL 425 >ECs4374 [P] COG1055 Na+/H+ antiporter NhaD and related arsenite permeases Ecs Escherichia coli O157:H7 Length = 429 Score = 593 bits (1529), Expect = e-169, Method: Compositional matrix adjust. Identities = 309/419 (73%), Positives = 359/419 (85%) Query: 7 IFLLTLTLVIWQPKGLGIGWSACGGAALALACGVIHLADIPVVWHIVWNATGTFVAIIII 66 IF+LT+ LVIWQPKGLGIGWSA GA LAL GV+H DIPVVW+IVWNAT F+A+III Sbjct: 7 IFVLTIVLVIWQPKGLGIGWSATLGAVLALVTGVVHPGDIPVVWNIVWNATAAFIAVIII 66 Query: 67 SLLLDKAGFFEWAALHVARWGGGRGRMLFVLLILLGAAVSALFANDGAALILTPIVISML 126 SLLLD++GFFEWAALHV+RWG GRGR+LF ++LLGAAV+ALFANDGAALILTPIVI+ML Sbjct: 67 SLLLDESGFFEWAALHVSRWGNGRGRLLFTWIVLLGAAVAALFANDGAALILTPIVIAML 126 Query: 127 LALRFSPAATLAFVMAAGFIADTASLPLVVSNLVNIVSADFFNIGFAQYASVMVPVNLVS 186 LAL FS TLAFVMAAGFIADTASLPL+VSNLVNIVSADFF +GF +YASVMVPV++ + Sbjct: 127 LALGFSKGTTLAFVMAAGFIADTASLPLIVSNLVNIVSADFFGLGFREYASVMVPVDIAA 186 Query: 187 VAATLLVLLIHFRRDLPERYDLAQLRSPASAIRDRATFIAGGWVLALLLAGFFWLEGKGL 246 + ATL++L ++FR+D+P+ YD+A L+SPA AI+D ATF G VL LLL GFF LE G+ Sbjct: 187 IVATLVMLHLYFRKDIPQNYDMALLKSPAEAIKDPATFKTGWVVLLLLLVGFFVLEPLGI 246 Query: 247 PISVVAAVGALILLLVAGRGRVISTRAVIKGAPWQVVFFSLGMYLVVYGLRNAGLTNALT 306 P+S +AAVGALIL +VA RG I+T V++GAPWQ+V FSLGMYLVVYGLRNAGLT L+ Sbjct: 247 PVSAIAAVGALILFVVAKRGHAINTGKVLRGAPWQIVIFSLGMYLVVYGLRNAGLTEYLS 306 Query: 307 GVLNEFATHGVWGAALGTGVLTALLSSIMNNMPTVLVGALSIDATSAQGVVKEAMVYANI 366 GVLN A +G+W A LGTG LTA LSSIMNNMPTVLVGALSID ++A GV+KEAMVYAN+ Sbjct: 307 GVLNVLADNGLWAATLGTGFLTAFLSSIMNNMPTVLVGALSIDGSTASGVIKEAMVYANV 366 Query: 367 IGCDLGPKITPIGSLATLLWLHVLDSKNIHISWGAYFRTGALLTLPVLLVTLSALALRL 425 IGCDLGPKITPIGSLATLLWLHVL KN+ ISWG YFRTG ++TLPVL VTL+ALALRL Sbjct: 367 IGCDLGPKITPIGSLATLLWLHVLSQKNMTISWGYYFRTGIIMTLPVLFVTLAALALRL 425 >arsB [P] COG1055 Na+/H+ antiporter NhaD and related arsenite permeases Eco Escherichia coli K12 Length = 436 Score = 592 bits (1527), Expect = e-169, Method: Compositional matrix adjust. Identities = 309/419 (73%), Positives = 359/419 (85%) Query: 7 IFLLTLTLVIWQPKGLGIGWSACGGAALALACGVIHLADIPVVWHIVWNATGTFVAIIII 66 IF+LT+ LVIWQPKGLGIGWSA GA LAL GV+H DIPVVW+IVWNAT F+A+III Sbjct: 14 IFVLTIVLVIWQPKGLGIGWSATLGAVLALVTGVVHPGDIPVVWNIVWNATAAFIAVIII 73 Query: 67 SLLLDKAGFFEWAALHVARWGGGRGRMLFVLLILLGAAVSALFANDGAALILTPIVISML 126 SLLLD++GFFEWAALHV+RWG GRGR+LF ++LLGAAV+ALFANDGAALILTPIVI+ML Sbjct: 74 SLLLDESGFFEWAALHVSRWGNGRGRLLFTWIVLLGAAVAALFANDGAALILTPIVIAML 133 Query: 127 LALRFSPAATLAFVMAAGFIADTASLPLVVSNLVNIVSADFFNIGFAQYASVMVPVNLVS 186 LAL FS TLAFVMAAGFIADTASLPL+VSNLVNIVSADFF +GF +YASVMVPV++ + Sbjct: 134 LALGFSKGTTLAFVMAAGFIADTASLPLIVSNLVNIVSADFFGLGFREYASVMVPVDIAA 193 Query: 187 VAATLLVLLIHFRRDLPERYDLAQLRSPASAIRDRATFIAGGWVLALLLAGFFWLEGKGL 246 + ATL++L ++FR+D+P+ YD+A L+SPA AI+D ATF G VL LLL GFF LE G+ Sbjct: 194 IVATLVMLHLYFRKDIPQNYDMALLKSPAEAIKDPATFKTGWVVLLLLLVGFFVLEPLGI 253 Query: 247 PISVVAAVGALILLLVAGRGRVISTRAVIKGAPWQVVFFSLGMYLVVYGLRNAGLTNALT 306 P+S +AAVGALIL +VA RG I+T V++GAPWQ+V FSLGMYLVVYGLRNAGLT L+ Sbjct: 254 PVSAIAAVGALILFVVAKRGHAINTGKVLRGAPWQIVIFSLGMYLVVYGLRNAGLTEYLS 313 Query: 307 GVLNEFATHGVWGAALGTGVLTALLSSIMNNMPTVLVGALSIDATSAQGVVKEAMVYANI 366 GVLN A +G+W A LGTG LTA LSSIMNNMPTVLVGALSID ++A GV+KEAMVYAN+ Sbjct: 314 GVLNVLADNGLWAATLGTGFLTAFLSSIMNNMPTVLVGALSIDGSTASGVIKEAMVYANV 373 Query: 367 IGCDLGPKITPIGSLATLLWLHVLDSKNIHISWGAYFRTGALLTLPVLLVTLSALALRL 425 IGCDLGPKITPIGSLATLLWLHVL KN+ ISWG YFRTG ++TLPVL VTL+ALALRL Sbjct: 374 IGCDLGPKITPIGSLATLLWLHVLSQKNMTISWGYYFRTGIIMTLPVLFVTLAALALRL 432 >PA2278 [P] COG1055 Na+/H+ antiporter NhaD and related arsenite permeases Pae Pseudomonas aeruginosa Length = 427 Score = 581 bits (1498), Expect = e-165, Method: Compositional matrix adjust. Identities = 304/413 (73%), Positives = 349/413 (84%) Query: 1 VLTALFIFLLTLTLVIWQPKGLGIGWSACGGAALALACGVIHLADIPVVWHIVWNATGTF 60 +L A IFL TL LVIWQP+GLGIGWSA GA LALA G + DIP VW+IVWNAT TF Sbjct: 1 MLIAFAIFLFTLVLVIWQPRGLGIGWSASIGALLALALGSVAPGDIPTVWNIVWNATATF 60 Query: 61 VAIIIISLLLDKAGFFEWAALHVARWGGGRGRMLFVLLILLGAAVSALFANDGAALILTP 120 +A+I+ISLLLD+AGFFEWAALHVARW GG GR LF +LLGAAVSALFANDGAALILTP Sbjct: 61 IAVIVISLLLDEAGFFEWAALHVARWAGGDGRRLFAFCVLLGAAVSALFANDGAALILTP 120 Query: 121 IVISMLLALRFSPAATLAFVMAAGFIADTASLPLVVSNLVNIVSADFFNIGFAQYASVMV 180 IV+SMLLALRFSPAATLAFVMAAGFIAD+ASLPLVVSNLVNIVSAD+F +GF +YA+VM+ Sbjct: 121 IVMSMLLALRFSPAATLAFVMAAGFIADSASLPLVVSNLVNIVSADYFGLGFGEYAAVML 180 Query: 181 PVNLVSVAATLLVLLIHFRRDLPERYDLAQLRSPASAIRDRATFIAGGWVLALLLAGFFW 240 PVNLVSVA +LLVL ++FRRDLP Y L QL+ P +AIRDRATF+ GGW+L +LLAG F Sbjct: 181 PVNLVSVATSLLVLFLYFRRDLPPVYALEQLKPPRAAIRDRATFVVGGWMLLVLLAGLFA 240 Query: 241 LEGKGLPISVVAAVGALILLLVAGRGRVISTRAVIKGAPWQVVFFSLGMYLVVYGLRNAG 300 LE G+P+S VAA A +LL VAGRGRVISTR V++ APWQ+V FSLGMYLVVYGL+NAG Sbjct: 241 LEPLGVPVSAVAAACAALLLAVAGRGRVISTRRVLREAPWQIVVFSLGMYLVVYGLKNAG 300 Query: 301 LTNALTGVLNEFATHGVWGAALGTGVLTALLSSIMNNMPTVLVGALSIDATSAQGVVKEA 360 LT+ L +LN A HGVW AALGTG+L+A LSS+MNNMP++L+GALSI A+ G V+EA Sbjct: 301 LTDLLAQLLNRLAEHGVWAAALGTGLLSAALSSVMNNMPSMLLGALSIQASDTAGAVREA 360 Query: 361 MVYANIIGCDLGPKITPIGSLATLLWLHVLDSKNIHISWGAYFRTGALLTLPV 413 M+YAN+IGCDLGPKITPIGSLATLLWLHVL K + I+WG YFR GALLTLPV Sbjct: 361 MIYANVIGCDLGPKITPIGSLATLLWLHVLARKGMRITWGYYFRVGALLTLPV 413 >YPO3347 [P] COG1055 Na+/H+ antiporter NhaD and related arsenite permeases Ype Yersinia pestis Length = 429 Score = 566 bits (1458), Expect = e-161, Method: Compositional matrix adjust. Identities = 305/419 (72%), Positives = 355/419 (84%) Query: 7 IFLLTLTLVIWQPKGLGIGWSACGGAALALACGVIHLADIPVVWHIVWNATGTFVAIIII 66 IF+LT+ LVIWQPKGLGIGWSA GA LAL GV+H++DIPVVW IVWNAT TF+AIIII Sbjct: 7 IFILTIVLVIWQPKGLGIGWSAMLGAGLALLTGVVHVSDIPVVWQIVWNATATFIAIIII 66 Query: 67 SLLLDKAGFFEWAALHVARWGGGRGRMLFVLLILLGAAVSALFANDGAALILTPIVISML 126 SLLLD++GFFEWAALHVARWG G GR LF +ILLGAAV+ALFANDGAALILTPIVI+ML Sbjct: 67 SLLLDESGFFEWAALHVARWGNGHGRRLFTYIILLGAAVAALFANDGAALILTPIVIAML 126 Query: 127 LALRFSPAATLAFVMAAGFIADTASLPLVVSNLVNIVSADFFNIGFAQYASVMVPVNLVS 186 LAL F ATLAFVMAAGFIADTASLPL+VSNLVNIVSADFFN+GF +YA+VMVPVNLV+ Sbjct: 127 LALGFGRGATLAFVMAAGFIADTASLPLIVSNLVNIVSADFFNLGFTEYAAVMVPVNLVA 186 Query: 187 VAATLLVLLIHFRRDLPERYDLAQLRSPASAIRDRATFIAGGWVLALLLAGFFWLEGKGL 246 V ATL +L + FR+D+P YDL+ L++P +AIRD TF G VLALLL GFF LE G+ Sbjct: 187 VIATLAMLHLFFRKDIPAVYDLSLLKAPQAAIRDMNTFKTGWLVLALLLIGFFALEPLGV 246 Query: 247 PISVVAAVGALILLLVAGRGRVISTRAVIKGAPWQVVFFSLGMYLVVYGLRNAGLTNALT 306 P+S+VAAVGALILL VA +G I+T V++GAPWQ+V FSLGMYLVVYGLRNAGLT+ ++ Sbjct: 247 PVSLVAAVGALILLAVAKKGHAINTGKVLRGAPWQIVIFSLGMYLVVYGLRNAGLTHYIS 306 Query: 307 GVLNEFATHGVWGAALGTGVLTALLSSIMNNMPTVLVGALSIDATSAQGVVKEAMVYANI 366 +LN G+W + LGTG LTA LSSIMNN+PTVLVGALSI+ ++A G++KEAM+YAN+ Sbjct: 307 ALLNRLGEQGLWASTLGTGFLTAFLSSIMNNLPTVLVGALSIEGSTATGLIKEAMIYANV 366 Query: 367 IGCDLGPKITPIGSLATLLWLHVLDSKNIHISWGAYFRTGALLTLPVLLVTLSALALRL 425 IG DLGPKIT IGSLATLLWLHVL KN+ I+WG YFR G ++TLPVLLVTLSALALRL Sbjct: 367 IGSDLGPKITLIGSLATLLWLHVLSQKNMTITWGYYFRVGIIMTLPVLLVTLSALALRL 425