BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0021.0072.p (556 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSc1126 [F] COG0504 CTP synthase (UTP-ammonia lyase) Rso Ralston... 853 0.0 NMB1554 [F] COG0504 CTP synthase (UTP-ammonia lyase) Nme Neisser... 729 0.0 NMA1742 [F] COG0504 CTP synthase (UTP-ammonia lyase) NmA Neisser... 729 0.0 PA3637 [F] COG0504 CTP synthase (UTP-ammonia lyase) Pae Pseudomo... 709 0.0 HI1077 [F] COG0504 CTP synthase (UTP-ammonia lyase) Hin Haemophi... 709 0.0 >RSc1126 [F] COG0504 CTP synthase (UTP-ammonia lyase) Rso Ralstonia solanacearum Length = 554 Score = 853 bits (2203), Expect = 0.0, Method: Compositional matrix adjust. Identities = 417/557 (74%), Positives = 475/557 (85%), Gaps = 8/557 (1%) Query: 1 MTKFVFVTGGVVSSLGKGIAAASLAAILESRGLKVTLLKLDPYINVDPGTMSPLQHGEVF 60 MTKFVFVTGGVVSSLGKGIAAASLAAILESRGLKVTLLKLDPYINVDPGTMSP QHGEVF Sbjct: 1 MTKFVFVTGGVVSSLGKGIAAASLAAILESRGLKVTLLKLDPYINVDPGTMSPFQHGEVF 60 Query: 61 VTDDGAETDLDLGHYERFISAKMKKVNNFTTGQVYESVIRKERRGEYLGKTVQVIPHITN 120 VT+DGAETDLDLGHYERF+SAKM+K NNFTTGQ+YESVIRKERRGEYLGKTVQVIPHITN Sbjct: 61 VTEDGAETDLDLGHYERFVSAKMRKANNFTTGQIYESVIRKERRGEYLGKTVQVIPHITN 120 Query: 121 EIQEFIHRGAEG-----FEVALVEIGGTVGDIESLPFLEAARQLSLRSGRNATAFVHLTL 175 EIQ FI RGA+ +VA+VEIGGTVGDIESLPFLEAARQ+SLR GRN AFVHLTL Sbjct: 121 EIQAFIERGAKASHDGKADVAIVEIGGTVGDIESLPFLEAARQMSLRLGRNQAAFVHLTL 180 Query: 176 VPFLASAGELKTKPTQHSVQKLREIGISPDALLCRADRRIPDDERDKISLFSNVAADAVI 235 VPF+ASAGELKTKPTQHSVQKLREIG+ P ALLCRADR IPDDER KISLF+N+ DAVI Sbjct: 181 VPFIASAGELKTKPTQHSVQKLREIGVQPTALLCRADRPIPDDERAKISLFANMPQDAVI 240 Query: 236 SVWDADSIYKIPQMLHDQGLDTIICEKLGLSPKPADLSMWDKLIDAQNNPSHEVTIGMVG 295 SVWD D+IYKIPQML++QGLD IICE+L + PADLSMW +++ NP HE+TIGMVG Sbjct: 241 SVWDVDTIYKIPQMLNEQGLDRIICEELRIDAPPADLSMWSRMVHTLENPQHEITIGMVG 300 Query: 296 KYVDLTESYKSLTEALRHAGIHTGSRVNIEYLDSEEIEANGTDSLNKYDAILVPGGFGKR 355 KYVDLTESYKSL EALRHAG+HT +RVNIEY+DSEE+E+ T L DAILVPGGFGKR Sbjct: 301 KYVDLTESYKSLIEALRHAGLHTSTRVNIEYIDSEELESGHTQVLESLDAILVPGGFGKR 360 Query: 356 GVEGKIAAARYARENKVPYLGICLGMQVALLEYARNKAGLSKANSTEFDPDTEQPVVALI 415 G EGKI A +YARE VPYLGICLGMQ+A++E+AR+ AG+ ANSTEF+ +TE PVVALI Sbjct: 361 GTEGKIRAIQYAREKTVPYLGICLGMQLAVIEFARHVAGMQDANSTEFNLETEHPVVALI 420 Query: 416 DEWQNHDGKVERRDANSDLGGTMRLGAQTCAVKPGTLAAEIYGDSVTERHRHRYEANNFY 475 EWQ+ DG+VE+R A+SDLGGTMRLGAQ V+ GT A++IYG V ERHRHRYE NN Y Sbjct: 421 TEWQDRDGRVEKRSADSDLGGTMRLGAQRVPVQTGTKASQIYGAEVNERHRHRYEVNNHY 480 Query: 476 LTRVEEAGMVVSARTPTEDLCEIMELPRTGENAHPFYIGVQYHPEFKSTPRDGHPLFISY 535 + ++E++GM++SARTP+E+L E+MELP HP+++GVQ+HPEF STPRDGHPLF +Y Sbjct: 481 VPQLEKSGMIISARTPSENLPEMMELPGA---MHPWFVGVQFHPEFTSTPRDGHPLFKAY 537 Query: 536 IRAALAHHAELQQDAAA 552 + AALAH Q A A Sbjct: 538 VEAALAHRQRQAQRAVA 554 >NMB1554 [F] COG0504 CTP synthase (UTP-ammonia lyase) Nme Neisseria meningitidis MC58 Length = 544 Score = 729 bits (1883), Expect = 0.0, Method: Compositional matrix adjust. Identities = 361/544 (66%), Positives = 429/544 (78%), Gaps = 9/544 (1%) Query: 1 MTKFVFVTGGVVSSLGKGIAAASLAAILESRGLKVTLLKLDPYINVDPGTMSPLQHGEVF 60 MTKF+FVTGGVVSSLGKGIAAAS+AAILESRGL VT+LKLDPYINVDPGTMSP QHGEVF Sbjct: 1 MTKFIFVTGGVVSSLGKGIAAASIAAILESRGLNVTMLKLDPYINVDPGTMSPFQHGEVF 60 Query: 61 VTDDGAETDLDLGHYERFISAKMKKVNNFTTGQVYESVIRKERRGEYLGKTVQVIPHITN 120 VTDDGAETDLDLGHYERFI + M + N+F+TGQVYE+VI KERRG+YLG TVQVIPHIT+ Sbjct: 61 VTDDGAETDLDLGHYERFIDSTMTRRNSFSTGQVYENVIAKERRGDYLGGTVQVIPHITD 120 Query: 121 EIQEFIHRGAEGFEVALVEIGGTVGDIESLPFLEAARQLSLRSGRNATAFVHLTLVPFLA 180 EI+ IH GA G++VA+VEIGGTVGDIESLPFLEA RQ+ + GRN T F HL+ VP++A Sbjct: 121 EIKRRIHEGAAGYDVAIVEIGGTVGDIESLPFLEAIRQMRSQLGRNNTLFAHLSYVPYIA 180 Query: 181 SAGELKTKPTQHSVQKLREIGISPDALLCRADRRIPDDERDKISLFSNVAADAVISVWDA 240 +AGE+KTKPTQH+V+++ IG+ PD L+CR DR +P DER KI+LF NV A++ +D Sbjct: 181 AAGEIKTKPTQHTVKEMLSIGLQPDILICRMDRTMPADERRKIALFCNVEERAIVGSYDV 240 Query: 241 DSIYKIPQMLHDQGLDTIICEKLGLSPKPADLSMWDKLIDAQNNPSHEVTIGMVGKYVDL 300 DSIY+ P+MLHDQG+D II E+L L+ + ADL+ W K++ A NP H V I MVGKYVDL Sbjct: 241 DSIYECPEMLHDQGIDNIITEQLQLNVQQADLTAWKKIVHAIQNPKHTVKIAMVGKYVDL 300 Query: 301 TESYKSLTEALRHAGIHTGSRVNIEYLDSEEIEANGTD--SLNKYDAILVPGGFGKRGVE 358 TESYKSL EAL+HAGIHT + V I ++DSE IE N D L DAILVPGGFG RGVE Sbjct: 301 TESYKSLIEALKHAGIHTETDVQITFVDSENIEKNKGDVSMLKDMDAILVPGGFGSRGVE 360 Query: 359 GKIAAARYARENKVPYLGICLGMQVALLEYARNKAGLSKANSTEFDPDTEQPVVALIDEW 418 GKIAA RYAREN VPYLGICLGMQ+AL+EYAR+ AGL ANSTEFD PVVALIDEW Sbjct: 361 GKIAAVRYARENNVPYLGICLGMQIALIEYARDVAGLKGANSTEFDLKCAAPVVALIDEW 420 Query: 419 QNHDGKVERRDANSDLGGTMRLGAQTCAVKPGTLAAEIYGDS-VTERHRHRYEANNFYLT 477 Q DG VE RD ++DLGGTMRLGAQ +K G+LAA+IYG + ERHRHRYE NN Y+ Sbjct: 421 QTADGSVETRDESTDLGGTMRLGAQEVELKAGSLAAKIYGSGHIRERHRHRYEVNNNYVP 480 Query: 478 RVEEAGMVVSARTP-TEDLCEIMELPRTGENAHPFYIGVQYHPEFKSTPRDGHPLFISYI 536 +E+AG+V+ + E L E +ELP HP++ Q+HPEF S PR GHPLF +++ Sbjct: 481 TLEQAGLVIGGVSAGRERLVETIELPN-----HPWFFACQFHPEFTSNPRKGHPLFTAFV 535 Query: 537 RAAL 540 +AAL Sbjct: 536 KAAL 539 >NMA1742 [F] COG0504 CTP synthase (UTP-ammonia lyase) NmA Neisseria meningitidis Z2491 Length = 544 Score = 729 bits (1883), Expect = 0.0, Method: Compositional matrix adjust. Identities = 360/544 (66%), Positives = 430/544 (79%), Gaps = 9/544 (1%) Query: 1 MTKFVFVTGGVVSSLGKGIAAASLAAILESRGLKVTLLKLDPYINVDPGTMSPLQHGEVF 60 MTKF+FVTGGVVSSLGKGIAAAS+AAILESRGL VT+LKLDPYINVDPGTMSP QHGEVF Sbjct: 1 MTKFIFVTGGVVSSLGKGIAAASIAAILESRGLNVTMLKLDPYINVDPGTMSPFQHGEVF 60 Query: 61 VTDDGAETDLDLGHYERFISAKMKKVNNFTTGQVYESVIRKERRGEYLGKTVQVIPHITN 120 VTDDGAETDLDLGHYERFI + M + N+F+TGQVYE+VI KERRG+YLG TVQVIPHIT+ Sbjct: 61 VTDDGAETDLDLGHYERFIDSTMTRRNSFSTGQVYENVIAKERRGDYLGGTVQVIPHITD 120 Query: 121 EIQEFIHRGAEGFEVALVEIGGTVGDIESLPFLEAARQLSLRSGRNATAFVHLTLVPFLA 180 EI+ IH GA G++VA+VEIGGTVGDIESLPFLEA RQ+ + GRN T F HL+ VP++A Sbjct: 121 EIKRRIHEGAAGYDVAIVEIGGTVGDIESLPFLEAIRQMRSQLGRNNTLFAHLSYVPYIA 180 Query: 181 SAGELKTKPTQHSVQKLREIGISPDALLCRADRRIPDDERDKISLFSNVAADAVISVWDA 240 +AGE+KTKPTQH+V+++ IG+ PD L+CR DR +P DER KI+LF NV A++ +D Sbjct: 181 AAGEIKTKPTQHTVKEMLSIGLQPDILICRMDRTMPADERRKIALFCNVEERAIVGSYDV 240 Query: 241 DSIYKIPQMLHDQGLDTIICEKLGLSPKPADLSMWDKLIDAQNNPSHEVTIGMVGKYVDL 300 DSIY+ P+MLHDQG+D II E+L L+ + ADL+ W K++ A NP H V I MVGKYVDL Sbjct: 241 DSIYECPEMLHDQGIDNIITEQLQLNVQQADLTAWKKIVHAIQNPKHTVKIAMVGKYVDL 300 Query: 301 TESYKSLTEALRHAGIHTGSRVNIEYLDSEEIEANGTD--SLNKYDAILVPGGFGKRGVE 358 TESYKSL EAL+HAG+HT + V I ++DSE IE N D L DAILVPGGFG RGVE Sbjct: 301 TESYKSLIEALKHAGVHTETDVQITFVDSESIEKNNGDVSMLKDMDAILVPGGFGSRGVE 360 Query: 359 GKIAAARYARENKVPYLGICLGMQVALLEYARNKAGLSKANSTEFDPDTEQPVVALIDEW 418 GKIAA RYAREN VPYLGICLGMQ+AL+EYAR+ AGL ANSTEFD PVVALIDEW Sbjct: 361 GKIAAVRYARENNVPYLGICLGMQIALIEYARDVAGLKGANSTEFDLKCAAPVVALIDEW 420 Query: 419 QNHDGKVERRDANSDLGGTMRLGAQTCAVKPGTLAAEIYG-DSVTERHRHRYEANNFYLT 477 Q DG VE RD ++DLGGTMRLGAQ +K G+LAA+IYG + + ERHRHRYE NN Y+ Sbjct: 421 QTADGSVETRDESADLGGTMRLGAQEVELKAGSLAAKIYGSEHIRERHRHRYEVNNNYVP 480 Query: 478 RVEEAGMVVSARTP-TEDLCEIMELPRTGENAHPFYIGVQYHPEFKSTPRDGHPLFISYI 536 +E+AG+V+ + E L E +ELP HP++ Q+HPEF S PR GHPLF +++ Sbjct: 481 TLEQAGLVIGGVSAGRERLVETIELPN-----HPWFFACQFHPEFTSNPRKGHPLFTAFV 535 Query: 537 RAAL 540 +AAL Sbjct: 536 KAAL 539 >PA3637 [F] COG0504 CTP synthase (UTP-ammonia lyase) Pae Pseudomonas aeruginosa Length = 542 Score = 709 bits (1829), Expect = 0.0, Method: Compositional matrix adjust. Identities = 341/543 (62%), Positives = 417/543 (76%), Gaps = 6/543 (1%) Query: 1 MTKFVFVTGGVVSSLGKGIAAASLAAILESRGLKVTLLKLDPYINVDPGTMSPLQHGEVF 60 MT+++FVTGGVVSSLGKGIA+ASLAAILE+RGLK+T+LKLDPYINVDPGTMSP QHGEVF Sbjct: 1 MTRYIFVTGGVVSSLGKGIASASLAAILEARGLKITMLKLDPYINVDPGTMSPFQHGEVF 60 Query: 61 VTDDGAETDLDLGHYERFISAKMKKVNNFTTGQVYESVIRKERRGEYLGKTVQVIPHITN 120 VT DGAETDLDLGHYERF+ M + NNFTTG+VY V+RKERRG+YLG TVQVIPHIT+ Sbjct: 61 VTQDGAETDLDLGHYERFVRTTMTQNNNFTTGRVYMDVLRKERRGDYLGATVQVIPHITD 120 Query: 121 EIQEFIHRGAEGFEVALVEIGGTVGDIESLPFLEAARQLSLRSGRNATAFVHLTLVPFLA 180 EI+ I +GA +VALVEIGGTVGDIES PFLEA RQL + G +HLTLVP++A Sbjct: 121 EIKRRIIKGAGDADVALVEIGGTVGDIESQPFLEAIRQLRVEIGAKRAMLMHLTLVPYIA 180 Query: 181 SAGELKTKPTQHSVQKLREIGISPDALLCRADRRIPDDERDKISLFSNVAADAVISVWDA 240 +AGE KTKPTQHSV++LR IG+ PD L+CR+D I R KI+LF+NV AVI++ D Sbjct: 181 TAGETKTKPTQHSVKELRSIGLQPDVLVCRSDHPIDVSSRRKIALFTNVEERAVIALEDV 240 Query: 241 DSIYKIPQMLHDQGLDTIICEKLGLSPKPADLSMWDKLIDAQNNPSHEVTIGMVGKYVDL 300 D+IY+IP +LH QGLD I+ E+ GL ADLS WD+++DA+ NP EVTI MVGKY++L Sbjct: 241 DTIYRIPSVLHAQGLDDIVVERFGLECGQADLSEWDRVVDAKLNPEREVTIAMVGKYMEL 300 Query: 301 TESYKSLTEALRHAGIHTGSRVNIEYLDSEEIEANGTDSLNKYDAILVPGGFGKRGVEGK 360 ++YKSL EA+ HAGI + ++VN+ Y+DSE+IE GT L DAILVPGGFG RGVEGK Sbjct: 301 LDAYKSLIEAMTHAGIQSRTKVNLRYIDSEDIEQQGTSLLEGVDAILVPGGFGLRGVEGK 360 Query: 361 IAAARYARENKVPYLGICLGMQVALLEYARNKAGLSKANSTEFDPDTEQPVVALIDEWQN 420 I+ +YARENK+PYLGICLGMQVA++EYARN G S ANSTEFD + PVV LI EWQ+ Sbjct: 361 ISTVQYARENKIPYLGICLGMQVAVIEYARNVLGWSDANSTEFDKSSGHPVVGLITEWQD 420 Query: 421 HDGKVERRDANSDLGGTMRLGAQTCAVKPGTLAAEIYG-DSVTERHRHRYEANNFYLTRV 479 G E R SDLGGTMRLGAQ C ++ GTL + Y D + ERHRHRYE NN L ++ Sbjct: 421 ATGATEIRTEASDLGGTMRLGAQECQLQTGTLVHDCYAKDVIVERHRHRYEVNNNLLPQL 480 Query: 480 EEAGMVVSARTPTEDLCEIMELPRTGENAHPFYIGVQYHPEFKSTPRDGHPLFISYIRAA 539 E+AG+ +S R+ L E++E P HP+++ Q+HPEF STPRDGHPLF ++ AA Sbjct: 481 EQAGLKISGRSGDGALVEVVEAPE-----HPWFVACQFHPEFTSTPRDGHPLFSGFVNAA 535 Query: 540 LAH 542 L + Sbjct: 536 LKY 538 >HI1077 [F] COG0504 CTP synthase (UTP-ammonia lyase) Hin Haemophilus influenzae Length = 545 Score = 709 bits (1829), Expect = 0.0, Method: Compositional matrix adjust. Identities = 345/543 (63%), Positives = 431/543 (79%), Gaps = 6/543 (1%) Query: 2 TKFVFVTGGVVSSLGKGIAAASLAAILESRGLKVTLLKLDPYINVDPGTMSPLQHGEVFV 61 T ++FVTGGVVSSLGKGIAAASLAAILE+RGL VT++KLDPYINVDPGTMSP QHGEVFV Sbjct: 3 TNYIFVTGGVVSSLGKGIAAASLAAILEARGLNVTIMKLDPYINVDPGTMSPTQHGEVFV 62 Query: 62 TDDGAETDLDLGHYERFISAKMKKVNNFTTGQVYESVIRKERRGEYLGKTVQVIPHITNE 121 T DGAETDLDLGHYERFI KM K NNFTTG++Y V+RKERRG+YLG T+QVIPHITNE Sbjct: 63 TQDGAETDLDLGHYERFIRTKMTKRNNFTTGKIYSEVLRKERRGDYLGATIQVIPHITNE 122 Query: 122 IQEFIHRGAEGFEVALVEIGGTVGDIESLPFLEAARQLSLRSGRNATAFVHLTLVPFLAS 181 I++ + GA+G +V +VE+GGTVGDIESLPFLEA RQL+++ GR T F+HLTLVP++ + Sbjct: 123 IKDRVIAGAQGHDVVIVEVGGTVGDIESLPFLEALRQLAVQVGREHTLFMHLTLVPYIPT 182 Query: 182 AGELKTKPTQHSVQKLREIGISPDALLCRADRRIPDDERDKISLFSNVAADAVISVWDAD 241 AGE+KTKPTQHSV++L IGI PD L+CR+DR IP +ER KI+LF NVA AVIS+ D + Sbjct: 183 AGEVKTKPTQHSVKELLSIGIQPDVLICRSDRMIPPNERAKIALFCNVAERAVISLKDVN 242 Query: 242 SIYKIPQMLHDQGLDTIICEKLGLSPKPADLSMWDKLIDAQNNPSHEVTIGMVGKYVDLT 301 SIY+IP +L QGLD +CE+ L+ ADL+ W++++ Q NP EVTIGMVGKY +L Sbjct: 243 SIYQIPALLKSQGLDDFVCERFRLTCPEADLTEWEQVLYKQANPVGEVTIGMVGKYTELP 302 Query: 302 ESYKSLTEALRHAGIHTGSRVNIEYLDSEEIEANGTDSLNKYDAILVPGGFGKRGVEGKI 361 ++YKS+ EAL+HAG+ VNI+Y+DS+++E G + L D ILVPGGFG RGVEGKI Sbjct: 303 DAYKSVNEALKHAGLTNRLSVNIKYIDSQDVETKGVEVLKGIDGILVPGGFGYRGVEGKI 362 Query: 362 AAARYARENKVPYLGICLGMQVALLEYARNKAGLSKANSTEFDPDTEQPVVALIDEWQNH 421 A+YARENK+PYLGICLGMQ+AL+EYARN AGL+KANS+EFD D EQPVVALI EWQ+ Sbjct: 363 RTAQYARENKIPYLGICLGMQIALIEYARNVAGLTKANSSEFDKDCEQPVVALITEWQDA 422 Query: 422 DGKVERRDANSDLGGTMRLGAQTCAVKPGTLAAEIYG-DSVTERHRHRYEANNFYLTRVE 480 +G E R SDLGGTMRLGAQ C + G+ A E+YG +++ ERHRHRYE NN L ++E Sbjct: 423 EGNTEVRTDESDLGGTMRLGAQQCHLVSGSRARELYGKETIEERHRHRYEVNNTLLPQIE 482 Query: 481 EAGMVVSARTPTEDLCEIMELPRTGENAHPFYIGVQYHPEFKSTPRDGHPLFISYIRAAL 540 +AG+ V+ + + L EI+E+P HP+++ Q+HPEF STPRDGHPLF +++AA Sbjct: 483 KAGLKVTGLSADKKLVEIIEVPN-----HPWFVACQFHPEFTSTPRDGHPLFAGFVKAAY 537 Query: 541 AHH 543 +H Sbjct: 538 ENH 540