BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0021.0047.p (522 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSc1292 [GEPR] COG0477 Permeases of the major facilitator superf... 665 0.0 STM2815 [GEPR] COG0477 Permeases of the major facilitator superf... 520 e-147 NMA2168 [GEPR] COG0477 Permeases of the major facilitator superf... 515 e-145 YPO3268 [GEPR] COG0477 Permeases of the major facilitator superf... 514 e-145 NMB0319 [GEPR] COG0477 Permeases of the major facilitator superf... 513 e-145 >RSc1292 [GEPR] COG0477 Permeases of the major facilitator superfamily Rso Ralstonia solanacearum Length = 518 Score = 665 bits (1716), Expect = 0.0, Method: Compositional matrix adjust. Identities = 326/522 (62%), Positives = 415/522 (79%), Gaps = 4/522 (0%) Query: 1 MATTPPKPYTPPPPLTGANLVLGTLSVSLAVFMNVLDSSIANVAIPTISGNLGVSVDEGT 60 M T P+P P LTGA L +GT+++SLA FMNVLDSSIANV+IP ISG+LGV+ ++GT Sbjct: 1 MTTAAPRPLQP---LTGAKLAIGTVALSLATFMNVLDSSIANVSIPAISGDLGVAPNQGT 57 Query: 61 WVITSFAAANAISIPLTGWLTQRLGAVRLFVTSVLLFVLASWLCGLAPTLPILLAARVLQ 120 WVITSFA ANAIS+PLTGWLTQR G VRLFVTS+LLFVL+SW CGLAP + L+AAR+LQ Sbjct: 58 WVITSFAVANAISVPLTGWLTQRFGQVRLFVTSILLFVLSSWACGLAPNMGTLIAARILQ 117 Query: 121 GLVAGPMVPLSQSLLLGAYPKSKSSFALALWGMTAVVAPVAGPALGGWITDSYTWPWIFY 180 G VAGPM+PLSQSLLL YP +KSS ALALWGMT +VAP+ GP GGWI+D+ TWPWIFY Sbjct: 118 GAVAGPMIPLSQSLLLSTYPPAKSSMALALWGMTTLVAPIMGPIFGGWISDNMTWPWIFY 177 Query: 181 INIPVGLIAAGVTLAIYRSRETPIHKLPIDKIGLALLVTWVAAFQIMLDKGKDLDWFSSP 240 INIPVG++AA T IY+ RE+P LPID+IGLALLV WV + Q+MLD+GK+LDWF+S Sbjct: 178 INIPVGILAAYATWVIYKDRESPTRALPIDRIGLALLVIWVGSLQLMLDRGKELDWFNSA 237 Query: 241 TIVTLGIIALIAFAYFVVWELNNDHPVVDLRLFGRRNFAGGTIAISIGYGVFFGNLVILP 300 IVTL ++A++ FA+F+VWEL DHPVVDL LF RNF+ G +AIS+ YG+FFGNLVILP Sbjct: 238 EIVTLTVVAVVGFAFFLVWELTEDHPVVDLTLFKGRNFSAGVVAISVAYGLFFGNLVILP 297 Query: 301 QWLQQYLGYRSIDSGLSTAPIGIFAVILMPLIGRFLPLVDARKVATASFIGFAIVFWLRS 360 WLQ +GY + D+GL AP+GIFA++L P+IG+ LP +DAR VAT +FI FA+VFW+RS Sbjct: 298 LWLQTIVGYTATDAGLVMAPVGIFAILLSPVIGKNLPKMDARWVATTAFITFALVFWMRS 357 Query: 361 RYNLQVDQMTVILPTLLQGIPTAMFFVPLTVLLLSGLPPERIPAAAGLSSFVRVFCGAVG 420 R+ +QVD T+++PTL+QG AMFF+PLT ++LSGL PERIPAA+GLS+FVR+ G +G Sbjct: 358 RFTIQVDTWTLMVPTLIQGAAMAMFFIPLTSIILSGLRPERIPAASGLSNFVRIMFGGIG 417 Query: 421 TSISTTAWNNRTIMHHAQLTEHATPYSPWLQETVNNLSSTLGLNAEQTAGMLERTITFQA 480 SISTT W+NR+ +HHAQL E A PY+P ++ + + +G+ + Q G +ER I+ QA Sbjct: 418 ASISTTVWDNRSALHHAQLVERANPYNPAYASSLGDYTQ-MGMPSLQANGAIERIISQQA 476 Query: 481 AMLGINDIFYVSAVIFIVIIPLIWIIKPSKGGAGAAEASAAH 522 AM+G NDIF++SAV+FIV+I LIW+ +P+K GA A+ AH Sbjct: 477 AMMGANDIFWISAVLFIVLIALIWLTRPAKSAGGAEAAAGAH 518 >STM2815 [GEPR] COG0477 Permeases of the major facilitator superfamily Sty Salmonella typhimurium LT2 Length = 512 Score = 520 bits (1339), Expect = e-147, Method: Compositional matrix adjust. Identities = 258/496 (52%), Positives = 354/496 (71%), Gaps = 2/496 (0%) Query: 14 PLTGANLVLGTLSVSLAVFMNVLDSSIANVAIPTISGNLGVSVDEGTWVITSFAAANAIS 73 PL GA LV+ T+++SLA FM VLDS+IANVAIPTI+GNLG S+ +GTWVITSF ANAIS Sbjct: 6 PLEGAQLVIMTIALSLATFMQVLDSTIANVAIPTIAGNLGSSLSQGTWVITSFGVANAIS 65 Query: 74 IPLTGWLTQRLGAVRLFVTSVLLFVLASWLCGLAPTLPILLAARVLQGLVAGPMVPLSQS 133 IPLTGWL +R G V+LF+ S + F ASW CG++ +L +L+ RV+QG+VAGP++PLSQS Sbjct: 66 IPLTGWLAKRFGEVKLFMWSTVAFAAASWACGVSSSLNMLIFFRVVQGVVAGPLIPLSQS 125 Query: 134 LLLGAYPKSKSSFALALWGMTAVVAPVAGPALGGWITDSYTWPWIFYINIPVGLIAAGVT 193 LLL YP +K S ALALW MT +VAP+ GP LGG+I+D+Y W WIF+IN+P+G+ +T Sbjct: 126 LLLNNYPPAKRSIALALWSMTVIVAPICGPILGGYISDNYHWGWIFFINVPIGIAVVLMT 185 Query: 194 LAIYRSRETPIHKLPIDKIGLALLVTWVAAFQIMLDKGKDLDWFSSPTIVTLGIIALIAF 253 L R RET + ID +GLALLV + + QIMLD+GK+LDWFSS I+ L ++A+IA Sbjct: 186 LHTLRGRETHTERRRIDAVGLALLVIGIGSLQIMLDRGKELDWFSSQEIIILTVVAVIAI 245 Query: 254 AYFVVWELNNDHPVVDLRLFGRRNFAGGTIAISIGYGVFFGNLVILPQWLQQYLGYRSID 313 ++ +VWEL +DHP+VDL LF RNF G + IS+ Y ++FG +V+LPQ LQ+ GY + Sbjct: 246 SFLIVWELTDDHPIVDLSLFKSRNFTIGCLCISLAYMLYFGAIVLLPQLLQEVYGYTATW 305 Query: 314 SGLSTAPIGIFAVILMPLIGRFLPLVDARKVATASFIGFAIVFWLRS-RYNLQVDQMTVI 372 +GL++AP+GI VIL P+IGRF +D R++ T SFI +A+ F+ R+ + +D Sbjct: 306 AGLASAPVGIIPVILSPIIGRFAHKLDMRRLVTFSFIMYAVCFYWRAWTFEPGMDFGASA 365 Query: 373 LPTLLQGIPTAMFFVPLTVLLLSGLPPERIPAAAGLSSFVRVFCGAVGTSISTTAWNNRT 432 P +QG A FF+PLT + LSGLPPER+ AA+ LS+F R G++GTSI+TT W +R Sbjct: 366 WPQFIQGFAVACFFMPLTTITLSGLPPERLAAASSLSNFTRTLAGSIGTSITTTMWTDRE 425 Query: 433 IMHHAQLTEHATPYSPWLQETVNNLSSTLGLNAEQTAGMLERTITFQAAMLGINDIFYVS 492 +HHAQLTE T Y+P Q + L LG+ +Q +G + + IT Q ++ N+IF++S Sbjct: 426 SLHHAQLTESVTAYNPNAQTMYDKLEG-LGMTHQQASGWIAQQITNQGLIISANEIFWMS 484 Query: 493 AVIFIVIIPLIWIIKP 508 A IF+V++ L+W KP Sbjct: 485 AGIFLVLLGLVWFAKP 500 >NMA2168 [GEPR] COG0477 Permeases of the major facilitator superfamily NmA Neisseria meningitidis Z2491 Length = 516 Score = 515 bits (1326), Expect = e-145, Method: Compositional matrix adjust. Identities = 259/505 (51%), Positives = 350/505 (69%), Gaps = 3/505 (0%) Query: 13 PPLTGANLVLGTLSVSLAVFMNVLDSSIANVAIPTISGNLGVSVDEGTWVITSFAAANAI 72 PPL GA L TLS+ LAVFM VLD++IANVA+P I+GNLG + +GTWVITSFA ANA+ Sbjct: 12 PPLKGAALAWVTLSLGLAVFMEVLDTTIANVAVPVIAGNLGAATTQGTWVITSFAVANAV 71 Query: 73 SIPLTGWLTQRLGAVRLFVTSVLLFVLASWLCGLAPTLPILLAARVLQGLVAGPMVPLSQ 132 S+PLTG+L +R+G V+LF + + FV+ SWLCG+AP L L+ R+LQG +AGP++PLSQ Sbjct: 72 SVPLTGFLAKRIGEVKLFTAAAVGFVITSWLCGIAPNLQSLVVFRILQGFIAGPLIPLSQ 131 Query: 133 SLLLGAYPKSKSSFALALWGMTAVVAPVAGPALGGWITDSYTWPWIFYINIPVGLIAAGV 192 SLL+ +YP +K + ALALW MT VVAPV GP LGGWI+ ++ W WIF+INIP+G+I+A + Sbjct: 132 SLLMASYPPAKRTLALALWAMTVVVAPVLGPILGGWISGNWHWGWIFFINIPIGIISAWI 191 Query: 193 TLAIYRSRETPIHKLPIDKIGLALLVTWVAAFQIMLDKGKDLDWFSSPTIVTLGIIALIA 252 T + RET K+P D +GL L+V + A Q+MLD+GK+LDWF+S I+TLG++AL+ Sbjct: 192 TWKHLKCRETETVKMPTDYVGLTLMVVGIGALQMMLDRGKELDWFASGEIITLGVVALVC 251 Query: 253 FAYFVVWELNNDHPVVDLRLFGRRNFAGGTIAISIGYGVFFGNLVILPQWLQQYLGYRSI 312 +YF+VWEL +P+VDL LF RNF G IA S+G+ V+ G L +LP LQ LGY S Sbjct: 252 LSYFIVWELGEKYPIVDLSLFKDRNFTVGIIATSLGFMVYMGTLTLLPLVLQTNLGYTST 311 Query: 313 DSGLSTAPIGIFAVILMPLIGRFLPLVDARKVATASFIGFAIVFWLRSRYNLQVDQMTVI 372 +GL+ AP+GI V L PLIGRF +D R + TASF+ FA F+ R+ + +D VI Sbjct: 312 WAGLAAAPVGILPVFLSPLIGRFGNKIDMRLLVTASFLTFAFTFYWRTDFYADMDIGNVI 371 Query: 373 LPTLLQGIPTAMFFVPLTVLLLSGLPPERIPAAAGLSSFVRVFCGAVGTSISTTAWNNRT 432 P QG+ AMFF+PLT + LS + +I AA LS+F+RV G VG S+ +T W R Sbjct: 372 WPQFWQGVGVAMFFLPLTTITLSHMKGGQIAAAGSLSNFLRVLMGGVGVSVVSTLWERRE 431 Query: 433 IMHHAQLTEHATPYSPWLQETVNNLSSTLGLNAEQTAGMLERTITFQAAMLGINDIFYVS 492 +HH + EH TPYS L ET +LS G++ QT G++ TIT Q ++G N+IF Sbjct: 432 ALHHTRFAEHITPYSATLHETAAHLSQH-GVSDIQTLGIINNTITQQGFIIGSNEIFMAG 490 Query: 493 AVIFIVIIPLIWIIKP--SKGGAGA 515 +++FI++IP+IW+ KP GG G Sbjct: 491 SLLFIIMIPVIWLAKPPFHNGGGGG 515 >YPO3268 [GEPR] COG0477 Permeases of the major facilitator superfamily Ype Yersinia pestis Length = 511 Score = 514 bits (1323), Expect = e-145, Method: Compositional matrix adjust. Identities = 259/497 (52%), Positives = 352/497 (70%), Gaps = 4/497 (0%) Query: 14 PLTGANLVLGTLSVSLAVFMNVLDSSIANVAIPTISGNLGVSVDEGTWVITSFAAANAIS 73 PL GA L T+++SLA FM VLDS+IANVAIPTI+G+LG S +GTWVITSF ANAIS Sbjct: 5 PLEGAPLAWMTVALSLATFMQVLDSTIANVAIPTIAGDLGSSNSQGTWVITSFGVANAIS 64 Query: 74 IPLTGWLTQRLGAVRLFVTSVLLFVLASWLCGLAPTLPILLAARVLQGLVAGPMVPLSQS 133 IP+TGWL +R+G VRLF+ S LFVLASWLCG++ +L +L+ RV+QGLVAGP++PLSQS Sbjct: 65 IPVTGWLAKRVGEVRLFLWSTGLFVLASWLCGMSNSLGMLIFFRVIQGLVAGPLIPLSQS 124 Query: 134 LLLGAYPKSKSSFALALWGMTAVVAPVAGPALGGWITDSYTWPWIFYINIPVGLIAAGVT 193 LLL YP +K S ALALW MT VVAP+ GP LGG+I+D+Y W WIF+INIP+GL+ + Sbjct: 125 LLLNNYPPAKRSMALALWSMTIVVAPIFGPILGGYISDNYHWGWIFFINIPIGLVVVLLA 184 Query: 194 LAIYRSRETPIHKLPIDKIGLALLVTWVAAFQIMLDKGKDLDWFSSPTIVTLGIIALIAF 253 + + RET PID IGL LLV + A QIMLD+GK+LDWF+S I+ L ++A++A Sbjct: 185 GSTLKGRETKTEIRPIDTIGLVLLVVGIGALQIMLDQGKELDWFNSTEIIVLTVVAVVAI 244 Query: 254 AYFVVWELNNDHPVVDLRLFGRRNFAGGTIAISIGYGVFFGNLVILPQWLQQYLGYRSID 313 + +VWEL +DHPV+DL LF RNF G + +S+ Y ++FG +V+LPQ LQ+ GY + Sbjct: 245 TFLIVWELTDDHPVIDLSLFKSRNFTIGCLCLSLAYMLYFGAIVLLPQLLQEVYGYTATW 304 Query: 314 SGLSTAPIGIFAVILMPLIGRFLPLVDARKVATASFIGFAIVFWLRSRYNLQ--VDQMTV 371 +GL++AP+GI V+L PLIGRF +D R++ T SFI +A+ F+ R+ Y + +D Sbjct: 305 AGLASAPVGILPVLLSPLIGRFAHRIDMRQLVTFSFIMYAVCFYWRA-YTFEPGMDFGAS 363 Query: 372 ILPTLLQGIPTAMFFVPLTVLLLSGLPPERIPAAAGLSSFVRVFCGAVGTSISTTAWNNR 431 P QG A FF+PLT + LSGLPPER+ AA+ LS+F+R G++GTSI+TT W R Sbjct: 364 AWPQFFQGFAIACFFMPLTTITLSGLPPERMAAASSLSNFMRTLAGSIGTSITTTLWTQR 423 Query: 432 TIMHHAQLTEHATPYSPWLQETVNNLSSTLGLNAEQTAGMLERTITFQAAMLGINDIFYV 491 +HHAQLTE PY+P + L LG++ +Q + L R IT Q ++ N+IF++ Sbjct: 424 ESLHHAQLTEFVNPYNPNATQAYQELEK-LGMSQQQASAYLAREITNQGLIISANEIFWL 482 Query: 492 SAVIFIVIIPLIWIIKP 508 SA +F++++ LIW +P Sbjct: 483 SAGVFLMLLALIWFARP 499 >NMB0319 [GEPR] COG0477 Permeases of the major facilitator superfamily Nme Neisseria meningitidis MC58 Length = 508 Score = 513 bits (1321), Expect = e-145, Method: Compositional matrix adjust. Identities = 258/505 (51%), Positives = 349/505 (69%), Gaps = 3/505 (0%) Query: 13 PPLTGANLVLGTLSVSLAVFMNVLDSSIANVAIPTISGNLGVSVDEGTWVITSFAAANAI 72 PPL GA L TLS+ LAVFM VLD++IANVA+P I+GNLG + +GTWVITSF+ ANA+ Sbjct: 4 PPLKGAALAWVTLSLGLAVFMEVLDTTIANVAVPVIAGNLGAATTQGTWVITSFSVANAV 63 Query: 73 SIPLTGWLTQRLGAVRLFVTSVLLFVLASWLCGLAPTLPILLAARVLQGLVAGPMVPLSQ 132 S+PLTG+L +R+G V+LF + + FV+ SWLCG+AP L L+ R+LQG +AGP++PLSQ Sbjct: 64 SVPLTGFLAKRIGEVKLFTAAAVGFVITSWLCGIAPNLQSLVVFRILQGFIAGPLIPLSQ 123 Query: 133 SLLLGAYPKSKSSFALALWGMTAVVAPVAGPALGGWITDSYTWPWIFYINIPVGLIAAGV 192 SLL+ +YP +K + ALALW MT VVAPV GP LGGWI+ ++ W WIF+INIP+G+I+A + Sbjct: 124 SLLMASYPPAKRTLALALWAMTVVVAPVLGPILGGWISGNWHWGWIFFINIPIGIISAWI 183 Query: 193 TLAIYRSRETPIHKLPIDKIGLALLVTWVAAFQIMLDKGKDLDWFSSPTIVTLGIIALIA 252 T + RET K+P D +GL L+V + A Q+MLD+GK+LDWF+S I+TLG++AL+ Sbjct: 184 TWKHLKYRETETVKMPTDYVGLTLMVVGIGALQMMLDRGKELDWFASGEIITLGVVALVC 243 Query: 253 FAYFVVWELNNDHPVVDLRLFGRRNFAGGTIAISIGYGVFFGNLVILPQWLQQYLGYRSI 312 +YF+VWEL +P+VDL LF RNF G IA S+G+ V+ G L +LP LQ LGY S Sbjct: 244 LSYFIVWELGEKYPIVDLSLFKDRNFTVGVIATSLGFMVYMGTLTLLPLVLQTNLGYTST 303 Query: 313 DSGLSTAPIGIFAVILMPLIGRFLPLVDARKVATASFIGFAIVFWLRSRYNLQVDQMTVI 372 +GL+ AP+GI V L PLIGRF +D R TASF+ FA F+ R+ + +D VI Sbjct: 304 WAGLAAAPVGILPVFLSPLIGRFGNKIDMRLFVTASFLTFAFTFYWRTDFYADMDIGNVI 363 Query: 373 LPTLLQGIPTAMFFVPLTVLLLSGLPPERIPAAAGLSSFVRVFCGAVGTSISTTAWNNRT 432 P QG+ AMFF+PLT + LS + +I AA LS+F+RV G VG S+ +T W R Sbjct: 364 WPQFWQGVGVAMFFLPLTTITLSHMKGGQIAAAGSLSNFLRVLMGGVGVSVVSTLWERRE 423 Query: 433 IMHHAQLTEHATPYSPWLQETVNNLSSTLGLNAEQTAGMLERTITFQAAMLGINDIFYVS 492 +HH + EH TPYS L ET +LS G++ QT G++ TIT Q ++G N+IF Sbjct: 424 ALHHTRFAEHITPYSATLHETAAHLSQH-GVSDIQTLGIINNTITQQGFIIGSNEIFMAG 482 Query: 493 AVIFIVIIPLIWIIKP--SKGGAGA 515 +++FI++IP+IW+ KP GG G Sbjct: 483 SLLFIIMIPVIWLAKPPFHNGGGGG 507