BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0019.0186.p (286 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value DRA0364 [IQR] COG1028 Dehydrogenases with different specificitie... 355 1e-97 BH1511 [IQR] COG1028 Dehydrogenases with different specificities... 352 6e-97 BS_yhdF [IQR] COG1028 Dehydrogenases with different specificitie... 350 2e-96 alr5182 [IQR] COG1028 Dehydrogenases with different specificitie... 346 3e-95 CAC1423 [IQR] COG1028 Dehydrogenases with different specificitie... 346 3e-95 >DRA0364 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Dra Deinococcus radiodurans Length = 390 Score = 355 bits (910), Expect = 1e-97, Method: Compositional matrix adjust. Identities = 174/285 (61%), Positives = 219/285 (76%), Gaps = 1/285 (0%) Query: 2 SDHKPEGLPPQHQTHQPGSEQEMHPRPHSAPAGQPGR-RLAGKVALITGGDSGIGRAVAL 60 +++ P+ +P + Q QPGSE EM P G +L GKVALI+GGDSGIGRAVA+ Sbjct: 105 TENMPQEVPAETQEQQPGSEAEMSLAPVVIRDDYRGSDKLKGKVALISGGDSGIGRAVAV 164 Query: 61 AYAREGARLAIVYLDEEEDARQTQKDIQALDAPCLLIPGDVGSPEFCRSAVRSVMDAYGR 120 +AREGA +AI+YLDE +DAR T K +QA L+I GD+G P+FC+ AV VM G+ Sbjct: 165 HFAREGADVAILYLDEHQDARDTLKMVQAEGRQGLIIAGDIGDPKFCQDAVAQVMKELGK 224 Query: 121 LDVLVNNAAQQYPAQSIEQISAEQLEHTFRTNIFSMFYLVKEAMPFLTRGARIINTTSVT 180 LD+LVNNAA+Q+P +++ I+ EQLE TFRTNIF MFYL + A+P L +GA I+NTTSVT Sbjct: 225 LDILVNNAAEQHPQENLTDITPEQLERTFRTNIFGMFYLTQAALPHLQKGAVIVNTTSVT 284 Query: 181 AYRGSKHLVDYAATKGAIVAFTRSLSQQLAPAGIHVNAVAPGPIWTPLIPASFSEEEVAS 240 AY+GS L+DY++TKGAI+AFTRSLSQ LA GI VNAVAPGPIWTPLIP++F ++ VA Sbjct: 285 AYKGSPELLDYSSTKGAILAFTRSLSQNLADKGIRVNAVAPGPIWTPLIPSTFDQKRVAE 344 Query: 241 FGKNVPLGRPGQPDEVAPAYVFLATEGASYMTGQVLHPNGGEIVN 285 GK PL RPGQP EVAP+YVFLA+E +SY+TGQVLHPNGG++VN Sbjct: 345 HGKKTPLERPGQPAEVAPSYVFLASEDSSYITGQVLHPNGGDVVN 389 >BH1511 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Bha Bacillus halodurans Length = 287 Score = 352 bits (903), Expect = 6e-97, Method: Compositional matrix adjust. Identities = 168/286 (58%), Positives = 216/286 (75%), Gaps = 1/286 (0%) Query: 1 MSDHKPEGLPPQHQTHQPGSEQEMHPRPHSAPAGQPGR-RLAGKVALITGGDSGIGRAVA 59 M+ P PPQHQ QPG EQEM+PRP A G +L+GKVALITGGDSGIGRAVA Sbjct: 1 MTKQYPSSQPPQHQMKQPGIEQEMNPRPVFDRADYRGSGKLSGKVALITGGDSGIGRAVA 60 Query: 60 LAYAREGARLAIVYLDEEEDARQTQKDIQALDAPCLLIPGDVGSPEFCRSAVRSVMDAYG 119 +A+A+EGA++AI YLDE DA +T++ ++ + C L+PGDVG C+ V+ ++ +G Sbjct: 61 VAFAKEGAKVAISYLDEHGDANETKQYVEQIGGVCHLLPGDVGEEAICQQIVQETVNQFG 120 Query: 120 RLDVLVNNAAQQYPAQSIEQISAEQLEHTFRTNIFSMFYLVKEAMPFLTRGARIINTTSV 179 RLD++VNNAA+Q+P +E I + QLE TFRTN+FS FY K A+P L +GA IINTTS+ Sbjct: 121 RLDIVVNNAAEQHPQAGLEAIDSTQLEQTFRTNVFSFFYTTKAALPHLQQGASIINTTSI 180 Query: 180 TAYRGSKHLVDYAATKGAIVAFTRSLSQQLAPAGIHVNAVAPGPIWTPLIPASFSEEEVA 239 TAY+GSK L+DYA+TKGAIVA TRSLS+ + GI VN VAPGPIWTPLIPASF ++VA Sbjct: 181 TAYQGSKDLIDYASTKGAIVALTRSLSESIVGQGIRVNGVAPGPIWTPLIPASFDAQKVA 240 Query: 240 SFGKNVPLGRPGQPDEVAPAYVFLATEGASYMTGQVLHPNGGEIVN 285 FG + P+ R GQP+E+A AYV+LA++ +SY++GQVLH NGG IVN Sbjct: 241 QFGSDTPMKRAGQPEELAAAYVYLASDDSSYVSGQVLHVNGGVIVN 286 >BS_yhdF [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Bsu Bacillus subtilis Length = 289 Score = 350 bits (898), Expect = 2e-96, Method: Compositional matrix adjust. Identities = 168/285 (58%), Positives = 212/285 (74%), Gaps = 1/285 (0%) Query: 3 DHKPEGLPPQHQTHQPGSEQEMHPRPHSAPAGQPGR-RLAGKVALITGGDSGIGRAVALA 61 D + EG PQHQ QPG E +M+P P S G +L GKVA+ITGGDSGIGRA A+A Sbjct: 5 DRQTEGQEPQHQDRQPGIESKMNPLPLSEDEDYRGSGKLKGKVAIITGGDSGIGRAAAIA 64 Query: 62 YAREGARLAIVYLDEEEDARQTQKDIQALDAPCLLIPGDVGSPEFCRSAVRSVMDAYGRL 121 +A+EGA ++I+YLDE DA +T+K I+ + CLLIPGDVG C AV+ +D +G+L Sbjct: 65 FAKEGADISILYLDEHSDAEETRKRIEKENVRCLLIPGDVGDENHCEQAVQQTVDHFGKL 124 Query: 122 DVLVNNAAQQYPAQSIEQISAEQLEHTFRTNIFSMFYLVKEAMPFLTRGARIINTTSVTA 181 D+LVNNAA+Q+P SI IS EQLE TFRTNIFSMF++ K+A+P L G IINTTS+TA Sbjct: 125 DILVNNAAEQHPQDSILNISTEQLEKTFRTNIFSMFHMTKKALPHLQEGCAIINTTSITA 184 Query: 182 YRGSKHLVDYAATKGAIVAFTRSLSQQLAPAGIHVNAVAPGPIWTPLIPASFSEEEVASF 241 Y G L+DY++TKGAIV+FTRS+++ LA GI VNAVAPGPIWTPLIPA+F EE+V Sbjct: 185 YEGDTALIDYSSTKGAIVSFTRSMAKSLADKGIRVNAVAPGPIWTPLIPATFPEEKVKQH 244 Query: 242 GKNVPLGRPGQPDEVAPAYVFLATEGASYMTGQVLHPNGGEIVNT 286 G + P+GRPGQP E A AYV LA++ +SYMTGQ +H NGG ++T Sbjct: 245 GLDTPMGRPGQPVEHAGAYVLLASDESSYMTGQTIHVNGGRFIST 289 >alr5182 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Nos Nostoc sp. PCC 7120 Length = 285 Score = 346 bits (888), Expect = 3e-95, Method: Compositional matrix adjust. Identities = 163/268 (60%), Positives = 209/268 (77%), Gaps = 1/268 (0%) Query: 19 GSEQEMHPRPHSAPAGQPGR-RLAGKVALITGGDSGIGRAVALAYAREGARLAIVYLDEE 77 G+E +M P+P + A G +L KVALITGGDSGIGRAVA+AYA+EGA +A VYL E Sbjct: 17 GTESKMQPKPQADDAQYRGSGKLKDKVALITGGDSGIGRAVAIAYAKEGADVAFVYLSEH 76 Query: 78 EDARQTQKDIQALDAPCLLIPGDVGSPEFCRSAVRSVMDAYGRLDVLVNNAAQQYPAQSI 137 +DA +T+ ++ + I GD+ FC+ A++ +D +G+LD+L+NNAA+Q+P +SI Sbjct: 77 DDAEETKNLVEEQGRRAVSIAGDITDEAFCQRAIQQTVDEFGKLDILINNAAEQHPQESI 136 Query: 138 EQISAEQLEHTFRTNIFSMFYLVKEAMPFLTRGARIINTTSVTAYRGSKHLVDYAATKGA 197 E I+ EQLE TFRTNIFSMFYL K A+ L +G+ IINTTSVTAY+GS L+DY++TKGA Sbjct: 137 EDITKEQLERTFRTNIFSMFYLTKAAIKHLKKGSAIINTTSVTAYKGSPQLLDYSSTKGA 196 Query: 198 IVAFTRSLSQQLAPAGIHVNAVAPGPIWTPLIPASFSEEEVASFGKNVPLGRPGQPDEVA 257 IVAFTRSLSQ L GI VNAVAPGPIWTPLIP++F E+V +FGK VP+ R GQP+EVA Sbjct: 197 IVAFTRSLSQNLISKGIRVNAVAPGPIWTPLIPSTFPAEKVETFGKQVPMQRAGQPEEVA 256 Query: 258 PAYVFLATEGASYMTGQVLHPNGGEIVN 285 P+YVFLA++ +SYM+GQVLHPNGGE+VN Sbjct: 257 PSYVFLASDDSSYMSGQVLHPNGGEVVN 284 >CAC1423 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Cac Clostridium acetobutylicum Length = 299 Score = 346 bits (888), Expect = 3e-95, Method: Compositional matrix adjust. Identities = 167/282 (59%), Positives = 208/282 (73%), Gaps = 1/282 (0%) Query: 6 PEGLPPQHQTHQPGSEQEMHPRP-HSAPAGQPGRRLAGKVALITGGDSGIGRAVALAYAR 64 P PPQHQ QPG E M PRP ++ P +L KVALITGGDSGIGRA A+A+A+ Sbjct: 18 PTNFPPQHQNRQPGIESVMRPRPIYNNPCYYASGKLRNKVALITGGDSGIGRAAAVAFAK 77 Query: 65 EGARLAIVYLDEEEDARQTQKDIQALDAPCLLIPGDVGSPEFCRSAVRSVMDAYGRLDVL 124 E A +AIVYL E DA +T++ I++L CL I GDV FCR AV + +G L++L Sbjct: 78 EKADVAIVYLYERNDAMETKRVIESLGQRCLTIEGDVRRDGFCREAVERTIRTFGNLNIL 137 Query: 125 VNNAAQQYPAQSIEQISAEQLEHTFRTNIFSMFYLVKEAMPFLTRGARIINTTSVTAYRG 184 VNNAA Q+P SI I+ EQLE+TFRTNIFSMFY+ K A+P+L G+ IINT S+TAY G Sbjct: 138 VNNAAVQFPQDSILNITNEQLENTFRTNIFSMFYITKAALPYLKYGSSIINTASITAYEG 197 Query: 185 SKHLVDYAATKGAIVAFTRSLSQQLAPAGIHVNAVAPGPIWTPLIPASFSEEEVASFGKN 244 K L+DY++TKGAIV+FTRSLS+ L GI VNAVAPGPIWTPLIPASFS VA+FGK+ Sbjct: 198 EKTLIDYSSTKGAIVSFTRSLSKSLVDKGIRVNAVAPGPIWTPLIPASFSAARVATFGKD 257 Query: 245 VPLGRPGQPDEVAPAYVFLATEGASYMTGQVLHPNGGEIVNT 286 P+ R GQP E+APAYV+LA++ +SY+TG+V+H NGG +V T Sbjct: 258 TPMKRAGQPYELAPAYVYLASDDSSYVTGEVIHINGGRMVTT 299