BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0019.0140.p (600 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value MTH444 [T] COG0642 Signal transduction histidine kinase Mth Meth... 236 2e-61 AGc3620 Non COG 183 1e-45 DR1174_4 [T] COG0642 Signal transduction histidine kinase Dra De... 179 2e-44 MA1270_4 [T] COG0642 Signal transduction histidine kinase Mac Me... 170 7e-42 slr0473 [T] COG4251 Bacteriophytochrome (light-regulated signal ... 169 2e-41 >MTH444 [T] COG0642 Signal transduction histidine kinase Mth Methanothermobacter thermautotrophicus Length = 373 Score = 236 bits (601), Expect = 2e-61, Method: Compositional matrix adjust. Identities = 121/248 (48%), Positives = 159/248 (64%), Gaps = 2/248 (0%) Query: 338 ERKRAEEEIEALNADLERQAQHLHNVNKELESFSYSVSHDLRAPLRAISGYAMILEEDYA 397 ER + LN +L++QA+ L + NKELE+F+YSVSHDLR PLRAI G++ IL EDY Sbjct: 123 ERIEKVRSLRELNLELKKQAEKLEDANKELEAFAYSVSHDLRVPLRAIDGFSRILVEDYE 182 Query: 398 HAIDEKGREQLQVIRRNVRKMDALINDLLKLAKSTTGELTLQRFSMDELVAQVVAGL--Q 455 +D++G L +IR N RKM LI+D+L L+++ E+ L M EL L Q Sbjct: 183 DKLDDEGVRILGIIRDNTRKMGQLIDDILLLSRAGRQEMNLAMLDMRELAESTYRELASQ 242 Query: 456 QENPGVIFDVPRLEGAVANRGLIAQVWENLLSNAVKFSSKSEQPRVCVTMQANADEYVYG 515 +E + F V L A+A+R L+ QV NLLSNA+KF+ + + V DE+ Y Sbjct: 243 EEGRSIEFSVADLPPAMADRALMGQVMGNLLSNAIKFTRDRDPAVIEVGYMDGGDEHTYY 302 Query: 516 VHDNGVGFDMRYAHKLFGTFQRLHRQEEYAGTGIGLALVQRIVVRHTGRVWAESKPREGA 575 V DNG GFDM+YA KLFG FQRLH QEE+ GTG+GL++VQRI+ RH GRVW E K GA Sbjct: 303 VKDNGAGFDMKYASKLFGLFQRLHSQEEFEGTGVGLSIVQRIIKRHGGRVWGEGKVDGGA 362 Query: 576 SFYFALPR 583 + YF LP+ Sbjct: 363 TIYFTLPK 370 >AGc3620 Non COG Length = 745 Score = 183 bits (464), Expect = 1e-45, Method: Compositional matrix adjust. Identities = 105/234 (44%), Positives = 141/234 (60%), Gaps = 6/234 (2%) Query: 351 ADLERQAQHLHNVNKELESFSYSVSHDLRAPLRAISGYAMILEEDYAHAIDEKGREQLQV 410 ADL R+ L NKELE+FSYSVSHDLRAP R I G+A +L E + A+DEK LQ+ Sbjct: 506 ADLTRE---LQRTNKELEAFSYSVSHDLRAPFRHIVGFAQLLRER-SDALDEKSLHYLQM 561 Query: 411 IRRNVRKMDALINDLLKLAKSTTGELTLQRFSMDELVAQVVAGLQQ--ENPGVIFDVPRL 468 I L++DLL ++ +LTL+ M ++V++V L + + + + L Sbjct: 562 ISEAALGAGRLVDDLLNFSQLGRTQLTLKPVDMQKVVSEVRRSLSHAVSDRQIEWRIGAL 621 Query: 469 EGAVANRGLIAQVWENLLSNAVKFSSKSEQPRVCVTMQANADEYVYGVHDNGVGFDMRYA 528 + L+ QVW NL+ NA+K+SS+ + ++ D+ Y V DNGVGFDM Y Sbjct: 622 PVIFGDPTLLRQVWYNLIENAIKYSSREPVSIITISAVETEDDVTYSVEDNGVGFDMAYY 681 Query: 529 HKLFGTFQRLHRQEEYAGTGIGLALVQRIVVRHTGRVWAESKPREGASFYFALP 582 +KLFG FQRL R E++ GTGIGLALV+RIV RH G V AE EGA+F F LP Sbjct: 682 NKLFGVFQRLQRVEDFEGTGIGLALVRRIVERHHGLVGAEGTVGEGATFSFTLP 735 >DR1174_4 [T] COG0642 Signal transduction histidine kinase Dra Deinococcus radiodurans Length = 255 Score = 179 bits (454), Expect = 2e-44, Method: Compositional matrix adjust. Identities = 107/250 (42%), Positives = 142/250 (56%), Gaps = 12/250 (4%) Query: 342 AEEEIEALNADLERQAQ----HLHNVNKELESFSYSVSHDLRAPLRAISGYAMILEEDYA 397 A+ E+ LN LE + Q L N+ELE+FSYSVSHDLR PLR I G+ +L +D A Sbjct: 2 AQHELRQLNQSLEERVQRRTLELEEANRELEAFSYSVSHDLRTPLRHIVGFGDLLRKDSA 61 Query: 398 HAIDEKGREQLQVIRRNVRKMDALINDLLKLAKSTTGELTLQRFSMDELVAQVVAGLQQE 457 A+ K + L VI +M LI+ LL+ ++ L L + ELV +V L+ + Sbjct: 62 EALSPKSQRYLGVITDAAGRMSGLIDSLLEFSRMGRQPLRLVPVDLTELVERVWQNLEPD 121 Query: 458 NPG-----VIFDVPRLEGAVANRGLIAQVWENLLSNAVKFSSKSEQPRVCVTMQANADEY 512 G + +P++ G A L+ V++NLLSNA+K+S E +V V + Sbjct: 122 RQGREVRLTLRPLPQVPGDPA---LLELVFQNLLSNALKYSRTREVAQVTVAASEDGGAA 178 Query: 513 VYGVHDNGVGFDMRYAHKLFGTFQRLHRQEEYAGTGIGLALVQRIVVRHTGRVWAESKPR 572 V DNGVGFD +Y KLFG FQRLHR EE+ G GIGLA V+RIV RH G+V S P Sbjct: 179 RITVTDNGVGFDPKYTDKLFGVFQRLHRAEEFDGIGIGLANVRRIVTRHGGQVSGSSVPG 238 Query: 573 EGASFYFALP 582 EGA+F LP Sbjct: 239 EGATFTVVLP 248 >MA1270_4 [T] COG0642 Signal transduction histidine kinase Mac Methanosarcina acetivorans str.C2A Length = 250 Score = 170 bits (431), Expect = 7e-42, Method: Compositional matrix adjust. Identities = 84/233 (36%), Positives = 142/233 (60%), Gaps = 5/233 (2%) Query: 353 LERQAQHLHNVNKELESFSYSVSHDLRAPLRAISGYAMILEEDYAHAIDEKGREQLQVIR 412 LE + + L +LE F+Y SHDL+ PLR I+ Y +L+ Y +DE+ + + Sbjct: 7 LELKLEELARSKADLEQFAYVSSHDLQEPLRMIASYLQLLQRRYQGELDERADKYIYFAV 66 Query: 413 RNVRKMDALINDLLKLAKSTTGELTLQRFSMDELVAQVVAGLQ---QENPGVIFDVPRLE 469 +M +LINDLL+ ++ TT + + ++ V++ L+ +EN + L Sbjct: 67 DGASRMQSLINDLLEFSRVTTKAREFEPTDCESILNYVLSDLEVSIKENEATV-SYDSLP 125 Query: 470 GAVANRGLIAQVWENLLSNAVKFSSKSEQPRVCVTMQANADEYVYGVHDNGVGFDMRYAH 529 +A+ + QV++NL+SNA+KF SK E P++ V+ + D++ + V DNG+G + +Y+ Sbjct: 126 EIMADGTQLTQVFQNLISNAIKFRSK-EAPKIHVSAEKEDDKWRFSVQDNGIGINPKYSE 184 Query: 530 KLFGTFQRLHRQEEYAGTGIGLALVQRIVVRHTGRVWAESKPREGASFYFALP 582 K+F F+RLH++EEY GTGIGL++ ++I+ RH G +W +S+P G++FYF LP Sbjct: 185 KIFEVFKRLHKREEYPGTGIGLSICKKIIERHGGDIWVKSEPGRGSTFYFTLP 237 >slr0473 [T] COG4251 Bacteriophytochrome (light-regulated signal transduction histidine kinase) Syn Synechocystis Length = 748 Score = 169 bits (428), Expect = 2e-41, Method: Compositional matrix adjust. Identities = 87/244 (35%), Positives = 143/244 (58%), Gaps = 10/244 (4%) Query: 341 RAEEEIEALNADLERQAQHLHNVNKELESFSYSVSHDLRAPLRAISGYAMILEEDYAHAI 400 R EE+ L +LER N +L+ F+Y SHDL+ PL +S Y +LE Y+ A+ Sbjct: 510 RQAEELAQLARNLERS-------NADLKKFAYIASHDLQEPLNQVSNYVQLLEMRYSEAL 562 Query: 401 DEKGREQLQVIRRNVRKMDALINDLLKLAKSTTGELTLQRFSMDELVAQVVAGLQQ--EN 458 DE ++ + V M LI+D+L AK T L + E+V + +A L+Q E Sbjct: 563 DEDAKDFIDFAVTGVSLMQTLIDDILTYAKVDTQYAQLTFTDVQEVVDKALANLKQRIEE 622 Query: 459 PGVIFDVPRLEGAVANRGLIAQVWENLLSNAVKFSSKSEQPRVCVTMQANADEYVYGVHD 518 G +V + +A++ + QV++NL++N +KF+ + P++ + D +V+ V D Sbjct: 623 SGAEIEVGSMPAVMADQIQLMQVFQNLIANGIKFAG-DKSPKIKIWGDRQEDAWVFAVQD 681 Query: 519 NGVGFDMRYAHKLFGTFQRLHRQEEYAGTGIGLALVQRIVVRHTGRVWAESKPREGASFY 578 NG+G D ++ ++F FQRLH ++EY GTG+GLA+ ++I+ H G++W ES P EG++FY Sbjct: 682 NGIGIDPQFFERIFVIFQRLHTRDEYKGTGMGLAICKKIIEGHQGQIWLESNPGEGSTFY 741 Query: 579 FALP 582 F++P Sbjct: 742 FSIP 745