BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0019.0047.p (553 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value DR1742 [G] COG0166 Glucose-6-phosphate isomerase Dra Deinococcus... 687 0.0 Rv0946c [G] COG0166 Glucose-6-phosphate isomerase Mtu Mycobacter... 595 e-170 MT0972 [G] COG0166 Glucose-6-phosphate isomerase MtC Mycobacteri... 595 e-170 ML0150 [G] COG0166 Glucose-6-phosphate isomerase Mle Mycobacteri... 584 e-166 VC0374 [G] COG0166 Glucose-6-phosphate isomerase Vch Vibrio chol... 578 e-165 >DR1742 [G] COG0166 Glucose-6-phosphate isomerase Dra Deinococcus radiodurans Length = 541 Score = 687 bits (1774), Expect = 0.0, Method: Compositional matrix adjust. Identities = 334/535 (62%), Positives = 401/535 (74%), Gaps = 11/535 (2%) Query: 22 LTEKSAWIALQEHHQYSARHFRLERLFAADDKRGEKLVAEAAGIYLDYSKNLVTTETMTL 81 LT+ AW AL++H+ Y + L LFAAD +RGEK+ AE AG+YLDYSK+ VT ET+ L Sbjct: 4 LTDLPAWQALEDHY-YELQGTHLRELFAADPERGEKMNAEGAGLYLDYSKHRVTDETLRL 62 Query: 82 LMNLARLISXSP---------PINATEQRSVLHTALRMPADARLVVEGEDVIASVQEVLS 132 L LA+ IN TE R+VLHTALR P DA + V+G++V+ V EVL Sbjct: 63 LRELAQATGVEARRDAMFRGEKINVTEGRAVLHTALRAPRDAVIEVDGKNVVPEVHEVLD 122 Query: 133 RMEAFAEQVRSGAWTGHTGRRIRHVVNIGIGGSDLGPMMAYEALRPYAQPDLSLHFLSDV 192 RM FA+ VRSG W G+TG+ I+++VNIGIGGSDLGP+MAYEAL+ YAQ DL++ F+S+V Sbjct: 123 RMATFADAVRSGEWLGYTGKPIKNIVNIGIGGSDLGPVMAYEALKHYAQRDLTVRFVSNV 182 Query: 193 DGAALLETVRHLPAEETLFIVCSKTFTTLETTTNARAARDWLVRQLGEEAAVARHFVGVT 252 DG L E R L E TLFIV SKTFTT ET TNAR+AR WL+ L ++AAV RHFV V+ Sbjct: 183 DGTDLTEKTRDLDPEVTLFIVSSKTFTTQETMTNARSARKWLLGSLKDDAAVTRHFVAVS 242 Query: 253 TNIEEASRFGIDPQNMFGFWDWVGGRYSMTSAIGLSTMIAIGPEHFREMLAGFHAMDEHF 312 TN EE +FGID NMFGFWDWVGGRYSM SAIGLS M+A+GPEHFREMLAGFH MDEHF Sbjct: 243 TNAEEVQKFGIDTANMFGFWDWVGGRYSMDSAIGLSLMVAVGPEHFREMLAGFHDMDEHF 302 Query: 313 RTAPLEANVPAILGMLTVWYTNFFGATSQAVLPYSQYLKRLPAYLQQLTMESNGKQVNLQ 372 RTAP E N+P ++G+L VWY +FFGA S AVLPY QYL PAYLQQL MESNGK V L Sbjct: 303 RTAPAEQNLPMLMGLLGVWYGDFFGAESLAVLPYDQYLASFPAYLQQLDMESNGKHVTLG 362 Query: 373 GDAVDYQTSPVYWGDNGINGQHSFYQLLHQGTQMIPCDFIGFCQPVEALGDHHALLMANM 432 G+ VDYQT P+ WG G NGQH+FYQL+HQGT++IPCDFIGFCQ + L HH LLMAN+ Sbjct: 363 GEPVDYQTGPIVWGQAGTNGQHAFYQLIHQGTKLIPCDFIGFCQTLNPLPPHHDLLMANV 422 Query: 433 FAQAEALAFGKNAQRVREEGTPESLTPHRVFPGNRPSNSMLVERLTPHSLGTLVALYEHS 492 FAQ EALAFGK ++V +G + PHRVF GNRP++++L +RLTP +LG L+ALYEH Sbjct: 423 FAQTEALAFGKTLEQVLADGVAPEVAPHRVFEGNRPTSTILADRLTPRTLGALIALYEHK 482 Query: 493 VFTQGVIWNIDSFDQWGVELGKQLAKRTARQLLDPAEP-LHHDSSTNALIRRYRS 546 VF QG +W+I+SFDQWGVELGK LAK+ +L EP L HDSSTNALIRRYR+ Sbjct: 483 VFVQGAVWDINSFDQWGVELGKVLAKKIDGELQSEGEPELQHDSSTNALIRRYRA 537 >Rv0946c [G] COG0166 Glucose-6-phosphate isomerase Mtu Mycobacterium tuberculosis H37Rv Length = 553 Score = 595 bits (1535), Expect = e-170, Method: Compositional matrix adjust. Identities = 300/542 (55%), Positives = 368/542 (67%), Gaps = 20/542 (3%) Query: 22 LTEKSAWIALQEHH-QYSARHFRLERLFAADDKRGEKLVAEAAGIYLDYSKNLVTTETMT 80 +T AW AL+ HH Q H R + FA D RG +L +Y+DYSK+ VT ET+ Sbjct: 9 ITATPAWDALRRHHDQIGNTHLR--QFFADDPGRGRELTVSVGDLYIDYSKHRVTRETLA 66 Query: 81 LLMNLARL---------ISXSPPINATEQRSVLHTALRMPADARLVVEGEDVIASVQEVL 131 LL++LAR + IN +E R+VLHTALR+P DA LVV+G+DV+ V VL Sbjct: 67 LLIDLARTAHLEERRDQMFAGVHINTSEDRAVLHTALRLPRDAELVVDGQDVVTDVHAVL 126 Query: 132 SRMEAFAEQVRSGAWTGHTGRRIRHVVNIGIGGSDLGPMMAYEALRPYAQPDLSLHFLSD 191 M AF +++RSG WTG TG+RI VVNIGIGGSDLGP+M Y+ALR YA +S F+S+ Sbjct: 127 DAMGAFTDRLRSGEWTGATGKRISTVVNIGIGGSDLGPVMVYQALRHYADAGISARFVSN 186 Query: 192 VDGAALLETVRHLPAEETLFIVCSKTFTTLETTTNARAARDWLVRQLGEEAAVARHFVGV 251 VD A L+ T+ L TLFIV SKTF+TLET TNA AAR WL LG+ AAV+RHFV V Sbjct: 187 VDPADLIATLADLDPATTLFIVASKTFSTLETLTNATAARRWLTDALGD-AAVSRHFVAV 245 Query: 252 TTNIEEASRFGIDPQNMFGFWDWVGGRYSMTSAIGLSTMIAIGPEHFREMLAGFHAMDEH 311 +TN FGI+ NMFGFWDWVGGRYS+ SAIGLS M IG + F + LAGFH +D H Sbjct: 246 STNKRLVDDFGINTDNMFGFWDWVGGRYSVDSAIGLSLMTVIGRDAFADFLAGFHIIDRH 305 Query: 312 FRTAPLEANVPAILGMLTVWYTNFFGATSQAVLPYSQYLKRLPAYLQQLTMESNGKQVNL 371 F TAPLE+N P +LG++ +WY+NFFGA S+ VLPYS L R PAYLQQLTMESNGK Sbjct: 306 FATAPLESNAPVLLGLIGLWYSNFFGAQSRTVLPYSNDLSRFPAYLQQLTMESNGKSTRA 365 Query: 372 QGDAVDYQTSPVYWGDNGINGQHSFYQLLHQGTQMIPCDFIGFCQPVEAL------GDHH 425 G V T ++WG+ G NGQH+FYQLLHQGT+++P DFIGF QP++ L G H Sbjct: 366 DGSPVSADTGEIFWGEPGTNGQHAFYQLLHQGTRLVPADFIGFAQPLDDLPTAEGTGSMH 425 Query: 426 ALLMANMFAQAEALAFGKNAQRVREEGTPESLTPHRVFPGNRPSNSMLVERLTPHSLGTL 485 LLM+N FAQ + LAFGK A+ + +GTP + H+V PGNRPS S+L RLTP LG L Sbjct: 426 DLLMSNFFAQTQVLAFGKTAEEIAADGTPAHVVAHKVMPGNRPSTSILASRLTPSVLGQL 485 Query: 486 VALYEHSVFTQGVIWNIDSFDQWGVELGKQLAKRTARQLLDPAE-PLHHDSSTNALIRRY 544 +ALYEH VFT+GV+W IDSFDQWGVELGK AK + P DSST+ L+RRY Sbjct: 486 IALYEHQVFTEGVVWGIDSFDQWGVELGKTQAKALLPVITGAGSPPPQSDSSTDGLVRRY 545 Query: 545 RS 546 R+ Sbjct: 546 RT 547 >MT0972 [G] COG0166 Glucose-6-phosphate isomerase MtC Mycobacterium tuberculosis CDC1551 Length = 553 Score = 595 bits (1535), Expect = e-170, Method: Compositional matrix adjust. Identities = 300/542 (55%), Positives = 368/542 (67%), Gaps = 20/542 (3%) Query: 22 LTEKSAWIALQEHH-QYSARHFRLERLFAADDKRGEKLVAEAAGIYLDYSKNLVTTETMT 80 +T AW AL+ HH Q H R + FA D RG +L +Y+DYSK+ VT ET+ Sbjct: 9 ITATPAWDALRRHHDQIGNTHLR--QFFADDPGRGRELTVSVGDLYIDYSKHRVTRETLA 66 Query: 81 LLMNLARL---------ISXSPPINATEQRSVLHTALRMPADARLVVEGEDVIASVQEVL 131 LL++LAR + IN +E R+VLHTALR+P DA LVV+G+DV+ V VL Sbjct: 67 LLIDLARTAHLEERRDQMFAGVHINTSEDRAVLHTALRLPRDAELVVDGQDVVTDVHAVL 126 Query: 132 SRMEAFAEQVRSGAWTGHTGRRIRHVVNIGIGGSDLGPMMAYEALRPYAQPDLSLHFLSD 191 M AF +++RSG WTG TG+RI VVNIGIGGSDLGP+M Y+ALR YA +S F+S+ Sbjct: 127 DAMGAFTDRLRSGEWTGATGKRISTVVNIGIGGSDLGPVMVYQALRHYADAGISARFVSN 186 Query: 192 VDGAALLETVRHLPAEETLFIVCSKTFTTLETTTNARAARDWLVRQLGEEAAVARHFVGV 251 VD A L+ T+ L TLFIV SKTF+TLET TNA AAR WL LG+ AAV+RHFV V Sbjct: 187 VDPADLIATLADLDPATTLFIVASKTFSTLETLTNATAARRWLTDALGD-AAVSRHFVAV 245 Query: 252 TTNIEEASRFGIDPQNMFGFWDWVGGRYSMTSAIGLSTMIAIGPEHFREMLAGFHAMDEH 311 +TN FGI+ NMFGFWDWVGGRYS+ SAIGLS M IG + F + LAGFH +D H Sbjct: 246 STNKRLVDDFGINTDNMFGFWDWVGGRYSVDSAIGLSLMTVIGRDAFADFLAGFHIIDRH 305 Query: 312 FRTAPLEANVPAILGMLTVWYTNFFGATSQAVLPYSQYLKRLPAYLQQLTMESNGKQVNL 371 F TAPLE+N P +LG++ +WY+NFFGA S+ VLPYS L R PAYLQQLTMESNGK Sbjct: 306 FATAPLESNAPVLLGLIGLWYSNFFGAQSRTVLPYSNDLSRFPAYLQQLTMESNGKSTRA 365 Query: 372 QGDAVDYQTSPVYWGDNGINGQHSFYQLLHQGTQMIPCDFIGFCQPVEAL------GDHH 425 G V T ++WG+ G NGQH+FYQLLHQGT+++P DFIGF QP++ L G H Sbjct: 366 DGSPVSADTGEIFWGEPGTNGQHAFYQLLHQGTRLVPADFIGFAQPLDDLPTAEGTGSMH 425 Query: 426 ALLMANMFAQAEALAFGKNAQRVREEGTPESLTPHRVFPGNRPSNSMLVERLTPHSLGTL 485 LLM+N FAQ + LAFGK A+ + +GTP + H+V PGNRPS S+L RLTP LG L Sbjct: 426 DLLMSNFFAQTQVLAFGKTAEEIAADGTPAHVVAHKVMPGNRPSTSILASRLTPSVLGQL 485 Query: 486 VALYEHSVFTQGVIWNIDSFDQWGVELGKQLAKRTARQLLDPAE-PLHHDSSTNALIRRY 544 +ALYEH VFT+GV+W IDSFDQWGVELGK AK + P DSST+ L+RRY Sbjct: 486 IALYEHQVFTEGVVWGIDSFDQWGVELGKTQAKALLPVITGAGSPPPQSDSSTDGLVRRY 545 Query: 545 RS 546 R+ Sbjct: 546 RT 547 >ML0150 [G] COG0166 Glucose-6-phosphate isomerase Mle Mycobacterium leprae Length = 554 Score = 584 bits (1505), Expect = e-166, Method: Compositional matrix adjust. Identities = 290/542 (53%), Positives = 369/542 (68%), Gaps = 20/542 (3%) Query: 22 LTEKSAWIALQEHH-QYSARHFRLERLFAADDKRGEKLVAEAAGIYLDYSKNLVTTETMT 80 +T AW AL+ HH + A H R + FA + RG +LV +Y+DYSK+ +T +T+ Sbjct: 10 ITATPAWDALRRHHDEIGATHLR--QFFADNPNRGRELVITVGDLYIDYSKHRITHDTVQ 67 Query: 81 LLMNLARLISXSPP---------INATEQRSVLHTALRMPADARLVVEGEDVIASVQEVL 131 LL++LAR + +N +E RSVLHTALR+P D L+V+G++V+ V VL Sbjct: 68 LLVDLARAANLEQRRDQMLAGVHVNTSENRSVLHTALRLPRDTELIVDGQNVVQDVHAVL 127 Query: 132 SRMEAFAEQVRSGAWTGHTGRRIRHVVNIGIGGSDLGPMMAYEALRPYAQPDLSLHFLSD 191 M F +++RSG WTG TG+RI VVNIGIGGSDLGP+M Y+ALR YA +S F+S+ Sbjct: 128 DVMGDFTDRLRSGEWTGATGKRINTVVNIGIGGSDLGPVMVYQALRHYADAGISARFVSN 187 Query: 192 VDGAALLETVRHLPAEETLFIVCSKTFTTLETTTNARAARDWLVRQLGEEAAVARHFVGV 251 +D A L + L TLFIV SKTF+TLET TNA AAR WL LGE AAV++HFV V Sbjct: 188 IDPADLTAKLSDLEPGTTLFIVASKTFSTLETLTNATAARRWLTDALGE-AAVSKHFVAV 246 Query: 252 TTNIEEASRFGIDPQNMFGFWDWVGGRYSMTSAIGLSTMIAIGPEHFREMLAGFHAMDEH 311 +TN FGI+ NMFGFW+WVGGRYS+ SAIGLS M +G E F + L+GFH +D+H Sbjct: 247 STNKRLVKDFGINTANMFGFWEWVGGRYSVDSAIGLSLMAVVGRESFADFLSGFHIVDQH 306 Query: 312 FRTAPLEANVPAILGMLTVWYTNFFGATSQAVLPYSQYLKRLPAYLQQLTMESNGKQVNL 371 F+ APLE+N P +LG++ +WY++F GA S+AVLPYS L R AYLQQLTMESNGK Sbjct: 307 FQNAPLESNAPVLLGLIGLWYSDFLGAQSRAVLPYSNDLARFAAYLQQLTMESNGKSTRA 366 Query: 372 QGDAVDYQTSPVYWGDNGINGQHSFYQLLHQGTQMIPCDFIGFCQP------VEALGDHH 425 G V T +YWG+ G NGQH+FYQLLHQGT+++P DFIGF QP V+ +G H Sbjct: 367 DGTPVTTNTGEIYWGETGTNGQHAFYQLLHQGTRLVPADFIGFSQPIDDLPTVDGIGSMH 426 Query: 426 ALLMANMFAQAEALAFGKNAQRVREEGTPESLTPHRVFPGNRPSNSMLVERLTPHSLGTL 485 LLM+N FAQ + LAFGK A+ + EGTP + PH+V PGNRP+ S+L RLTP LG L Sbjct: 427 DLLMSNFFAQTQVLAFGKTAEEIAAEGTPAEVVPHKVMPGNRPTTSILANRLTPSVLGQL 486 Query: 486 VALYEHSVFTQGVIWNIDSFDQWGVELGKQLAKRTARQLLDPAEPLHH-DSSTNALIRRY 544 +ALYEH VFT+GVIW IDSFDQWGVELGK+ A+ + A P DSST+ L+RRY Sbjct: 487 IALYEHQVFTEGVIWGIDSFDQWGVELGKKQAEALLPVITGNASPAQQLDSSTDTLVRRY 546 Query: 545 RS 546 R+ Sbjct: 547 RT 548 >VC0374 [G] COG0166 Glucose-6-phosphate isomerase Vch Vibrio cholerae Length = 550 Score = 578 bits (1491), Expect = e-165, Method: Compositional matrix adjust. Identities = 287/542 (52%), Positives = 371/542 (68%), Gaps = 20/542 (3%) Query: 23 TEKSAWIALQEHHQYSARHFRLERLFAADDKRGEKLVAE-AAGIYLDYSKNLVTTETMTL 81 T+ AW AL H + SA+ L+ LFA D +R K A I +DYSKNLV ETM Sbjct: 8 TQTQAWKALTAHFE-SAQDMDLKALFAQDSERFAKYSARFGQDILVDYSKNLVNAETMQH 66 Query: 82 LMNLAR---------LISXSPPINATEQRSVLHTALRMPADARLVVEGEDVIASVQEVLS 132 L LA+ + IN TE R+VLHTALR +++ ++V GEDV+ +V VL+ Sbjct: 67 LFALAKETDLQSAITAMFKGEAINQTEDRAVLHTALRNRSNSPVLVNGEDVMPAVNAVLA 126 Query: 133 RMEAFAEQVRSGAWTGHTGRRIRHVVNIGIGGSDLGPMMAYEALRPYAQPDLSLHFLSDV 192 +M+AF+E+V G W G TG+ I VVNIGIGGSDLGP M EAL PY + L++HF+S+V Sbjct: 127 KMKAFSERVIGGEWKGFTGKAITDVVNIGIGGSDLGPYMVTEALVPY-KNHLTMHFVSNV 185 Query: 193 DGAALLETVRHLPAEETLFIVCSKTFTTLETTTNARAARDWLVRQLGEEAAVARHFVGVT 252 DG + ET++++ E TLF+V SKTFTT ET TNA ARDW ++ G+EA VA+HF ++ Sbjct: 186 DGTHMAETLKNVDPETTLFLVASKTFTTQETMTNAHTARDWFLKAAGDEAHVAKHFAALS 245 Query: 253 TNIEEASRFGIDPQNMFGFWDWVGGRYSMTSAIGLSTMIAIGPEHFREMLAGFHAMDEHF 312 TN + + FGID NMF FWDWVGGRYS+ SAIGLS +++IG ++F E+LAG H MD+HF Sbjct: 246 TNGKAVAEFGIDTDNMFEFWDWVGGRYSLWSAIGLSIILSIGYDNFVELLAGAHEMDQHF 305 Query: 313 RTAPLEANVPAILGMLTVWYTNFFGATSQAVLPYSQYLKRLPAYLQQLTMESNGKQVNLQ 372 P E+N+P IL ++ +WY NF GA S+A+LPY QYL R AY QQ MESNGK V+ Sbjct: 306 VNTPFESNIPVILALIGIWYNNFHGAESEAILPYDQYLHRFAAYFQQGNMESNGKYVDRN 365 Query: 373 GDAVDYQTSPVYWGDNGINGQHSFYQLLHQGTQMIPCDFIGFCQPVEALGDHHALLMANM 432 G+ V YQT P+ WG+ G NGQH+FYQL+HQGT++IPCDFI +GDHH LM+N Sbjct: 366 GNPVTYQTGPIIWGEPGTNGQHAFYQLIHQGTKLIPCDFIAPAVSHNLVGDHHQKLMSNF 425 Query: 433 FAQAEALAFGKNAQRVREE--------GTPESLTPHRVFPGNRPSNSMLVERLTPHSLGT 484 FAQ EALAFGK+AQ V+ E +L P +VF GNRP+NS+LV+++TP +LG Sbjct: 426 FAQTEALAFGKSAQAVQAELEKAGKSAAEIAALVPFKVFEGNRPTNSILVKQITPRTLGN 485 Query: 485 LVALYEHSVFTQGVIWNIDSFDQWGVELGKQLAKRTARQLLDPAEPLHHDSSTNALIRRY 544 L+A+YEH +F QGVIWNI SFDQWGVELGKQLA + +L D A HDSSTN LI + Sbjct: 486 LIAMYEHKIFVQGVIWNIFSFDQWGVELGKQLANQILPELADSAAVTSHDSSTNGLINAF 545 Query: 545 RS 546 ++ Sbjct: 546 KA 547