BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0019.0030.p (476 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value PA1438 [T] COG0642 Signal transduction histidine kinase Pae Pseu... 390 e-108 YPO2000 [T] COG0642 Signal transduction histidine kinase Ype Yer... 278 3e-74 RSp0488 [T] COG0642 Signal transduction histidine kinase Rso Ral... 218 2e-56 ZybcZ [T] COG0642 Signal transduction histidine kinase EcZ Esche... 211 2e-54 ECs0608 [T] COG0642 Signal transduction histidine kinase Ecs Esc... 211 2e-54 >PA1438 [T] COG0642 Signal transduction histidine kinase Pae Pseudomonas aeruginosa Length = 481 Score = 390 bits (1001), Expect = e-108, Method: Compositional matrix adjust. Identities = 218/455 (47%), Positives = 286/455 (62%), Gaps = 7/455 (1%) Query: 19 SITARLVLMSAASALLIFAVAGVVLYTVLKGELLRHERDALFTTLNDISYQIERAGNTER 78 S++ RL M A +A++IFA+ G +LY +L + R ++ + N +S ++ ER Sbjct: 12 SLSTRLAGMFAGAAVVIFALIGTMLYCILDRQTERLQQGEVDVRFNMVSRMLDHPDLAER 71 Query: 79 WARVQLKLSTLSQADQHVFFWIASDDPRYTYGDLTRLAPSAINHADGKQVGRLHLPGRAY 138 W +Q KL LSQ + + FWI SDDPRY YG + I ADG L LP Y Sbjct: 72 WPHLQGKLDNLSQEYELIRFWIDSDDPRYHYGRFSEPVQRLI--ADGAGRYELELPEHRY 129 Query: 139 PLHIMTRTLPAFEDRPEVRVTVGVDGAPYFEMRRTFLLATSISSLLGIVLAVISSYWIAR 198 L LPA E RP + +D A + E R + L S LG++LA + +WIAR Sbjct: 130 ALTARVGVLPAREGRPRLTYVTAIDSAAFHEARTSTLKWLLGLSALGVLLASLLGHWIAR 189 Query: 199 AGLEGLKKGGAARAQSFSPRKLSARMPVEALPEELSVLADAFNGALERIEQAYTQLEAFN 258 GL + + + A+ SPR+LS R+ + LP EL L AFNGAL+R+EQAY +LE+FN Sbjct: 190 LGLWPVHRL-SEEARRISPRQLSQRLQLSPLPAELRELVGAFNGALDRLEQAYVRLESFN 248 Query: 259 ADVAHELRTPLANLIGETQVALARERSAGEFKDVLQSNLEELDRIRSIVNDMLFLARSDQ 318 ADVAHELRTPL NLIG+TQVAL+RERS +++VLQSNLEEL+R+R+IVNDMLFLAR+DQ Sbjct: 249 ADVAHELRTPLTNLIGQTQVALSRERSGEHYEEVLQSNLEELERLRAIVNDMLFLARADQ 308 Query: 319 GEAATARVPVRVAEAVQKTVDFFEFVLDDTGMSITVAGDLEATATMETALFKRALTNLIQ 378 G A R +A + TVDF E + D+ G+ I V G EA A +E ALF+RA+TNL+ Sbjct: 309 GRLACEREETSLAGEIATTVDFLEVIFDEAGVGIEVRG--EARALVERALFQRAVTNLLY 366 Query: 379 NAIQHSPQGAQLRIDISGGEEMVRVAVTNPGPAIDEQHLPRLFDRFYRVDSARQDINGSH 438 NA QH+ G LR+ + + VRVAV+NPG I ++H LF+RFYRVD+AR N Sbjct: 367 NAAQHTAAGGTLRVGVERRGDEVRVAVSNPGVPIADEHRRHLFERFYRVDAARS--NSEA 424 Query: 439 GHGLGLAIVKAVARMHGGRAFASSSGGHNTIGFTI 473 HGLGL+IVKAVA MHGG F S+ G NT GFT+ Sbjct: 425 NHGLGLSIVKAVASMHGGSVFVDSADGWNTFGFTV 459 >YPO2000 [T] COG0642 Signal transduction histidine kinase Ype Yersinia pestis Length = 463 Score = 278 bits (710), Expect = 3e-74, Method: Compositional matrix adjust. Identities = 186/467 (39%), Positives = 274/467 (58%), Gaps = 21/467 (4%) Query: 16 LRQSITARLVLMSAASALLIFAVAGVVLYTVLKGELLRHERDALFTTLNDISYQIERAGN 75 +++SI+ RL LM A +++LI + G+VL + L L + + L T + ++ I Sbjct: 4 IKRSISGRLALMFALASILIVSALGIVLRSSLHNSLQKQMHNELQFTESLMAPWILSRTT 63 Query: 76 TERWARVQLKLSTLSQADQ-HVFFWIASDDPRYTYGDLTRLAPSAINHADGKQVGRLHLP 134 + W + K + L+ A+ V +W+ SDDP+ G AP + A + G +P Sbjct: 64 LDGWQTLATKFTDLAAAEGGRVQYWVLSDDPQLQVGGP---APRGVTWASLSK-GFSKVP 119 Query: 135 G---RAYPLHIMTRTLPAFEDRPEVRVTVGVDGAPYF----EMRRTFLLATSISSLLGIV 187 G + L ++ +PA +RP +R V +D PY E RT ++ T+I G++ Sbjct: 120 GATDESCSLFLLMSEIPAQGERPALRYVVAIDSTPYMGTLNEFTRTLIVITAI----GVL 175 Query: 188 LAVISSYWIARAGLEGLKKGGAARAQSFSPRKLSARMPVEALPEELSVLADAFNGALERI 247 + + IAR G+ + K + +AQ +P R+ LP+EL LA AFNG LER Sbjct: 176 FVALLGFVIARIGMRPVNKL-SEQAQHLAPGNHGQRLDTLTLPDELQKLAVAFNGVLERQ 234 Query: 248 EQAYTQLEAFNADVAHELRTPLANLIGETQVALARERSAGEFKDVLQSNLEELDRIRSIV 307 E A+ QLE+FNADVAHELRTPL NL+G+TQ+ L+R+R E +D+L+SNLEEL+R+ SIV Sbjct: 235 EIAWRQLESFNADVAHELRTPLTNLMGQTQLGLSRKRETHELEDLLESNLEELERMTSIV 294 Query: 308 NDMLFLARSDQGEAATARVPVRVAEAVQKTVDFFEFVLDDTGMSITVAGDLEATATMETA 367 NDMLFL+ + GE AT V + E KT ++ E + +SI V GD+ TA ++ Sbjct: 295 NDMLFLSHAQAGEHATQLTDVSLREETYKTTEYVEPSFAEKNLSIHVEGDI--TARIDRR 352 Query: 368 LFKRALTNLIQNAIQHSPQGAQLRIDISGGEEMVRVAVTNPGPAIDEQHLPRLFDRFYRV 427 LF R+L NL++N+ +H+ G +++ IS + +AV N G I +HL RLF+RFYRV Sbjct: 353 LFHRSLANLLENSARHAVTGTTVKVTISRENNLASIAVANIGAPIAAEHLNRLFERFYRV 412 Query: 428 DSARQDINGSHGHGLGLAIVKAVARMHGGRAFASSSGGHNTIGFTIA 474 DS+R + +H HGLGL+IV+AVA MH G FASS G NT G T+A Sbjct: 413 DSSRAR-SDTH-HGLGLSIVRAVAIMHRGDVFASSQNGINTFGLTLA 457 >RSp0488 [T] COG0642 Signal transduction histidine kinase Rso Ralstonia solanacearum Length = 465 Score = 218 bits (555), Expect = 2e-56, Method: Compositional matrix adjust. Identities = 119/273 (43%), Positives = 166/273 (60%), Gaps = 5/273 (1%) Query: 193 SYWIARAGLEGLKKGGAARAQSFSPRKLSARMPVEALPEELSVLADAFNGALERIEQAYT 252 S W+ R+ L+GL + G +A S P +L R+ +E P ELS L A N L R++ + Sbjct: 187 SLWLVRSTLKGLARIGR-QAASVVPSQLDTRLTLEGAPRELSDLLAALNAMLTRLQDGFA 245 Query: 253 QLEAFNADVAHELRTPLANLIGETQVALARERSAGEFKDVLQSNLEELDRIRSIVNDMLF 312 +L F+AD+AH+ RTPLANLIG+T+V LA R AGE++ VL+S+LEE R+ ++ DMLF Sbjct: 246 RLSQFSADLAHDFRTPLANLIGQTEVTLAHPRPAGEYRAVLESSLEEYARLSRMIEDMLF 305 Query: 313 LARSDQGEAATARVPVRVAEAVQKTVDFFEFVLDDTGMSITVAGDLEATATMETALFKRA 372 LAR+D A + P+ +Q VD+FE V D ++I V G+ A + L +RA Sbjct: 306 LARADHARVALSVAPLDARHEIQVLVDYFEAVAADRDITIQVCGNGRVRADL--TLLRRA 363 Query: 373 LTNLIQNAIQHSPQGAQLRIDISGGEEMVRVAVTNPGPAIDEQHLPRLFDRFYRVDSARQ 432 + NL+ NA++H+P GA++ + + +AV NPGP I LP LFDRFYR D AR Sbjct: 364 INNLLDNALRHTPGGARIDVAVQVLPHSTAIAVRNPGPGIPAASLPLLFDRFYRGDPARA 423 Query: 433 DINGSHGHGLGLAIVKAVARMHGGRAFASSSGG 465 N GLGLAIV+ + +HGG A ASS G Sbjct: 424 --NSERSAGLGLAIVQTIMDLHGGTAQASSPPG 454 >ZybcZ [T] COG0642 Signal transduction histidine kinase EcZ Escherichia coli O157:H7 EDL933 Length = 482 Score = 211 bits (538), Expect = 2e-54, Method: Compositional matrix adjust. Identities = 147/428 (34%), Positives = 220/428 (51%), Gaps = 35/428 (8%) Query: 63 LNDISYQIERAGN--TERWARVQLKLSTLSQADQHVFFWIASDDPRYTYG-----DLTRL 115 L +IS +ER N E AR + L + +V +A + Y D+ Sbjct: 51 LKEISATLERVLNHPDETQARRLMTLEDIVSGYSNVLISLADSHGKTVYHSPGAPDIREF 110 Query: 116 APSAINHAD--GKQVGRLHLPGRAYPLHIMTRTLPAFEDRPEVRVTVG--VDGAPYFEMR 171 A AI D G +V L P P H + + + VG VDG P + Sbjct: 111 ARDAIPDKDARGGEVFLLSGPTMMMPGHGHGHM--EHSNWRMISLPVGPLVDGKPIY--- 165 Query: 172 RTFLLATSISSLLG---------IVLAVISSYWIARAGLEGLKKGGAA------RAQSFS 216 T +A SI L I+ A + S I L + KG A + Q+ + Sbjct: 166 -TLYIALSIDFHLHYINDLMNKLIMTASVISILIVFIVLLAVHKGHAPIRSVSRQIQNIT 224 Query: 217 PRKLSARMPVEALPEELSVLADAFNGALERIEQAYTQLEAFNADVAHELRTPLANLIGET 276 + L R+ + +P EL L +FN +ERIE +T+ F+AD+AHE+RTP+ NLI +T Sbjct: 225 SKDLDVRLDPQTVPIELEQLVLSFNHMIERIEDVFTRQSNFSADIAHEIRTPITNLITQT 284 Query: 277 QVALARERSAGEFKDVLQSNLEELDRIRSIVNDMLFLARSDQGEAATARVPVRVAEAVQK 336 ++AL++ RS E +DVL SNLEEL R+ +V+DMLFLA++D + + + +A+ V K Sbjct: 285 EIALSQSRSQKELEDVLYSNLEELTRMAKMVSDMLFLAQADNNQLIPEKKMLNLADEVGK 344 Query: 337 TVDFFEFVLDDTGMSITVAGDLEATATMETALFKRALTNLIQNAIQHSPQGAQLRIDISG 396 DFFE + +D G+ + GD E + + +RAL+NL+ NA++++P G + + Sbjct: 345 VFDFFEALAEDRGVELQFVGD-ECQVAGDPLMLRRALSNLLSNALRYTPPGEAIVVRCQT 403 Query: 397 GEEMVRVAVTNPGPAIDEQHLPRLFDRFYRVDSARQDINGSHGHGLGLAIVKAVARMHGG 456 + +V+V V NPG I +HLPRLFDRFYRVD +RQ G G+GLAIVK++ H G Sbjct: 404 VDHLVQVIVENPGTPIAPEHLPRLFDRFYRVDPSRQ--RKGEGSGIGLAIVKSIVVAHKG 461 Query: 457 RAFASSSG 464 +S+ Sbjct: 462 TVAVTSNA 469 >ECs0608 [T] COG0642 Signal transduction histidine kinase Ecs Escherichia coli O157:H7 Length = 482 Score = 211 bits (538), Expect = 2e-54, Method: Compositional matrix adjust. Identities = 147/428 (34%), Positives = 220/428 (51%), Gaps = 35/428 (8%) Query: 63 LNDISYQIERAGN--TERWARVQLKLSTLSQADQHVFFWIASDDPRYTYG-----DLTRL 115 L +IS +ER N E AR + L + +V +A + Y D+ Sbjct: 51 LKEISATLERVLNHPDETQARRLMTLEDIVSGYSNVLISLADSHGKTVYHSPGAPDIREF 110 Query: 116 APSAINHAD--GKQVGRLHLPGRAYPLHIMTRTLPAFEDRPEVRVTVG--VDGAPYFEMR 171 A AI D G +V L P P H + + + VG VDG P + Sbjct: 111 ARDAIPDKDARGGEVFLLSGPTMMMPGHGHGHM--EHSNWRMISLPVGPLVDGKPIY--- 165 Query: 172 RTFLLATSISSLLG---------IVLAVISSYWIARAGLEGLKKGGAA------RAQSFS 216 T +A SI L I+ A + S I L + KG A + Q+ + Sbjct: 166 -TLYIALSIDFHLHYINDLMNKLIMTASVISILIVFIVLLAVHKGHAPIRSVSRQIQNIT 224 Query: 217 PRKLSARMPVEALPEELSVLADAFNGALERIEQAYTQLEAFNADVAHELRTPLANLIGET 276 + L R+ + +P EL L +FN +ERIE +T+ F+AD+AHE+RTP+ NLI +T Sbjct: 225 SKDLDVRLDPQTVPIELEQLVLSFNHMIERIEDVFTRQSNFSADIAHEIRTPITNLITQT 284 Query: 277 QVALARERSAGEFKDVLQSNLEELDRIRSIVNDMLFLARSDQGEAATARVPVRVAEAVQK 336 ++AL++ RS E +DVL SNLEEL R+ +V+DMLFLA++D + + + +A+ V K Sbjct: 285 EIALSQSRSQKELEDVLYSNLEELTRMAKMVSDMLFLAQADNNQLIPEKKMLNLADEVGK 344 Query: 337 TVDFFEFVLDDTGMSITVAGDLEATATMETALFKRALTNLIQNAIQHSPQGAQLRIDISG 396 DFFE + +D G+ + GD E + + +RAL+NL+ NA++++P G + + Sbjct: 345 VFDFFEALAEDRGVELQFVGD-ECQVAGDPLMLRRALSNLLSNALRYTPPGEAIVVRCQT 403 Query: 397 GEEMVRVAVTNPGPAIDEQHLPRLFDRFYRVDSARQDINGSHGHGLGLAIVKAVARMHGG 456 + +V+V V NPG I +HLPRLFDRFYRVD +RQ G G+GLAIVK++ H G Sbjct: 404 VDHLVQVIVENPGTPIAPEHLPRLFDRFYRVDPSRQ--RKGEGSGIGLAIVKSIVVAHKG 461 Query: 457 RAFASSSG 464 +S+ Sbjct: 462 TVAVTSNA 469