BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0015.0521.p (522 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSc2727 [GEPR] COG0477 Permeases of the major facilitator superf... 686 0.0 PA3137 [GEPR] COG0477 Permeases of the major facilitator superfa... 347 4e-95 mll0994 [GEPR] COG0477 Permeases of the major facilitator superf... 333 7e-91 RC0200 [GEPR] COG0477 Permeases of the major facilitator superfa... 285 2e-76 RP157 [GEPR] COG0477 Permeases of the major facilitator superfam... 279 1e-74 >RSc2727 [GEPR] COG0477 Permeases of the major facilitator superfamily Rso Ralstonia solanacearum Length = 511 Score = 686 bits (1769), Expect = 0.0, Method: Compositional matrix adjust. Identities = 354/493 (71%), Positives = 415/493 (84%) Query: 30 GTLGALMATLDISIVNSSLPTIQGEIGASGTEGTWIATAYLVAEIVIIPMSAWLERLLGL 89 GTLGA+MATLDISIVNS+LPTIQGEIGA+ TEGTWIATAYLVAEI+IIP++ WLE+LLGL Sbjct: 19 GTLGAMMATLDISIVNSALPTIQGEIGATSTEGTWIATAYLVAEIIIIPLAGWLEKLLGL 78 Query: 90 RVLLLTAASLFTLFSVLCGLSTTLPMMIVGRVGQGFTGGALIPTAMTIIATRLPRSQQPV 149 R LLL A LFT FS+LCG++ TLPMM++GR GQGFTGG LIPTAMTIIA RLPR+QQP+ Sbjct: 79 RNLLLAATGLFTGFSMLCGVAETLPMMVIGRAGQGFTGGVLIPTAMTIIAARLPRAQQPL 138 Query: 150 GNALFGATAILGPVLGPVMGGWLTENVSWHYAFFINLPVGAALITLLLVAIPYERPKFEQ 209 G ALFG+T ILGPV GP++GGW+T ++WHYAFFINLP+ L LLL+ +P+ERP+ Sbjct: 139 GTALFGSTVILGPVFGPMLGGWMTTQLNWHYAFFINLPICGVLAALLLLGMPHERPRTAL 198 Query: 210 LAEADWFGIAGLALGLGGLTVVLEEGEREQWFSSPDIRWLAATSVLGFILLAIGQVRARH 269 L EADW GIAGLALGLGG+TVVLEEG+R QWF+SP IRWLAA S LGF LL GQ RAR Sbjct: 199 LREADWAGIAGLALGLGGMTVVLEEGQRLQWFTSPAIRWLAAVSALGFGLLGWGQARARA 258 Query: 270 PVIQLRLLRDRQFGSVVMMAMIVGVALYGTAYVIPQFLSGIAGYNSLQSGWIVLLSGVPM 329 PVI+L LLRDRQFG++ +MA+ +ALYGTAYVIPQFL GIAGY++LQSGWIVLLSG+PM Sbjct: 259 PVIRLGLLRDRQFGAIAVMAIAASMALYGTAYVIPQFLVGIAGYDALQSGWIVLLSGLPM 318 Query: 330 ILMMPFTPLLMRLVDIRIAVGTGFLLLATSAFIETDLSPLSYGGSFVASQLMRGVGTVLA 389 I++MP PL++R +D+R+AVG G L+LA SA+IET LSPLS G SFVASQLMRG+GTVL Sbjct: 319 IVLMPMLPLMLRWLDVRLAVGGGLLVLALSAYIETGLSPLSTGNSFVASQLMRGLGTVLT 378 Query: 390 MLFLNQAAIRSVPPSQAGDASGLYSAARNLGGSLALAAIAVIQDQRLWLHSRRLEESLNA 449 M+FLNQAAIRSVPPSQA DASGLY+ RNLGGS+ALA IA +Q+QRLWLHSRR+E++L A Sbjct: 379 MMFLNQAAIRSVPPSQASDASGLYNGLRNLGGSIALACIATLQEQRLWLHSRRIEDTLQA 438 Query: 450 NSDLVQSGIAAQAHLLGGQDVAIQLMGATIQAQALTMTYADLFWMLGVAILCVTPLVLFL 509 N+ VQ IA QAH LG Q A+ M +IQ QALTM YADLFW+L VAIL VTPLV+FL Sbjct: 439 NAAGVQDYIAGQAHALGSQAAALLSMEQSIQVQALTMAYADLFWLLTVAILLVTPLVVFL 498 Query: 510 RPLPTNAAPVASH 522 RPLP +A PVA H Sbjct: 499 RPLPRHAGPVAGH 511 >PA3137 [GEPR] COG0477 Permeases of the major facilitator superfamily Pae Pseudomonas aeruginosa Length = 499 Score = 347 bits (890), Expect = 4e-95, Method: Compositional matrix adjust. Identities = 194/482 (40%), Positives = 280/482 (58%) Query: 32 LGALMATLDISIVNSSLPTIQGEIGASGTEGTWIATAYLVAEIVIIPMSAWLERLLGLRV 91 LGA MA LDI I NSSL IQG + A+ EG+WI+T+YLVAEI++IPM+AWL +LL R Sbjct: 6 LGAFMAVLDIQITNSSLKDIQGALAATLEEGSWISTSYLVAEIIMIPMTAWLVQLLSARR 65 Query: 92 LLLTAASLFTLFSVLCGLSTTLPMMIVGRVGQGFTGGALIPTAMTIIATRLPRSQQPVGN 151 L + + F + S+LC + L MIV R QGFTGGALIP A T+ +LP +P G Sbjct: 66 LAVMISVGFLVSSLLCSFAWNLESMIVFRAMQGFTGGALIPLAFTLALVKLPEHHRPKGM 125 Query: 152 ALFGATAILGPVLGPVMGGWLTENVSWHYAFFINLPVGAALITLLLVAIPYERPKFEQLA 211 ALF TA P +GP +GGWLTEN W Y F+IN+P G +I LL + + P +E L Sbjct: 126 ALFAITATFAPSIGPTLGGWLTENFGWEYIFYINVPPGLLMIAGLLYGLEKKAPHWELLK 185 Query: 212 EADWFGIAGLALGLGGLTVVLEEGEREQWFSSPDIRWLAATSVLGFILLAIGQVRARHPV 271 D+ GI L +GLG L V LEEG R+ W S I L + ++ +L I Q+ +P+ Sbjct: 186 STDYAGIVTLGIGLGCLQVFLEEGHRKDWLESQLIVSLGSVALFSLVLFVILQLSRPNPL 245 Query: 272 IQLRLLRDRQFGSVVMMAMIVGVALYGTAYVIPQFLSGIAGYNSLQSGWIVLLSGVPMIL 331 I L +LR+R FG + ++ +G+ LYG+ YV+P +L+ I GYN++Q G +++ G+P + Sbjct: 246 IDLGILRNRNFGLASISSIGLGMGLYGSIYVLPLYLAQIQGYNAMQIGEVIMWMGIPQLF 305 Query: 332 MMPFTPLLMRLVDIRIAVGTGFLLLATSAFIETDLSPLSYGGSFVASQLMRGVGTVLAML 391 ++P P LM+LV R+ GF L ++F L+P G F QL+R +G + M+ Sbjct: 306 LIPLVPKLMKLVSPRLLCAAGFGLFGLASFFSGVLNPDFAGPQFNQIQLLRALGQPMIMV 365 Query: 392 FLNQAAIRSVPPSQAGDASGLYSAARNLGGSLALAAIAVIQDQRLWLHSRRLEESLNANS 451 ++ A + P AG AS L++ RNLGG++ +A +A + D R ++ L E+L + Sbjct: 366 TISLIATAYLQPQDAGSASSLFNILRNLGGAIGIALLATLLDSRAKVYFDYLREALVPTN 425 Query: 452 DLVQSGIAAQAHLLGGQDVAIQLMGATIQAQALTMTYADLFWMLGVAILCVTPLVLFLRP 511 V +A A LG Q A+ + QA+ M Y D F ++G+ + VL R Sbjct: 426 PQVDERLAQLAAQLGSQQAALGKLSEITHQQAMIMAYNDAFHVIGMVLAVSMLAVLLTRS 485 Query: 512 LP 513 LP Sbjct: 486 LP 487 >mll0994 [GEPR] COG0477 Permeases of the major facilitator superfamily Mlo Mesorhizobium loti Length = 537 Score = 333 bits (853), Expect = 7e-91, Method: Compositional matrix adjust. Identities = 197/523 (37%), Positives = 297/523 (56%), Gaps = 17/523 (3%) Query: 2 SSAAPAKPIGQ--GAQPEKADAAAWLAVAAGTLGALMATLDISIVNSSLPTIQGEIGASG 59 S APA+P G+ A W+AV +LGA MA L+I IVN+SL IQG IGA Sbjct: 7 SMPAPARPARNETGSAGTAASPRVWVAVVGSSLGAFMAVLNIQIVNASLADIQGAIGAGI 66 Query: 60 TEGTWIATAYLVAEIVIIPMSAWLERLLGLRVLLLTAASLFTLFSVLCGLSTTLPMMIVG 119 +G WI+TAYL+AEIV+IP++ WL ++ LR L+ A LF FSV C + L MIV Sbjct: 67 DDGGWISTAYLIAEIVVIPLTGWLSQVFSLRNYLIANAVLFLAFSVACAFAANLGQMIVL 126 Query: 120 RVGQGFTGGALIPTAMTIIATRLPRSQQPVGNALFGATAILGPVLGPVMGGWLTENVSWH 179 R QGFTGG LIP A TI+ T LP+++QP+G ALF +A P +GP +GG+LTEN W Sbjct: 127 RAIQGFTGGVLIPMAFTIVITLLPKARQPIGLALFAMSATFAPAIGPTIGGYLTENWGWQ 186 Query: 180 YAFFINLPVGAALITLLLVAIPYERPKFEQLAEADWFGIAGLALGLGGLTVVLEEGEREQ 239 Y F++N+ GA ++ +L ++ + + L E DW GIA +A+GL L VLEEG + Sbjct: 187 YIFYVNIVPGALMVGMLWFSLDRQPMRLALLGEGDWPGIATMAIGLAALQTVLEEGNKND 246 Query: 240 WFSSPDIRWLAATSVLGFILLAIGQVRARHPVIQLRLLRDRQFGSVVMMAMIVGVALYGT 299 WF S + LA + + L ++ + HP++ LRLL R FG ++ ++G ALYG+ Sbjct: 247 WFGSLFVLRLAIVAAVSLSLFVWIELTSSHPLLNLRLLLRRNFGFGILANFMLGTALYGS 306 Query: 300 AYVIPQFLSGIAGYNSLQSGWIVLLSGVPMILMMPFTPLLMRLVDIRIAVGTGFLLLATS 359 +++P +L+ I GYN+ Q G ++ +G+P +L++P P LM+ D+R+ + TGF L A S Sbjct: 307 VFILPVYLARIQGYNAEQIGLVLAWTGLPQLLLIPLVPYLMQRFDVRLVIVTGFALFAAS 366 Query: 360 AFIETDLSPLSYGGSFVASQLMRGVGTVLAMLFLNQAAIRSVPPSQAGDASGLYSAARNL 419 F+ ++ ++R +G L L+ A+ + AG AS L++ RNL Sbjct: 367 NFMNVHMTAGYASDQLFWPNIVRAIGQALVFAPLSAIAVSGIEQENAGSASSLFNMIRNL 426 Query: 420 GGSLALAAIAVIQDQRLWLHSRRLEESLNANSDLVQSGIAA----------QAHLLGGQD 469 GG++ +A + +R HS L +S++ + +S IA H+L Q Sbjct: 427 GGAVGIALLQTFLTKRQQYHSNVLVQSISLFEEATRSRIAKLTAYFLSHGVSDHVLAAQK 486 Query: 470 --VAIQLMGATIQAQALTMTYADLFWMLGVAILCVTPLVLFLR 510 +AI L ++ QA M ++D F++LGVA++ L L+ Sbjct: 487 GVIAIAL---RVRQQAFIMAFSDTFFLLGVALVIALAATLLLK 526 >RC0200 [GEPR] COG0477 Permeases of the major facilitator superfamily Rco Rickettsia conorii Length = 519 Score = 285 bits (728), Expect = 2e-76, Method: Compositional matrix adjust. Identities = 171/509 (33%), Positives = 280/509 (55%), Gaps = 14/509 (2%) Query: 15 QPEKADAAAWLAVAAGTLGALMATLDISIVNSSLPTIQGEIGASGTEGTWIATAYLVAEI 74 QP A +G M+ LDI IV SSL I + AS E +W+ T+YL+AE+ Sbjct: 7 QPPALSKKQLFAFFGMVVGMFMSVLDIQIVASSLSVIAAGLAASSDELSWVQTSYLIAEV 66 Query: 75 VIIPMSAWLERLLGLRVLLLTAASLFTLFSVLCGLSTTLPMMIVGRVGQGFTGGALIPTA 134 +IIP++ +L RLL R+ AA FT+ S+LC L+T + MI+ R QGF GGA+IPT Sbjct: 67 IIIPITGFLARLLTTRISYFIAALGFTVMSILCSLATNIESMIIFRALQGFFGGAMIPTV 126 Query: 135 MTIIATRLPRSQQPVGNALFGATAILGPVLGPVMGGWLTENVSWHYAFFINLPVGAALIT 194 + + P SQ+P+ L G + P LGP +GG++TE +SWH+ F +N+ G + T Sbjct: 127 FSTVFILFPASQRPIVTILIGLVVTVAPTLGPTLGGYITEILSWHFMFLLNVIPGIFVCT 186 Query: 195 LLLVAIPYERPKFEQLAEADWFGIAGLALGLGGLTVVLEEGEREQWFSSPDIRWLAATSV 254 ++ + +++P ++ L D+ GI +AL LG L VLEEG ++ W I +L+ T V Sbjct: 187 VVFLYGDFDKPNYKLLKNFDFLGILLMALTLGLLQYVLEEGNKKGWLEDNLILFLSITVV 246 Query: 255 LGFILLAIGQVRARHPVIQLR--LLRDRQFGSVVMMAMIVGVALYGTAYVIPQFLSGIAG 312 LGFILL I ++ +P++ L+ L +D FG + + ++G+ LYGT Y++P FL IAG Sbjct: 247 LGFILLIIRELTCINPILDLKTFLYKDFTFGC--LYSFVMGIGLYGTVYILPLFLFTIAG 304 Query: 313 YNSLQSGWIVLLSGVPMILMMPFTPLLMRL-VDIRIAVGTGFLLLATSAFIETDLSPLSY 371 Y++LQ G ++++G L P ++ L VD+R+ + G A + + L+P S Sbjct: 305 YDTLQIGATMMVTGGAQFLSAPLAGRMLGLGVDLRLMLIIGLGGFALGCHLNSFLTPDSK 364 Query: 372 GGSFVASQLMRGVGTVLAMLFLNQAAIRSVPPSQAGDASGLYSAARNLGGSLALAAIAVI 431 +FV Q +RG+ + + N A+ ++P + G+ASGLY+ RNLGG++ LA I+ I Sbjct: 365 FAAFVLPQFVRGLSLMFCFIPTNNIALGNMPKERVGNASGLYNLTRNLGGAVGLAIISTI 424 Query: 432 QDQRLWLHSRRLEESLNANSDLVQSGIAAQAHLLGG-----QDVAIQLMGATIQAQALTM 486 + L E++++ S + + + LL G + + L+ + A + Sbjct: 425 LTNDTKTFMQYLSENISSTSIMALEQLDSYTELLSGKVLNPEKASYLLLANKLNHDAFVI 484 Query: 487 TYADLFWMLGVAILCVTPLVLFLRPLPTN 515 ++F M+G+ + ++ L P +N Sbjct: 485 AINNIFNMIGLLFV----FIMLLIPFTSN 509 >RP157 [GEPR] COG0477 Permeases of the major facilitator superfamily Rpr Rickettsia prowazekii Length = 519 Score = 279 bits (714), Expect = 1e-74, Method: Compositional matrix adjust. Identities = 165/499 (33%), Positives = 276/499 (55%), Gaps = 14/499 (2%) Query: 25 LAVAAGTLGALMATLDISIVNSSLPTIQGEIGASGTEGTWIATAYLVAEIVIIPMSAWLE 84 LA +G M+ LDI IV SSL I + AS E +W+ T+YL+AE++IIP++ +L Sbjct: 17 LAFFGMIVGMFMSVLDIQIVASSLSVIAAGLAASSDELSWVQTSYLIAEVIIIPITGFLA 76 Query: 85 RLLGLRVLLLTAASLFTLFSVLCGLSTTLPMMIVGRVGQGFTGGALIPTAMTIIATRLPR 144 RLL R+ AA FT+ SVLC L+ + MI+ R QGF GGA+IP + + P Sbjct: 77 RLLSTRICYFIAALGFTIMSVLCSLANNIESMIIFRALQGFFGGAMIPLVFSTVYIIFPA 136 Query: 145 SQQPVGNALFGATAILGPVLGPVMGGWLTENVSWHYAFFINLPVGAALITLLLVAIPYER 204 SQ+P L G + P LGP +GG++TE +SWH+ F +N+ G + T++ + + +++ Sbjct: 137 SQRPTVTILIGLVVTVAPTLGPTLGGYITEILSWHFMFLLNVIPGIFVCTVVFLYVNFDK 196 Query: 205 PKFEQLAEADWFGIAGLALGLGGLTVVLEEGEREQWFSSPDIRWLAATSVLGFILLAIGQ 264 P ++ L D+ GI ++L LG L VLEEG +E W I +L+ T LGFILL I + Sbjct: 197 PNYQLLKNFDFLGILLMSLTLGLLQYVLEEGNKEGWLDDNLILFLSITVALGFILLIIRE 256 Query: 265 VRARHPVIQLR--LLRDRQFGSVVMMAMIVGVALYGTAYVIPQFLSGIAGYNSLQSGWIV 322 + +P++ L+ L +D FG + + ++G+ LYG Y++P FL IA Y++LQ G + Sbjct: 257 LTFINPILDLKTFLYKDFTFGCI--YSFVMGIGLYGAVYILPLFLFTIAEYDTLQIGATM 314 Query: 323 LLSGVPMILMMPFTPLLMRL-VDIRIAVGTGFLLLATSAFIETDLSPLSYGGSFVASQLM 381 +++GV L P ++ L +D+R+ + G A + + L+P S +F+ Q + Sbjct: 315 MVTGVAQFLSAPLAGRMLGLGIDLRMMLTIGLGGFALGCHLNSCLTPDSKFAAFILPQFV 374 Query: 382 RGVGTVLAMLFLNQAAIRSVPPSQAGDASGLYSAARNLGGSLALAAIAVIQDQRLWLHSR 441 RG + + N A+ ++P + G+ASGLY+ RNLGG++ LA I+ I + + Sbjct: 375 RGFSLMFCFIPTNNIALGNMPKEKVGNASGLYNLTRNLGGAVGLAIISTILSNDTKIFMQ 434 Query: 442 RLEESLNANSDLVQSGIAAQAHLLGGQDV-----AIQLMGATIQAQALTMTYADLFWMLG 496 L E+++ S + + + + LL G+ + + L+ + A + ++F M+G Sbjct: 435 YLSENISYTSIIALTRLDSYTELLSGKILNPEQGSYLLLANKLNNDAFVIAINNIFNMIG 494 Query: 497 VAILCVTPLVLFLRPLPTN 515 + + ++ L P +N Sbjct: 495 LLFV----FIMLLIPFTSN 509