BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0015.0347.p (476 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value VC1411 [GEPR] COG0477 Permeases of the major facilitator superfa... 633 0.0 RSc1852 [GEPR] COG0477 Permeases of the major facilitator superf... 577 e-164 YPO3268 [GEPR] COG0477 Permeases of the major facilitator superf... 414 e-115 RSc1292 [GEPR] COG0477 Permeases of the major facilitator superf... 412 e-115 STM2815 [GEPR] COG0477 Permeases of the major facilitator superf... 395 e-109 >VC1411 [GEPR] COG0477 Permeases of the major facilitator superfamily Vch Vibrio cholerae Length = 511 Score = 633 bits (1632), Expect = 0.0, Method: Compositional matrix adjust. Identities = 304/473 (64%), Positives = 372/473 (78%) Query: 4 NVSVSTIAGALGASTSQGTYVITSYAVAEAITVPLTGWLANRFGTVRVFILSMVMFGLFS 63 NVSVS IAG+LG STSQGTYVITSYAVAEAI+VPLTGWLA+RFG++RVF+ ++FG+FS Sbjct: 39 NVSVSNIAGSLGTSTSQGTYVITSYAVAEAISVPLTGWLASRFGSIRVFVTCFLLFGVFS 98 Query: 64 ALCGLANSLGMLIAFRVMQGLAGGPLMPLSQTLLLRIFPKEKAPAAVGLWAMTTLVAPIA 123 LCGLANS+ L+ FRV+ G GGPLMPLSQTL++RIFPK K+ AA+G+W+MTTLVAPI Sbjct: 99 LLCGLANSMSTLVMFRVLLGFVGGPLMPLSQTLMIRIFPKNKSHAAIGIWSMTTLVAPIM 158 Query: 124 GPILGGVLCDQYSWPYIFWINVPVALICGYLGWRMLKRFETKTSKLPIDRVGLILMVVWV 183 GPILGGVLCDQ SWPYIF+I +P A+ L W++LK+FETKT+ ID+VGL L+VVWV Sbjct: 159 GPILGGVLCDQLSWPYIFFIKMPFAIAAALLCWKLLKKFETKTTHSKIDKVGLALLVVWV 218 Query: 184 AALQLMLDEGKEKDWFASTEIVLLAVTAVVFFIAFLIWELTEHNPIVDLRVFRHRGFTAS 243 AALQLMLDEGK+ DWF S+ IV LAV AV+ FIAFLIWELTE NP+VDL+VFRHRG++ S Sbjct: 219 AALQLMLDEGKDHDWFESSRIVFLAVIAVIGFIAFLIWELTERNPVVDLKVFRHRGYSIS 278 Query: 244 VTTICLAFGAFFGSVVLTPLWLQGYMGYTATWSGCISALTGILAVLTAPMVAKMSTTVDA 303 + T+ LAFGAFF V+TPLWLQ YMGYTAT SG +A GILAV AP+VA +S+ D Sbjct: 279 MVTLSLAFGAFFSISVVTPLWLQIYMGYTATISGHATASMGILAVFLAPIVANLSSKFDP 338 Query: 304 RKLVCIGVTWLGFITFLRAFNNTDMSFFQIGWPLFLQGIGLPLFFVPLTGLALSSVNEEE 363 R V GV WLG TF+R FN DM+F QI WPLF QGIG+PLFFVPLT +AL SV E Sbjct: 339 RPFVFAGVMWLGLWTFMRGFNTVDMTFSQISWPLFFQGIGMPLFFVPLTAIALGSVKPHE 398 Query: 364 TASAAGLMSFCRTMAGAIATSIVNTSWENDATYFHAELSGLVDRSGDAVNAMMASGMSAE 423 SAAGLM+F RT++GA ATS++NTSWE++ Y HAEL+GL D++G A AM SGMSAE Sbjct: 399 MESAAGLMNFIRTLSGAFATSMINTSWEHETRYVHAELAGLTDKAGVATQAMQNSGMSAE 458 Query: 424 QATGSLAQTVQNQAVMLATNHIFMMAAVSFSLAALAVWLAPKPTRVADTTSAH 476 Q ++ +QNQ+VM+ATN +F++ A+ F AA +W APKP + DT++ H Sbjct: 459 QTRSAMDWILQNQSVMVATNQLFIVIALIFVFAACMIWFAPKPKQAVDTSAVH 511 >RSc1852 [GEPR] COG0477 Permeases of the major facilitator superfamily Rso Ralstonia solanacearum Length = 512 Score = 577 bits (1487), Expect = e-164, Method: Compositional matrix adjust. Identities = 291/474 (61%), Positives = 360/474 (75%), Gaps = 1/474 (0%) Query: 4 NVSVSTIAGALGASTSQGTYVITSYAVAEAITVPLTGWLANRFGTVRVFILSMVMFGLFS 63 NVSV I+G LG STSQGT+VITSYAVAEAI VPLTGWLA+RFGTVRVF ++M FGLFS Sbjct: 39 NVSVPNISGNLGVSTSQGTWVITSYAVAEAILVPLTGWLASRFGTVRVFAVAMGCFGLFS 98 Query: 64 ALCGLANSLGMLIAFRVMQGLAGGPLMPLSQTLLLRIFPKEKAPAAVGLWAMTTLVAPIA 123 ALCGLA SLGML+A R+ QGLAGGPLMPLSQTLLLRIFPKEKA AA+GLW+MTT+VAP+ Sbjct: 99 ALCGLALSLGMLVAARICQGLAGGPLMPLSQTLLLRIFPKEKAGAAIGLWSMTTIVAPVL 158 Query: 124 GPILGGVLCDQYSWPYIFWINVPVALICGYLGWRMLKRFETKTSKLPIDRVGLILMVVWV 183 GPILGG LCD+YSWP+IF+IN+P+A+ C + W+ML R+E+ ++ PID+VGL L+V+WV Sbjct: 159 GPILGGYLCDEYSWPWIFYINLPIAVGCAWAAWKMLARYESPIARNPIDKVGLALLVLWV 218 Query: 184 AALQLMLDEGKEKDWFASTEIVLLAVTAVVFFIAFLIWELTEHNPIVDLRVFRHRGFTAS 243 +LQ+MLDEGK+ DWFAS+ I LAV A + F AFLIWEL +P V+LRVFRHRGF+AS Sbjct: 219 GSLQIMLDEGKQLDWFASSTIAGLAVVAAIGFAAFLIWELHAEHPAVNLRVFRHRGFSAS 278 Query: 244 VTTICLAFGAFFGSVVLTPLWLQGYMGYTATWSGCISALTGILAVLTAPMVAKMSTTVDA 303 V TI LAFGAFFG+ VLTP WLQ +MGYTA +G +A +G A+ AP+ A + VDA Sbjct: 279 VLTISLAFGAFFGANVLTPQWLQSFMGYTALEAGKTTAWSGFFALFAAPIAAGLGGKVDA 338 Query: 304 RKLVCIGVTWLGFITFLRAFNNTDMSFFQIGWPLFLQGIGLPLFFVPLTGLALSSVNEEE 363 RKLV GV WLG IT R TDM+++Q+ PL G+G+P FFVP TGLA++SV+EEE Sbjct: 339 RKLVFGGVIWLGIITLWRTVATTDMTYWQVAVPLMAMGLGIPFFFVPTTGLAMASVDEEE 398 Query: 364 TASAAGLMSFCRTMAGAIATSIVNTSWENDATYFHAELSGLVDRSGDAVNAMMASGMSAE 423 ASAAGLM+F RT++GA ATS++ T W++ AT HAEL G+ D G + +G + + Sbjct: 399 MASAAGLMNFLRTLSGAFATSLITTLWDDRATLHHAELVGVSDGDGSVRTMLEGAGSTLD 458 Query: 424 QATGSLAQTVQNQAVMLATNHIFMMAAVSFSLAALAVWLAPKPTR-VADTTSAH 476 S+ Q + +Q+VMLATN I V+F LAA A+WLAPKP R VA T H Sbjct: 459 AINQSIDQLLTSQSVMLATNDIMAWVGVAFVLAASAIWLAPKPRRTVAPGTGGH 512 >YPO3268 [GEPR] COG0477 Permeases of the major facilitator superfamily Ype Yersinia pestis Length = 511 Score = 414 bits (1063), Expect = e-115, Method: Compositional matrix adjust. Identities = 219/479 (45%), Positives = 303/479 (63%), Gaps = 6/479 (1%) Query: 4 NVSVSTIAGALGASTSQGTYVITSYAVAEAITVPLTGWLANRFGTVRVFILSMVMFGLFS 63 NV++ TIAG LG+S SQGT+VITS+ VA AI++P+TGWLA R G VR+F+ S +F L S Sbjct: 33 NVAIPTIAGDLGSSNSQGTWVITSFGVANAISIPVTGWLAKRVGEVRLFLWSTGLFVLAS 92 Query: 64 ALCGLANSLGMLIAFRVMQGLAGGPLMPLSQTLLLRIFPKEKAPAAVGLWAMTTLVAPIA 123 LCG++NSLGMLI FRV+QGL GPL+PLSQ+LLL +P K A+ LW+MT +VAPI Sbjct: 93 WLCGMSNSLGMLIFFRVIQGLVAGPLIPLSQSLLLNNYPPAKRSMALALWSMTIVVAPIF 152 Query: 124 GPILGGVLCDQYSWPYIFWINVPVALICGYLGWRMLKRFETKTSKLPIDRVGLILMVVWV 183 GPILGG + D Y W +IF+IN+P+ L+ L LK ETKT PID +GL+L+VV + Sbjct: 153 GPILGGYISDNYHWGWIFFINIPIGLVVVLLAGSTLKGRETKTEIRPIDTIGLVLLVVGI 212 Query: 184 AALQLMLDEGKEKDWFASTEIVLLAVTAVVFFIAFLIWELTEHNPIVDLRVFRHRGFTAS 243 ALQ+MLD+GKE DWF STEI++L V AVV ++WELT+ +P++DL +F+ R FT Sbjct: 213 GALQIMLDQGKELDWFNSTEIIVLTVVAVVAITFLIVWELTDDHPVIDLSLFKSRNFTIG 272 Query: 244 VTTICLAFGAFFGSVVLTPLWLQGYMGYTATWSGCISALTGILAVLTAPMVAKMSTTVDA 303 + LA+ +FG++VL P LQ GYTATW+G SA GIL VL +P++ + + +D Sbjct: 273 CLCLSLAYMLYFGAIVLLPQLLQEVYGYTATWAGLASAPVGILPVLLSPLIGRFAHRIDM 332 Query: 304 RKLVCIGVTWLGFITFLRAFN-NTDMSFFQIGWPLFLQGIGLPLFFVPLTGLALSSVNEE 362 R+LV + RA+ M F WP F QG + FF+PLT + LS + E Sbjct: 333 RQLVTFSFIMYAVCFYWRAYTFEPGMDFGASAWPQFFQGFAIACFFMPLTTITLSGLPPE 392 Query: 363 ETASAAGLMSFCRTMAGAIATSIVNTSWENDATYFHAELSGLVD----RSGDAVNAMMAS 418 A+A+ L +F RT+AG+I TSI T W + HA+L+ V+ + A + Sbjct: 393 RMAAASSLSNFMRTLAGSIGTSITTTLWTQRESLHHAQLTEFVNPYNPNATQAYQELEKL 452 Query: 419 GMSAEQATGSLAQTVQNQAVMLATNHIFMMAAVSFSLAALAVWLAPKP-TRVADTTSAH 476 GMS +QA+ LA+ + NQ ++++ N IF ++A F + +W A P T AH Sbjct: 453 GMSQQQASAYLAREITNQGLIISANEIFWLSAGVFLMLLALIWFARPPFTSGGGGGGAH 511 >RSc1292 [GEPR] COG0477 Permeases of the major facilitator superfamily Rso Ralstonia solanacearum Length = 518 Score = 412 bits (1059), Expect = e-115, Method: Compositional matrix adjust. Identities = 214/472 (45%), Positives = 303/472 (64%), Gaps = 11/472 (2%) Query: 4 NVSVSTIAGALGASTSQGTYVITSYAVAEAITVPLTGWLANRFGTVRVFILSMVMFGLFS 63 NVS+ I+G LG + +QGT+VITS+AVA AI+VPLTGWL RFG VR+F+ S+++F L S Sbjct: 39 NVSIPAISGDLGVAPNQGTWVITSFAVANAISVPLTGWLTQRFGQVRLFVTSILLFVLSS 98 Query: 64 ALCGLANSLGMLIAFRVMQGLAGGPLMPLSQTLLLRIFPKEKAPAAVGLWAMTTLVAPIA 123 CGLA ++G LIA R++QG GP++PLSQ+LLL +P K+ A+ LW MTTLVAPI Sbjct: 99 WACGLAPNMGTLIAARILQGAVAGPMIPLSQSLLLSTYPPAKSSMALALWGMTTLVAPIM 158 Query: 124 GPILGGVLCDQYSWPYIFWINVPVALICGYLGWRMLKRFETKTSKLPIDRVGLILMVVWV 183 GPI GG + D +WP+IF+IN+PV ++ Y W + K E+ T LPIDR+GL L+V+WV Sbjct: 159 GPIFGGWISDNMTWPWIFYINIPVGILAAYATWVIYKDRESPTRALPIDRIGLALLVIWV 218 Query: 184 AALQLMLDEGKEKDWFASTEIVLLAVTAVVFFIAFLIWELTEHNPIVDLRVFRHRGFTAS 243 +LQLMLD GKE DWF S EIV L V AVV F FL+WELTE +P+VDL +F+ R F+A Sbjct: 219 GSLQLMLDRGKELDWFNSAEIVTLTVVAVVGFAFFLVWELTEDHPVVDLTLFKGRNFSAG 278 Query: 244 VTTICLAFGAFFGSVVLTPLWLQGYMGYTATWSGCISALTGILAVLTAPMVAKMSTTVDA 303 V I +A+G FFG++V+ PLWLQ +GYTAT +G + A GI A+L +P++ K +DA Sbjct: 279 VVAISVAYGLFFGNLVILPLWLQTIVGYTATDAGLVMAPVGIFAILLSPVIGKNLPKMDA 338 Query: 304 RKLVCIGVTWLGFITFLRAFNNTDMSFFQIGWPLFLQGIGLPLFFVPLTGLALSSVNEEE 363 R + + ++R+ + + + P +QG + +FF+PLT + LS + E Sbjct: 339 RWVATTAFITFALVFWMRSRFTIQVDTWTLMVPTLIQGAAMAMFFIPLTSIILSGLRPER 398 Query: 364 TASAAGLMSFCRTMAGAIATSIVNTSWENDATYFHAELSGLVDRSGDAVNAMMAS----- 418 +A+GL +F R M G I SI T W+N + HA+ LV+R+ A +S Sbjct: 399 IPAASGLSNFVRIMFGGIGASISTTVWDNRSALHHAQ---LVERANPYNPAYASSLGDYT 455 Query: 419 --GMSAEQATGSLAQTVQNQAVMLATNHIFMMAAVSFSLAALAVWLAPKPTR 468 GM + QA G++ + + QA M+ N IF ++AV F + +WL +P + Sbjct: 456 QMGMPSLQANGAIERIISQQAAMMGANDIFWISAVLFIVLIALIWLT-RPAK 506 >STM2815 [GEPR] COG0477 Permeases of the major facilitator superfamily Sty Salmonella typhimurium LT2 Length = 512 Score = 395 bits (1015), Expect = e-109, Method: Compositional matrix adjust. Identities = 209/468 (44%), Positives = 294/468 (62%), Gaps = 5/468 (1%) Query: 4 NVSVSTIAGALGASTSQGTYVITSYAVAEAITVPLTGWLANRFGTVRVFILSMVMFGLFS 63 NV++ TIAG LG+S SQGT+VITS+ VA AI++PLTGWLA RFG V++F+ S V F S Sbjct: 34 NVAIPTIAGNLGSSLSQGTWVITSFGVANAISIPLTGWLAKRFGEVKLFMWSTVAFAAAS 93 Query: 64 ALCGLANSLGMLIAFRVMQGLAGGPLMPLSQTLLLRIFPKEKAPAAVGLWAMTTLVAPIA 123 CG+++SL MLI FRV+QG+ GPL+PLSQ+LLL +P K A+ LW+MT +VAPI Sbjct: 94 WACGVSSSLNMLIFFRVVQGVVAGPLIPLSQSLLLNNYPPAKRSIALALWSMTVIVAPIC 153 Query: 124 GPILGGVLCDQYSWPYIFWINVPVALICGYLGWRMLKRFETKTSKLPIDRVGLILMVVWV 183 GPILGG + D Y W +IF+INVP+ + + L+ ET T + ID VGL L+V+ + Sbjct: 154 GPILGGYISDNYHWGWIFFINVPIGIAVVLMTLHTLRGRETHTERRRIDAVGLALLVIGI 213 Query: 184 AALQLMLDEGKEKDWFASTEIVLLAVTAVVFFIAFLIWELTEHNPIVDLRVFRHRGFTAS 243 +LQ+MLD GKE DWF+S EI++L V AV+ ++WELT+ +PIVDL +F+ R FT Sbjct: 214 GSLQIMLDRGKELDWFSSQEIIILTVVAVIAISFLIVWELTDDHPIVDLSLFKSRNFTIG 273 Query: 244 VTTICLAFGAFFGSVVLTPLWLQGYMGYTATWSGCISALTGILAVLTAPMVAKMSTTVDA 303 I LA+ +FG++VL P LQ GYTATW+G SA GI+ V+ +P++ + + +D Sbjct: 274 CLCISLAYMLYFGAIVLLPQLLQEVYGYTATWAGLASAPVGIIPVILSPIIGRFAHKLDM 333 Query: 304 RKLVCIGVTWLGFITFLRAFN-NTDMSFFQIGWPLFLQGIGLPLFFVPLTGLALSSVNEE 362 R+LV + RA+ M F WP F+QG + FF+PLT + LS + E Sbjct: 334 RRLVTFSFIMYAVCFYWRAWTFEPGMDFGASAWPQFIQGFAVACFFMPLTTITLSGLPPE 393 Query: 363 ETASAAGLMSFCRTMAGAIATSIVNTSWENDATYFHAELSGLVDRSGDAVNAMMAS---- 418 A+A+ L +F RT+AG+I TSI T W + + HA+L+ V M Sbjct: 394 RLAAASSLSNFTRTLAGSIGTSITTTMWTDRESLHHAQLTESVTAYNPNAQTMYDKLEGL 453 Query: 419 GMSAEQATGSLAQTVQNQAVMLATNHIFMMAAVSFSLAALAVWLAPKP 466 GM+ +QA+G +AQ + NQ ++++ N IF M+A F + VW A P Sbjct: 454 GMTHQQASGWIAQQITNQGLIISANEIFWMSAGIFLVLLGLVWFAKPP 501