BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0015.0203.p (422 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value AF0367 [GEPR] COG0477 Permeases of the major facilitator superfa... 159 1e-38 ZyhjX [GEPR] COG0477 Permeases of the major facilitator superfam... 153 7e-37 ECs4432 [GEPR] COG0477 Permeases of the major facilitator superf... 153 7e-37 STM2574 [GEPR] COG0477 Permeases of the major facilitator superf... 152 1e-36 yhjX [GEPR] COG0477 Permeases of the major facilitator superfami... 151 2e-36 >AF0367 [GEPR] COG0477 Permeases of the major facilitator superfamily Afu Archaeoglobus fulgidus Length = 397 Score = 159 bits (401), Expect = 1e-38, Method: Compositional matrix adjust. Identities = 110/404 (27%), Positives = 202/404 (50%), Gaps = 17/404 (4%) Query: 16 LRNRWFQLLIGLICMMAISSPQYVWTLFTKPLTAKLGVPLSELQITFSMLIVLQTFFSPF 75 + ++W + G + + + Y W++F PL G + + FS+ +++ Sbjct: 1 MASKWLVIFAGFLLNLMLGI-VYAWSVFVNPLMNTFGWSKTIASLPFSIFLLIFALMMVP 59 Query: 76 QGSLIERFGARRLIAIGTFMSGLSWILAAQASTIGMFY---LAYGLVGGLGTGIVYVGVV 132 G +R G R++ +G + G+ ++L+ +I Y +YG++ G G G+ Y + Sbjct: 60 AGRTQDRIGPRKVAMLGGVLLGVGFLLSGLIESIQSPYWLIFSYGVIAGAGCGLGYACPI 119 Query: 133 GQMVRWFPDRRGFAVGMVAAGYGMGAILTTFPISASLASA-GLETTLWQFGLVFAVIGVL 191 +WFP+R G A G+V G+GM A++ P+ L G+ TT + G++ ++ V Sbjct: 120 PVARKWFPERVGLATGLVVMGFGMSALIFA-PLERILIDTYGISTTFYILGVILLIVAVF 178 Query: 192 AAQALRSPDASHAAAMPAPA---IAASKLDL--RQMLRTPLFWLMFVMMTMMSTSGLMVT 246 AA L +P A PA + K +L +MLR F+++++ M+ +GLMV Sbjct: 179 AASLLSNPPELPAVQASNPAKVEVVTGKPELGPSEMLRDYRFYVLWLSFFFMALAGLMVI 238 Query: 247 SQMATFARDFGVANVMVFGLAALPLALTIDRLTNGLTRPFFGWISDRYGRENTMFFAFAL 306 +A +A++ G+ + A A++I + N + RP G +SD+ GR TMF F + Sbjct: 239 GHIAPYAQERGLEPL------AAAFAVSILSVANAVGRPGAGALSDKIGRAMTMFVLFLI 292 Query: 307 EGVAMALWLATRENAVLFVLLSGIVFFGWGEIFSLFPSTLTDTFGTRNATANYGWLYISQ 366 +G+ + + + + + I+ F +G FSLFPS D FGT+N NYG ++ S Sbjct: 293 QGITLIAFPHVALTLITIYICAAIIGFNYGANFSLFPSATGDFFGTKNLGVNYGLVFTSY 352 Query: 367 GIGSIFGGPLAAMMHEKTGSWHPVFGTAITLDILTACLALMVLK 410 G+G + G +A + + TGS+ F A L ++ A ++ ++ + Sbjct: 353 GVGGLVGPIMAGYVFDVTGSYEIAFLVAGVLALIAAFMSFLLRR 396 >ZyhjX [GEPR] COG0477 Permeases of the major facilitator superfamily EcZ Escherichia coli O157:H7 EDL933 Length = 400 Score = 153 bits (387), Expect = 7e-37, Method: Compositional matrix adjust. Identities = 113/376 (30%), Positives = 178/376 (47%), Gaps = 21/376 (5%) Query: 9 PASAQGLLRNRWFQLLIGLICMMAISSPQYVWTLFTKPLTAKLGVPLSELQITFSMLIVL 68 P++ Q R RW L+ +I A+ S Y W+LF L+AKL P+S++ +F +L + Sbjct: 3 PSNYQ---RTRWLTLIGTIITQFALGSV-YTWSLFNGALSAKLDAPVSQVAFSFGLLSLG 58 Query: 69 QTFFSPFQGSLIERFGARRLIAIGTFMSGLSWILAAQASTIGMFYLAYGLVGGLGTGIVY 128 S G L ERFG +R+ + GL + L A + + M +L+ G++ GL G Y Sbjct: 59 LAISSSVAGKLQERFGVKRVTIASGILLGLGFFLTAHSDNLMMLWLSAGVLVGLADGAGY 118 Query: 129 VGVVGQMVRWFPDRRGFAVGMVAAGYGMGAILTTFPISASLASAGLETTLWQFGLVFAVI 188 + + V+WFP+R+G YG+G++ F + L + GLE T +G + V+ Sbjct: 119 LLTLSNCVKWFPERKGLISAFAIGSYGLGSLGFKFIDTQLLETVGLEKTFVIWGAIALVM 178 Query: 189 GVLAAQALRSPDASHAAAMPAPAIAASKLDLRQMLRTPLFWLMFVMMTMMSTSGLMVTSQ 248 V A ++ DA + + L + +R P +W++ VM SGL V Sbjct: 179 IVFGATLMK--DAPKQEVKTSNGVVEKDYTLAESMRKPQYWMLAVMFLTACMSGLYV--- 233 Query: 249 MATFARDFGVANVMVFGLAALPL-----ALTIDRLTNGLTRPFFGWISDRYGRENTMFFA 303 GVA + LA L + A+T+ + N R G +SD+ R + Sbjct: 234 -------IGVAKDIAQSLAHLDVVSAANAVTVISIANLSGRLVLGILSDKIARIRVITIG 286 Query: 304 FALEGVAMALWLATRENAVLFVLLSGIVFFGWGEIFSLFPSTLTDTFGTRNATANYGWLY 363 + V MA L NAV F V F +G ++FPS +++ FG N NYG +Y Sbjct: 287 QVISLVGMAALLFAPLNAVTFFAAIACVAFNFGGTITVFPSLVSEFFGLNNLAKNYGVIY 346 Query: 364 ISQGIGSIFGGPLAAM 379 + GIGSI G +A++ Sbjct: 347 LGFGIGSICGSIIASL 362 >ECs4432 [GEPR] COG0477 Permeases of the major facilitator superfamily Ecs Escherichia coli O157:H7 Length = 400 Score = 153 bits (387), Expect = 7e-37, Method: Compositional matrix adjust. Identities = 113/376 (30%), Positives = 178/376 (47%), Gaps = 21/376 (5%) Query: 9 PASAQGLLRNRWFQLLIGLICMMAISSPQYVWTLFTKPLTAKLGVPLSELQITFSMLIVL 68 P++ Q R RW L+ +I A+ S Y W+LF L+AKL P+S++ +F +L + Sbjct: 3 PSNYQ---RTRWLTLIGTIITQFALGSV-YTWSLFNGALSAKLDAPVSQVAFSFGLLSLG 58 Query: 69 QTFFSPFQGSLIERFGARRLIAIGTFMSGLSWILAAQASTIGMFYLAYGLVGGLGTGIVY 128 S G L ERFG +R+ + GL + L A + + M +L+ G++ GL G Y Sbjct: 59 LAISSSVAGKLQERFGVKRVTIASGILLGLGFFLTAHSDNLMMLWLSAGVLVGLADGAGY 118 Query: 129 VGVVGQMVRWFPDRRGFAVGMVAAGYGMGAILTTFPISASLASAGLETTLWQFGLVFAVI 188 + + V+WFP+R+G YG+G++ F + L + GLE T +G + V+ Sbjct: 119 LLTLSNCVKWFPERKGLISAFAIGSYGLGSLGFKFIDTQLLETVGLEKTFVIWGAIALVM 178 Query: 189 GVLAAQALRSPDASHAAAMPAPAIAASKLDLRQMLRTPLFWLMFVMMTMMSTSGLMVTSQ 248 V A ++ DA + + L + +R P +W++ VM SGL V Sbjct: 179 IVFGATLMK--DAPKQEVKTSNGVVEKDYTLAESMRKPQYWMLAVMFLTACMSGLYV--- 233 Query: 249 MATFARDFGVANVMVFGLAALPL-----ALTIDRLTNGLTRPFFGWISDRYGRENTMFFA 303 GVA + LA L + A+T+ + N R G +SD+ R + Sbjct: 234 -------IGVAKDIAQSLAHLDVVSAANAVTVISIANLSGRLVLGILSDKIARIRVITIG 286 Query: 304 FALEGVAMALWLATRENAVLFVLLSGIVFFGWGEIFSLFPSTLTDTFGTRNATANYGWLY 363 + V MA L NAV F V F +G ++FPS +++ FG N NYG +Y Sbjct: 287 QVISLVGMAALLFAPLNAVTFFAAIACVAFNFGGTITVFPSLVSEFFGLNNLAKNYGVIY 346 Query: 364 ISQGIGSIFGGPLAAM 379 + GIGSI G +A++ Sbjct: 347 LGFGIGSICGSIIASL 362 >STM2574 [GEPR] COG0477 Permeases of the major facilitator superfamily Sty Salmonella typhimurium LT2 Length = 398 Score = 152 bits (385), Expect = 1e-36, Method: Compositional matrix adjust. Identities = 109/403 (27%), Positives = 201/403 (49%), Gaps = 13/403 (3%) Query: 18 NRWFQLLIGLICMMAISSPQYVWTLFTKPLTAKLGVPLSELQITFSMLIVLQTFFSPFQG 77 NRW +L +C+ + Y ++ F PL A+ + L + FS+ + + + G Sbjct: 6 NRW-GMLAAHVCINFVLGGVYAFSYFKTPLMAQYHWDPATLALAFSINMGIIPLPMIWGG 64 Query: 78 SLIERFGARRLIAIGTFMSGLSWILAAQASTIGMFYLAYGLVGGLGTGIVYVGVVGQMVR 137 +I+ ++ I IG + L +IL+ + M +L YG++ GLG+G+ + G + +++ Sbjct: 65 RMIDNGKGKQAIVIGGILFSLGFILSGFVDNLPMLFLTYGVIAGLGSGLAFTGNLNNILK 124 Query: 138 WFPDRRGFAVGMVAAGYGMGAILTTFPISASLA-SAGLETTLWQFGLVFAVIGVLAAQAL 196 +FPDRRG A G+V AG G+G +L T +A + + L G+V+ V+ + + Sbjct: 125 FFPDRRGLASGIVLAGVGVGTLLCTRLAEYFMAQTHDVSRALLYLGIVYLVVIFIVQFFI 184 Query: 197 RSPDASHAAAMPAPAIAASKLDLRQMLRTPLFWLMFVMMTMMSTSGLMVTSQMATFARDF 256 RS A + + A + D R ML+ FWL+F+++ + SG++++S A Sbjct: 185 RSAPAKDSGGIKASPLDK---DYRHMLKDLRFWLLFMILALGVFSGMVISSSSAQIG--- 238 Query: 257 GVANVMVFGLAALPLALTIDRLTNGLTRPFFGWISDRYGRENTMFFAFALEGVAMALWLA 316 + +GL + L +++ + N + R F+G ++D+ G NT+ + V M L L Sbjct: 239 ----MTQYGLLSGALVVSLVSIFNSIGRLFWGGLTDKLGGYNTLVIVYLFTCVCMLLLLF 294 Query: 317 TRENAVLFVLLSGIVFFGWGEIFSLFPSTLTDTFGTRNATANYGWLYISQGIGSIFGGPL 376 N +F + V F + I +FP + FG RN NYG++Y +G++ + Sbjct: 295 FNGNTSVFYFSALGVGFAYAGILVIFPGLTSQNFGMRNQGLNYGFMYFGFAVGAVIAPYV 354 Query: 377 AAMMHEKTGSWHPVFGTAITLDILTACLALMVLKPWRARYLAK 419 + + + TGS++ VF T+ +L + ++ K + A LAK Sbjct: 355 TSAIAKYTGSYNTVF-ILTTVLLLIGVVLTLITKKYVATVLAK 396 >yhjX [GEPR] COG0477 Permeases of the major facilitator superfamily Eco Escherichia coli K12 Length = 402 Score = 151 bits (382), Expect = 2e-36, Method: Compositional matrix adjust. Identities = 112/376 (29%), Positives = 178/376 (47%), Gaps = 21/376 (5%) Query: 9 PASAQGLLRNRWFQLLIGLICMMAISSPQYVWTLFTKPLTAKLGVPLSELQITFSMLIVL 68 P++ Q R RW L+ +I A+ S Y W+LF L+AKL P+S++ +F +L + Sbjct: 3 PSNYQ---RTRWLTLIGTIITQFALGSV-YTWSLFNGALSAKLDAPVSQVAFSFGLLSLG 58 Query: 69 QTFFSPFQGSLIERFGARRLIAIGTFMSGLSWILAAQASTIGMFYLAYGLVGGLGTGIVY 128 S G L ERFG +R+ + GL + L A + + M +L+ G++ GL G Y Sbjct: 59 LAISSSVAGKLQERFGVKRVTMASGILLGLGFFLTAHSDNLMMLWLSAGVLVGLADGAGY 118 Query: 129 VGVVGQMVRWFPDRRGFAVGMVAAGYGMGAILTTFPISASLASAGLETTLWQFGLVFAVI 188 + + V+WFP+R+G YG+G++ F + L + GLE T +G + ++ Sbjct: 119 LLTLSNCVKWFPERKGLISAFAIGSYGLGSLGFKFIDTQLLETVGLEKTFVIWGAIALLM 178 Query: 189 GVLAAQALRSPDASHAAAMPAPAIAASKLDLRQMLRTPLFWLMFVMMTMMSTSGLMVTSQ 248 V A ++ DA + + L + +R P +W++ VM SGL V Sbjct: 179 IVFGATLMK--DAPKQEVKTSNGVVEKDYTLAESMRKPQYWMLAVMFLTACMSGLYV--- 233 Query: 249 MATFARDFGVANVMVFGLAALPL-----ALTIDRLTNGLTRPFFGWISDRYGRENTMFFA 303 GVA + LA L + A+T+ + N R G +SD+ R + Sbjct: 234 -------IGVAKDIAQSLAHLDVVSAANAVTVISIANLSGRLVLGILSDKIARIRVITIG 286 Query: 304 FALEGVAMALWLATRENAVLFVLLSGIVFFGWGEIFSLFPSTLTDTFGTRNATANYGWLY 363 + V MA L NAV F V F +G ++FPS +++ FG N NYG +Y Sbjct: 287 QVISLVGMAALLFAPLNAVTFFAAIACVAFNFGGTITVFPSLVSEFFGLNNLAKNYGVIY 346 Query: 364 ISQGIGSIFGGPLAAM 379 + GIGSI G +A++ Sbjct: 347 LGFGIGSICGSIIASL 362