BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0015.0152.p (606 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSp0008 [T] COG4191 Signal transduction histidine kinase regulat... 385 e-106 RSc0331 [T] COG4191 Signal transduction histidine kinase regulat... 358 3e-98 PA1336 [T] COG4191 Signal transduction histidine kinase regulati... 339 1e-92 PA5165 [T] COG4191 Signal transduction histidine kinase regulati... 331 4e-90 PA5512 [T] COG4191 Signal transduction histidine kinase regulati... 302 1e-81 >RSp0008 [T] COG4191 Signal transduction histidine kinase regulating C4-dicarboxylate transport system Rso Ralstonia solanacearum Length = 634 Score = 385 bits (988), Expect = e-106, Method: Compositional matrix adjust. Identities = 237/596 (39%), Positives = 337/596 (56%), Gaps = 32/596 (5%) Query: 25 YRIALGRAESDQQNQAAAQLQIAALDLESILQKYEALPFALGFQSDVRQVLQHPEDALSV 84 Y +AL R + + +A + A +L L +YE+LP + + L P + Sbjct: 38 YALALQRYVAARAEEAGQRTTFYAQNLRGTLARYESLPRLAALEHVLHVALTAPHARDAA 97 Query: 85 DRLNRA--FKTIQQQSRAVNIFMLNRQGVTLASSNWDEEFSYVGRDFGFRPYFREAIQGR 142 R K +Q + +++++ G TLA+SNWD S++GR++ FRPYF +A++ Sbjct: 98 LRRAADAYLKEVQAAADLTAVYLMDATGQTLAASNWDLPSSFIGRNYAFRPYFVDAMREG 157 Query: 143 AGRFYGIGNISSEPGYFIAQPIYRRQDQAEGDLPIGVMVVKVDLAEFEHTWRSSSDPITL 202 GRFYG+GN + E GYF+A P+ EG PIG + VK++L FE T S D + L Sbjct: 158 FGRFYGVGNTTGETGYFLAAPVR------EGGQPIGALAVKINLDSFEATLARSGDTVLL 211 Query: 203 TDAGGVVFLSNRPEWKYHSLQALSAPVQRELEGTHQYADLPITPVST-----------LP 251 D GV+FLS+ PEWKY +L LSA + L+ T QY + P+ +P Sbjct: 212 VDRHGVIFLSSVPEWKYRTLGTLSAAQRAALDATRQYGPHALAPLDPRAGSVPFSADQVP 271 Query: 252 PALQRGF-GTHVS------RPVGRLGWQLMLFPSQARMQRSAMLSAMAAALFMVALAISL 304 L+ G VS RPVG LGWQ+ + +R+A+++ +AA Sbjct: 272 QTLRVALPGRSVSTLRVQYRPVGLLGWQVAVLIDPRDERRTALVAGASAAFATALAFAVC 331 Query: 305 LAWYQHRRRLQERLASRNALRRAAEELDQKIAQRTQELTAANQAIAAKYAKLQQTESLLR 364 +A RR +E+ +R ALR +L+ +IAQRT ELT+AN A+A+K L + +LR Sbjct: 332 VALRLRARRHEEQRRARAALREVQRDLEARIAQRTAELTSANAALASKVEALDTAQRILR 391 Query: 365 TTQDELVQAGKLAMLGQMAAGMTHELNQPLAAIRAFADNSVKFLARGQTAQVAENLEHIS 424 T+D VQAGKLA+LGQMAAG+THELNQPL A+ +DN+ + RG+ +V NL HIS Sbjct: 392 ETRDAAVQAGKLAVLGQMAAGITHELNQPLTALTTLSDNANQLAERGRVDEVRGNLAHIS 451 Query: 425 HASASMGKIIGQLKGFARKSGQAVAAVDLRHAVEASLRLLASDFEKQEVETHIAMPLAVH 484 + MG+I+ +KGFARK A AAV + A+ +L L+ + + V + Sbjct: 452 QLAHRMGRIVSHIKGFARKGDAARAAVPVEEAIRQALMLVETRRRQAGVPVVVGPVPPGV 511 Query: 485 VT-GDAVRTEQVIVNLLRNALDAVEEAPRKCVCVILEVDAERQQAVLRI--RDSGAGIAD 541 +AVR EQV+VNL+RNA+DA EAPR + V A+ A++RI RD+G GIA Sbjct: 512 AVWANAVRLEQVLVNLIRNAIDATAEAPRPEAAGV-RVTAQADDALVRITVRDAGPGIAP 570 Query: 542 EVVPHLFEPFFTTKSSSKGLGLGLAISSSIVQAMNGQLSAHNHEQ--GGAEFVVRL 595 EV+PHLFEPFFTTK+ +GLGLGLAIS +IV+ G+L N + GGA FV+ L Sbjct: 571 EVLPHLFEPFFTTKADGQGLGLGLAISLAIVEDFGGRLEGRNADDGAGGAAFVIEL 626 >RSc0331 [T] COG4191 Signal transduction histidine kinase regulating C4-dicarboxylate transport system Rso Ralstonia solanacearum Length = 665 Score = 358 bits (918), Expect = 3e-98, Method: Compositional matrix adjust. Identities = 232/602 (38%), Positives = 335/602 (55%), Gaps = 34/602 (5%) Query: 21 CGLTYRIALGRAESDQQNQAAAQLQIAALDLESILQKYEALPFALGFQSDVRQVLQHPED 80 C T+ + R S Q A A++ A +L+S L +YE LP + + +L HP Sbjct: 60 CATTFVVTWNRGLSQAQQAAGARVDRYAANLKSTLDRYEYLPALVALHPFIHDLLAHPTP 119 Query: 81 ALSVDRLNRAFKTIQQQSRAVNIFMLNRQGVTLASSNWDEEFSYVGRDFGFRPYFREAIQ 140 +V R N + + ++RA +++ G+ LA+SN++ S+VG ++ FRPYF++A Sbjct: 120 D-NVARANHYLREVNDRARATATYVIAPTGLALAASNYNLPDSFVGAEYLFRPYFQQAAA 178 Query: 141 GRAGRFYGIGNISSEPGYFIAQPIYRRQDQAEGDLPIGVMVVKVDLAEFEHTWRSSSDPI 200 G GRFYGIG EPGY+I+QP+ + G + IGV VVK++L F +S+P+ Sbjct: 179 GHVGRFYGIGITREEPGYYISQPVMQ-----NGSV-IGVTVVKLNLEWFGRASHDASEPV 232 Query: 201 TLTDAGGVVFLSNRPEWKYHSLQALSAPVQRELEGTHQYADLPITPVSTLP--PALQRGF 258 + D GV+FLS+ P W+Y +++ L+ +Q +L+ T QY ITP+ P PA + Sbjct: 233 MVADENGVIFLSSVPAWQYRTVEPLTPELQAQLQATRQYFRKQITPLPLQPEMPAFLKLV 292 Query: 259 GTH--------------------VSRPVGRLGWQLMLFPSQARMQRSAMLSAMAAALFMV 298 G VSR + WQLM + +A + +AAA Sbjct: 293 GRMPDGARLVRVGDRINAPRYLLVSRELVEPDWQLMYLTPIDPVMGAARSATVAAAFAFA 352 Query: 299 ALAISLLAWYQHRRRLQERLASRNALRRAAEELDQKIAQRTQELTAANQAIAAKYAKLQQ 358 + + L W Q R RL+E L R L A ++L++++ RT +L A N+ + + + Sbjct: 353 FVCLLLFYWRQRRLRLREMLRGRRLLEAAYDQLERRVEDRTADLMATNEQLQHEIVDRTR 412 Query: 359 TESLLRTTQDELVQAGKLAMLGQMAAGMTHELNQPLAAIRAFADNSVKFLARGQTAQVAE 418 E+ LR TQDELVQA KLA LGQMAAG+THELNQPLAA+R F+DN+ L RGQ A+ Sbjct: 413 AEAELRATQDELVQASKLAALGQMAAGITHELNQPLAALRTFSDNTRILLERGQHGAAAD 472 Query: 419 NLEHISHASASMGKIIGQLKGFARKSGQAVAAVDLRHAVEASLRLLASDFEKQEVETHIA 478 NL I+ + MGKI QLK FA +S + +A V +R A++ L LL + E H Sbjct: 473 NLRAIADLTERMGKITAQLKLFAGRSRRRLADVQVRVALDHVLALLRPRLAEVETALHWR 532 Query: 479 MPLAVHVT-GDAVRTEQVIVNLLRNALDAV--EEAPR--KCVCVILEVDAERQQAVLRIR 533 +P A V D ++ EQV++NL+ NALDA+ + PR + I D Q + +R Sbjct: 533 LPEAACVVRADELKLEQVLINLIGNALDAIAANDLPRPGRIDIDIGPADGAPAQLCIVVR 592 Query: 534 DSGAGIADEVVPHLFEPFFTTKSSSKGLGLGLAISSSIVQAMNGQLSAHNHEQGGAEFVV 593 D+G GIA + +PHLFEPFFTTK +GLGLGLAIS+SI + G LSA N GGA+F + Sbjct: 593 DNGPGIAADAMPHLFEPFFTTKEIGQGLGLGLAISTSIARDFGGSLSAANVPGGGAQFTL 652 Query: 594 RL 595 L Sbjct: 653 SL 654 >PA1336 [T] COG4191 Signal transduction histidine kinase regulating C4-dicarboxylate transport system Pae Pseudomonas aeruginosa Length = 633 Score = 339 bits (870), Expect = 1e-92, Method: Compositional matrix adjust. Identities = 215/576 (37%), Positives = 318/576 (55%), Gaps = 32/576 (5%) Query: 43 QLQIAALDLESILQKYEALPFALGFQSDVRQVLQHPEDALSVDRLNRAFKTIQQQSRAVN 102 QL++ A +ES + KY LP L + V +L P +++N + + +++ + Sbjct: 60 QLELHARTVESEISKYTYLPSLLELERSVSHLLTDPT-PYRRNQVNAYLEGLNRRAGSRA 118 Query: 103 IFMLNRQGVTLASSNWDEEFSYVGRDFGFRPYFREAIQGRAGRFYGIGNISSEPGYFIAQ 162 +++L+ G LA+SNW + SY+G D FR Y+++A++G+ GRFYGIG+ EPGY++A Sbjct: 119 VYLLDTNGRVLATSNWSDPDSYLGEDLSFRAYWQDAMKGKPGRFYGIGSTRGEPGYYLAH 178 Query: 163 PIYRRQDQAEGDLPIGVMVVKVDLAEFEHTWRSSSDPITLTDAGGVVFLSNRPEWKYHSL 222 + G IGV VVKV + E W + ++D G++ LS+ P + ++ Sbjct: 179 GL------VHGGRIIGVAVVKVKMDALEERWEKARLEAFVSDENGIIILSSNPALRLKAV 232 Query: 223 QALSAPVQRELEGTHQY--------ADLPITPVS------TLPPALQRGFGTHVS----- 263 ++LSA + L + QY L P++ + P Q G V+ Sbjct: 233 RSLSADDKERLARSMQYYWWALNEWQPLQREPLAAGVEKLSFPADEQHPRGEAVTYLAQT 292 Query: 264 RPVGRLGWQLMLFPSQARMQRSAMLSAMAAALFMVALAISLLAWYQHRRRLQERLASRNA 323 R + W L L ++R A+ + M AA+ LA L+AW + R+ L RLA+R A Sbjct: 293 RALNDTPWNLTLLSPLEDLRRDAVRNGMLAAIGFALLAFLLIAWNERRKVLATRLAAREA 352 Query: 324 LRRAAEELDQKIAQRTQELTAANQAIAAKYAKLQQTESLLRTTQDELVQAGKLAMLGQMA 383 L+RA EL+ KIA+RT +L A+N + A+ + QQ E LR QDELVQAGKLA++GQM+ Sbjct: 353 LQRANGELEVKIAERTADLQASNARLTAEIHERQQAEDTLRKAQDELVQAGKLAVIGQMS 412 Query: 384 AGMTHELNQPLAAIRAFADNSVKFLARGQTAQVAENLEHISHASASMGKIIGQLKGFARK 443 + HELNQPLAA+R + N+V+FL RG+ + NL I+ MG+I L+ FAR+ Sbjct: 413 TSIAHELNQPLAALRTLSGNTVRFLQRGKLETASTNLATINELVDRMGRITASLRAFARR 472 Query: 444 SGQAVAAVDLRHAVEASLRLLASDFEKQEVETHIAMPLAVHVTGDAVRTEQVIVNLLRNA 503 S A A L AV+A+L +L E+ H V + D R EQ++VNLL NA Sbjct: 473 SDDAGQA-SLAKAVDAALLILHGRLEQDPPTLHRHFD-DVRLGIDQTRLEQILVNLLANA 530 Query: 504 LDAVE-EAPRKCVCVILEVDAERQQAVLRIRDSGAGIADEVVPHLFEPFFTTKSSSKGLG 562 LDA+ +A R+ + LE E ++ VLR+RD+G GI HLFEPFFTTK GLG Sbjct: 531 LDAMSGQADRQ---LWLEGRREEERYVLRVRDNGPGIPPAARVHLFEPFFTTKPGEHGLG 587 Query: 563 LGLAISSSIVQAMNGQLSAHNHEQGGAEFVVRLPLL 598 LGL +S+S+ A G LS + E GG F + L L+ Sbjct: 588 LGLTLSASLATAAGGSLSVQHPESGGTAFELSLSLV 623 >PA5165 [T] COG4191 Signal transduction histidine kinase regulating C4-dicarboxylate transport system Pae Pseudomonas aeruginosa Length = 612 Score = 331 bits (848), Expect = 4e-90, Method: Compositional matrix adjust. Identities = 212/565 (37%), Positives = 321/565 (56%), Gaps = 22/565 (3%) Query: 36 QQNQAAAQLQIAALDLESILQKYEALPFALGFQSDVRQVLQHPEDALSVDRLNRAFKTIQ 95 +QN+ L +A +L L++YE LP LG +RQ LQ P D L N A I+ Sbjct: 52 EQNRQTLDLYVA--NLLGTLRRYEELPQILGGLPVLRQALQQPGDPLLQKIANEALADIR 109 Query: 96 QQSRAVNIFMLNRQGVTLASSNWDEEFSYVGRDFGFRPYFREAIQGRAGRFYGIGNISSE 155 +++ A I++L G T +SNW + S+V R+F FRPY+REA+QGR RF+G+G S + Sbjct: 110 RRTGADVIYLLQPDGTTQVASNWAQADSFVHRNFAFRPYYREAMQGRLARFFGLGTTSIK 169 Query: 156 PGYFIAQPIYRRQDQAEGDLPIGVMVVKVDLAEFEHTWRSSSDPITLTDAGGVVFLSNRP 215 GY+ A + EG IGV+VVKVDL E W +S + + + D GVV LS+R Sbjct: 170 RGYYFASAV------KEGSRIIGVLVVKVDLEHIERLWGNSPEQLLVIDNYGVVILSSRE 223 Query: 216 EWKYHSLQALSAPVQRELEGTHQYADLPITPVSTLPPALQRGFGTHVSRPVGRLGWQLML 275 +W++H+ + LSA + E+ +A++P P LQ+ SR + GW + + Sbjct: 224 DWRFHASRPLSAAERDEI-----HANIPYPVQDPKPLRLQQSAWLSQSRTLPETGWTVSI 278 Query: 276 FPSQARMQRSAMLSAMAAALFMVALAISLLAWYQHRRRLQERLASRNALRRAAEELDQKI 335 + + ++R + ++AL + L RR +R+A +R +L++++ Sbjct: 279 YAPRTLIERPVRSVLLIGGATLLALLLLLTLLTLSRRHYLDRIALEAEAKR---QLEERV 335 Query: 336 AQRTQELTAANQAIAAKYAKLQQTESLLRTTQDELVQAGKLAMLGQMAAGMTHELNQPLA 395 +RT+EL AN + + + +Q + L QDE+VQAGKL LG M+A ++HELNQPLA Sbjct: 336 LERTRELENANAQLQQEVHEREQAQRELMRAQDEVVQAGKLTALGTMSASISHELNQPLA 395 Query: 396 AIRAFADNSVKFLARGQTAQVAENLEHISHASASMGKIIGQLKGFARKSGQAVAAVDLRH 455 AIR++ADN+ L +T NLE IS + M II LK +AR + +A V L+ Sbjct: 396 AIRSYADNARVLLDHQRTEDARGNLEQISDLTTRMASIIAHLKAYARGARRAPENVQLQP 455 Query: 456 AVEASLRLLASDFEKQEVETHIAMPLA-VHVTGDAVRTEQVIVNLLRNALDAV-EEAPRK 513 A+E +L ++AS VE +P A + V R Q++ NLL NALDA+ E+AP + Sbjct: 456 AIEDALSMVASRRRAMNVELLRDVPDAPLWVQAGETRLRQILGNLLTNALDALAEKAPPR 515 Query: 514 CVCVILEVDAERQQAVLRIRDSGAGIADEVVPHLFEPFFTTKSSSKGLGLGLAISSSIVQ 573 + VI D + L +RD+G G +++ + H EPFFTTK+++KGLGLGLAI ++++ Sbjct: 516 RLWVIASQD--QHGVTLTLRDNGPGFSEDALAHAHEPFFTTKTTAKGLGLGLAICDNLLR 573 Query: 574 AMNGQLSAHNHEQGGAEFVVRLPLL 598 A+ G+L NH +GGA VVRL LL Sbjct: 574 ALGGRLEMGNHLEGGA--VVRLHLL 596 >PA5512 [T] COG4191 Signal transduction histidine kinase regulating C4-dicarboxylate transport system Pae Pseudomonas aeruginosa Length = 588 Score = 302 bits (774), Expect = 1e-81, Method: Compositional matrix adjust. Identities = 210/588 (35%), Positives = 301/588 (51%), Gaps = 68/588 (11%) Query: 31 RAESDQQNQAAAQLQIAALDLESILQKYEALPFALGFQSDVRQVLQHPEDALSVDRLNRA 90 RAE +Q + QL + A L+++++++ +LP L D+R L P D RLN Sbjct: 37 RAEGEQVRK---QLDLYAGSLQTLIERFRSLPAVLALDPDLRAALAGPIDGELQQRLNLK 93 Query: 91 FKTIQQQSRAVNIFMLNRQGVTLASSNWDEEFSYVGRDFGFRPYFREAIQGRAGRFYGIG 150 ++I +R+ + +L+R G+ +A+SNW+ SYVG ++GFRPYFR+ I +GRFY +G Sbjct: 94 LESINLAARSSTLELLDRTGLAVAASNWNLPTSYVGHNYGFRPYFRQTIAQGSGRFYAVG 153 Query: 151 NISSEPGYFIAQPIYRRQDQAEGDLPIGVMVVKVDLAEFEHTWRSSSDPITLTDAGGVVF 210 IS PGYF++ + +AE +G +VVK++ + E W + D + +DA G+VF Sbjct: 154 VISGIPGYFLSHAV-----RAEDGSFLGAIVVKLEFPDLERQWNQTPDLVLASDAKGIVF 208 Query: 211 LSNRPEWKYHSLQALSAPVQRELEGTHQYADLPITPV--STLPPALQRGFGTHVSRPVGR 268 L+N W+Y L+ L + EL T QY P+TP+ TL R +G R + R Sbjct: 209 LANHAGWRYRELEPLDTVDRFELAETRQYDRQPLTPLRHQTL-----RSYGE--DRRLAR 261 Query: 269 L-------------------GWQLMLFPSQARMQRSAMLSAMAAALFMVALAISLLAWYQ 309 + GW L L A +Q + +AAA LA+ L + Sbjct: 262 VESADGEKDYLWQSLDLPNDGWTLHLLRDTASIQDDVATARLAAA--GTWLALVFLGLFL 319 Query: 310 HRRRLQERLASRNALRRAAEELDQKIAQRTQELTAANQAIAAKYAKLQQTESLLRTTQDE 369 H+R RL +R+ EEL++ + QRT + LRT QD Sbjct: 320 HQRWRIARLR-----QRSREELERLVEQRTAD---------------------LRTAQDG 353 Query: 370 LVQAGKLAMLGQMAAGMTHELNQPLAAIRAFADNSVKFLARGQTAQVAENLEHISHASAS 429 LVQA KLA LGQM+A + HE+NQPL A R + L G+ + + L I Sbjct: 354 LVQAAKLAALGQMSAALAHEINQPLTAQRMQLASLRLLLDAGRHDEARQALPRIDQMLER 413 Query: 430 MGKIIGQLKGFARKS-GQAVAAVDLRHAVEASLRLLASDFEKQEVETHIAMPLAVHVTGD 488 M + G LK FARKS G ++L H VE + +LL + VE A+ V GD Sbjct: 414 MAALTGHLKTFARKSAGGLRERIELGHVVEQAQQLLLPRIRAERVEIEQALLWPAWVMGD 473 Query: 489 AVRTEQVIVNLLRNALDAVEEAPRKCVCVILEVDAERQQAVLRIRDSGAGIADEVVPHLF 548 A+R EQV+VNLLRNALDAV R + + L+ VL + D+G GI E + +F Sbjct: 474 AIRLEQVLVNLLRNALDAVAGQERPWIRLALQRLG--GDWVLSVADNGGGIPAEHLGSVF 531 Query: 549 EPFFTTKSSSKGLGLGLAISSSIVQAMNGQLSAHNHEQGGAEFVVRLP 596 +PFFTTK +GLGLGLA+S IV + G+L N E GA F + LP Sbjct: 532 DPFFTTKPVGEGLGLGLAVSYGIVHELGGRLQVANAE-AGAVFSLILP 578