BLASTP 2.2.21 [Jun-14-2009]

Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Reference for compositional score matrix adjustment: Altschul, Stephen F., 
John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis,
Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches
using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109.

Query= 0015.0056.p         (164 letters)

Database: COGmodified 
           192,987 sequences; 59,019,183 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

RSc0946 [H] COG0262 Dihydrofolate reductase Rso Ralstonia solana...   184   1e-46
BS_dfrA [H] COG0262 Dihydrofolate reductase Bsu Bacillus subtilis     158   5e-39
lin1987 [H] COG0262 Dihydrofolate reductase Lin Listeria innocua      143   1e-34
BH3450 [H] COG0262 Dihydrofolate reductase Bha Bacillus halodurans    142   2e-34
BMEI0609 [H] COG0262 Dihydrofolate reductase Bme Brucella melite...   137   1e-32

>RSc0946 [H] COG0262 Dihydrofolate reductase Rso Ralstonia solanacearum
          Length = 167

 Score =  184 bits (466), Expect = 1e-46,   Method: Compositional matrix adjust.
 Identities = 95/158 (60%), Positives = 112/158 (70%), Gaps = 2/158 (1%)

Query: 8   LTIVVATDLNNGIGIRNTLPWHLPEDLAHFKRTTSGHAILMGRKTFESIGRPLPNRRNIV 67
           LT++VA   N  IG  NTLPW LPEDLAHFKRTT G  I+MGRKT+ESIGRPLP RRNIV
Sbjct: 4   LTLIVARARNGVIGRDNTLPWRLPEDLAHFKRTTMGAPIVMGRKTYESIGRPLPGRRNIV 63

Query: 68  ITRNTEWQHAGVETAASLQDAAALAQGAPA-FIIGGAQIYAEALPLVDRLIITRINQAFD 126
           +TR+ +    G E A SL+DA  L  G    F+IGGAQ+YA+ALP  DRLI+T I+  F+
Sbjct: 64  VTRSAKLALPGCEIAHSLEDAQRLCIGVEQIFLIGGAQLYADALPSADRLIVTEIDADFE 123

Query: 127 CDAFFPALDPLLWQETAREDHRSET-SGLDYAFVTYER 163
            DA FPA DP +W E ARE H +   +  DYAFVTYER
Sbjct: 124 GDAHFPAPDPAVWHEVARETHHAAAPNDFDYAFVTYER 161


>BS_dfrA [H] COG0262 Dihydrofolate reductase Bsu Bacillus subtilis
          Length = 168

 Score =  158 bits (399), Expect = 5e-39,   Method: Compositional matrix adjust.
 Identities = 73/159 (45%), Positives = 101/159 (63%), Gaps = 2/159 (1%)

Query: 8   LTIVVATDLNNGIGIRNTLPWHLPEDLAHFKRTTSGHAILMGRKTFESIGRPLPNRRNIV 67
           ++ + A D N  IG  N LPWHLP DLA+FK+ TSGH+I+MGRKTFESIGRPLPNR+NIV
Sbjct: 2   ISFIFAMDANRLIGKDNDLPWHLPNDLAYFKKITSGHSIIMGRKTFESIGRPLPNRKNIV 61

Query: 68  ITRNTEWQHAGVETAASLQDAAALAQG-APAFIIGGAQIYAEALPLVDRLIITRINQAFD 126
           +T   + +  G    +SL+D   +  G    F+IGGAQ+Y +  P  DRL +T+I+  F+
Sbjct: 62  VTSAPDSEFQGCTVVSSLKDVLDICSGPEECFVIGGAQLYTDLFPYADRLYMTKIHHEFE 121

Query: 127 CDAFFPALDPLLWQETAREDH-RSETSGLDYAFVTYERR 164
            D  FP  D   W+  + E   + E +  DY F+ YE++
Sbjct: 122 GDRHFPEFDESNWKLVSSEQGTKDEKNPYDYEFLMYEKK 160


>lin1987 [H] COG0262 Dihydrofolate reductase Lin Listeria innocua
          Length = 160

 Score =  143 bits (361), Expect = 1e-34,   Method: Compositional matrix adjust.
 Identities = 70/158 (44%), Positives = 100/158 (63%), Gaps = 2/158 (1%)

Query: 8   LTIVVATDLNNGIGIRNTLPWHLPEDLAHFKRTTSGHAILMGRKTFESIGRPLPNRRNIV 67
           +  V A D    IG  N +PWHLP DL  FK+TT+G  ++MGRKT+ES+G+ LPNR+ IV
Sbjct: 2   IIFVWAQDRAGNIGKDNKMPWHLPGDLQFFKKTTTGKTLVMGRKTYESLGKALPNRKTIV 61

Query: 68  ITRNTEWQHAGVETAASLQDAAALAQ-GAPAFIIGGAQIYAEALPLVDRLIITRINQAFD 126
           +TR+ E Q    E   S  +  ALA+ G P +++GGA+IY   + + D+LI+T+I+  FD
Sbjct: 62  LTRDNELQLDDAEILHSRDEVLALAETGEPIYVVGGAEIYRLFMDVADKLIVTKIDAEFD 121

Query: 127 CDAFFPALDPLLWQETAREDH-RSETSGLDYAFVTYER 163
            D  FP +D   + E A+E H + E +  +Y F TYER
Sbjct: 122 ADTAFPEVDWENFSEVAKEPHEKDEKNKYNYTFYTYER 159


>BH3450 [H] COG0262 Dihydrofolate reductase Bha Bacillus halodurans
          Length = 163

 Score =  142 bits (359), Expect = 2e-34,   Method: Compositional matrix adjust.
 Identities = 68/159 (42%), Positives = 100/159 (62%), Gaps = 2/159 (1%)

Query: 8   LTIVVATDLNNGIGIRNTLPWHLPEDLAHFKRTTSGHAILMGRKTFESIGRPLPNRRNIV 67
           ++ +VA D +  IG  N LPW LP DLAHFKR TSGH ++MGRKT+ESIG+PLPNRRN+V
Sbjct: 2   ISFIVAMDKHRLIGKENDLPWRLPADLAHFKRVTSGHTVIMGRKTYESIGKPLPNRRNVV 61

Query: 68  ITRNTEWQHAGVETAASLQDAAALAQGA-PAFIIGGAQIYAEALPLVDRLIITRINQAFD 126
           +TR+  +   GV+   S+ +A  L +     F+IGG++++    P  DR+ +T I++ FD
Sbjct: 62  VTRSQAYTAEGVDIVHSIDEAIRLTEHENETFVIGGSELFKAFWPHADRMYVTYIDEVFD 121

Query: 127 CDAFFPALDPLLWQETAREDHR-SETSGLDYAFVTYERR 164
            D +FP +D   W+  + E     E +   + F  YER+
Sbjct: 122 GDTYFPEIDGQEWELVSVEAGTIDEKNVYPHEFRVYERQ 160


>BMEI0609 [H] COG0262 Dihydrofolate reductase Bme Brucella melitensis
          Length = 172

 Score =  137 bits (344), Expect = 1e-32,   Method: Compositional matrix adjust.
 Identities = 71/165 (43%), Positives = 99/165 (60%), Gaps = 8/165 (4%)

Query: 8   LTIVVATDLNNGIGIRNTLPWHLPEDLAHFKRTTSGHAILMGRKTFESIGRPLPNRRNIV 67
           ++IVVA   NN IG  N +PW L  DL  FK  T G  ++MGR+T++S+GRPLP R NIV
Sbjct: 6   VSIVVAASENNVIGQENDMPWRLSTDLKRFKALTLGKPVIMGRRTWQSLGRPLPGRANIV 65

Query: 68  ITRNTEWQHAGVETAASLQDAAALAQGAPA-------FIIGGAQIYAEALPLVDRLIITR 120
           ITR+ +++  G E   SL+DA ALA+   A        +IGG QIY +A+PL DRL +TR
Sbjct: 66  ITRDADFRAEGAEVVGSLEDALALARKFAAEGGVDEICVIGGGQIYVQAMPLADRLHLTR 125

Query: 121 INQAFDCDAFFPALDPLLWQETARED-HRSETSGLDYAFVTYERR 164
           +    + D +FP ++P  WQ  + ED    +       ++ YERR
Sbjct: 126 VLSVIEGDTYFPEINPQDWQLLSSEDVPAGDKDSYPTRYMLYERR 170