BLASTP 2.2.21 [Jun-14-2009]

Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Reference for compositional score matrix adjustment: Altschul, Stephen F., 
John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis,
Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches
using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109.

Query= 0014.0008.p         (161 letters)

Database: COGmodified 
           192,987 sequences; 59,019,183 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

RSc2628 [H] COG0801 7,8-dihydro-6-hydroxymethylpterin-pyrophosph...   152   4e-37
VC0593 [H] COG0801 7,8-dihydro-6-hydroxymethylpterin-pyrophospho...   118   5e-27
BH0095 [H] COG0801 7,8-dihydro-6-hydroxymethylpterin-pyrophospho...   114   1e-25
SPy1100 [H] COG0801 7,8-dihydro-6-hydroxymethylpterin-pyrophosph...   112   4e-25
ZfolK [H] COG0801 7,8-dihydro-6-hydroxymethylpterin-pyrophosphok...   109   3e-24

>RSc2628 [H] COG0801 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase Rso
           Ralstonia solanacearum
          Length = 169

 Score =  152 bits (383), Expect = 4e-37,   Method: Compositional matrix adjust.
 Identities = 79/156 (50%), Positives = 108/156 (69%)

Query: 6   TLAWIGIGGNLGDARATVEEAIAHLARLPESQLLRSSSLYRTAPIDSSGDDYVNAVALVS 65
           T+A+IGIG NLGDAR  V++A+  LA+     +   SSLYR+AP+D++GDDY+NAV  + 
Sbjct: 2   TVAYIGIGANLGDARQAVKDAVVCLAQQVGISITGKSSLYRSAPVDATGDDYINAVVRID 61

Query: 66  TSLSALELLHALQAIELQHGRERPYRNAPRTLDLDVLMYGEAQLEDEKLIVPHPRMAQRA 125
           T  +A +LL     IE Q GRERP+RNAPRTLDLD+L+YG+  L   +L VPHPR+ QRA
Sbjct: 62  THFTAGQLLRICHHIEDQFGRERPFRNAPRTLDLDLLLYGDQTLTSPELTVPHPRVGQRA 121

Query: 126 FVLVPMLEIDAQVRIPGLGAARDFLDAITDQPISRL 161
           F L+P+ E+   + IPG+GA    L  + DQ I ++
Sbjct: 122 FTLLPLHELAPDLVIPGIGAVAALLPGVADQVIEKM 157


>VC0593 [H] COG0801 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase Vch
           Vibrio cholerae
          Length = 167

 Score =  118 bits (296), Expect = 5e-27,   Method: Compositional matrix adjust.
 Identities = 65/137 (47%), Positives = 86/137 (62%), Gaps = 2/137 (1%)

Query: 7   LAWIGIGGNLGDARATVEEAIAHLARLPESQLLRSSSLYRTAPIDSSGD-DYVNAVALVS 65
           LA+I IG NLGD  A  + AI  L  LP+S+L+ +SSLY + P+      DY+NAVA + 
Sbjct: 3   LAYIAIGSNLGDPVAQAQLAIQQLTLLPKSRLIAASSLYSSTPMGPQNQPDYINAVAAIE 62

Query: 66  TSLSALELLHALQAIELQHGRERPY-RNAPRTLDLDVLMYGEAQLEDEKLIVPHPRMAQR 124
           T L+ LELL   Q IEL+ GR R   R  PRTLDLD+++YG   +E E+L +PH  M  R
Sbjct: 63  TELTPLELLDCTQRIELEQGRVRKSERWGPRTLDLDIVLYGNEVIETERLTIPHYGMKVR 122

Query: 125 AFVLVPMLEIDAQVRIP 141
            FVL P+ EI   + +P
Sbjct: 123 EFVLYPLAEIAPNLTLP 139


>BH0095 [H] COG0801 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase Bha
           Bacillus halodurans
          Length = 174

 Score =  114 bits (285), Expect = 1e-25,   Method: Compositional matrix adjust.
 Identities = 60/150 (40%), Positives = 86/150 (57%), Gaps = 1/150 (0%)

Query: 8   AWIGIGGNLGDARATVEEAIAHLARLPESQLLRSSSLYRTAPIDSSGDD-YVNAVALVST 66
            +I +G N+GD    +EEAI  LA   +  +   SS+Y T P+  +    ++N V  VST
Sbjct: 5   CYIALGSNIGDRSRFLEEAIQQLAEHDKVTVTCCSSIYETDPVGYTDQSPFLNMVVEVST 64

Query: 67  SLSALELLHALQAIELQHGRERPYRNAPRTLDLDVLMYGEAQLEDEKLIVPHPRMAQRAF 126
           SL   +LL   Q IE   GRER  R  PRTLDLD+L+Y +   E E LI+PHPRM +RAF
Sbjct: 65  SLPVEQLLEVTQKIERYCGRERHIRWGPRTLDLDILLYDQENREMENLIIPHPRMWERAF 124

Query: 127 VLVPMLEIDAQVRIPGLGAARDFLDAITDQ 156
           VL+P++E++  +  P        +  + D+
Sbjct: 125 VLIPLMELNPSIVAPSGKTIEQVVRELKDK 154


>SPy1100 [H] COG0801 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase Spy
           Streptococcus pyogenes M1 GAS
          Length = 166

 Score =  112 bits (280), Expect = 4e-25,   Method: Compositional matrix adjust.
 Identities = 58/156 (37%), Positives = 96/156 (61%), Gaps = 2/156 (1%)

Query: 6   TLAWIGIGGNLGDARATVEEAIAHLARLPESQLLRSSSLYRTAPIDSSGD-DYVNAVALV 64
           T+ ++ +G N+GD  A +++A+  LA LP+++LL  SS+Y T     +G  D++N    +
Sbjct: 2   TIVYLSLGTNMGDRAAYLQKALEALADLPQTRLLAQSSIYETTAWGKTGQADFLNMACQL 61

Query: 65  STSLSALELLHALQAIELQHGRERPYRNAPRTLDLDVLMYGEAQLEDEKLIVPHPRMAQR 124
            T L+A + L   QAIE   GR R  +   RT+D+D+L++GE   + ++L VPHP M +R
Sbjct: 62  DTQLTAADFLKETQAIEQSLGRVRHEKWGSRTIDIDILLFGEEVYDTKELKVPHPYMTER 121

Query: 125 AFVLVPMLEIDAQVRI-PGLGAARDFLDAITDQPIS 159
           AFVL+P+LE+   +++ P     RD+L A+    I+
Sbjct: 122 AFVLIPLLELQPDLKLPPNHKFLRDYLAALDQSDIT 157


>ZfolK [H] COG0801 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase EcZ
           Escherichia coli O157:H7 EDL933
          Length = 160

 Score =  109 bits (272), Expect = 3e-24,   Method: Compositional matrix adjust.
 Identities = 61/150 (40%), Positives = 85/150 (56%), Gaps = 2/150 (1%)

Query: 6   TLAWIGIGGNLGDARATVEEAIAHLARLPESQLLRSSSLYRTAPIDSSGD-DYVNAVALV 64
           T+A+I IG NL      V  A+  L  +PES +L  SS YRT P+      DY+NA   +
Sbjct: 2   TVAYIAIGSNLASPLEQVNAALKALGDIPESHILTVSSFYRTPPLGPQDQPDYLNAAVAL 61

Query: 65  STSLSALELLHALQAIELQHGRERPY-RNAPRTLDLDVLMYGEAQLEDEKLIVPHPRMAQ 123
            T+L+  ELL+  Q IELQ GR R   R  PRTLDLD++++G   +  E+L VPH  M  
Sbjct: 62  ETTLAPEELLNHTQQIELQQGRVRKAERWGPRTLDLDIMLFGNETINTERLTVPHYDMKN 121

Query: 124 RAFVLVPMLEIDAQVRIPGLGAARDFLDAI 153
           R F+L P+ EI  ++  P     R+ L ++
Sbjct: 122 RGFMLWPLFEIAPELVFPDGETLREILTSL 151