BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0012.0175.p (399 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value CAC3482 [GEPR] COG0477 Permeases of the major facilitator superf... 273 6e-73 CAC0560 [GEPR] COG0477 Permeases of the major facilitator superf... 269 1e-71 YPO3263 [GEPR] COG0477 Permeases of the major facilitator superf... 219 7e-57 ECs3543 [GEPR] COG0477 Permeases of the major facilitator superf... 202 1e-51 Z3982 [GEPR] COG0477 Permeases of the major facilitator superfam... 201 2e-51 >CAC3482 [GEPR] COG0477 Permeases of the major facilitator superfamily Cac Clostridium acetobutylicum Length = 394 Score = 273 bits (698), Expect = 6e-73, Method: Compositional matrix adjust. Identities = 153/378 (40%), Positives = 227/378 (60%), Gaps = 5/378 (1%) Query: 1 MKTSSYANQRTGNISMMTAACGIAVANVYLCQPLLPAISASFSITSEQAGRVATAAQIGY 60 M+ S N+ I +M+ ACG+ VAN+Y QPLL IS +F+++ G A QIGY Sbjct: 9 MENKSILNKLL--IMVMSIACGLTVANLYYIQPLLADISKTFNVSEISVGSAAMLTQIGY 66 Query: 61 ALGILLVVPLADRVSVTKLIRVLLALSAFFLLSAAAAPNIEILTLASLAITVATVIPQIL 120 A+G++L++PL D LI +L S L S + NI ILT++S A+ ++IPQ++ Sbjct: 67 AVGMVLILPLGDIKERRNLITTILLFSVISLASMFFSSNIYILTISSFAVGFTSIIPQLI 126 Query: 121 IPIAVSTSSPEKAGSVVGTLQSGLIAGILLSRTFSGLIAQYSGSWRFSYVAAAACTVVLL 180 IP+A S+ + G ++GT+ SGL+ GIL+SRTFSG++ Y G WR Y+ AA + L+ Sbjct: 127 IPLAAQLSNQKDRGRIIGTVMSGLLIGILVSRTFSGILGAYWG-WRVVYIIAAIMMIFLM 185 Query: 181 LTLPRALPKRELPPVNISYFALIGSLPGLVSKWTHLRLSALLGALVFGAFSAFWATLAFH 240 + L + LP + P N+ Y L+ S+ L+ LR +++ GA++F AFSAFW +L F Sbjct: 186 IALRKLLPVSK-PSSNVKYIELLKSMFQLIKSEPVLREASINGAMMFAAFSAFWTSLTFL 244 Query: 241 LAEQPFGYGSAEAGLFGLWGAAGALIAPLFGKIADRHGPSILNVISITAAALAFACFAGY 300 L + GS AGLFGL G +GAL APL G+IAD+ GP + I I +++ F Sbjct: 245 LQSPHYNMGSQAAGLFGLVGVSGALAAPLVGRIADKKGPRFIIGICIPIITISYLLFLLL 304 Query: 301 GNIYVAAIVIGVNFLDFANQAGQIANQTRIFKLDPTARARLNTVYMVATFGGGAVGSTLG 360 G + +++GV LD Q+G ++NQTR+ L+ R R+NTVYMV+ F GGA GS +G Sbjct: 305 G-FKIFGLILGVMLLDLGVQSGNVSNQTRVHSLNEKMRNRINTVYMVSFFLGGAFGSFMG 363 Query: 361 SYAWSKHQWSGVWMTGFA 378 S+ + W GV + G + Sbjct: 364 SFTYVHFGWYGVCIFGIS 381 >CAC0560 [GEPR] COG0477 Permeases of the major facilitator superfamily Cac Clostridium acetobutylicum Length = 441 Score = 269 bits (687), Expect = 1e-71, Method: Compositional matrix adjust. Identities = 163/379 (43%), Positives = 223/379 (58%), Gaps = 6/379 (1%) Query: 14 ISMMTAACGIAVANVYLCQPLLPAISASFSITSEQAGRVATAAQIGYALGILLVVPLADR 73 I +M C + VAN+Y CQPLL I+ SF++T AG V T Q+GYALG+L +VPL D Sbjct: 53 IFIMALTCTVTVANLYYCQPLLGQIAKSFNVTEANAGFVVTLTQVGYALGMLFLVPLGDI 112 Query: 74 VSVTKLIRVLLALSAFFLLSAAAAPNIEILTLASLAITVATVIPQILIPIAVSTSSPEKA 133 KLI +L L + FL +A + N +L + S I T++PQ+++P A S PE+ Sbjct: 113 KERKKLIIEMLLLVSVFLFAAFISRNYYVLLVTSFLIGFTTIVPQLIVPFAAHLSKPEER 172 Query: 134 GSVVGTLQSGLIAGILLSRTFSGLIAQYSGSWRFSYVAAAACTVVLLLTLPRALPKRELP 193 G V+G + SGL+ GILLSR FSG+I G WR Y+ A+ V L + PK + P Sbjct: 173 GQVIGNVLSGLLIGILLSRVFSGIIGDILG-WRNVYLIASLLMVSFLFIIVFLFPKSK-P 230 Query: 194 PVNISYFALIGSLPGLVSKWTHLRLSALLGALVFGAFSAFWATLAFHLAEQPFGYGSAEA 253 ISY LI S+ GL+ + LR +++ GAL+FG+FS FW L F L + + GS EA Sbjct: 231 TSKISYKKLIFSMWGLIKREKVLREASINGALMFGSFSIFWTALVFLLESKVYNMGSKEA 290 Query: 254 GLFGLWGAAGALIAPLFGKIADRHGPSILNVISITAAALAFACFAGYG-NIYVAAIVIGV 312 G FGL G GAL AP+ GK+AD+ P +I + +A+ CF G G IY +VIGV Sbjct: 291 GFFGLVGIVGALAAPVVGKVADKKTPRFAVGFAIIFSTIAYVCFWGMGYKIY--GLVIGV 348 Query: 313 NFLDFANQAGQIANQTRIFKLDPTARARLNTVYMVATFGGGAVGSTLGSYAWSKHQWSGV 372 LD NQ GQ++NQ R+ + R+R+NTV+MV+ F GG++GS + + W K WSGV Sbjct: 349 ILLDLGNQTGQVSNQARVQAISDQERSRINTVFMVSYFIGGSIGSFVAAVFWQKFGWSGV 408 Query: 373 WMTG-FALIGGAAFLLFIW 390 G F I F FI+ Sbjct: 409 CAIGMFFQIIAVIFHYFIY 427 >YPO3263 [GEPR] COG0477 Permeases of the major facilitator superfamily Ype Yersinia pestis Length = 399 Score = 219 bits (559), Expect = 7e-57, Method: Compositional matrix adjust. Identities = 143/366 (39%), Positives = 216/366 (59%), Gaps = 3/366 (0%) Query: 14 ISMMTAACGIAVANVYLCQPLLPAISASFSITSEQAGRVATAAQIGYALGILLVVPLADR 73 I +M+ A G+AVA+ Y QPLL I+ +F+++ QAG + TAAQ+GYA+G++ +VPL D Sbjct: 14 IVLMSVATGLAVASNYYAQPLLETIATNFNLSVNQAGFIVTAAQLGYAVGLMFLVPLGDM 73 Query: 74 VSVTKLIRVLLALSAFFLLSAAAAPNIEILTLASLAITVATVIPQILIPIAVSTSSPEKA 133 LI + L+A +L A + N+ ++ + + + +V+ Q+L+P+A + ++PEK Sbjct: 74 FERRGLIVGMTLLAAGGMLITAMSQNLTMMIIGTALTGLFSVVAQLLVPLAATLAAPEKR 133 Query: 134 GSVVGTLQSGLIAGILLSRTFSGLIAQYSGSWRFSYVAAAACTVVLLLTLPRALPKRELP 193 G VVG + SGL+ GILL+RT +G +A G WR Y A+A ++ L L R LP+ + Sbjct: 134 GKVVGIIMSGLLLGILLARTVAGALATL-GGWRTIYWVASALMFIMALVLWRCLPRYK-Q 191 Query: 194 PVNISYFALIGSLPGLVSKWTHLRLSALLGALVFGAFSAFWATLAFHLAEQPFGYGSAEA 253 ++Y L+GS+ L LR ALLGAL F FS W ++AF LA PFGY A Sbjct: 192 HTGLNYGQLLGSIFALFIHTPVLRTRALLGALSFANFSVLWTSMAFLLAAPPFGYSEATI 251 Query: 254 GLFGLWGAAGALIAPLFGKIADRHGPSILNVISITAAALAFACFAGYGNIYVAAIVIGVN 313 GLFGL GAAGAL+A G++AD+ + + L++ A +G + A++IG+ Sbjct: 252 GLFGLVGAAGALMATKAGQLADKGKARVTTSAGLVLLLLSWLPIA-FGQHSIIALIIGII 310 Query: 314 FLDFANQAGQIANQTRIFKLDPTARARLNTVYMVATFGGGAVGSTLGSYAWSKHQWSGVW 373 LD A QA + NQ+ ++++ P AR RL YM + F GGA+GS + + A+ W GV Sbjct: 311 VLDLAVQAVHVTNQSVMYRMMPEARNRLTAGYMTSYFIGGALGSLISAAAYQHAGWYGVS 370 Query: 374 MTGFAL 379 G L Sbjct: 371 TAGLVL 376 >ECs3543 [GEPR] COG0477 Permeases of the major facilitator superfamily Ecs Escherichia coli O157:H7 Length = 394 Score = 202 bits (514), Expect = 1e-51, Method: Compositional matrix adjust. Identities = 144/366 (39%), Positives = 214/366 (58%), Gaps = 9/366 (2%) Query: 14 ISMMTAACGIAVANVYLCQPLLPAISASFSITSEQAGRVATAAQIGYALGILLVVPLADR 73 I +M+ A G+AVA+ Y QPLL I+ +FS+++ AG + TAAQ+GYA G+L +VPL D Sbjct: 13 IVLMSIATGLAVASNYYAQPLLDTIARNFSLSASSAGFIVTAAQLGYAAGLLFLVPLGDM 72 Query: 74 VSVTKLIRVLLALSAFFLLSAAAAPNIEILTLASLAITVATVIPQILIPIAVSTSSPEKA 133 +LI + L+A +L A++ ++ ++ L + + +V+ QIL+P+A + +SP+K Sbjct: 73 FERRRLIVSMTLLAAGGMLITASSQSLAMMILGTALTGLFSVVAQILVPLAATLASPDKR 132 Query: 134 GSVVGTLQSGLIAGILLSRTFSGLIAQYSGSWRFSYVAAAACTVVLLLTLPRALPKRELP 193 G VVGT+ SGL+ GILL+RT +GL+A G WR + A+ ++ L L R LP+ + Sbjct: 133 GKVVGTIMSGLLLGILLARTVAGLLANL-GGWRTVFWVASVLMALMALALWRGLPQMK-S 190 Query: 194 PVNISYFALIGSLPGLVSKWTHLRLSALLGALVFGAFSAFWATLAFHLAEQPFGYGSAEA 253 +++Y L+GS+ + LR ALLG L F FS W ++AF LA PF Y Sbjct: 191 ETHLNYPQLLGSVFSMFISNKILRTRALLGCLTFANFSILWTSMAFLLAAPPFNYSDGVI 250 Query: 254 GLFGLWGAAGALIAPLFGKIADR---HGPSILNVISITAAALAFACFAGYGNIYVAAIVI 310 GLFGL GAAGAL A G AD+ H + ++ + + LA +G+ V A++I Sbjct: 251 GLFGLAGAAGALGARPAGGFADKGKSHHTTTFGLLLLLLSWLAI----WFGHTSVLALII 306 Query: 311 GVNFLDFANQAGQIANQTRIFKLDPTARARLNTVYMVATFGGGAVGSTLGSYAWSKHQWS 370 G+ LD Q I NQT I+++ P AR RL YM + F GGA GS + + AW W+ Sbjct: 307 GILVLDLTVQGVHITNQTVIYRIHPDARNRLTAGYMTSYFIGGAAGSLISASAWQHGGWA 366 Query: 371 GVWMTG 376 GV + G Sbjct: 367 GVCLAG 372 >Z3982 [GEPR] COG0477 Permeases of the major facilitator superfamily EcZ Escherichia coli O157:H7 EDL933 Length = 394 Score = 201 bits (511), Expect = 2e-51, Method: Compositional matrix adjust. Identities = 144/366 (39%), Positives = 214/366 (58%), Gaps = 9/366 (2%) Query: 14 ISMMTAACGIAVANVYLCQPLLPAISASFSITSEQAGRVATAAQIGYALGILLVVPLADR 73 I +M+ A G+AVA+ Y QPLL I+ +FS+++ AG + TAAQ+GYA G+L +VPL D Sbjct: 13 IVLMSIATGLAVASNYYAQPLLDTIARNFSLSASSAGFIVTAAQLGYAAGLLFLVPLGDM 72 Query: 74 VSVTKLIRVLLALSAFFLLSAAAAPNIEILTLASLAITVATVIPQILIPIAVSTSSPEKA 133 +LI + L+A +L A++ ++ ++ L + + +V+ QIL+P+A + +SP+K Sbjct: 73 FERRRLIVSMTLLAAGGMLITASSQSLAMMILGTALTGLFSVVAQILVPLAATLASPDKR 132 Query: 134 GSVVGTLQSGLIAGILLSRTFSGLIAQYSGSWRFSYVAAAACTVVLLLTLPRALPKRELP 193 G VVGT+ SGL+ GILL+RT +GL+A G WR + A+ ++ L L R LP+ + Sbjct: 133 GKVVGTIMSGLLLGILLARTVAGLLANL-GGWRTVFWVASVLMALMALALWRGLPQMK-S 190 Query: 194 PVNISYFALIGSLPGLVSKWTHLRLSALLGALVFGAFSAFWATLAFHLAEQPFGYGSAEA 253 +++Y L+GS+ + LR ALLG L F FS W ++AF LA PF Y Sbjct: 191 ETHLNYPQLLGSVFSMFISNKILRTRALLGCLTFANFSIXWTSMAFLLAAPPFNYSDGVI 250 Query: 254 GLFGLWGAAGALIAPLFGKIADR---HGPSILNVISITAAALAFACFAGYGNIYVAAIVI 310 GLFGL GAAGAL A G AD+ H + ++ + + LA +G+ V A++I Sbjct: 251 GLFGLAGAAGALGARPAGGFADKGKSHHTTTFGLLLLLLSWLAI----WFGHTSVLALII 306 Query: 311 GVNFLDFANQAGQIANQTRIFKLDPTARARLNTVYMVATFGGGAVGSTLGSYAWSKHQWS 370 G+ LD Q I NQT I+++ P AR RL YM + F GGA GS + + AW W+ Sbjct: 307 GILVLDLTVQGVHITNQTVIYRIHPDARNRLTAGYMTSYFIGGAAGSLISASAWQHGGWA 366 Query: 371 GVWMTG 376 GV + G Sbjct: 367 GVCLAG 372