BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0012.0154.p (423 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value PA2091 [GEPR] COG0477 Permeases of the major facilitator superfa... 86 1e-16 PA2589 [GEPR] COG0477 Permeases of the major facilitator superfa... 84 7e-16 BS_ybfB [GEPR] COG0477 Permeases of the major facilitator superf... 80 6e-15 BH2694 [GEPR] COG0477 Permeases of the major facilitator superfa... 77 5e-14 AF0367 [GEPR] COG0477 Permeases of the major facilitator superfa... 64 6e-10 >PA2091 [GEPR] COG0477 Permeases of the major facilitator superfamily Pae Pseudomonas aeruginosa Length = 427 Score = 86.3 bits (212), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 112/388 (28%), Positives = 168/388 (43%), Gaps = 15/388 (3%) Query: 40 CMGLSFAP--VFMGTFPLFLEPVSRQFHWSAATFPQAMLISGLTGALSGPLVGRLIDTMG 97 +G+ F P + + +F LF+EP++ W + + GL ALS PL G L+D G Sbjct: 34 VVGVIFGPTGLVISSFSLFIEPIAADLDWDRGQSALPVTLLGLAVALSSPLKGWLVDRWG 93 Query: 98 VRKVLLPGLLAWAAILAAMSLLNGSIILLYVISALMGPLAATCGPVALAKVVSSWFDRSR 157 R ++LP A A LA+++L + T G + A+++ WF+R R Sbjct: 94 ARALVLPLTAALALCLASLALARSG---WQLYLLFALLGLLTPGNIPYARILGGWFERRR 150 Query: 158 GIALTAVLGGSVAIFTSLMLVLTRVLILDIGWQGAYLALAGLIVAIAMPVSYFFLKEAPQ 217 G A +LG + L L L I GW+ +L L +A+P+ Y +E P Sbjct: 151 GAAY-GILGLGFGVGGPLALYLGSACIDAFGWRATFLVYGLLEGLLALPLLYALFRERPG 209 Query: 218 SSPSVIMGKPDIASMDLKPMTAFTSRAFWTVILASTLVCASCSGLSSHFVPWAGERGVSS 277 P P A P A+ S FW ++ L + +G+ H VP ERG+S Sbjct: 210 DLPQARR-TPADALPGATPGQAWRSADFWLIVGNLILGVFAVTGVMVHGVPLLQERGLSR 268 Query: 278 ATATFALTLYSLAGPFSSLLAGGAADRLPRPGM----LAIVFALPLLGFLAMLTSQEWAV 333 AT L + S G DR P + + LL L + W Sbjct: 269 EVATDVLAALWVGMIVSQPALGYLLDRYDTPRIALPFALLAALGLLLLLLGGPPALLWGA 328 Query: 334 VIGLALMGSGFAAVAGLLPFFTSRYFGLANASTIFGVAVGLT-TLSLGVGPVVLGILRDK 392 V L+G G G +F SRYFGL + S I+G T +++ +G +LG D+ Sbjct: 329 VF---LIGLGAGGETGTTQYFVSRYFGLRHFSVIYGSIQPFTFAIAISLGSWLLGYFYDR 385 Query: 393 WGAYTPASPVLAGALSLAIILALTLPRY 420 G+Y ++ VL GA +A L + L RY Sbjct: 386 AGSYAGSTLVLLGAFGVAAGLLVMLGRY 413 >PA2589 [GEPR] COG0477 Permeases of the major facilitator superfamily Pae Pseudomonas aeruginosa Length = 404 Score = 84.0 bits (206), Expect = 7e-16, Method: Compositional matrix adjust. Identities = 118/409 (28%), Positives = 185/409 (45%), Gaps = 15/409 (3%) Query: 22 ARTEMSREGIVVAIACSICMGLSFAPVFMGTFPLFLEPVSRQFHWSAATFPQAMLISGLT 81 A+ E S V +A + + L + + TF LF+ P+S ++ W A + + GL Sbjct: 2 AQREFSATSGGVLLASVVAIMLGPTGILLNTFSLFIAPMSAEYAWDRAEVSLLVTLFGLA 61 Query: 82 GALSGPLVGRLIDTMGVRKVLLPGLLAWAAILAAMSLLNGSIILLYVISALMGPLAATCG 141 A++ PL G LID G R+ +L A + L ++ +N ++ LY + L+G LA G Sbjct: 62 VAITSPLKGWLIDRWGARRTMLGLTAALSLPLLGLAAVN-AVWQLYALFLLIGLLAP--G 118 Query: 142 PVALAKVVSSWFDRSRGIALTAVLGGSVAIFTSLMLVLTRVLILDIGWQGAYLALAGLIV 201 + +++ WF + G+A + G +LV + L GW+GA+L L + Sbjct: 119 NLPYGRILGLWFRQRLGVAYGLLGLGFGVGGPLGLLVGHQSLE-AWGWRGAFLVYGVLEL 177 Query: 202 AIAMPVSYFFLKE-APQSSPSVIMGKPDIASMDLKPMTAFTSRAFWTVILASTLVCASCS 260 +A+P+ + +E AP + + + A A+ S +FW V+ L S Sbjct: 178 GLALPLLAWLFREPAPDAGVAAGTAVAETALSGSTAPQAWRSASFWLVLGNQVLAVFVMS 237 Query: 261 GLSSHFVPWAGERGVSSATATFALTLYSLAGPFSSLLAGGAADRLPRPGMLAIVFAL-PL 319 G+ +H VP ERG+S A AL+ + S L G DR+ P +A+ FAL + Sbjct: 238 GIMTHGVPMLVERGLSRGEAGTALSALWVGMMLSQPLMGWLLDRVATP-RVALPFALAAV 296 Query: 320 LGFLAMLTSQE----WAVVIGLALMGSGFAAVAGLLPFFTSRYFGLANASTIFGVAVGLT 375 LG L W V L+G G +G + RYFGL + I+G T Sbjct: 297 LGMAWFLVGDTPSGLWLAVF---LVGLGGGGESGTTKYLLMRYFGLRSFGVIYGSIQPFT 353 Query: 376 -TLSLGVGPVVLGILRDKWGAYTPASPVLAGALSLAIILALTLPRYPRR 423 LS+ +G +LG L D+ Y A VL A SLA YP++ Sbjct: 354 FALSISLGAYLLGWLYDRAEGYGTAEWVLLAAFSLAACSLFAFRPYPQK 402 >BS_ybfB [GEPR] COG0477 Permeases of the major facilitator superfamily Bsu Bacillus subtilis Length = 416 Score = 80.5 bits (197), Expect = 6e-15, Method: Compositional matrix adjust. Identities = 106/396 (26%), Positives = 185/396 (46%), Gaps = 45/396 (11%) Query: 52 TFPLFLEPVSRQFHWSAATFPQAMLISGLTGALSGPLVGRLIDTMGVRKVLLPGLLAWAA 111 +F F+EP RQF +T +S + +S P++GRL+D G R V LAW+A Sbjct: 27 SFGAFVEPWERQFSIDRSTISLISTVSFIVYGISQPVIGRLVDKWGARAV-----LAWSA 81 Query: 112 ILAAMSLLNGSII-------LLYVISALMGPLAATCGPVALAKVVSSWFDRSRGIALTAV 164 +L +S+ ++ LLY + +G A+ VA + +V +WF + RG+A + Sbjct: 82 LLTGVSIFLTYLVTSPWQLFLLYGLGVSLGVGGAS--NVAASVLVVNWFSKKRGLAFGIM 139 Query: 165 LGGSVAIFTSLMLVL--TRVLILDIGWQGAYLALAGLIVAIAMPVSYFFLKEAPQSSPSV 222 G A ML++ + +LI W+ + L L++ I P + L+ P + Sbjct: 140 EAGFGA---GQMLLVPGSLMLIHWFSWKLTVVVLGLLLIVIVFPAALLMLRNNPSEKNTE 196 Query: 223 IMGKPDIASMDLKPMTA-------FTSRAFWTVILASTLVCASCSGL-SSHFVPWAGERG 274 +G + + P T F R FW +I + + GL +H +P++ + G Sbjct: 197 PIGGLAASEKETAPKTTALSVAGMFRMRQFWFLIFPFLICGFTTVGLMDTHLIPFSHDHG 256 Query: 275 VSSATATFALTL---YSLAGPFSSLLAGGAADRLPRPGMLAIVFALPLLGFLAMLTSQEW 331 S+ + A++L +++AG LL+G ADR +L I++A+ L + ++ S E Sbjct: 257 FSTTVTSAAVSLLAGFNIAGI---LLSGIVADRWSSRKILCILYAVRALSIVILIYSHEP 313 Query: 332 AVVIGLALMGS--GFAAVAGLLPFFTSRYFGLANASTIFGVAVGLTTLSLGVGP----VV 385 +++ A++ FA VA ++YF N S G+ +G +L+ +G V Sbjct: 314 YLLLAFAILFGLVDFATVAP-TQMLATQYF--QNYSI--GLMIGWLSLAHQIGSALGAYV 368 Query: 386 LGILRDKWGAYTPASPVLAGALSLAIILALTLPRYP 421 G++ G YT A + G L LA ++ + L R P Sbjct: 369 PGVIYTVTGEYTLAFYLSIGMLVLASVMNVML-REP 403 >BH2694 [GEPR] COG0477 Permeases of the major facilitator superfamily Bha Bacillus halodurans Length = 418 Score = 77.4 bits (189), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 95/398 (23%), Positives = 178/398 (44%), Gaps = 43/398 (10%) Query: 52 TFPLFLEPVSRQFHWSAATFPQAMLISGLTGALSGPLVGRLIDTMGVRKVLLPG--LLAW 109 +F F++P +F + +S + +S PL+G+L+D +G R +L L+ Sbjct: 28 SFGAFVQPWETEFSMDRGSISLISTLSFIVYGISQPLIGKLVDRLGARFILSCSTLLVGV 87 Query: 110 AAILAAMSLLNGSIILLYVISALMGPLAATCGPVALAKVVSSWFDRSRGIALTAVLGGSV 169 + +L M+ + +LY + +G A+ VA V+++WF++ RG+A + G Sbjct: 88 SFVLTTMATQPWHLFILYGVVVSIGVGGAS--NVAATVVITNWFNKKRGLAFGIIEAG-- 143 Query: 170 AIFTSLMLVL---TRVLILDIGWQGAYLALAGLIVAIAMPVSYFFLKEAP-QSSPSVIMG 225 F + ++L + +LI + W+ + L + I P+ L+ P + I G Sbjct: 144 --FGAGQMILVPGSLMLIQWLDWKATVVILGFFLAVIVFPIVLLLLRNHPSEKQVEPIGG 201 Query: 226 KPDIASMDLKPMTA-------FTSRAFWTVILASTLVCASCSGL-SSHFVPWAGERGVSS 277 + + P +A F R FW ++L + + +GL +H +P + + G S+ Sbjct: 202 VREEEETNTSPNSATFSNWSVFRMRPFWFLVLPFAICGFTTTGLMDTHLIPLSHDHGFST 261 Query: 278 ATATFALTLYSLAGPFSSLLAGGAADRLPRPGMLAIVFALPLLGFLAMLTSQEWAVVIGL 337 + + A++L + LL+G ADR L +++ L + ++ S + Sbjct: 262 SVTSAAVSLLAGFNIVGILLSGVIADRWSSRKFLFLLYVARALSLVILVHSHD------- 314 Query: 338 ALMGSGFAAVAGLLPFFT--------SRYFGLANASTIFGVAVGLTTLSLGVGP----VV 385 L+ GFA + GL+ F T ++YF + G+ +G LS VG V Sbjct: 315 PLLLLGFAILFGLVDFATVAPTQLLATQYFKRYS----IGLMIGWLFLSHQVGSALGAYV 370 Query: 386 LGILRDKWGAYTPASPVLAGALSLAIILALTLPRYPRR 423 G+L ++ G+YT + V L +A I L LP ++ Sbjct: 371 PGLLYEQTGSYTVSLYVSIVILIVAAICNLFLPEPNKQ 408 >AF0367 [GEPR] COG0477 Permeases of the major facilitator superfamily Afu Archaeoglobus fulgidus Length = 397 Score = 63.9 bits (154), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 111/387 (28%), Positives = 172/387 (44%), Gaps = 59/387 (15%) Query: 55 LFLEPVSRQFHWSA--ATFPQAMLISGLTGALSGPLVGRLIDTMGVRKV-LLPGLLAWAA 111 +F+ P+ F WS A+ P ++ + L AL GR D +G RKV +L G+L Sbjct: 26 VFVNPLMNTFGWSKTIASLPFSIFL--LIFALMMVPAGRTQDRIGPRKVAMLGGVLLGVG 83 Query: 112 ILAAMSLLNGSIILLYVISALMGPLA-ATCG-----PVALAKVVSSWFDRSRGIALTAVL 165 L +S L SI Y + G +A A CG P+ +A+ WF G+A V+ Sbjct: 84 FL--LSGLIESIQSPYWLIFSYGVIAGAGCGLGYACPIPVAR---KWFPERVGLATGLVV 138 Query: 166 GG---SVAIFTSLMLVLTRVLILDIGWQGAYLALAGLIVAIAMPVSYFFLKEAPQ----- 217 G S IF L R+LI G + L G+I+ I + L P+ Sbjct: 139 MGFGMSALIFAPL----ERILIDTYGISTTFYIL-GVILLIVAVFAASLLSNPPELPAVQ 193 Query: 218 -SSP---SVIMGKPDIASMDLKPMTAFTSRAFWTVILASTLVCASCSGLSSHFVPWAGER 273 S+P V+ GKP+ L P F+ + L+ + + + H P+A ER Sbjct: 194 ASNPAKVEVVTGKPE-----LGPSEMLRDYRFYVLWLSFFFMALAGLMVIGHIAPYAQER 248 Query: 274 GVSSATATFALTLYSLAGPFSSLLAGGAADRLPRPGMLAIVF---ALPLLGF----LAML 326 G+ A FA+++ S+A AG +D++ R + ++F + L+ F L ++ Sbjct: 249 GLEPLAAAFAVSILSVANAVGRPGAGALSDKIGRAMTMFVLFLIQGITLIAFPHVALTLI 308 Query: 327 TSQEWAVVIGLALMGSGFAAVAGLLPFFTSRYFGLANASTIFGVAVGLTTLSLG----VG 382 T + I A++G + A L P T +FG N GV GL S G VG Sbjct: 309 T-----IYICAAIIGFNYGANFSLFPSATGDFFGTKN----LGVNYGLVFTSYGVGGLVG 359 Query: 383 PVVLGILRDKWGAYTPASPVLAGALSL 409 P++ G + D G+Y A ++AG L+L Sbjct: 360 PIMAGYVFDVTGSYEIAF-LVAGVLAL 385