BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0012.0147.p (381 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value PA1352 [GEPR] COG0477 Permeases of the major facilitator superfa... 271 1e-72 SMa1959 [GEPR] COG0477 Permeases of the major facilitator superf... 259 5e-69 YPO3263 [GEPR] COG0477 Permeases of the major facilitator superf... 247 4e-65 b2681m [GEPR] COG0477 Permeases of the major facilitator superfa... 240 4e-63 ECs3543 [GEPR] COG0477 Permeases of the major facilitator superf... 238 2e-62 >PA1352 [GEPR] COG0477 Permeases of the major facilitator superfamily Pae Pseudomonas aeruginosa Length = 403 Score = 271 bits (694), Expect = 1e-72, Method: Compositional matrix adjust. Identities = 220/377 (58%), Positives = 272/377 (72%) Query: 1 LLLLFALASGLSVANVYYAQPLLDALSQDFRINQSAIGGVVTATQLGCALALLFLVPLGD 60 L+LLFA+A GLSVANVYYAQPLLD L +F I Q+ +G + TQ GCALALL +VPLGD Sbjct: 12 LVLLFAVACGLSVANVYYAQPLLDVLGAEFAIGQAGVGLLFGTTQAGCALALLLVVPLGD 71 Query: 61 KVARKKLTGLQLSGLICALVTVGLARTSCTLLAGMLAVGLLGTAMTQGLIAYAASVASES 120 + R++L +QL L+ +L+ VG A + L G+L +GLLGTAMTQGL+AYAA++A+ Sbjct: 72 LLERRRLMFVQLLLLVLSLLLVGFAGDTLGLALGLLGLGLLGTAMTQGLLAYAAALAAPG 131 Query: 121 ERGRVVGAAQTGVFIGLLLSRVFSGAISDVTGWRGVYFCAALMMLLLAWPLWRGLPAVPV 180 ERGRVVGAAQ GV IGLLL+R +G ++D+ GWR VY +A M L LWR LPA P Sbjct: 132 ERGRVVGAAQGGVVIGLLLARSLAGLLADLGGWRSVYLVSAASMGGLGLLLWRVLPAAPS 191 Query: 181 SSNGLSYARLLASMWSLLRHDKVLQVRGTLAMLMFASFNIFWSALVLPLSASPYHFSHTA 240 + GL+Y +LL SM+ LL +VLQVRG L +LMFA+F +FWS+LVL L A P+ SH+A Sbjct: 192 NELGLTYRQLLGSMFDLLASQRVLQVRGLLGLLMFAAFGVFWSSLVLLLGAPPHSLSHSA 251 Query: 241 IGAFGLVGVIGALAASRAGRWADKGHAQRTSAAALSLLLLAWWPLSLMDGSLWALVAGII 300 IGAFGLVG +GAL A+RAG AD+GHAQ S AL LLLL+W PL+L SL AL+ G++ Sbjct: 252 IGAFGLVGALGALGAARAGSLADRGHAQALSGGALLLLLLSWLPLALGAHSLAALILGVL 311 Query: 301 LLDLGGQALHVTNQSLILRSSPGAHGRLIGVYMLFYTVGSGLGALSTTVVYAAHGWRGVC 360 LLDL GQA+HV NQSL+ P AH RL+G YMLFY GSGLGA + T +YA GW V Sbjct: 312 LLDLAGQAIHVLNQSLVFAIDPRAHSRLVGCYMLFYAAGSGLGASAGTAMYAWAGWDAVS 371 Query: 361 LLGAAVSFIALLFWLTT 377 LLGAA+S AL FW T Sbjct: 372 LLGAAISLAALAFWWFT 388 >SMa1959 [GEPR] COG0477 Permeases of the major facilitator superfamily Sme Sinorhizobium meliloti Length = 469 Score = 259 bits (663), Expect = 5e-69, Method: Compositional matrix adjust. Identities = 181/381 (47%), Positives = 241/381 (63%), Gaps = 1/381 (0%) Query: 1 LLLLFALASGLSVANVYYAQPLLDALSQDFRINQSAIGGVVTATQLGCALALLFLVPLGD 60 L LLFA ASGL+VAN Y+A PLLD ++ D + ++ IG VV ATQLG L L+ LVP+GD Sbjct: 88 LTLLFAAASGLAVANAYFAHPLLDVIADDLSLPRATIGFVVGATQLGYGLGLVLLVPVGD 147 Query: 61 KVARKKLTGLQLSGLICALVTVGLARTSCTLLAGMLAVGLLGTAMTQGLIAYAASVASES 120 V R+ L +Q + AL+ VG A T L ++A+G A TQ +AYAAS+A Sbjct: 148 LVDRRNLVIIQSLLSVLALLCVGFAPTEEVLFPALIAMGFFAVA-TQAFVAYAASLARPE 206 Query: 121 ERGRVVGAAQTGVFIGLLLSRVFSGAISDVTGWRGVYFCAALMMLLLAWPLWRGLPAVPV 180 ERG VVG +G+ +G+LL+R +GA+ D+ GWR VY +A L + L R +PA P Sbjct: 207 ERGAVVGTVTSGIVLGILLARTVAGAVVDIAGWRAVYLLSAAFTLAITAILARVVPAQPK 266 Query: 181 SSNGLSYARLLASMWSLLRHDKVLQVRGTLAMLMFASFNIFWSALVLPLSASPYHFSHTA 240 S +SY +L+ S+++L + VL+VR LA L+FA + LVLPLSA PY SH A Sbjct: 267 SGPAVSYPKLIGSLFTLFLQEPVLRVRAILAFLIFADVTTLLTPLVLPLSAPPYSLSHAA 326 Query: 241 IGAFGLVGVIGALAASRAGRWADKGHAQRTSAAALSLLLLAWWPLSLMDGSLWALVAGII 300 IG FGL G GAL ASRAGRW D+G QR + AL+L+L +W + L+ S+ LV G++ Sbjct: 327 IGLFGLAGAAGALGASRAGRWTDEGFGQRVTGVALTLMLCSWILIGLLPYSILFLVTGVL 386 Query: 301 LLDLGGQALHVTNQSLILRSSPGAHGRLIGVYMLFYTVGSGLGALSTTVVYAAHGWRGVC 360 LLD G QA+HV +Q LI R P A RL YM+FY+ GS LG+ +T+VYA W GV Sbjct: 387 LLDFGLQAVHVASQGLIYRVRPEAQSRLTAAYMVFYSTGSALGSSISTLVYARWAWTGVS 446 Query: 361 LLGAAVSFIALLFWLTTCRRR 381 +LGA ++ ALLFW T +R Sbjct: 447 MLGAGIAAAALLFWAITLPKR 467 >YPO3263 [GEPR] COG0477 Permeases of the major facilitator superfamily Ype Yersinia pestis Length = 399 Score = 247 bits (630), Expect = 4e-65, Method: Compositional matrix adjust. Identities = 156/386 (40%), Positives = 240/386 (62%), Gaps = 16/386 (4%) Query: 1 LLLLFALASGLSVANVYYAQPLLDALSQDFRINQSAIGGVVTATQLGCALALLFLVPLGD 60 L++L ++A+GL+VA+ YYAQPLL+ ++ +F ++ + G +VTA QLG A+ L+FLVPLGD Sbjct: 13 LIVLMSVATGLAVASNYYAQPLLETIATNFNLSVNQAGFIVTAAQLGYAVGLMFLVPLGD 72 Query: 61 KVARKKLTGLQLSGLICALVTVGLARTSCTLLAGMLAVGLLGTAMT-------QGLIAYA 113 R+ GLI + + T ++ L + ++GTA+T Q L+ A Sbjct: 73 MFERR--------GLIVGMTLLAAGGMLITAMSQNLTMMIIGTALTGLFSVVAQLLVPLA 124 Query: 114 ASVASESERGRVVGAAQTGVFIGLLLSRVFSGAISDVTGWRGVYFCAALMMLLLAWPLWR 173 A++A+ +RG+VVG +G+ +G+LL+R +GA++ + GWR +Y+ A+ +M ++A LWR Sbjct: 125 ATLAAPEKRGKVVGIIMSGLLLGILLARTVAGALATLGGWRTIYWVASALMFIMALVLWR 184 Query: 174 GLPAVPVSSNGLSYARLLASMWSLLRHDKVLQVRGTLAMLMFASFNIFWSALVLPLSASP 233 LP GL+Y +LL S+++L H VL+ R L L FA+F++ W+++ L+A P Sbjct: 185 CLPRYK-QHTGLNYGQLLGSIFALFIHTPVLRTRALLGALSFANFSVLWTSMAFLLAAPP 243 Query: 234 YHFSHTAIGAFGLVGVIGALAASRAGRWADKGHAQRTSAAALSLLLLAWWPLSLMDGSLW 293 + +S IG FGLVG GAL A++AG+ ADKG A+ T++A L LLLL+W P++ S+ Sbjct: 244 FGYSEATIGLFGLVGAAGALMATKAGQLADKGKARVTTSAGLVLLLLSWLPIAFGQHSII 303 Query: 294 ALVAGIILLDLGGQALHVTNQSLILRSSPGAHGRLIGVYMLFYTVGSGLGALSTTVVYAA 353 AL+ GII+LDL QA+HVTNQS++ R P A RL YM Y +G LG+L + Y Sbjct: 304 ALIIGIIVLDLAVQAVHVTNQSVMYRMMPEARNRLTAGYMTSYFIGGALGSLISAAAYQH 363 Query: 354 HGWRGVCLLGAAVSFIALLFWLTTCR 379 GW GV G + + ++ WL R Sbjct: 364 AGWYGVSTAGLVLCLLNIVTWLVGKR 389 >b2681m [GEPR] COG0477 Permeases of the major facilitator superfamily Eco Escherichia coli K12 Length = 392 Score = 240 bits (613), Expect = 4e-63, Method: Compositional matrix adjust. Identities = 159/388 (40%), Positives = 243/388 (62%), Gaps = 18/388 (4%) Query: 1 LLLLFALASGLSVANVYYAQPLLDALSQDFRINQSAIGGVVTATQLGCALALLFLVPLGD 60 L++L ++A+GL+VA+ YYAQPLLD ++++F ++ S+ G +VTA QLG A LLFLVPLGD Sbjct: 12 LIVLMSIATGLAVASNYYAQPLLDTIARNFSLSASSAGFIVTAAQLGYAAGLLFLVPLGD 71 Query: 61 KVARKKLTGLQLSGLICALVTVGLARTSCTLLAGMLAVGLLGTAMT-------QGLIAYA 113 R++L + ++ L L+T + LA+ +LGTA+T Q L+ A Sbjct: 72 MFERRRLI-VSMTLLXXMLITAS---------SQSLAMMILGTALTGLFSVVAQILVPLA 121 Query: 114 ASVASESERGRVVGAAQTGVFIGLLLSRVFSGAISDVTGWRGVYFCAALMMLLLAWPLWR 173 A++AS +RG+VVG +G+ +G+LL+R +G ++++ GWR V++ A+++M L+A LWR Sbjct: 122 ATLASPDKRGKVVGTIMSGLLLGILLARTVAGLLANLGGWRTVFWVASVLMALMALALWR 181 Query: 174 GLPAVPVSSNGLSYARLLASMWSLLRHDKVLQVRGTLAMLMFASFNIFWSALVLPLSASP 233 GLP + S L+Y +LL S++S+ DK+L+ R L L FA+F+I W+++ L+A P Sbjct: 182 GLPQMK-SETHLNYPQLLGSVFSMFISDKILRTRALLGCLTFANFSILWTSMAFLLAAPP 240 Query: 234 YHFSHTAIGAFGLVGVIGALAASRAGRWADKGHAQRTSAAALSLLLLAWWPLSLMDGSLW 293 +++S IG FGL G GAL A AG +ADKG + T+ L LLLL+W + S+ Sbjct: 241 FNYSDGVIGLFGLAGAAGALGARPAGGFADKGKSHHTTTFGLLLLLLSWLAIWFGHTSVL 300 Query: 294 ALVAGIILLDLGGQALHVTNQSLILRSSPGAHGRLIGVYMLFYTVGSGLGALSTTVVYAA 353 AL+ GI++LDL Q +H+TNQ++I R P A RL YM Y +G G+L + + Sbjct: 301 ALIIGILVLDLTVQGVHITNQTVIYRIHPDARNRLTAGYMTSYFIGGAAGSLISASAWQH 360 Query: 354 HGWRGVCLLGAAVSFIALLFWLTTCRRR 381 GW GVCL GA ++ + LL W R+ Sbjct: 361 GGWAGVCLAGATIALVNLLVWWRGFHRQ 388 >ECs3543 [GEPR] COG0477 Permeases of the major facilitator superfamily Ecs Escherichia coli O157:H7 Length = 394 Score = 238 bits (606), Expect = 2e-62, Method: Compositional matrix adjust. Identities = 157/388 (40%), Positives = 241/388 (62%), Gaps = 16/388 (4%) Query: 1 LLLLFALASGLSVANVYYAQPLLDALSQDFRINQSAIGGVVTATQLGCALALLFLVPLGD 60 L++L ++A+GL+VA+ YYAQPLLD ++++F ++ S+ G +VTA QLG A LLFLVPLGD Sbjct: 12 LIVLMSIATGLAVASNYYAQPLLDTIARNFSLSASSAGFIVTAAQLGYAAGLLFLVPLGD 71 Query: 61 KVARKKLTGLQLSGLICALVTVGLARTSCTLLAGMLAVGLLGTAMT-------QGLIAYA 113 R++L I ++ + T + LA+ +LGTA+T Q L+ A Sbjct: 72 MFERRRL--------IVSMTLLAAGGMLITASSQSLAMMILGTALTGLFSVVAQILVPLA 123 Query: 114 ASVASESERGRVVGAAQTGVFIGLLLSRVFSGAISDVTGWRGVYFCAALMMLLLAWPLWR 173 A++AS +RG+VVG +G+ +G+LL+R +G ++++ GWR V++ A+++M L+A LWR Sbjct: 124 ATLASPDKRGKVVGTIMSGLLLGILLARTVAGLLANLGGWRTVFWVASVLMALMALALWR 183 Query: 174 GLPAVPVSSNGLSYARLLASMWSLLRHDKVLQVRGTLAMLMFASFNIFWSALVLPLSASP 233 GLP + S L+Y +LL S++S+ +K+L+ R L L FA+F+I W+++ L+A P Sbjct: 184 GLPQMK-SETHLNYPQLLGSVFSMFISNKILRTRALLGCLTFANFSILWTSMAFLLAAPP 242 Query: 234 YHFSHTAIGAFGLVGVIGALAASRAGRWADKGHAQRTSAAALSLLLLAWWPLSLMDGSLW 293 +++S IG FGL G GAL A AG +ADKG + T+ L LLLL+W + S+ Sbjct: 243 FNYSDGVIGLFGLAGAAGALGARPAGGFADKGKSHHTTTFGLLLLLLSWLAIWFGHTSVL 302 Query: 294 ALVAGIILLDLGGQALHVTNQSLILRSSPGAHGRLIGVYMLFYTVGSGLGALSTTVVYAA 353 AL+ GI++LDL Q +H+TNQ++I R P A RL YM Y +G G+L + + Sbjct: 303 ALIIGILVLDLTVQGVHITNQTVIYRIHPDARNRLTAGYMTSYFIGGAAGSLISASAWQH 362 Query: 354 HGWRGVCLLGAAVSFIALLFWLTTCRRR 381 GW GVCL GA ++ + LL W R+ Sbjct: 363 GGWAGVCLAGATIALVNLLVWWRGFHRQ 390