BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0012.0144.p (527 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value AGpA277 [GEPR] COG0477 Permeases of the major facilitator superf... 242 2e-63 SMc00563 [GEPR] COG0477 Permeases of the major facilitator super... 238 2e-62 AGc2011 [GEPR] COG0477 Permeases of the major facilitator superf... 223 7e-58 BMEII0794 [GEPR] COG0477 Permeases of the major facilitator supe... 182 2e-45 BMEII0795 [GEPR] COG0477 Permeases of the major facilitator supe... 69 2e-11 >AGpA277 [GEPR] COG0477 Permeases of the major facilitator superfamily Atu Agrobacterium tumefaciens strain C58 (Cereon) Length = 477 Score = 242 bits (617), Expect = 2e-63, Method: Compositional matrix adjust. Identities = 160/428 (37%), Positives = 231/428 (53%), Gaps = 1/428 (0%) Query: 15 EAPAFPGSPYIATHAPGRRAAYAAIAVLAGIGATFGNGMVNVNIASLAGGQGLYTAEASL 74 E P GSP HA R AYA +A+L G+ GN +V VNI L G L + +A+ Sbjct: 23 ERPVVAGSPATPEHALTLRIAYALVAILVGLIGGLGNALVMVNITELKTGLALSSVQAAW 82 Query: 75 LPAVYVGFNACANLILVKARAQFGIPQVTLTLLATYALAALLHLCVPGLAAAIVVRAACG 134 LP Y N ANL+L+K R Q+G+ TL L YAL +L +L + +RAA G Sbjct: 83 LPTAYAMTNISANLLLIKFRQQYGLCVFTLVALGLYALLSLTYLLTADHWLTLAIRAASG 142 Query: 135 LAAAALTTTTIYHLLQVFSLKARPLALVVGVSLPQFGPPLARLMSLDFLAESQWQGLLLT 194 AAALT ++++++Q + R L++G+ + Q PLA ++S S WQ + L Sbjct: 143 FVAAALTPLSLFYVMQALPGRWRVRGLILGLGISQCAFPLATVISPWLSISSHWQSIFLL 202 Query: 195 ELCIALVLLGAMTLVPLPPSERSQAFEGMDLVTISLLVPAGLLLSAVLGLGRILWWTDTP 254 E +A + L A+ LPP+ER + FE D +T LL + L++AVLGLGR+ W P Sbjct: 203 EAGLAFLSLAAVGTFRLPPAERERVFEPSDFLTFLLLASSLALIAAVLGLGRLEGWFKAP 262 Query: 255 WLGLALAGALVLASAAWMIERQRARPLLQLRWMLTGDIVRFAMVAFLVRIALAEQTYGAV 314 W+ L+ AL + AA ++E+ R PLL LRW+ + DI R A + R+ LAEQ A Sbjct: 263 WIIWFLSLALPMIIAALILEKGRTVPLLNLRWLGSDDIARLAFAILMARVVLAEQNV-AT 321 Query: 315 GLLSAGGLNNDQLHGLFLAVTAAMFLGIIVAALTLSERNLPWQVAVAALCIALAAWLDSG 374 LSA G +++ L L + + G+IV+A+ ++ L + +A IA A +S Sbjct: 322 KFLSALGGSDEHLRALSIVTFVSAVAGVIVSAIAVNVEKLVMPMMLAVTAIAAATLAESS 381 Query: 375 SNSLTRPPQLMLSQSLVAFGTTLFVGPTLVFGFLRMSARGGDHLVSFIVLFSVSQNIGGL 434 + SL P LSQ++++F F+GP LV G +GG L+SFIVLF +IG Sbjct: 382 ATSLEHLPWFYLSQAVISFAAMFFLGPALVLGITSALQKGGRELLSFIVLFGAINSIGAF 441 Query: 435 AGSALLGS 442 G AL GS Sbjct: 442 TGQALFGS 449 >SMc00563 [GEPR] COG0477 Permeases of the major facilitator superfamily Sme Sinorhizobium meliloti Length = 531 Score = 238 bits (607), Expect = 2e-62, Method: Compositional matrix adjust. Identities = 168/498 (33%), Positives = 271/498 (54%), Gaps = 26/498 (5%) Query: 15 EAPAFPGSPYIATHAPGRRAAYAAIAVLAGIGATFGNGMVNVNIASLAGGQGLYTAEASL 74 A A PGS I G+ A Y A + L + G + + N+A + G + EA+ Sbjct: 2 NAVAAPGSMRI-----GKSALYIAGSALLFLTQGLGMNLASANLAQVQGSLSATSVEAAW 56 Query: 75 LPAVYVGFNACANLILVKARAQFGIPQVTLTLLATYALAALLHLCVPGLAAAIVVRAACG 134 L A Y+ N + LVK RAQ+G+ + + + +A+L+++ V L +A+VVR G Sbjct: 57 LAAAYMAPNVSLSAALVKIRAQYGLRRFAEIGIVGFVIASLMNVFVSDLHSAVVVRFISG 116 Query: 135 LAAAALTTTTIYHLLQVFSLKARPL--ALVVGVSLPQFGPPLARLMSLDFLAESQWQGLL 192 +AAA ++T ++L+ F AR L AL + ++ P+ RL+S + + QW GL Sbjct: 117 IAAAPMSTLGFLYMLEAFP-PARKLTVALALALTCTTLAAPITRLISPELIEIGQWHGLY 175 Query: 193 LTELCIALVLLGAMTLVPLPPSERSQAFEGMDLVTISLLVPAGLLLSAVLGLGRILWWTD 252 E+ +AL+ L + L+PL P ++ + D+++ LL ++ VL +GR+ WW + Sbjct: 176 TLEMALALIALPIIYLLPLTPVPHAKVIQRADILSYLLLAVGFGCVAVVLVMGRLYWWFE 235 Query: 253 TPWLGLALAGALVLASAAWMIERQRARPLLQLRWMLTGDIVRFAMVAFLVRIALAEQTYG 312 PWLG+ LA ++V +A +IE R +PL+ +RW+ + +IV FA V + R+ +EQ+ Sbjct: 236 APWLGMLLALSVVTLTAVVLIELNREQPLIDIRWLASREIVHFAAVLLIFRLVASEQSAI 295 Query: 313 AVGLLSAGGLNNDQLHGLFLAVTAAMFLGIIVAALTLSERNLPWQVAVAALCIALAAWLD 372 A GL DQL L+ + A+ G ++ A + + +A +A A++D Sbjct: 296 ATNFYQLLGLQYDQLATLYWIILASSLGGGLLCAALMKPGHADAVHVLALGMLAAGAYMD 355 Query: 373 SGSNSLTRPPQLMLSQSLVAFGTTLFVGPTLVFGFLRMSARGGDHLVSFIVLFSVSQNIG 432 S + SLTRP Q+ +SQ+LVA GT LF+ P + GF A+G +++SFIV+F +Q+IG Sbjct: 356 SHATSLTRPEQMYVSQALVAAGTALFLPPAMARGFTAALAKGPSYILSFIVVFLFTQSIG 415 Query: 433 GLAGSALLGSVQTIMAKVHAQVMSERLLASDPQTAARLAQGSGA---------------- 476 GL GSA G+ T+ K HA +++E+++ S+P A R+ Q SGA Sbjct: 416 GLMGSAAFGTFVTLREKFHANILAEQIVLSNPLVAQRIGQLSGAYAKAIVDRALLNGEGV 475 Query: 477 --LLQSLMTEANTLAYND 492 L Q++ EAN LAYND Sbjct: 476 ALLGQTITREANILAYND 493 >AGc2011 [GEPR] COG0477 Permeases of the major facilitator superfamily Atu Agrobacterium tumefaciens strain C58 (Cereon) Length = 583 Score = 223 bits (569), Expect = 7e-58, Method: Compositional matrix adjust. Identities = 173/557 (31%), Positives = 270/557 (48%), Gaps = 35/557 (6%) Query: 3 DRLPDRPAPAAPEAP---------AFPGSPYIATHAPGRRAAYAAIAVLAGIGATFGNGM 53 LP++ A P+ A P +P R + + I G + Sbjct: 24 SELPEKDATVPPDTASTAETMVEAAIPAAPQPVERPLWLRLCFIFAGLSFFITQGLGMNL 83 Query: 54 VNVNIASLAGGQGLYTAEASLLPAVYVGFNACANLILVKARAQFGI-PQVTLTLLATYAL 112 V NI L G AE + L A Y+ A ++ L K RAQ+G+ P L+++A + + Sbjct: 84 VMANIYQLQGEFSATVAEVAWLSAAYMAPYATFSIALFKVRAQYGLRPFAELSIIA-FVV 142 Query: 113 AALLHLCVPGLAAAIVVRAACGLAAAALTTTTIYHLLQVFSLKARPLALVVGVSLPQ--F 170 A+ L+L V L +AIV+R G+AAA +++ ++L+ F AR +L ++L Sbjct: 143 ASCLNLFVTDLHSAIVIRFVSGMAAAPISSLGFLYILEAFP-PARKFSLGFSIALTGTLL 201 Query: 171 GPPLARLMSLDFLAESQWQGLLLTELCIALVLLGAMTLVPLPPSERSQAFEGMDLVTISL 230 PLAR++S L W L E+ AL+ L + ++ + P R++ E MD+++ L Sbjct: 202 SAPLARIVSPSLLEIDGWNALYSMEVGFALISLAVIYVLKVTPPPRAKVIERMDILSYVL 261 Query: 231 LVPAGLLLSAVLGLGRILWWTDTPWLGLALAGALVLASAAWMIERQRARPLLQLRWMLTG 290 L+ +L LGR WW +T WLG LA ++ L + IE R PLL LRW+ + Sbjct: 262 FAGGLGCLAVMLTLGRFYWWFETWWLGALLATSIALLTLMAFIELPRKNPLLDLRWIFSK 321 Query: 291 DIVRFAMVAFLVRIALAEQTYGAVGLLSAGGLNNDQLHGLFLAVTAAMFLGIIVAALTLS 350 + V + R +EQ+ AV GL NDQ L+ V A LG A + Sbjct: 322 TNLHVMAVLLIYRAVSSEQSSTAVSFYQQLGLLNDQTTTLYALVLLATVLGGAACAWLML 381 Query: 351 ERNLPWQVAVAALCIALAAWLDSGSNSLTRPPQLMLSQSLVAFGTTLFVGPTLVFGFLRM 410 + + +A IA ++LDS S ++TRP Q+ SQ ++AFG +F+ P + GF Sbjct: 382 SKYVDTAHVIALTLIAAGSFLDSQSTNMTRPEQMYFSQMMIAFGAAMFLPPVMAKGFAAA 441 Query: 411 SARGGDHLVSFIVLFSVSQNIGGLAGSALLGSVQTIMAKVHAQVMSERLLASDPQTAARL 470 RG +LV+FI +F +Q G + + LLGS T+ K H+ ++ E +L ++P A R+ Sbjct: 442 LGRGAPYLVNFIAIFLFTQITGSMLMTGLLGSFVTLREKFHSNILVENILLTNPLVAQRV 501 Query: 471 AQGSGA------------------LLQSLMTEANTLAYNDVFRLVA-LAALAVAAYLACE 511 +Q SGA L Q + EA LAYND F L++ ++ALA+A L Sbjct: 502 SQLSGAYSHVITDPALLKAEGLTLLAQQVSREAYVLAYNDTFLLISVVSALALAVLLIHL 561 Query: 512 TWSRRRA--ARQRLEYA 526 W R R +R++ + A Sbjct: 562 VWMRVRPFLSREKTDTA 578 >BMEII0794 [GEPR] COG0477 Permeases of the major facilitator superfamily Bme Brucella melitensis Length = 330 Score = 182 bits (462), Expect = 2e-45, Method: Compositional matrix adjust. Identities = 110/305 (36%), Positives = 166/305 (54%), Gaps = 19/305 (6%) Query: 238 LSAVLGLGRILWWTDTPWLGLALAGALVLASAAWMIERQRARPLLQLRWMLTGDIVRFAM 297 L VL G+ WW + PW+G+ LA +++ + A IE R +PL+ L W+ + +I+RF + Sbjct: 22 LVVVLVQGKNYWWFEAPWIGVCLAISILSLAIAAAIELNRDQPLMNLHWLASPEILRFTL 81 Query: 298 VAFLVRIALAEQTYGAVGLLSAGGLNNDQLHGLFLAVTAAMFLGIIVAALTLSERNLPWQ 357 + + R+ LAEQT GA+GL GL + Q GL+ + A F G I L +P Sbjct: 82 ILLVFRMVLAEQTSGALGLFQVFGLQDAQSKGLYTLILLASFAGGITCGALLKVERVPVI 141 Query: 358 VAVAALCIALAAWLDSGSNSLTRPPQLMLSQSLVAFGTTLFVGPTLVFGFLRMSARGGDH 417 A LCIA+ A+LDS + +LTRP + +SQ L+AFG LF+ P ++ G + +G + Sbjct: 142 FGFALLCIAVGAFLDSHATNLTRPHNVYVSQGLIAFGGALFLPPAMLAGITKAMKQGPAY 201 Query: 418 LVSFIVLFSVSQNIGGLAGSALLGSVQTIMAKVHAQVMSERLLASDPQTAARL------- 470 + SFIV+F +QNIGGL GSAL + +I K H+ + E+L+ SDP A R+ Sbjct: 202 MTSFIVVFLFTQNIGGLIGSALFSTFISIREKYHSAHLVEQLVMSDPLVAQRVQALSGTY 261 Query: 471 -----------AQGSGALLQSLMTEANTLAYNDVFRLVA-LAALAVAAYLACETWSRRRA 518 A+G L Q + EA L+YND F ++ +AA+A+ + + RA Sbjct: 262 AKVLADQGLTKAEGPVLLGQQVTKEATILSYNDAFLAISVIAAIALCCQVTYRVYEAFRA 321 Query: 519 ARQRL 523 R L Sbjct: 322 RRSAL 326 >BMEII0795 [GEPR] COG0477 Permeases of the major facilitator superfamily Bme Brucella melitensis Length = 244 Score = 69.3 bits (168), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 49/176 (27%), Positives = 85/176 (48%), Gaps = 1/176 (0%) Query: 53 MVNVNIASLAGGQGLYTAEASLLPAVYVGFNACANLILVKARAQFGIPQVTLTLLATYAL 112 ++ N + G G E + L A Y+ A ++L+K R QFG+ + +A + + Sbjct: 22 FISANTQQIQGSLGASLTETTWLVAAYMAPFASLTILLLKIRTQFGLRRFAEVAIAVFLV 81 Query: 113 AALLHLCVPGLAAAIVVRAACGLAAAALTTTTIYHLLQVF-SLKARPLALVVGVSLPQFG 171 A+LLHL V + +AI VR G AA +++ ++L+ F K R L + ++ Sbjct: 82 ASLLHLLVYDVWSAIPVRFIAGAAAVPISSVGFLYMLEAFPPDKKRTWGLSLALTCSGAA 141 Query: 172 PPLARLMSLDFLAESQWQGLLLTELCIALVLLGAMTLVPLPPSERSQAFEGMDLVT 227 P AR++S QWQ L + E+ +AL + ++PL R++ +D V Sbjct: 142 GPFARIISPMLFDIGQWQQLYMLEIGLALACFAVVYVLPLTQIPRAKVLHWLDFVV 197