BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0012.0120.p (303 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value YPO1933 [R] COG3618 Predicted metal-dependent hydrolase of the T... 184 2e-46 AGl3341 [R] COG3618 Predicted metal-dependent hydrolase of the T... 120 5e-27 RSp0233 [R] COG3618 Predicted metal-dependent hydrolase of the T... 107 5e-23 Cgl0451 Non COG 78 2e-14 >YPO1933 [R] COG3618 Predicted metal-dependent hydrolase of the TIM-barrel fold Ype Yersinia pestis Length = 289 Score = 184 bits (467), Expect = 2e-46, Method: Compositional matrix adjust. Identities = 107/278 (38%), Positives = 150/278 (53%), Gaps = 12/278 (4%) Query: 33 QPPRLKAPALACDSHHHIYDAR--FPVSPHWRGGRPDGATVADYRRLMAKLGIARNVVVQ 90 +P P ACDSH H+ R +P+ R P A Y ++A G++R V+VQ Sbjct: 16 EPSIFALPEDACDSHAHVISPRAIYPMVAE-RSYTPPPAPEEKYLSMLAATGMSRGVLVQ 74 Query: 91 PSTYGSDNRCLLDALTQFGAQARGIVVIDDDVELAQLKEMDQLGVRGVRVNFLSPQSWGI 150 S YGSDNR +L L + RG+ V+ +DV +L++M GVRG+R+N L G Sbjct: 75 ISVYGSDNRYMLQVLKRHPEYLRGVAVVTEDVTDQELQDMALAGVRGLRINVLFGGGIGF 134 Query: 151 TTVDRLLRTAKRVAPLGWHVQVLMSGAQIAEHEAVLAGLPTPVVIDHLGRIPQPQGLDHP 210 ++ L A ++APLGWH+Q LM Q+ + LP P VIDH+G +P GL+HP Sbjct: 135 DAMENL---ASKIAPLGWHMQFLMDVRQLPALIPRMKKLPCPCVIDHMGHMPVSLGLNHP 191 Query: 211 GAQAILRLLAKGNTWIKLSEPYADTLQGPPDYPDTSLLARX------QRTLWGSDWPHPT 264 G Q +L ++ + W+KLS Y + Y D A+ R +WGSDWPH + Sbjct: 192 GYQTLLHMVREYGWWVKLSGAYRISESWQDGYLDVVPFAQKLIETAPDRMVWGSDWPHVS 251 Query: 265 EKIKPDDAVLFDLLAAWAPDPALRHQILVSNPASLFGF 302 PD L +LLAAW PD +R++ILV NPA L+ F Sbjct: 252 VSRMPDTGGLRNLLAAWVPDEQVRNRILVDNPARLYDF 289 >AGl3341 [R] COG3618 Predicted metal-dependent hydrolase of the TIM-barrel fold Atu Agrobacterium tumefaciens strain C58 (Cereon) Length = 292 Score = 120 bits (300), Expect = 5e-27, Method: Compositional matrix adjust. Identities = 75/240 (31%), Positives = 114/240 (47%), Gaps = 13/240 (5%) Query: 73 DYRRLMAKLGIARNVVVQPSTYGSDNRCLLDALTQFGAQARGIVVIDDDVELAQLKEMDQ 132 DYRRLM LGI R ++ Q + + DN L + + G A +V+ID ++++ Sbjct: 52 DYRRLMQWLGIDRVIITQGNAHQRDNGNTLACVAEMGEAAHAVVIIDATTTEKDMEKLTA 111 Query: 133 LGVRGVRVNFLSPQSWGITTVDRLLRTAKRVAPLGWHVQVLMSGAQIAEHEAVLAGLPTP 192 G G R+ L G + L +R W V V G + +H L + + Sbjct: 112 AGTVGARIMDLPG---GAVNLSELDAVDERAHAADWMVAVQFDGNGLLDHLPRLQKIRSR 168 Query: 193 VVIDHLGRIPQPQGLDHPGAQAILRLLAKGNTWIKLSEPYADTLQGPPDYPDTSLLARX- 251 V DH G+ + D P A+L+L+ +GN W K + Y + + P Y D + +R Sbjct: 169 WVFDHHGKFFKGIRTDGPEMAALLKLIDRGNLWFKFAGVYESSRKSWP-YADVAAFSRVI 227 Query: 252 -----QRTLWGSDWPHPTEK---IKPDDAVLFDLLAAWAPDPALRHQILVSNPASLFGFS 303 +R +WG++WPH + + PDDA L +L W PD A RH+ LV NP +LF S Sbjct: 228 AAHAPERIVWGTNWPHNSVRETAAYPDDARLAELTLGWLPDEAARHRALVENPEALFKLS 287 >RSp0233 [R] COG3618 Predicted metal-dependent hydrolase of the TIM-barrel fold Rso Ralstonia solanacearum Length = 302 Score = 107 bits (266), Expect = 5e-23, Method: Compositional matrix adjust. Identities = 94/320 (29%), Positives = 138/320 (43%), Gaps = 35/320 (10%) Query: 1 MVNRRQFLAG--SLLACTAARSAIAQSIPNSAGDQPPRLKAPALACDSHHHIYDARFPVS 58 M RR F G ++L TA + + +P A D+H H++ P++ Sbjct: 1 MPTRRAFNTGLLAMLGATALAGCVTRGMPAP--------TARITGIDTHAHVFKRGLPLA 52 Query: 59 PHWRGGRPDGATVADYRRLMAKLGIARNVVVQPSTYGSDNRCLLDALTQFGAQARGIVVI 118 R AT+ Y + G++ V++QPS G DN LL AL Q + RG+ VI Sbjct: 53 GARRYAPSYDATLPAYLAQLDAHGLSHGVLIQPSFLGGDNSYLLAALRQAPQRLRGVAVI 112 Query: 119 DDDVELAQLKEMDQLGVRGVRVNFLSPQSWGITTVDRLLR------TAKRVAPLGWHVQV 172 D L +++ G+ G+R+N I D LR R+ LGWHV++ Sbjct: 113 DPAAPEPFLAQLNAEGIVGIRLNL-------IGAPDPQLRAPAWQAALHRLHALGWHVEL 165 Query: 173 LMSGAQIAEHEAVLAGLPTPVVIDHLGRIPQPQGLDHPGAQAILRLLAKGNTWIKLSEPY 232 ++ L VV+DH GR ++ PG A+L W+K+S Y Sbjct: 166 HTQAHRLPALLPPLLEAQVDVVVDHFGRPDPALSVEDPGFAALLAAGRTRRVWVKVSGAY 225 Query: 233 ADTLQGPPDYPDTSLLARXQ------RTLWGSDWPHP--TEKIKPDDAVLF-DLLAAWAP 283 + G + + + R + R +WGSDWPH +I D A F D L P Sbjct: 226 RNGDAGRGEAIALAAMPRLKDALGTDRLVWGSDWPHTQYESRIGYDSARAFADTL---LP 282 Query: 284 DPALRHQILVSNPASLFGFS 303 D RHQ+LV PA LF F+ Sbjct: 283 DAGDRHQVLVETPARLFRFA 302 >Cgl0451 Non COG Length = 250 Score = 78.2 bits (191), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 59/178 (33%), Positives = 86/178 (48%), Gaps = 11/178 (6%) Query: 45 DSHHHIYDARFPVSPHWRGGRPDGATVADYRRLMAKLGIARNVVVQPSTYGSDNRCLLDA 104 DSH HI D + P+ + G P+ TV DY + L +A +V S D L DA Sbjct: 6 DSHFHIIDPQHPLIEN-NGYLPEPFTVEDYTARVEGLEVAGGAIVSGSFQAFDQGYLKDA 64 Query: 105 LTQFGAQARGIVVIDDDVELAQLKEMDQLGVRGVRVNFLSPQSWGITTVDRLLRTAKRVA 164 L G G+ I D ++ ++D+ GV+ VR+N S G+ ++ L R +A Sbjct: 65 LAVLGPGYVGVTQIPADTSDQEILDLDKAGVKAVRLNLKRGGSAGLDDLETLARRVHDLA 124 Query: 165 PLGWHVQVLMSGAQIAEHEAVLAGLPTPVVIDHLGRIPQPQGLDHPGAQAILRLLAKG 222 GWH ++ + ++ E E+ LA LP V IDHL GL G A+LRL+ G Sbjct: 125 --GWHTELYVDARELDELESTLASLPA-VSIDHL-------GLHRDGLPALLRLVENG 172