BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0012.0119.p (440 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSp0182 [GEPR] COG0477 Permeases of the major facilitator superf... 342 9e-94 STM1107 [GEPR] COG0477 Permeases of the major facilitator superf... 322 2e-87 YPO2237 [GEPR] COG0477 Permeases of the major facilitator superf... 304 2e-82 BMEII1096 [GEPR] COG0477 Permeases of the major facilitator supe... 304 3e-82 RSc2352 [GEPR] COG0477 Permeases of the major facilitator superf... 298 2e-80 >RSp0182 [GEPR] COG0477 Permeases of the major facilitator superfamily Rso Ralstonia solanacearum Length = 453 Score = 342 bits (877), Expect = 9e-94, Method: Compositional matrix adjust. Identities = 174/395 (44%), Positives = 251/395 (63%), Gaps = 7/395 (1%) Query: 11 EQETVRKVTWRLLPFLMLCYLFAFIDRGNIGMAALQMNHDIGLSPKMFGFASSLFFIAYF 70 E+ VRK+TWR+LPF+ Y+ +++DR NIG AALQMN ++ LS + FGF S +FFI YF Sbjct: 26 ERAIVRKITWRILPFVFALYIISYLDRANIGYAALQMNQELALSSEAFGFVSGIFFIGYF 85 Query: 71 IFEVPSNLALQKFGARKWLARIMVTWGLISACTAFVQGPTSLYFVRFILGAAEAGFFPGV 130 +FEVPSNL L +FGAR+W+ARI+VTWGL++ +AFVQ T LY +RF+LG AEAGFFPG+ Sbjct: 86 LFEVPSNLMLNRFGARRWIARILVTWGLVAMGSAFVQSATQLYALRFLLGVAEAGFFPGI 145 Query: 131 VLYLTYWVPSAYRARIVALFMVAIPAASFVASPVSALLLQMDGIGGLR--GWHWLFLLEG 188 ++YLTYW + A VALF AIP + V +P+S + MD + L+ GW W+ LLEG Sbjct: 146 IVYLTYWFRARELATTVALFTAAIPVSYVVGAPLSTWI--MDHVHWLQWSGWRWMLLLEG 203 Query: 189 LPTVLLGVVCLFFLTDRPDQARWLNDAQRQWLVATMNKEAASRTAKQHIPLWKLFSQPHV 248 P V+ G++C +L DRP ARWL++A+R WL+A + ++ +R A H+ K+ + P V Sbjct: 204 APAVIGGLLCYGYLADRPKDARWLSEAERDWLLAELERDRKARPAAAHLATLKVMTHPRV 263 Query: 249 WGMALVCACASAAGSVLNVWQPQLLKSF--GLTVMQTGLVNSIPYLVASVLMVWWGRHSD 306 +A + + W PQ++K F L+ + GL+ +PY+ A+ +M+WW R SD Sbjct: 264 LYLAFIYFVYQCGSLGIGYWMPQIIKGFSSALSHTEVGLIAMLPYVFATAVMIWWSRRSD 323 Query: 307 RTGERRWHTAIPLILIGGGLALASLANTLAPVVLLLTMVLIGAYSFKGPFWAMASTWLAT 366 ERR H+A+PL + A A + +L++ L G Y+FK PFWA+ + +L Sbjct: 324 LRAERRLHSAVPLGVAALAFVGAGFIGHPAVAMAMLSLSLAGLYAFKSPFWALPTLFLTR 383 Query: 367 GSAAAGLAGINAVSNLIGGGLMVNAYGWIKDATGS 401 +AA +A IN+V NL GG + A G+ K S Sbjct: 384 STAAVSIAVINSVGNL-GGFVGPFAIGYFKGQMHS 417 >STM1107 [GEPR] COG0477 Permeases of the major facilitator superfamily Sty Salmonella typhimurium LT2 Length = 458 Score = 322 bits (824), Expect = 2e-87, Method: Compositional matrix adjust. Identities = 180/434 (41%), Positives = 253/434 (58%), Gaps = 13/434 (2%) Query: 11 EQETVRKVTWRLLPFLMLCYLFAFIDRGNIGMAALQMNHDIGLSPKMFGFASSLFFIAYF 70 +Q + K+ RL+ FL + ++F+F+DR NIG A L M D+GLS MFG A++LF+ Y Sbjct: 25 QQTVINKLFRRLIVFLFVLFIFSFLDRINIGFAGLTMGQDLGLSATMFGLATTLFYATYV 84 Query: 71 IFEVPSNLALQKFGARKWLARIMVTWGLISACTAFVQGPTSLYFVRFILGAAEAGFFPGV 130 IF +PSN+ L GAR W+A IMV WG+ S T F GP SLY +R ++G EAGF PG+ Sbjct: 85 IFGIPSNVMLSIVGARHWIATIMVLWGIASTATMFAVGPKSLYVLRMLVGITEAGFLPGI 144 Query: 131 VLYLTYWVPSAYRARIVALFMVAIPAASFVASPVSALLLQMDGIGGLRGWHWLFLLEGLP 190 +LYLTYW P+ +RAR ALFM+A+PA + + S VS +L +DGI L GW WLFLLEG P Sbjct: 145 LLYLTYWFPAFFRARANALFMIAMPATTALGSIVSGYILSLDGIFNLHGWQWLFLLEGFP 204 Query: 191 TVLLGVVCLFFLTDRPDQARWLNDAQRQWLVATMNKE---------AASRTAKQHIPLWK 241 +VLLG++ F+L D P +A+WL ++ L M+ + A S A Q LW+ Sbjct: 205 SVLLGIMVWFYLDDTPAKAKWLTAEDKKCLQEMMDSDRLTLVQPEGAISHNAMQQRSLWR 264 Query: 242 LFSQPHVWGMALVCACASAAGSVLNVWQPQLLKSF--GLTVMQTGLVNSIPYLVASVLMV 299 P V L C + S +++W PQ+LKSF G + + GL+ +IP + + M+ Sbjct: 265 EVFTPIVLMYTLAYFCLTNTLSAISIWTPQILKSFNEGSSNITIGLLAAIPQICTILGMI 324 Query: 300 WWGRHSDRTGERRWHTAIPLILIGGGLALASLANTLAPVVLLLTMVLIGAYSFKGPFWAM 359 +W RHSD+ ER+ HTA+P + G LAS + +L + M G++S FW Sbjct: 325 YWSRHSDKHQERKHHTALPFLFAAAGWLLASATDHNLIQLLGIVMASTGSFSAMAIFWTT 384 Query: 360 ASTWLATGSAAAGLAGINAVSNLIGGGLMVNAYGWIKDATGSYAMALLPLVGLSVVSVAI 419 ++ + A G+A INA N IG L GW+KD TGS+ L + L VV AI Sbjct: 385 PDQSISLRARAIGIAVINATGN-IGSALSPFMIGWLKDITGSFNSGLWFVASLLVVGAAI 443 Query: 420 L-LVLSRKSRVAAT 432 + L+ + SR AT Sbjct: 444 IWLIPMKASRPRAT 457 >YPO2237 [GEPR] COG0477 Permeases of the major facilitator superfamily Ype Yersinia pestis Length = 436 Score = 304 bits (779), Expect = 2e-82, Method: Compositional matrix adjust. Identities = 165/431 (38%), Positives = 258/431 (59%), Gaps = 9/431 (2%) Query: 2 ETIQDDKRLEQET--VRKVTWRLLPFLMLCYLFAFIDRGNIGMAALQMNHDIGLSPKMFG 59 E++ +L++E RK W LLP LMLCY+ ++DR N+G A LQM D+ S ++G Sbjct: 7 ESLSQPTQLQEENNAYRKTVWHLLPLLMLCYVLNYLDRVNVGFAKLQMADDLQFSDTVYG 66 Query: 60 FASSLFFIAYFIFEVPSNLALQKFGARKWLARIMVTWGLISACTAFVQGPTSLYFVRFIL 119 + +FFI YF E+PSNL L + GAR W+ARIM+TWG+ISAC AFV P S Y +RF+L Sbjct: 67 LGAGMFFIGYFFLEIPSNLILHRVGARLWIARIMITWGIISACMAFVTTPMSFYVMRFLL 126 Query: 120 GAAEAGFFPGVVLYLTYWVPSAYRARIVALFMVAIPAASFVASPVSALLLQ-MDGIGGLR 178 G AEAGFFPG++LY++YW PS R R+ LF++++P + + +P+S ++Q +G G Sbjct: 127 GVAEAGFFPGIILYISYWFPSHRRGRVYGLFVISVPLSGIIGAPLSGWIMQYFNGFQGYA 186 Query: 179 GWHWLFLLEGLPTVLLGVVCLFFLTDRPDQARWLNDAQRQWLVATMNKEAASRTAKQHIP 238 GW W+F+LEG+P+VL+G++ ++ L DR A WL D ++ L + EAA H Sbjct: 187 GWQWMFILEGIPSVLVGILIIYKLKDRITHATWLTDKEKDILQTNIENEAAHYA---HSR 243 Query: 239 LWKLFSQPHVWGMALVCACASAAGSVLNVWQPQLLKSFGL-TVMQTGLVNSIPYLVASVL 297 L F QP VW + L+ C + + W P L++ G+ ++ G + +IP A+V Sbjct: 244 LRDAFLQPRVWLLTLIYFCLISGFYTIGFWLPTLIRDSGVKDILSIGFLTAIPSAAAAVT 303 Query: 298 MVWWGRHSDRTGERRWHTAIPLILIGGGLALAS-LANTLAPVVLLLTMVLIGAYSFKGPF 356 M+ R +DR ERRWH A+ +L G+ L++ ++ + ++ LT+ +GA S F Sbjct: 304 MIVVSRSADRLRERRWHLALTAVLGAVGIILSTYFSDNIVVAMVCLTIGAMGALSTIPLF 363 Query: 357 WAMASTWLATGSAAAGLAGINAVSNLIGGGLMVNAYGWIKDATGSYAMALLPLVGLSVVS 416 W++ + +L +AAAG+A IN+ NL GG + G++KD T S +L + + Sbjct: 364 WSLPTAFLGGSAAAAGIAFINSWGNL-GGFVAPYMMGYLKDLTQSTTTGMLIISTTLFIG 422 Query: 417 VAILLVLSRKS 427 A++ ++ K+ Sbjct: 423 AALVFLIPAKA 433 >BMEII1096 [GEPR] COG0477 Permeases of the major facilitator superfamily Bme Brucella melitensis Length = 451 Score = 304 bits (778), Expect = 3e-82, Method: Compositional matrix adjust. Identities = 170/424 (40%), Positives = 254/424 (59%), Gaps = 9/424 (2%) Query: 4 IQDDKRLEQETVRKVTWRLLPFLMLCYLFAFIDRGNIGMAALQMNHDIGLSPKMFGFASS 63 I + +E T RKV +R++P LM+CY+ A++DR N+G A LQM+ ++G S ++G + Sbjct: 26 ITSPEVVENMTYRKVAFRIIPLLMICYIIAYLDRVNVGFAKLQMSEELGFSEAIYGLGAG 85 Query: 64 LFFIAYFIFEVPSNLALQKFGARKWLARIMVTWGLISACTAFVQGPTSLYFVRFILGAAE 123 LFFI YF FE+PSN+ L K GAR W+ARIM+TWGL+SA AFVQ Y +RF+LGAAE Sbjct: 86 LFFIGYFFFEIPSNILLHKLGARLWIARIMITWGLLSALFAFVQTEWQFYILRFLLGAAE 145 Query: 124 AGFFPGVVLYLTYWVPSAYRARIVALFMVAIPAASFVASPVSA-LLLQMDGIGGLRGWHW 182 AGF+PGV+LYLTYW PS R + ALF PAA +P+S ++ Q G +GW W Sbjct: 146 AGFYPGVILYLTYWFPSHRRGNMFALFQAGSPAAGIFGNPLSGWIMDQFHDTAGWQGWQW 205 Query: 183 LFLLEGLPTVLLGVVCLFFLTDRPDQARWLNDAQRQWLVATMNKEAASRTAKQHIPLWKL 242 +F+LE +P V+LGVV L +L + A+WL + ++ + + + EA S+ L L Sbjct: 206 MFVLEAIPAVVLGVVILLYLDNSVKAAKWLTEEEKA--IISRDIEADSKGKAASHSLMSL 263 Query: 243 FSQPHVWGMALVCACASAAGSVLNVWQPQLLKSFGLTVMQT-GLVNSIPYLVASVLMVWW 301 P +W M L+ C L +W P L+++ G+T T GL+ +IP++ A + MV + Sbjct: 264 VKNPMLWVMMLIYFCFVMGQHGLTLWMPTLIRASGVTSNVTIGLLGAIPFICAIIAMVIF 323 Query: 302 GRHSDRTGERRWHTAIPLILIGGGLALASLANTLAPVVLLLTMVLIGAYSFKGPFWAMAS 361 R +D ERRWH +P +L G +A+ A ++ L+M G + FW++ + Sbjct: 324 SRSADHYRERRWHLVVPALLGAVGFVVAASATNTTVSIIFLSMAAAGVLACAPLFWSLPT 383 Query: 362 TWLATGSAAAGLAGINAVSNLIGGGLMVNAY--GWIKDATGSYAMALLPLVGLSVVSVAI 419 L+ +AAAG+A IN+V+NL G ++ Y G I+DAT S + + L G ++ AI Sbjct: 384 AILSGAAAAAGIALINSVANLAG---FISPYMVGIIRDATHSSELGMYVLAGFLILGAAI 440 Query: 420 LLVL 423 +L + Sbjct: 441 VLCI 444 >RSc2352 [GEPR] COG0477 Permeases of the major facilitator superfamily Rso Ralstonia solanacearum Length = 442 Score = 298 bits (762), Expect = 2e-80, Method: Compositional matrix adjust. Identities = 170/400 (42%), Positives = 245/400 (61%), Gaps = 7/400 (1%) Query: 5 QDDKRLEQETVRKVTWRLLPFLMLCYLFAFIDRGNIGMAALQMNHDIGLSPKMFGFASSL 64 Q E+ T RKV+WRL+PFL+LCY+ A++DR N+G A LQM +D+ S ++G + + Sbjct: 18 QSASGFEEATYRKVSWRLIPFLLLCYVVAYLDRVNVGFAKLQMLNDLKFSETVYGLGAGI 77 Query: 65 FFIAYFIFEVPSNLALQKFGARKWLARIMVTWGLISACTAFVQGPTSLYFVRFILGAAEA 124 FFI YF+FEVPSN+ L + GAR W+ARIM++WGLISA FV P Y +RF+LG AEA Sbjct: 78 FFIGYFLFEVPSNVILHRVGARMWIARIMISWGLISAAMMFVTTPAMFYVMRFLLGLAEA 137 Query: 125 GFFPGVVLYLTYWVPSAYRARIVALFMVAIPAASFVASPVSALLLQ-MDGIGGLRGWHWL 183 GFFPG++LYLTYW P+ R R FM A+ + + P+S L+ G+ GL GW W+ Sbjct: 138 GFFPGIILYLTYWYPAERRGRTTTFFMTAVALSGVIGGPISGWALKTFGGVYGLAGWQWM 197 Query: 184 FLLEGLPTVLLGVVCLFFLTDRPDQARWLNDAQRQWLVATMNKEAASRTAKQHIPLWKLF 243 FL+EG+P+V++G+ L +L +R ARWL D ++ L + E A K+ P+ + Sbjct: 198 FLIEGIPSVVIGLCVLAYLDNRISHARWLTDEEKALLTRNIAAEEAQ---KEDAPIAAIM 254 Query: 244 SQPHVWGMALVCACASAAGSVLNVWQPQLLKSFGL-TVMQTGLVNSIPYLVASVLMVWWG 302 + P VW M+L+ ++ W P L+K G+ + GL+ +IPY A V MV Sbjct: 255 ASPRVWLMSLIYFSFVMGLYGVSFWLPTLIKQTGVADPLSVGLLTAIPYGAAVVAMVLVA 314 Query: 303 RHSDRTGERRWHTAIPLILIGGGLALASLANTLAPVVL-LLTMVLIGAYSFKGPFWAMAS 361 R +DRT ERRWH AIP + GL L+++ +T + + LT+ +G + FW++ + Sbjct: 315 RSADRTRERRWHIAIPALAGAIGLVLSAVWHTNTTLAMAALTLGTMGILTTLPLFWSLPT 374 Query: 362 TWLATGSAAAGLAGINAVSNLIGGGLMVNAYGWIKDATGS 401 +LA AAAG+A IN++ NL G L A GW+KD T S Sbjct: 375 AFLAGTGAAAGIALINSLGNL-AGFLSPYAVGWLKDTTRS 413