BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0012.0115.p (435 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value YPO2237 [GEPR] COG0477 Permeases of the major facilitator superf... 304 2e-82 RSp0182 [GEPR] COG0477 Permeases of the major facilitator superf... 299 7e-81 RSc2352 [GEPR] COG0477 Permeases of the major facilitator superf... 290 3e-78 BMEII1096 [GEPR] COG0477 Permeases of the major facilitator supe... 283 4e-76 AGc4908 [GEPR] COG0477 Permeases of the major facilitator superf... 274 3e-73 >YPO2237 [GEPR] COG0477 Permeases of the major facilitator superfamily Ype Yersinia pestis Length = 436 Score = 304 bits (779), Expect = 2e-82, Method: Compositional matrix adjust. Identities = 164/377 (43%), Positives = 235/377 (62%), Gaps = 13/377 (3%) Query: 1 MSQVSTQAAAHAAAAGTIAAVSEEAIMKKVMRRLIPFILLCYVVSYLDRINVGFAALTMN 60 MS+ ST++ + E +K + L+P ++LCYV++YLDR+NVGFA L M Sbjct: 1 MSESSTESLSQPTQLQ-----EENNAYRKTVWHLLPLLMLCYVLNYLDRVNVGFAKLQMA 55 Query: 61 KDLGLTPSQFGLGAGLFFIGYFFFEIPSNLALHRFGARMWISRIMISWGVISMATAFVVG 120 DL + + +GLGAG+FFIGYFF EIPSNL LHR GAR+WI+RIMI+WG+IS AFV Sbjct: 56 DDLQFSDTVYGLGAGMFFIGYFFLEIPSNLILHRVGARLWIARIMITWGIISACMAFVTT 115 Query: 121 PKSFALARFLLGMAEAGFTPGIYLYFTQWFPGAWRGKATAFFLIGIPVANIIGSPLSGAL 180 P SF + RFLLG+AEAGF PGI LY + WFP RG+ F+I +P++ IIG+PLSG + Sbjct: 116 PMSFYVMRFLLGVAEAGFFPGIILYISYWFPSHRRGRVYGLFVISVPLSGIIGAPLSGWI 175 Query: 181 ME-LHGMWGFKGWQVLLLLEALPAVLLGVLCLFLLPDRPSKAAWLTPSEKQWLENELSTE 239 M+ +G G+ GWQ + +LE +P+VL+G+L ++ L DR + A WLT EK L+ + E Sbjct: 176 MQYFNGFQGYAGWQWMFILEGIPSVLVGILIIYKLKDRITHATWLTDKEKDILQTNIENE 235 Query: 240 QNVLAARHGN-KLKDAFTNWRVFALAGANFCGIIGSLSIGLWLPQIIREFGLPS-HQVGL 297 AA + + +L+DAF RV+ L FC I G +IG WLP +IR+ G+ +G Sbjct: 236 ----AAHYAHSRLRDAFLQPRVWLLTLIYFCLISGFYTIGFWLPTLIRDSGVKDILSIGF 291 Query: 298 VAAIPYLVGAVAMTLWARLANRSAHRLFFVAGAIVLAALSLAISAFLHTPL-LKMLAITI 356 + AIP AV M + +R A+R R + +A VL A+ + +S + + + M+ +TI Sbjct: 292 LTAIPSAAAAVTMIVVSRSADRLRERRWHLALTAVLGAVGIILSTYFSDNIVVAMVCLTI 351 Query: 357 AVASILSFQATFWAIPS 373 LS FW++P+ Sbjct: 352 GAMGALSTIPLFWSLPT 368 >RSp0182 [GEPR] COG0477 Permeases of the major facilitator superfamily Rso Ralstonia solanacearum Length = 453 Score = 299 bits (766), Expect = 7e-81, Method: Compositional matrix adjust. Identities = 167/381 (43%), Positives = 238/381 (62%), Gaps = 11/381 (2%) Query: 6 TQAAAHAAAAGTIAAV-----SEEAIMKKVMRRLIPFILLCYVVSYLDRINVGFAALTMN 60 TQA+A A A GTIAA E AI++K+ R++PF+ Y++SYLDR N+G+AAL MN Sbjct: 4 TQASAGAPAVGTIAARHPAAPDERAIVRKITWRILPFVFALYIISYLDRANIGYAALQMN 63 Query: 61 KDLGLTPSQFGLGAGLFFIGYFFFEIPSNLALHRFGARMWISRIMISWGVISMATAFVVG 120 ++L L+ FG +G+FFIGYF FE+PSNL L+RFGAR WI+RI+++WG+++M +AFV Sbjct: 64 QELALSSEAFGFVSGIFFIGYFLFEVPSNLMLNRFGARRWIARILVTWGLVAMGSAFVQS 123 Query: 121 PKSFALARFLLGMAEAGFTPGIYLYFTQWFPGAWRGKATAFFLIGIPVANIIGSPLSGAL 180 RFLLG+AEAGF PGI +Y T WF A F IPV+ ++G+PLS + Sbjct: 124 ATQLYALRFLLGVAEAGFFPGIIVYLTYWFRARELATTVALFTAAIPVSYVVGAPLSTWI 183 Query: 181 MELHGMW-GFKGWQVLLLLEALPAVLLGVLCLFLLPDRPSKAAWLTPSEKQWLENELSTE 239 M+ H W + GW+ +LLLE PAV+ G+LC L DRP A WL+ +E+ WL EL + Sbjct: 184 MD-HVHWLQWSGWRWMLLLEGAPAVIGGLLCYGYLADRPKDARWLSEAERDWLLAELERD 242 Query: 240 QNVL-AARHGNKLKDAFTNWRVFALAGANFCGIIGSLSIGLWLPQIIREF--GLPSHQVG 296 + AA H LK T+ RV LA F GSL IG W+PQII+ F L +VG Sbjct: 243 RKARPAAAHLATLK-VMTHPRVLYLAFIYFVYQCGSLGIGYWMPQIIKGFSSALSHTEVG 301 Query: 297 LVAAIPYLVGAVAMTLWARLANRSAHRLFFVAGAIVLAALSLAISAFLHTPLLKMLAITI 356 L+A +PY+ M W+R ++ A R A + +AAL+ + F+ P + M +++ Sbjct: 302 LIAMLPYVFATAVMIWWSRRSDLRAERRLHSAVPLGVAALAFVGAGFIGHPAVAMAMLSL 361 Query: 357 AVASILSFQATFWAIPSGFLT 377 ++A + +F++ FWA+P+ FLT Sbjct: 362 SLAGLYAFKSPFWALPTLFLT 382 >RSc2352 [GEPR] COG0477 Permeases of the major facilitator superfamily Rso Ralstonia solanacearum Length = 442 Score = 290 bits (743), Expect = 3e-78, Method: Compositional matrix adjust. Identities = 162/354 (45%), Positives = 224/354 (63%), Gaps = 6/354 (1%) Query: 23 EEAIMKKVMRRLIPFILLCYVVSYLDRINVGFAALTMNKDLGLTPSQFGLGAGLFFIGYF 82 EEA +KV RLIPF+LLCYVV+YLDR+NVGFA L M DL + + +GLGAG+FFIGYF Sbjct: 24 EEATYRKVSWRLIPFLLLCYVVAYLDRVNVGFAKLQMLNDLKFSETVYGLGAGIFFIGYF 83 Query: 83 FFEIPSNLALHRFGARMWISRIMISWGVISMATAFVVGPKSFALARFLLGMAEAGFTPGI 142 FE+PSN+ LHR GARMWI+RIMISWG+IS A FV P F + RFLLG+AEAGF PGI Sbjct: 84 LFEVPSNVILHRVGARMWIARIMISWGLISAAMMFVTTPAMFYVMRFLLGLAEAGFFPGI 143 Query: 143 YLYFTQWFPGAWRGKATAFFLIGIPVANIIGSPLSG-ALMELHGMWGFKGWQVLLLLEAL 201 LY T W+P RG+ T FF+ + ++ +IG P+SG AL G++G GWQ + L+E + Sbjct: 144 ILYLTYWYPAERRGRTTTFFMTAVALSGVIGGPISGWALKTFGGVYGLAGWQWMFLIEGI 203 Query: 202 PAVLLGVLCLFLLPDRPSKAAWLTPSEKQWLENELSTEQNVLAARHGNKLKDAFTNWRVF 261 P+V++G+ L L +R S A WLT EK L ++ E+ A + + + RV+ Sbjct: 204 PSVVIGLCVLAYLDNRISHARWLTDEEKALLTRNIAAEE---AQKEDAPIAAIMASPRVW 260 Query: 262 ALAGANFCGIIGSLSIGLWLPQIIREFGLPSH-QVGLVAAIPYLVGAVAMTLWARLANRS 320 ++ F ++G + WLP +I++ G+ VGL+ AIPY VAM L AR A+R+ Sbjct: 261 LMSLIYFSFVMGLYGVSFWLPTLIKQTGVADPLSVGLLTAIPYGAAVVAMVLVARSADRT 320 Query: 321 AHRLFFVAGAIVLAALSLAISAFLHT-PLLKMLAITIAVASILSFQATFWAIPS 373 R + +A + A+ L +SA HT L M A+T+ IL+ FW++P+ Sbjct: 321 RERRWHIAIPALAGAIGLVLSAVWHTNTTLAMAALTLGTMGILTTLPLFWSLPT 374 >BMEII1096 [GEPR] COG0477 Permeases of the major facilitator superfamily Bme Brucella melitensis Length = 451 Score = 283 bits (725), Expect = 4e-76, Method: Compositional matrix adjust. Identities = 150/370 (40%), Positives = 228/370 (61%), Gaps = 4/370 (1%) Query: 6 TQAAAHAAAAGTIAAVSEEAIMKKVMRRLIPFILLCYVVSYLDRINVGFAALTMNKDLGL 65 +A ++ A T V E +KV R+IP +++CY+++YLDR+NVGFA L M+++LG Sbjct: 16 VKAMKNSNTAITSPEVVENMTYRKVAFRIIPLLMICYIIAYLDRVNVGFAKLQMSEELGF 75 Query: 66 TPSQFGLGAGLFFIGYFFFEIPSNLALHRFGARMWISRIMISWGVISMATAFVVGPKSFA 125 + + +GLGAGLFFIGYFFFEIPSN+ LH+ GAR+WI+RIMI+WG++S AFV F Sbjct: 76 SEAIYGLGAGLFFIGYFFFEIPSNILLHKLGARLWIARIMITWGLLSALFAFVQTEWQFY 135 Query: 126 LARFLLGMAEAGFTPGIYLYFTQWFPGAWRGKATAFFLIGIPVANIIGSPLSGALME-LH 184 + RFLLG AEAGF PG+ LY T WFP RG A F G P A I G+PLSG +M+ H Sbjct: 136 ILRFLLGAAEAGFYPGVILYLTYWFPSHRRGNMFALFQAGSPAAGIFGNPLSGWIMDQFH 195 Query: 185 GMWGFKGWQVLLLLEALPAVLLGVLCLFLLPDRPSKAAWLTPSEKQWLENELSTEQNVLA 244 G++GWQ + +LEA+PAV+LGV+ L L + A WLT EK + ++ + A Sbjct: 196 DTAGWQGWQWMFVLEAIPAVVLGVVILLYLDNSVKAAKWLTEEEKAIISRDIEADSKGKA 255 Query: 245 ARHGNKLKDAFTNWRVFALAGANFCGIIGSLSIGLWLPQIIREFGLPSH-QVGLVAAIPY 303 A H L N ++ + FC ++G + LW+P +IR G+ S+ +GL+ AIP+ Sbjct: 256 ASH--SLMSLVKNPMLWVMMLIYFCFVMGQHGLTLWMPTLIRASGVTSNVTIGLLGAIPF 313 Query: 304 LVGAVAMTLWARLANRSAHRLFFVAGAIVLAALSLAISAFLHTPLLKMLAITIAVASILS 363 + +AM +++R A+ R + + +L A+ ++A + ++ +++A A +L+ Sbjct: 314 ICAIIAMVIFSRSADHYRERRWHLVVPALLGAVGFVVAASATNTTVSIIFLSMAAAGVLA 373 Query: 364 FQATFWAIPS 373 FW++P+ Sbjct: 374 CAPLFWSLPT 383 >AGc4908 [GEPR] COG0477 Permeases of the major facilitator superfamily Atu Agrobacterium tumefaciens strain C58 (Cereon) Length = 487 Score = 274 bits (701), Expect = 3e-73, Method: Compositional matrix adjust. Identities = 139/356 (39%), Positives = 214/356 (60%), Gaps = 1/356 (0%) Query: 21 VSEEAIMKKVMRRLIPFILLCYVVSYLDRINVGFAALTMNKDLGLTPSQFGLGAGLFFIG 80 VSE+A++ K+ RL+PF+ L Y+++Y+DR NV +A L M L L+ +GLGA LFFIG Sbjct: 64 VSEKALISKITWRLMPFLGLLYLIAYIDRQNVSYAKLQMVDALSLSEYAYGLGASLFFIG 123 Query: 81 YFFFEIPSNLALHRFGARMWISRIMISWGVISMATAFVVGPKSFALARFLLGMAEAGFTP 140 YF FE+PSNL L+RFGA W +RI++SWG +++A A+ F + RFLLG+ EAGF P Sbjct: 124 YFLFEVPSNLFLNRFGASKWFARILVSWGAVTIALAYTQNATMFYILRFLLGLCEAGFFP 183 Query: 141 GIYLYFTQWFPGAWRGKATAFFLIGIPVANIIGSPLSGALMELHGMWGFKGWQVLLLLEA 200 G+ T WFP +RG+ F+I +AN +G+PL G L++L G G+ GW+ + L Sbjct: 184 GVLFLMTLWFPRDYRGRMIGLFMIFSALANAVGAPLGGMLLDLDGFLGYAGWEWVFLATG 243 Query: 201 LPAVLLGVLCLFLLPDRPSKAAWLTPSEKQWLENELSTEQNVLAARHGNKLKDAFTNWRV 260 +PAV+ G++ F L D P KA +LT EK WL+N L+ E+N H A N RV Sbjct: 244 IPAVIAGIVTFFYLDDTPDKAKFLTQDEKDWLKNRLA-EENKGMEEHAEDGFKALVNPRV 302 Query: 261 FALAGANFCGIIGSLSIGLWLPQIIREFGLPSHQVGLVAAIPYLVGAVAMTLWARLANRS 320 +A + + + WLP I++ FG+ + G + IP+++ A+A+ + A+++ Sbjct: 303 LFMALCYVGFPLAAYGLSYWLPTIVKSFGVSNTTNGFINIIPWIIVAIALFVVPSAADKA 362 Query: 321 AHRLFFVAGAIVLAALSLAISAFLHTPLLKMLAITIAVASILSFQATFWAIPSGFL 376 ++ ++ G + A L +SA L P+L+ + +A A I + Q FW++P FL Sbjct: 363 KNKTPYIVGPAFVGAFCLLMSALLSDPVLQFAFLCVAAAGIFAGQPVFWSLPGRFL 418