BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0012.0072.p (593 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value PA2265 [E] COG2303 Choline dehydrogenase and related flavoprotei... 829 0.0 Cj0415 [E] COG2303 Choline dehydrogenase and related flavoprotei... 410 e-114 RSp0904 [E] COG2303 Choline dehydrogenase and related flavoprote... 127 8e-29 AGl980 [E] COG2303 Choline dehydrogenase and related flavoprotei... 112 2e-24 VNG1035C [E] COG2303 Choline dehydrogenase and related flavoprot... 110 8e-24 >PA2265 [E] COG2303 Choline dehydrogenase and related flavoproteins Pae Pseudomonas aeruginosa Length = 591 Score = 829 bits (2142), Expect = 0.0, Method: Compositional matrix adjust. Identities = 392/588 (66%), Positives = 472/588 (80%), Gaps = 1/588 (0%) Query: 6 MKAVDVVIVGFGWTGAIMAKEMTEAGQSVVALERGVYRDTYPDGAYPKTINELEYQQRFK 65 +K VD V+VGFGWTGAI+AKE+TEAG +VVALERG RDTYPDGAYP T++EL Y R K Sbjct: 5 LKPVDAVVVGFGWTGAILAKELTEAGLNVVALERGENRDTYPDGAYPNTLDELTYNTRGK 64 Query: 66 LFQNLNKSSFTFRRKTGDSAIPYRQIAMFKPGEGVGGAGLHWSGCHWRILPEELRMRSHY 125 LFQNL+KS+ + R D+A+PYRQ++ F PG+GVGGAGLHWSG H+RI+PEELR+RSHY Sbjct: 65 LFQNLSKSTVSIRHGINDTALPYRQLSAFLPGDGVGGAGLHWSGVHFRIMPEELRLRSHY 124 Query: 126 EERYGKGFIPKDMTLQDWGVTYEELEPYFDFAEKMMGTSGTAYRVGGKVVDDSGNPFEAN 185 EERYGK FIP+ MT+QD+GV+YEELEP+FDFAEK+ GTSGTA+ V G+VV GNPF A+ Sbjct: 125 EERYGKKFIPEGMTIQDYGVSYEELEPHFDFAEKVFGTSGTAHTVKGQVVG-KGNPFAAD 183 Query: 186 RSDNFPLPAQKEQYQAALFRKAAQQAGFHPFTLPSANASAPYVNQYGCQMGPCTFCGYCS 245 RSD+FPLPA ++ Y A LFRKAA++ G HP+ LP+ANAS P+ N YG QMGPC FCG+CS Sbjct: 184 RSDDFPLPALRQVYSAQLFRKAAEELGLHPYDLPAANASGPWTNPYGVQMGPCNFCGFCS 243 Query: 246 GYACYNYSKASPNVNIMPALRKSALFELRSSCNVLRIELDSTRKKATGVTYVDANGDTVF 305 GYACY YSKASPN+NI+PALR++ LFELR++CNVL++ LDS ++ATGVTYVDA G + Sbjct: 244 GYACYMYSKASPNLNILPALRQTPLFELRANCNVLKVNLDSDGRQATGVTYVDAQGREIV 303 Query: 306 QPANIVIASTFAYNNARLFLLSGIGKPYDPVSNTGAVGRNIAFQMMSTINAFFDPGKNIN 365 QPA +VI S F ++N RL LLSGIGKPYDP + G VG+N A+Q M+TI AFFD + N Sbjct: 304 QPAKLVIISAFQFHNVRLLLLSGIGKPYDPRTGEGVVGKNFAYQNMATIKAFFDKDVHTN 363 Query: 366 GFIGAGGNGVAVDDFNGDHMDHGPLGFVGGSPIWCNPAGAKPISGIAVPSGTPKWGRDWK 425 F+G GG GVAVDDFN D+ DHGPLGFVGGSP+W N AG+KPI G+AVP GTP WG WK Sbjct: 364 PFVGTGGGGVAVDDFNADNFDHGPLGFVGGSPMWVNQAGSKPIGGLAVPPGTPSWGSGWK 423 Query: 426 RAVKASYLNTMSFDVHGANMVYRDVYVDLDPNYKDAFGQPLLRFTFDWKDNDIRMSRYVT 485 +AVK +Y +T+S D HG+NM YRD Y+DLDP YKDA+GQPLLR TFDWKDN+IRMSRYVT Sbjct: 424 QAVKDAYTHTVSMDAHGSNMTYRDNYLDLDPTYKDAYGQPLLRMTFDWKDNEIRMSRYVT 483 Query: 486 DQAVKIAHELKAREIKVTVKDFGAAPDLRSYQTTHWAGGVAMGTDPSTSVVNRYLQSWDV 545 + KIA + + I V+VK+FG + R YQTTH GG MG+DP TSV+NRYLQSWDV Sbjct: 484 EHMRKIAEAMNPKAISVSVKNFGDHFNTRVYQTTHLLGGAIMGSDPKTSVLNRYLQSWDV 543 Query: 546 HNVFAVGSGVFAQGIGYNPTGAAVALTYWSARAIREQYLKDPRPLVSA 593 HNVF +G+ F QG GYNPTG AL YWSA+AIREQYLK+P PLV A Sbjct: 544 HNVFVMGASAFPQGTGYNPTGLVAALAYWSAKAIREQYLKNPGPLVQA 591 >Cj0415 [E] COG2303 Choline dehydrogenase and related flavoproteins Cje Campylobacter jejuni Length = 573 Score = 410 bits (1055), Expect = e-114, Method: Compositional matrix adjust. Identities = 221/589 (37%), Positives = 332/589 (56%), Gaps = 25/589 (4%) Query: 6 MKAVDVVIVGFGWTGAIMAKEMTEAGQSVVALERGVYRDTYPDGAYPKTINELEYQQRFK 65 +K VDVV VG GWTG I+A E+T+AG +V++LERG + T + +E Y + Sbjct: 5 LKKVDVVTVGAGWTGGIVAAELTKAGLNVLSLERGHMQST---ENFNYIHDEWRYGINYG 61 Query: 66 LFQNLNKSSFTFRRKTGDSAIPYRQIAMFKPGEGVGGAGLHWSGCHWRILPEELRMRSHY 125 L Q+ +K + TFR A+PYR++ F G VGGAG+HW+G +R +P + +++ Sbjct: 62 LMQDCSKDTVTFRHDPSGLALPYRKMGSFLLGNNVGGAGVHWNGWTFRFMPYDFEIQTLS 121 Query: 126 EERYGKGFIPKDMTLQDWGVTYEELEPYFDFAEKMMGTSGTAYRVGGKVVDDSGNPFEAN 185 ++RYG + D TLQDWGVTY+++EPY+D EK G SG + K+ A Sbjct: 122 KQRYGNK-LGNDYTLQDWGVTYKDMEPYYDRFEKTCGVSGEPNPLAEKM--------GAF 172 Query: 186 RSDNFPLPAQKEQYQAALFRKAAQQAGFHPFTLPSANASAPYVNQYGCQMGPCTFCGYCS 245 RS +P + F AA+ + H + LP++N+ Y N G + PC +C YC Sbjct: 173 RSSPYPQEPLENTKMLKRFESAAKSSNLHTYRLPASNSKGGYTNPDGQDLAPCQYCAYCE 232 Query: 246 GYACYNYSKASPNVNIMPALRKSALFELRSSCNVLRIELDSTRKKATGVTYVDANG-DTV 304 + C +KASP ++P + + +R+ NV +I K TGV +VD Sbjct: 233 RFGCEYGAKASPLNTVIPKAMSTGKYTIRTYSNVTQIL--KKDGKVTGVKFVDTRTMKEY 290 Query: 305 FQPANIVIASTFAYNNARLFLLSGIGKPYDPVSNTGAVGRNIAFQMMSTINAFFDPGKNI 364 QPA+IV+ +++ +NNA+L ++S IG+ YDP + G +GRN +QM AFFD + Sbjct: 291 IQPADIVVLTSYMFNNAKLLMVSNIGEQYDPKTGKGTLGRNYCYQMNMGTTAFFD--EQF 348 Query: 365 NGFIGAGGNGVAVDDFNGDHMDHGPLGFVGGSPIWCNPAGAKPISGIAVPSGTPKWGRDW 424 N F+G+G G DDFNGD+ DH F+ G+ I+ G +PI +P+G P WG ++ Sbjct: 349 NTFMGSGALGTTSDDFNGDNFDHSKEKFLHGAMIYSVQLGTRPIQSAPLPAGAPTWGAEF 408 Query: 425 KRAVKASYLNTMSFDVHGANMVYRDVYVDLDPNYKDAFGQPLLRFTFDWKDNDIRMSRYV 484 K+A+ ++ ++ GA++ +++ Y+ LDP YKDAFG PLLR T+++ D D + +++ Sbjct: 409 KKALNYNFTRAITVGGQGASLPHKNNYLSLDPTYKDAFGMPLLRLTYNFTDQDRALHKFI 468 Query: 485 TDQAVKIAHELK-AREIK--VTVKDFGAAPDLRSYQTTHWAGGVAMGTDPSTSVVNRYLQ 541 TD+ ++A ++ + IK +KD+ P YQ+TH GG MG D TSVVN YLQ Sbjct: 469 TDKTAEVAKRMQGVKSIKKGAYLKDYSVVP----YQSTHNTGGTTMGADRETSVVNTYLQ 524 Query: 542 SWDVHNVFAVGSGVFAQGIGYNPTGAAVALTYWSARAIREQYLKDPRPL 590 WD N+F VG+G F GYNPT AL Y A I +Y K + L Sbjct: 525 HWDADNLFVVGAGNFQHNSGYNPTDTVGALAYRCAEGIL-KYHKSGKSL 572 >RSp0904 [E] COG2303 Choline dehydrogenase and related flavoproteins Rso Ralstonia solanacearum Length = 647 Score = 127 bits (319), Expect = 8e-29, Method: Compositional matrix adjust. Identities = 142/548 (25%), Positives = 218/548 (39%), Gaps = 91/548 (16%) Query: 97 GEGVGGAGLHWSGCHWRILPEELRMRSHYEERYGKGFIPKD-MTLQDWGVTYEELEPYFD 155 G +GG + W +R LP + R++++YE G + K+ + DW + Y+E+ PYF Sbjct: 96 GSVLGGGSVLWGTWSFRPLPIDFRLKTYYERTGELGQLQKEGYNVADWPLAYQEMMPYFH 155 Query: 156 FAEKMMGTSG-----------------TAYRVGGKV---VDDSGNPFEANRSDNFPLPAQ 195 AE ++G SG R GG+ D P A FPL A Sbjct: 156 VAETLLGVSGDRAGMNRSIRESAWYQDLRTRFGGEAWFGTDAQWLPDAA-----FPLGAY 210 Query: 196 KEQYQAALFRKAAQQAGFHPFTLPSA------------NASAPYVNQYGCQMG------- 236 + G HPF P+A A A +NQ+ ++ Sbjct: 211 PTTPVGRIVSDGMDHKGMHPFPTPTAIVQPGSAGFGTQAAIANALNQHRDELDGVLWNRP 270 Query: 237 -----------PCTFCGYCSGYACYNYS--KASPNVNIMPALRKSALFELRSSCNVLRIE 283 C CGYC Y C+ + K + L + E+R + L + Sbjct: 271 AEQLWSSQIRQACNMCGYCGEYLCWGRTSPKWGTADTTLRELGQRDNAEIRCNAKTLEVL 330 Query: 284 LDSTRKKATGVTYVDANG----DTVFQPANIVIASTFAYNNARLFLLSGIGKPYDPVSNT 339 D+ ++ATGV Y+D V Q A VI S A +RL LLSG P +++ Sbjct: 331 YDAASRRATGVAYLDLTDPDHPRRVEQFAETVIISCGAVQTSRLLLLSG--PPEGLGNSS 388 Query: 340 GAVGRNIAFQM----MSTINAFFDPGKNINGFIGAGGNGVAVDDFNGDHMDHGPLGFVGG 395 G +GRN F + M T+ G+ ++G +G GN D + + G ++ G Sbjct: 389 GQLGRNAMFHLFGLGMRTVLGEAFQGR-LHGELGPTGNTSTFDTY---FVRDGDGRWIKG 444 Query: 396 SPIWCNPAGAKPIS-GIAVPSGTPKWGRDWKRAVKASYLNTMSFDVH--GANMVYRDVYV 452 + + A P+ + +G+ K G + +N +F++ G ++ + V Sbjct: 445 GHL-TSAAKKNPLEDAVNAVNGSSKAGA----FLDQLLVNNRTFEIRLTGDDLPCPENRV 499 Query: 453 DLDPNYKDAFGQPLLRFTFDWKDNDIRMSRYV----------TDQAVKIAHELKAREIKV 502 LDP + D +G P+ R + +D +++V A+K EL A Sbjct: 500 SLDPTHVDEYGVPVARISRR-SISDAAGNKFVGPNEQRLDAAAQGAMKAVFELYAARRGA 558 Query: 503 TVKDFGAAPDLRSYQTTHWAGGVAMGTDPSTSVVNRYLQSWDVHNVFAVGSGVFAQGIGY 562 + S H G MG DP+TSVVNRY + DV NVF V S G+G Sbjct: 559 LAAAPKPTQAILSLVGDHQMGTCRMGEDPATSVVNRYGRLHDVENVFVVDSSFMPTGLGL 618 Query: 563 NPTGAAVA 570 NP VA Sbjct: 619 NPMVTVVA 626 >AGl980 [E] COG2303 Choline dehydrogenase and related flavoproteins Atu Agrobacterium tumefaciens strain C58 (Cereon) Length = 561 Score = 112 bits (281), Expect = 2e-24, Method: Compositional matrix adjust. Identities = 147/594 (24%), Positives = 226/594 (38%), Gaps = 86/594 (14%) Query: 10 DVVIVGFGWTGAIMAKEMTEAGQSVVALERGVYRDTYPDGAYPKTINE-LEYQQRFKLFQ 68 D ++VG G +G AKE+T+ G V+ LERG + D Y E +Y R + Q Sbjct: 7 DAIVVGSGISGGWAAKELTQKGLKVLMLERGRNIEHVTD--YQNADKEAWDYPHRNRATQ 64 Query: 69 NLNKSSFTFRRK-----------TGDSAIPYRQIAMFK--PGEGVGGAGLHWSGCHWRIL 115 + R + PY + F G VGG L W +R Sbjct: 65 EMKAKYPVLSRDYLLEEATLGMWADEQETPYVEEKRFDWFRGYHVGGRSLLWGRQTYRWS 124 Query: 116 PEELRMRSHYEERYGKGFIPKDMTLQDWGVTYEELEPYFDFAEKMMGTSGTAYRVGGKVV 175 + + KD DW + YE++ P++D+ E+ G SG+ R G ++ Sbjct: 125 QTDFEANA------------KDGIAVDWPIRYEDVSPWYDYVERFAGISGS--REGLDIL 170 Query: 176 DDSGNPFEANRSDNF--PLPAQKEQYQAALFRKAAQQAGFHPFTLPSANASAPYVNQYGC 233 D F P+P + A K A + H AN + +Q Sbjct: 171 PDG----------EFLPPIPLNFVEQDVASRLKKAFKGTRHLINSRCANITQELPDQ--- 217 Query: 234 QMGPCTFCGYCSGYACYNYSKASPNVNIMPALRKSALFELRSSCNVLRIELDSTRKKATG 293 + PC F C C S + +PA + LR V I D +KKA G Sbjct: 218 ERTPCQFRNKCR-LGCPFGGYFSTQASTLPAAVATGNLTLRPFSIVKEILYDKDKKKARG 276 Query: 294 VTYVDAN--------GDTVFQPANIVIASTFAYNNARLFLLSGIGKPYDPVSNTGAVGRN 345 V +DA D +F A+ + ++ N+A G+G S++G +G N Sbjct: 277 VEIIDAETNLTYEYTADIIFLNASTLNSTWVLMNSATDVWEGGLG------SSSGELGHN 330 Query: 346 IA---FQMMST--INAFFDPGKNINGFIGAGGNGVAVDDF--NGDHMDHGPLGFVGGSPI 398 + F+M +T ++ F D F G G + F GD GF G Sbjct: 331 VMDHHFRMGATGQVDGFED-----FYFKGRRPAGFYIPRFRNTGDDKRKYLRGF-GYQGS 384 Query: 399 WCNPAGAKPISGIAVPSGTPKWGRDWKRAVKASYLNTMSFDVHGANMVYRDVYVDLDPNY 458 + I+ + + G D+K + T+ G + Y D V LD + Sbjct: 385 ASRSRWEREIAELNI-------GADYKDTLTEPGGWTIGMTAFGEMLPYHDNRVKLDHDK 437 Query: 459 KDAFGQPLLRFTFDWKDNDIRMSRYVTDQAVKIAHELKAREIKVTVKDFGAAPDLRSYQT 518 KD +G P+L + K N++ M + + AV++ + + +K + + AP + Sbjct: 438 KDKWGLPVLSMNVEMKQNELDMREDMVNDAVEMFEAVGIKNVKPSRGTY--APGM----G 491 Query: 519 THWAGGVAMGTDPSTSVVNRYLQSWDVHNVFAVGSGVFAQGIGYNPTGAAVALT 572 H G MG DP TSV+N Q WD NVF NP+ +ALT Sbjct: 492 IHEMGTARMGRDPKTSVLNGNNQVWDAPNVFVTDGACMTSASCVNPSLTYMALT 545 >VNG1035C [E] COG2303 Choline dehydrogenase and related flavoproteins Hbs Halobacterium sp. NRC-1 Length = 529 Score = 110 bits (276), Expect = 8e-24, Method: Compositional matrix adjust. Identities = 153/600 (25%), Positives = 223/600 (37%), Gaps = 96/600 (16%) Query: 1 MANKNMKAVDVVIVGFGWTGAIMAKEMTEAGQSVVALERGVYRDTYPDGAYPKTINELEY 60 M+ + DV ++G G G ++A + G SVV LE G D + E Sbjct: 1 MSRRPSPNADVCVIGAGPAGGLIADRLASDGHSVVVLEAGPRFDAA----------DRER 50 Query: 61 QQRFKLFQNLNKSSF-------TFRRKTGDSAIPYRQIAMFKPGEGVGGAGLHWSGCHWR 113 + + +S TGD P + +GVGG+ LHW G R Sbjct: 51 RMERSIRPAHGPASVWEMGGPRDAYASTGDRYYPLNAARV----KGVGGSTLHWQGMVMR 106 Query: 114 ILPEELRMRSHYEERYGKGFIPKDMTLQDWGVTYEELEPYFDFAEKMMGTSGTAYRVGGK 173 + ++ R+ S G G DW Y+ L+PY+ AE +G SG Sbjct: 107 LHEQDFRLAS----ATGVG--------ADWPFDYDTLKPYYAAAESALGVSGA------- 147 Query: 174 VVDDSGNPFEANRSDNFPLPAQKEQYQAALFRKAAQQAGFHPFTLPSANASAPYVNQYGC 233 S NPF R P PA Y +LF A + G ++P+A SA + C Sbjct: 148 ----SDNPFAPPREQPHPQPAFPPSYSDSLFADACESLGIATHSVPNARLSAGRETRRAC 203 Query: 234 QMGPCTFCGYCSGYACYNYSKASPNVNIMPALRKSALFELRSSCNVLRIELDSTRKKATG 293 +G T C A Y+ + V++ A A + V R+E D+ + TG Sbjct: 204 -VGYGTCQPVCPSGAKYDAT-----VHVDRATDAGA--RVIDEAPVQRLEHDAAGDRVTG 255 Query: 294 VTYVDANGDTVFQPANIVIASTFAYNNARLFLLSGIGKPYDPVSN-TGAVGRNIAFQMMS 352 Y +G T Q A + + RL LLS + D ++N +G VGR Sbjct: 256 AVYATPDGTTHRQSATEFVLAAGGIETPRLLLLSDSDRYPDGLANSSGLVGRY------- 308 Query: 353 TINAFFDPGKNINGFIGAGG--------NGVAVDDFNGDHMDHGPLGFVGGSPI-WCNPA 403 F D + F GAGG N V + P G G + + N A Sbjct: 309 ----FMD-----HLFAGAGGTLDEPTRQNHVGFNTTESHQYYDRPDGSRGAIKLEFLNYA 359 Query: 404 GAKPISGIAVPSGTPKWGRDWKRAVKASYLNTMSFDVHGANMVYR----DVYVDLDPNYK 459 G P +A+ G DW A+ + + +V + + V L P Sbjct: 360 GPSPAE-MAL------SGDDWGDAMCDRIRDASGTHIAVGGLVEQQPRPENRVRLHPERT 412 Query: 460 DAFGQPLLRFTFDWKDNDIRMSRYVTDQAVKIAHELKAREIKVTVKDFGAAPDLRSYQTT 519 D G P+ + + R + +I EL A +I+ TV P Sbjct: 413 DVHGNPVPDVVWSLSAYERRTIERANEIQREILTELGA-DIEWTVGPEDTGPAF------ 465 Query: 520 HWAGGVAMGTDPSTSVVNRYLQSWDVHNVFAVGSGVFAQGIGYNPTGAAVALTYWSARAI 579 H G MGTDP+ SVV+ L++ D+ N+ S VF NPT AL +A I Sbjct: 466 HHMGTTRMGTDPAESVVDPRLRTHDLSNLSVASSSVFPTAGAMNPTLTIAALALKAADHI 525