BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0011.0019.p (405 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value lin2476 [GEPR] COG0477 Permeases of the major facilitator superf... 118 2e-26 BS_yuxJ [GEPR] COG0477 Permeases of the major facilitator superf... 117 5e-26 SA0115 [GEPR] COG0477 Permeases of the major facilitator superfa... 105 3e-22 L129379 [GEPR] COG0477 Permeases of the major facilitator superf... 99 2e-20 CAP0029 [GEPR] COG0477 Permeases of the major facilitator superf... 87 5e-17 >lin2476 [GEPR] COG0477 Permeases of the major facilitator superfamily Lin Listeria innocua Length = 403 Score = 118 bits (296), Expect = 2e-26, Method: Compositional matrix adjust. Identities = 98/384 (25%), Positives = 171/384 (44%), Gaps = 14/384 (3%) Query: 9 LRYLMAIQLLSMGAMEMSGPFWPLHLRELAPMSAATLAWVSMAVYAGPLLMTMLTAPWWG 68 L LM LL +M M PF L++ S A + + ++ L+ + +P WG Sbjct: 8 LYILMLANLLMSASMTMIMPFLSLYIETFGDYSNAYVQRWAGYIFGVTFLVAFIFSPIWG 67 Query: 69 RLGDRTGHKPMVVRALLALAVSQLMAAWTDSVTVVLLARLIQGALGGFIATAQAYGAGLA 128 R+GD+ G+K +++ L+V + + SVT +L+ R+ G + GFI + A+ A Sbjct: 68 RIGDKHGYKGILILTSFGLSVCIFLMGFAHSVTYLLILRIFMGVVTGFIGVSNAFIARQT 127 Query: 129 TPAQRSSLMARLQVATAMGSALGPWLGGILFDLWGFWIVNLTTALVCVLCALLAAVALPF 188 + ++ LQ+ G GP +GG + DL+GF T + ++ AL+ A + Sbjct: 128 PRNEAGKILGTLQLGGVTGMLFGPLIGGAMADLFGFKDTFTITGIAMMVAALIVAFGVKE 187 Query: 189 VKPAAPTDRQRASSKPVAPTAA---ERPALQAFQGLLLGILLVQAGKIMPQAFFAVY-AD 244 ++ T+ Q+ ++K V A + L+ +++ L+Q Q A+Y D Sbjct: 188 IR----TEEQKEAAKVVYSRRAVLKQIFTLRVLFTVMVITALIQIANFSVQPLLALYVGD 243 Query: 245 QVLHANASF-TGLCYGATALGLCIAAPLWARAFAALAPEQVLQRVKWITLACAATLALQS 303 N +F +GL + AT G + W + E++L I L AA + Sbjct: 244 MTQSDNIAFLSGLAFSATGFGNLVMTRKWGQLGDKYGYEKILN----ILLIMAAVFVIPQ 299 Query: 304 MSHVPAW-FVAARLLWGVFLGALLPVFYTLLSRQADGHRQGWVLGAGNSAAKAGALLGTA 362 W F+ R L+G+ +G ++P + A G QG +LG SA G ++G Sbjct: 300 AFATNLWVFIFFRFLFGIAIGGMVPCTTAYIRLAAPGVMQGEMLGYNQSARFLGNVIGPI 359 Query: 363 AGALAMGWLPISEVFWPNAAVYLI 386 G G+ I VF + ++L+ Sbjct: 360 LGGTLAGFTGIPSVFLFMSFMFLV 383 >BS_yuxJ [GEPR] COG0477 Permeases of the major facilitator superfamily Bsu Bacillus subtilis Length = 356 Score = 117 bits (293), Expect = 5e-26, Method: Compositional matrix adjust. Identities = 104/356 (29%), Positives = 160/356 (44%), Gaps = 16/356 (4%) Query: 57 LLMTMLTAPWWGRLGDRTGHKPMVVRALLALAVSQLMAAWTDSVTVVLLARLIQGALGGF 116 +LM L +P+WGR GD+ G+K +++ +A+S + SV + R+ G + GF Sbjct: 10 ILMAFLVSPFWGRFGDKRGYKKILMATGTGIALSIFFMGFVTSVYQLFFLRMAMGLVTGF 69 Query: 117 IATAQAYGAGLATPAQRSSLMARLQVATAMGSALGPWLGGILFDLWGFWIVNLTTALVCV 176 I T+ A + + + LQ+ GS GP LGG+L D +GF T+ V Sbjct: 70 IPTSLAMISAQTPKSSAGKTLGTLQMGQVSGSLFGPLLGGMLADRFGFTYTFFITSFVIF 129 Query: 177 LCALLAAVALPFVKPAAPT-DRQRASSKPVAPTAAERPALQAFQGLLLGILLVQAGKIMP 235 LL + A T R S K V PAL ++L +L+Q G Sbjct: 130 SSVLLVLFGVKEKHLAEKTAKRTSYSRKEVLSYIFHHPALWV---MMLLTMLIQTGNFSI 186 Query: 236 QAFFAVYADQVLHANAS---FTGLCYGATALGLCIAAPLWARAFAALAPEQVLQRVKWIT 292 Q A+Y ++ LH + F+G+ + AT LG + L AR + L +R+ I Sbjct: 187 QPLLALYVNE-LHGPVNLAFFSGMAFSATGLG----SLLLARKWGDLGDRYGHRRI-LIG 240 Query: 293 LACAATLAL--QSMSHVPAWFVAARLLWGVFLGALLPVFYTLLSRQADGHRQGWVLGAGN 350 L AA+ Q+++ + + R L+G+ +G LLP + QA G QG VLG Sbjct: 241 LLLAASFFFIPQALASSLSVLLVFRFLFGMAMGGLLPCITAAIRVQAPGSIQGEVLGYNV 300 Query: 351 SAAKAGALLGTAAGALAMGWLPISEVFWPNAAVYLIVAAALHGLQR-RSDTREAAS 405 S G +LG G + IS F+ A ++ A L +Q+ R D+ AS Sbjct: 301 SFRFLGNVLGPLLGGIISSHFTISATFYVTAFLFFAGACMLWIMQKLRKDSYAKAS 356 >SA0115 [GEPR] COG0477 Permeases of the major facilitator superfamily Sau Staphylococcus aureus N315 Length = 418 Score = 105 bits (261), Expect = 3e-22, Method: Compositional matrix adjust. Identities = 96/364 (26%), Positives = 166/364 (45%), Gaps = 29/364 (7%) Query: 16 QLLSMGAMEMSGPFWPLHLRELAPMSAATLA-WVSMAVYAGPLLMTMLTAPWWGRLGDRT 74 Q +++ + + P P+++ L +S + W +A+ A P + TM+ +P WG+LGD+ Sbjct: 18 QFIAIAGLTVLVPLLPIYMASLQNLSVVEIQLWSGIAI-AAPAVTTMIASPIWGKLGDKI 76 Query: 75 GHKPMVVRALLALAVSQLMAAWTDSVTVVLLARLIQGALGGFIATAQAYGAGLATPAQRS 134 K MV+RALL LAV + A + +L RL+QG GG + + A+ + A R Sbjct: 77 SRKWMVLRALLGLAVCLFLMALCTTPLQFVLVRLLQGLFGGVVDASSAFASAEAPAEDRG 136 Query: 135 SLMARLQVATAMGSALGPWLGGILFDLWGFWIVNLTTALVCVLCALLAAVALPFVKPAAP 194 ++ RLQ + + GS +GP +GG+ + GF + ++ A++ + + A+ L Sbjct: 137 KVLGRLQSSVSAGSLVGPLIGGVTASILGFSALLMSIAVITFIVCIFGALKL------IE 190 Query: 195 TDRQRASSKPVAPTAAERPALQAFQGLLLGILLVQAGKIMPQAFFAVY---------ADQ 245 T S P R +FQ LL + + A FA+Y A Sbjct: 191 TTHMPKSQTPNINKGIRR----SFQCLLCTQQTCRFIIVGVLANFAMYGMLTALSPLASS 246 Query: 246 VLHA---NASFTGLCYGATALGLCIAAPLWARAFAALAPEQVLQRVK-WITLACAATLAL 301 V H + S G A ++APLW R + ++ V + T+AC + L Sbjct: 247 VNHTAIDDRSVIGFLQSAFWTASILSAPLWGR----FNDKSYVKSVYIFATIACGCSAIL 302 Query: 302 QSMSHVPAWFVAARLLWGVFLGALLPVFYTLLSRQADGHRQGWVLGAGNSAAKAGALLGT 361 Q ++ + +AAR+L G+ AL+ ++ +G +G NS G ++G+ Sbjct: 303 QGLATNIEFLMAARILQGLTYSALIQSVMFVVVNACHQQLKGTFVGTTNSMLVVGQIIGS 362 Query: 362 AAGA 365 +GA Sbjct: 363 LSGA 366 >L129379 [GEPR] COG0477 Permeases of the major facilitator superfamily Lla Lactococcus lactis Length = 398 Score = 98.6 bits (244), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 86/354 (24%), Positives = 159/354 (44%), Gaps = 12/354 (3%) Query: 28 PFWPLHLRELAPMSAATLAWVSMAVYAGPLLMTMLTAPWWGRLGDRTGHKPMVVRALLAL 87 PF L++ L S L S V++ ++ + +P WGRL D+ G K M++RA L + Sbjct: 28 PFISLYISTLGHYSKTELNIWSGLVFSSTFIVLAIVSPLWGRLADQKGRKLMLLRASLGM 87 Query: 88 AVSQLMAAWTDSVTVVLLARLIQGALGGFIATAQAYGAGLATPAQRSSLMARLQVATAMG 147 A+S + A+ + +L+ R++ GA GF++ + A A A + ++++ L + G Sbjct: 88 AISISLMAFVTAAWQLLILRMLLGAFSGFVSNSMALMASSAPKEKSGAVLSLLTTGSVAG 147 Query: 148 SALGPWLGGILFDLWGFWIVNLTTALVCVLCALLAAVALPFVKPAAPTDRQRASSKPVAP 207 + +GP +GGIL ++ G+ V T ++ L LA + + P +++ S Sbjct: 148 TLIGPIIGGILVNITGYRRVFSVTGIIMFLVFFLALFFVK--EIFKPVEKKNMLSYKQVW 205 Query: 208 TAAERPALQAFQGLLLGILLVQAGKIMPQAFFAVYADQVLHANASFT---GLCYGATALG 264 PA+ G+ L+ Q ++Y +++H + T G+ A + Sbjct: 206 EVVTHPAI--IWGMFFATLITQMTNQSINPVLSLYVQELMHGQGNITFMAGIVAAAPGIV 263 Query: 265 LCIAAPLWARAFAALAPEQVLQRVKWITLACAATLALQSMSHVPAWF-VAARLLWGVFLG 323 +AAP R + ++L + +L + A+ + WF + RLL GV Sbjct: 264 TLVAAPFLGRLGDKVGQRKILGFGLFFSLIVFSITAMTT----NVWFLIVMRLLVGVSDA 319 Query: 324 ALLPVFYTLLSRQADGHRQGWVLGAGNSAAKAGALLGTAAGALAMGWLPISEVF 377 A+LP +L++++ G + SA GA G G+ G++ VF Sbjct: 320 AILPSVQAILAKESPQAITGRIFSYNQSAQSIGAFAGPLLGSAIAGFIDYRYVF 373 >CAP0029 [GEPR] COG0477 Permeases of the major facilitator superfamily Cac Clostridium acetobutylicum Length = 399 Score = 87.4 bits (215), Expect = 5e-17, Method: Compositional matrix adjust. Identities = 90/394 (22%), Positives = 160/394 (40%), Gaps = 30/394 (7%) Query: 22 AMEMSGPFWPLHLRELAPMSAATLAWVSMAVYAGPLLMTMLTAPWWGRLGDRTGHKPMVV 81 M P PL++R L S++ + S + +++ + +P WG+ D+ G KPM++ Sbjct: 21 GMSQIAPVLPLYIRHLGVNSSSLVEEFSGIAFGITFIVSAIFSPIWGQAADKFGRKPMLL 80 Query: 82 RALLALAVSQLMAAWTDSVTVVLLARLIQGALGGFIATAQAYGAGLATPAQRSS---LMA 138 RA + + + +V V+++ RL+QG + G+ + A +AT + + Sbjct: 81 RASFGMGIIIFSMGFVSNVYVLIVLRLLQGVITGY---STACTTLIATQTDKEHAGWALG 137 Query: 139 RLQVATAMGSALGPWLGGILFDLWGFWIVNLTTA--LVCVLCALLAAVALPFVKPAAPTD 196 L A GS LGP +GG + + +G V T L+ V A + V FV+ D Sbjct: 138 TLSTAGIAGSLLGPTIGGFVEEAFGTQNVFFITGALLIIVFIATMLFVKEDFVRENKKVD 197 Query: 197 RQRASSKPVAPTAAERPALQAFQGLLLGILLVQAGKIMPQAFFAVYADQVLHANASFTGL 256 + V + L F +L + L IM + + + + H A GL Sbjct: 198 SMKKVWNSVPEKSLTITILVTF--FILTLALYSIEPIMTE-YVSKLSRNTSHV-AFIAGL 253 Query: 257 CYGATALGLCIAAPLWARAFAALAPEQVLQRVKWITLACAATLALQSMSHVPAWFVAA-- 314 + A+ L +AAP + + P +++ L + + +P FV Sbjct: 254 VFSASGLANIVAAPRLGKISDKIGPHKIM----------LGALIVAGIVFIPQAFVKNPW 303 Query: 315 -----RLLWGVFLGALLPVFYTLLSRQADGHRQGWVLGAGNSAAKAGALLGTAAGALAMG 369 R L G+ G L P L+ + G + G SA G G+ G Sbjct: 304 QLMFFRFLLGLASGGLTPSVNILVKKITPTAITGRIFGLSMSAGYLGVFGGSVLGGQVSA 363 Query: 370 WLPISEVFWPNAAVYLIVAA-ALHGLQRRSDTRE 402 +L I VF+ +++ LI A + ++ + +E Sbjct: 364 YLGIRYVFFITSSLLLINAVWVYFKVYKKLNLKE 397