BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0010.0065.p (255 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSc2356_1 [H] COG1587 Uroporphyrinogen-III synthase Rso Ralstoni... 168 1e-41 PA5259 [H] COG1587 Uroporphyrinogen-III synthase Pae Pseudomonas... 86 1e-16 STM3937 [H] COG1587 Uroporphyrinogen-III synthase Sty Salmonella... 85 2e-16 hemD [H] COG1587 Uroporphyrinogen-III synthase Eco Escherichia c... 80 6e-15 ZhemD [H] COG1587 Uroporphyrinogen-III synthase EcZ Escherichia ... 79 8e-15 >RSc2356_1 [H] COG1587 Uroporphyrinogen-III synthase Rso Ralstonia solanacearum Length = 368 Score = 168 bits (425), Expect = 1e-41, Method: Compositional matrix adjust. Identities = 106/255 (41%), Positives = 144/255 (56%), Gaps = 6/255 (2%) Query: 3 VVVTRPLQQAGGFAERVQQLGRRAVVFPLLAIGPVEDDSELKATLARLHDFALVVFVSPN 62 V+VTRP QA +++ G R + FPLL I P + +L+A LA +ALVVFVSPN Sbjct: 24 VIVTRPRAQAPMLVAALERHGLRTLQFPLLDIAPTPNLDDLRAALADPSRYALVVFVSPN 83 Query: 63 AIDAAFAHL-QG--WPRNVPIGIVGEGSRVALRGHGVDGANATIYGP-QRAD--KMDSEE 116 A+ AFA + +G WP++VP +VG S AL HGV + P AD + DSE Sbjct: 84 AVQQAFAAMPEGFRWPQDVPAAVVGPASAQALAAHGVAAPTYRVIRPDSHADDARQDSEA 143 Query: 117 LFKSLPLEQLRGRRALIVRGQAGRDFLSEALQQQGVEIEFLTAYRRLAPELNPQSRLQLL 176 L+ L + L GR LIVRG GR++L++ L++ GV + + AYRR P + + L Sbjct: 144 LYARLDVATLSGREVLIVRGNGGREWLADRLREAGVAVRTVEAYRRSVPVPDTAAWAALR 203 Query: 177 DLLDGGADWVITSSEALRNLLHLARLAGGEERVVKLQRQRIVVSHHRIAETAREQGFVQV 236 ++L G W +TSSEA RNL LAR + V L H RI E A+ GF V Sbjct: 204 EVLAGRHAWTLTSSEAARNLDSLARASLSAAEVEALYAAPCFAPHARIVEQAQSLGFRDV 263 Query: 237 VLTGSGDERLLAALV 251 LTG+GD+RLLA ++ Sbjct: 264 TLTGAGDDRLLAGVL 278 >PA5259 [H] COG1587 Uroporphyrinogen-III synthase Pae Pseudomonas aeruginosa Length = 251 Score = 85.5 bits (210), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 79/247 (31%), Positives = 123/247 (49%), Gaps = 31/247 (12%) Query: 3 VVVTRPLQQAGGFAERVQQLGRRAVVFPLLAIGPVEDDSELKATLARLHDFALVVFVSPN 62 +++TRP ++ A + + G + PLLAI P+E+ E + + L + VV VS Sbjct: 6 LLLTRPDEECAALAASLGEAGVHSSSLPLLAIDPLEETPEQRTLMLDLDRYCAVVVVSKP 65 Query: 63 AIDAAFAHL-QGWPR--NVPIGIVGEGSRVALRGHGVDGANATIYGPQRADKMDSEELFK 119 A L + WP+ VG + L +G+D + P++ D DSE L Sbjct: 66 AARLGLERLDRYWPQPPQQTWCSVGAATAAILEAYGLD-----VTYPEQGD--DSEALL- 117 Query: 120 SLPLEQLRGR----RALIVRGQAGRDFLSEALQQQGVEIEFLTAYRRLAP-----ELNPQ 170 +LP Q R + LI+RG+ GR+FL+E L+ QGV++++L YRR AP EL + Sbjct: 118 ALPAFQDSLRVHDPKVLIMRGEGGREFLAERLRGQGVQVDYLPLYRRRAPDYPAGELLAR 177 Query: 171 SRLQLLDLLDGGADWVITSSEALRNLLHLARLAGGEERVVKLQRQRIVVSHHRIAETARE 230 R + L+ L V++S + L+NL LA E + R + V R+AE ARE Sbjct: 178 VRAERLNGL------VVSSGQGLQNLYQLAAADWPE-----IGRLPLFVPSPRVAEMARE 226 Query: 231 QGFVQVV 237 G +V+ Sbjct: 227 LGAQRVI 233 >STM3937 [H] COG1587 Uroporphyrinogen-III synthase Sty Salmonella typhimurium LT2 Length = 246 Score = 84.7 bits (208), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 79/253 (31%), Positives = 117/253 (46%), Gaps = 11/253 (4%) Query: 1 LPVVVTRPLQQAGGFAERVQQLGRRAVVFPLLAIGPVEDDSELKATLARLHDFALVVFVS 60 + +++TRP R++ LG+ A FPL+ + L LA L + LV +S Sbjct: 1 MSILITRPSPAGEALVSRLRALGQVAWSFPLIEFVAGRELPTLADRLATLTENDLVFALS 60 Query: 61 PNAIDAAFAHLQGWPRNVPIG--IVGEGSRVALRGHGVDGANATIYGPQRADKMDSEELF 118 +A+ A A LQ RN P+ G AL H V G + I P D+ SE L Sbjct: 61 QHAVAFAHAQLQRDGRNWPVAPRYFAIGRTTALALHTVSGFD--IRYP--LDREISEALL 116 Query: 119 KSLPLEQLRGRRALIVRGQAGRDFLSEALQQQGVEIEFLTAYRRLAPELNPQSRLQLLDL 178 + L+ + G+RALI+RG GR+ L E L +G E+ F Y+R A + Sbjct: 117 QLPELQNIAGKRALILRGNGGRELLGETLTARGAEVSFCECYQRCAKHYDGAEEAMRWH- 175 Query: 179 LDGGADWVITSSEALRNLLHLARLAGGEERVVKLQRQRIVVSHHRIAETAREQGFVQVVL 238 G V+TS E L+ L L E ++ R R++V R+A ARE G+ + + Sbjct: 176 TRGVTTLVVTSGEMLQRLWSLTPQWYREHWLL---RCRLLVVSERLAHLARELGWQDIKV 232 Query: 239 TGSGD-ERLLAAL 250 + D + LL AL Sbjct: 233 ADNADNDALLRAL 245 >hemD [H] COG1587 Uroporphyrinogen-III synthase Eco Escherichia coli K12 Length = 246 Score = 79.7 bits (195), Expect = 6e-15, Method: Compositional matrix adjust. Identities = 79/265 (29%), Positives = 122/265 (46%), Gaps = 35/265 (13%) Query: 1 LPVVVTRPLQQAGGFAERVQQLGRRAVVFPLLAIGPVEDDSELKATLARLHDFALVVFVS 60 + ++VTRP R++ LG+ A FPL+ P + +L LA L + L+ +S Sbjct: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60 Query: 61 PNAIDAAFAHLQ------GWPRNVPIGIVGEGSRVALRGHGVDGANATIYGPQRADKMDS 114 +A+ AFA Q WPR +G + +AL H V G I PQ D+ S Sbjct: 61 QHAV--AFAQSQLHQQDRKWPRLPDYFAIGRTTALAL--HTVSGQK--ILYPQ--DREIS 112 Query: 115 EELFKSLPLEQLRGRRALIVRGQAGRDFLSEALQQQGVEIEFLTAYRRLAPELNPQSRLQ 174 E L + L+ + G+RALI+RG GR+ + + L +G E+ F Y+R A Sbjct: 113 EVLLQLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIH-------- 164 Query: 175 LLDLLDGGADW--------VITSSEALRNLLHLARLAGGEERVVKLQRQRIVVSHHRIAE 226 D + W V+TS E L+ L L E ++ R++V R+A+ Sbjct: 165 -YDGAEEAMRWQAREVTMVVVTSGEMLQQLWSLIPQWYREHWLLHC---RLLVVSERLAK 220 Query: 227 TAREQGFVQVVLTGSGD-ERLLAAL 250 ARE G+ + + + D + LL AL Sbjct: 221 LARELGWQDIKVADNADNDALLRAL 245 >ZhemD [H] COG1587 Uroporphyrinogen-III synthase EcZ Escherichia coli O157:H7 EDL933 Length = 246 Score = 79.3 bits (194), Expect = 8e-15, Method: Compositional matrix adjust. Identities = 79/260 (30%), Positives = 123/260 (47%), Gaps = 25/260 (9%) Query: 1 LPVVVTRPLQQAGGFAERVQQLGRRAVVFPLLAIGPVEDDSELKATLARLHDFALVVFVS 60 + ++VTRP R++ LG+ A FPL+ P +L LA L + L+ +S Sbjct: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGRQLPQLADQLAALGESDLLFALS 60 Query: 61 PNAIDAAFAHLQ------GWPRNVPIGIVGEGSRVALRGHGVDGANATIYGPQRADKMDS 114 +A+ AFA Q WPR +G + +AL H V G I PQ D+ S Sbjct: 61 QHAV--AFAQSQLHQQDRKWPRLPNYFAIGRTTALAL--HTVSGQK--ILYPQ--DREIS 112 Query: 115 EELFKSLPLEQLRGRRALIVRGQAGRDFLSEALQQQGVEIEFLTAYRRLAPELN---PQS 171 E L + L+ + G+RALI+RG GR+ + + L +G E+ F Y+R A + Sbjct: 113 EVLLQLPELQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAM 172 Query: 172 RLQLLDLLDGGADWVITSSEALRNLLHLARLAGGEERVVKLQRQRIVVSHHRIAETAREQ 231 R Q ++ V+TS E L+ L L E ++ R++V R+A+ ARE Sbjct: 173 RWQSREVTTV----VVTSGEMLQQLWSLIPQWYREHWLLHC---RLLVVSERLAKLAREL 225 Query: 232 GFVQVVLTGSGD-ERLLAAL 250 G+ + + + D + LL AL Sbjct: 226 GWQDIKVADNADNDALLRAL 245