BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0010.0019.p (229 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value BMEII0141 [C] COG1012 NAD-dependent aldehyde dehydrogenases Bme ... 180 2e-45 MA4079 [C] COG1012 NAD-dependent aldehyde dehydrogenases Mac Met... 176 5e-44 feaB [C] COG1012 NAD-dependent aldehyde dehydrogenases Eco Esche... 168 8e-42 STM3129 [C] COG1012 NAD-dependent aldehyde dehydrogenases Sty Sa... 163 2e-40 PA4073 [C] COG1012 NAD-dependent aldehyde dehydrogenases Pae Pse... 162 7e-40 >BMEII0141 [C] COG1012 NAD-dependent aldehyde dehydrogenases Bme Brucella melitensis Length = 271 Score = 180 bits (457), Expect = 2e-45, Method: Compositional matrix adjust. Identities = 89/148 (60%), Positives = 105/148 (70%) Query: 1 MELGGNDAAIVLEDADPKAIAPGLFWGAFLNMGQTCACAKRLYVPDALHDRIVAELKAII 60 +ELGGNDA IVL DADP IA GLFWGAF+N GQTCA KRLYV D ++D + L Sbjct: 124 LELGGNDAGIVLPDADPARIAEGLFWGAFINSGQTCAALKRLYVHDHIYDDVCRHLTEYA 183 Query: 61 AATPMGDGLQPGIAMGPVQNPMQLKKVAALVESAREEGATIVCGGVLPDGPGNFYPLTLV 120 A +GDGL +G VQN MQ KV LV+ AR +GA I+ GG +GPG FYP+TLV Sbjct: 184 ANIIIGDGLDEKSVLGLVQNAMQFNKVRELVDDARAKGARILIGGEAAEGPGYFYPITLV 243 Query: 121 TDLRDGARLVDEEQFGPVLPIIRYSDLE 148 D+ +G RLVDEEQFGPVLPIIRYSD++ Sbjct: 244 ADIDNGTRLVDEEQFGPVLPIIRYSDID 271 >MA4079 [C] COG1012 NAD-dependent aldehyde dehydrogenases Mac Methanosarcina acetivorans str.C2A Length = 479 Score = 176 bits (445), Expect = 5e-44, Method: Compositional matrix adjust. Identities = 93/233 (39%), Positives = 139/233 (59%), Gaps = 5/233 (2%) Query: 1 MELGGNDAAIVLEDADPKAIAPGLFWGAFLNMGQTCACAKRLYVPDALHDRIVAELKAII 60 +ELGG+D +V +DAD ++ A G G F N GQTC KRLYV +++ + + +L+ I Sbjct: 246 LELGGSDPMLVCDDADLESAAAGALRGRFYNCGQTCTAVKRLYVFESVAEEFIKKLETGI 305 Query: 61 AATPMGDGLQPGIAMGPVQNPMQLKKVAALVESAREEGA-TIVCGGVLPD----GPGNFY 115 + +G+G+ I+MGP+ N Q + + L E+ A I+ GG +P+ G F+ Sbjct: 306 KSLRLGNGMDKNISMGPLNNRTQWEYIKELAAEIEEKDAGRIITGGKVPEFKDSEKGYFF 365 Query: 116 PLTLVTDLRDGARLVDEEQFGPVLPIIRYSDLEQAIANANRLDVGLGASVWSSDTQRAAE 175 TLV+D+ +RL+ EE FGP+LP++ +L++AI AN GLGAS+W+ + RA + Sbjct: 366 EPTLVSDVPGDSRLLKEEVFGPLLPVVTVKNLDEAIVGANSTCYGLGASIWTKNIDRARK 425 Query: 176 VATRLQAGTVWVNQHGMVHPMVPFGGNKRSGWGLEFGQEGLKGVTQPQVISLK 228 +L AG +W+NQH V P VPFGG K SG+G E G E L + + I LK Sbjct: 426 GCEQLNAGIIWINQHLKVAPEVPFGGVKESGFGRENGPESLSEYLETKTIMLK 478 >feaB [C] COG1012 NAD-dependent aldehyde dehydrogenases Eco Escherichia coli K12 Length = 500 Score = 168 bits (426), Expect = 8e-42, Method: Compositional matrix adjust. Identities = 87/228 (38%), Positives = 137/228 (60%) Query: 1 MELGGNDAAIVLEDADPKAIAPGLFWGAFLNMGQTCACAKRLYVPDALHDRIVAELKAII 60 +ELGG + AIVL+DADP+ + GL G+FLN GQ CA + R+Y+ L D +V+ + + Sbjct: 272 LELGGKNPAIVLKDADPQWVIEGLMTGSFLNQGQVCAASSRIYIEAPLFDTLVSGFEQAV 331 Query: 61 AATPMGDGLQPGIAMGPVQNPMQLKKVAALVESAREEGATIVCGGVLPDGPGNFYPLTLV 120 + +G G+ P + P+ + KV + ++ A+ + A ++ G P G G + TLV Sbjct: 332 KSLQVGPGMSPVAQINPLVSRAHCDKVCSFLDDAQAQQAELIRGSNGPAGEGYYVAPTLV 391 Query: 121 TDLRDGARLVDEEQFGPVLPIIRYSDLEQAIANANRLDVGLGASVWSSDTQRAAEVATRL 180 + RL EE FGPV+ ++R +D E+A+ AN + GL ASVW+ + +A E + RL Sbjct: 392 VNPDAKLRLTREEVFGPVVNLVRVADGEEALQLANDTEYGLTASVWTQNLSQALEYSDRL 451 Query: 181 QAGTVWVNQHGMVHPMVPFGGNKRSGWGLEFGQEGLKGVTQPQVISLK 228 QAGTVWVN H ++ +PFGG K+SG G +FG + L G + + + ++ Sbjct: 452 QAGTVWVNSHTLIDANLPFGGMKQSGTGRDFGPDWLDGWCETKSVCVR 499 >STM3129 [C] COG1012 NAD-dependent aldehyde dehydrogenases Sty Salmonella typhimurium LT2 Length = 494 Score = 163 bits (413), Expect = 2e-40, Method: Compositional matrix adjust. Identities = 89/228 (39%), Positives = 126/228 (55%) Query: 1 MELGGNDAAIVLEDADPKAIAPGLFWGAFLNMGQTCACAKRLYVPDALHDRIVAELKAII 60 +ELGG +AA+ L D +A+ G+ +LN GQ CA A+R Y+P D ++ L+ + Sbjct: 266 LELGGKNAALFLNDLTAQAMVNGILEAGYLNQGQICAAAERFYLPQEKLDTVMTLLRQRL 325 Query: 61 AATPMGDGLQPGIAMGPVQNPMQLKKVAALVESAREEGATIVCGGVLPDGPGNFYPLTLV 120 + G L MGP+ N +QL+KV L++ AREEG TIV GG G G F T V Sbjct: 326 SEIVPGSPLDEKTVMGPLANQVQLEKVLRLIQRAREEGDTIVYGGETLPGEGYFLQPTAV 385 Query: 121 TDLRDGARLVDEEQFGPVLPIIRYSDLEQAIANANRLDVGLGASVWSSDTQRAAEVATRL 180 + L+ EE FGPV I Y + ++A+++ N GL ASVWS + +A A + Sbjct: 386 KVRSKNSTLMHEETFGPVCSFIGYQNEKEALSHINDSPFGLAASVWSENISKALRYAEDI 445 Query: 181 QAGTVWVNQHGMVHPMVPFGGNKRSGWGLEFGQEGLKGVTQPQVISLK 228 AG VWVN H + P VPFGG K SG G EFG + T+ + + ++ Sbjct: 446 DAGMVWVNMHTFLDPAVPFGGMKGSGIGREFGSAFIDDYTELKSVMVR 493 >PA4073 [C] COG1012 NAD-dependent aldehyde dehydrogenases Pae Pseudomonas aeruginosa Length = 495 Score = 162 bits (409), Expect = 7e-40, Method: Compositional matrix adjust. Identities = 84/227 (37%), Positives = 128/227 (56%) Query: 1 MELGGNDAAIVLEDADPKAIAPGLFWGAFLNMGQTCACAKRLYVPDALHDRIVAELKAII 60 +ELGG I+L+D A G F N GQ C RLYV D+++ L AI Sbjct: 267 LELGGKSPVIILDDTSLDMAAAGSAGAIFFNQGQVCTAGSRLYVQRKRFDQVLERLAAIA 326 Query: 61 AATPMGDGLQPGIAMGPVQNPMQLKKVAALVESAREEGATIVCGGVLPDGPGNFYPLTLV 120 +G GL P + P+ + Q ++V ++ES EGA++VCGG G + T++ Sbjct: 327 GDLSIGPGLDPTTQINPLVSARQQERVLGMIESGVAEGASVVCGGARQGETGFYVQPTIL 386 Query: 121 TDLRDGARLVDEEQFGPVLPIIRYSDLEQAIANANRLDVGLGASVWSSDTQRAAEVATRL 180 D+ G ++V EE FGPVL + DL++A+ AN GLGAS+WS+D ++ ++ R+ Sbjct: 387 ADVTPGMQVVREEIFGPVLVATPFDDLDEAVRLANDSIYGLGASIWSNDLRQVMDLVPRI 446 Query: 181 QAGTVWVNQHGMVHPMVPFGGNKRSGWGLEFGQEGLKGVTQPQVISL 227 +AGTVWVN H ++ P +PFGG K+SG G E G ++ T+ + + + Sbjct: 447 KAGTVWVNAHNLLDPSMPFGGFKQSGIGREMGHAAIEAYTENKSVCI 493