BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0010.0017.p (789 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value PA3079 [R] COG1033 Predicted exporters of the RND superfamily Pa... 494 e-139 MJ1562 [R] COG1033 Predicted exporters of the RND superfamily Mj... 72 7e-12 AF0459 [R] COG1033 Predicted exporters of the RND superfamily Af... 68 9e-11 Cj1373 [R] COG1033 Predicted exporters of the RND superfamily Cj... 63 3e-09 TP0790 [R] COG1033 Predicted exporters of the RND superfamily Tp... 62 6e-09 >PA3079 [R] COG1033 Predicted exporters of the RND superfamily Pae Pseudomonas aeruginosa Length = 793 Score = 494 bits (1273), Expect = e-139, Method: Compositional matrix adjust. Identities = 291/787 (36%), Positives = 447/787 (56%), Gaps = 18/787 (2%) Query: 13 LEASLFRLRIPILTLLLAFTAVLSYFALQLRMDAGFEKQMPTHHEYIDTFKQYRDDVLG- 71 LE +F R ++ L + + L Y A Q+R FEK +P H +I ++R+D+ Sbjct: 15 LERLIFNNRPVVIFLCVLVSVFLFYQATQVRPSTSFEKMIPLEHPFIQKMLEHRNDLANL 74 Query: 72 ANRLNIVLRARKGSIWTREGLTRLSEMTQAVMFLPNISRLGVQSLWTPNTFVNEITEEGF 131 N + I + A G I+T+E + L ++ V ++P + R G++SLW+P+ E+TEEGF Sbjct: 75 GNTVRISVEAVNGDIFTKEYMETLRQIHDEVFYIPGVDRSGLKSLWSPSVRWTEVTEEGF 134 Query: 132 RADPVIPGTVIPSALTPETIEQIRNTAVNGGFVGTLISRNQDSAMIVAEINEF--DVKGD 189 VIP T S P +E++RN + G +G L++ N S+++ + E + K Sbjct: 135 AGGEVIPQTYDGS---PRALEELRNNVLKSGQIGRLVANNFKSSIVDVPLLEMYPNPKNQ 191 Query: 190 ----KVDYLAYNKLLND-LRAKYE--NADFEVQIIGFAKQIGDVADGAEGVLKFCAMALL 242 K+DY ++ L + +R KY+ N + +V I+GFAK++GD+ DG V+ F + LL Sbjct: 192 SELIKLDYRQFSHELEEKIRDKYQLQNPNVKVHIVGFAKKVGDLIDGLVMVVGFFGICLL 251 Query: 243 LTTIAVYWYCRSLPFTLLPVACSLVSLVWQFGTLRLLGYGLDPLAVLVPFLVFAIGVSHG 302 +T + +YW+ + + T+ + +LV+++WQ G L L+G+GLDP ++LVPFL+FAIG+SHG Sbjct: 252 ITLVLLYWFTKCIRSTIAVLITTLVAVLWQLGLLNLVGFGLDPYSMLVPFLIFAIGISHG 311 Query: 303 VQQINTIVRGIASGQSCEAAARASFKGLLIPGVLALVTALVSFVTLVMIPIPMVRELAIT 362 VQ+IN I + + AAR +F+ L +PG++A++ V F+TL++I I ++RELAI Sbjct: 312 VQKINGIALQSSGADNALMAARLTFRQLFLPGMIAILADAVGFITLLVIDIGVIRELAIG 371 Query: 363 ASIGVGYKIITNLVMLPLAASLLKVGKTYADSAMRAQQARGRWLAVLSRSAQPRVARSIV 422 ASIGV + TNL++LP+A S + + K + + +LS + P+VA + Sbjct: 372 ASIGVAVIVFTNLILLPVAISYIGISKKAVQRSKDDAVREHPFWRLLSNFSSPKVAPVSI 431 Query: 423 VITLLVLAGSAWYSHDRLVGTLQPGAPELHADARYNRDARWIADNYGNGLDWLTVILSTP 482 I LL+L G WY +G L GAPEL D+RYN D +I NY D L V++ T Sbjct: 432 AIALLMLGGGLWYGKHLKIGDLDQGAPELRPDSRYNLDNDFIIRNYSTSSDVLVVMVKTS 491 Query: 483 SNSCDNVSFGRYQDQFDTVMRHVPGVLSVSSFADQMKIYNEGYNEGNPAMFTVPLDAANY 542 C D+ + + GV S S K +G NEGN T+ + N Sbjct: 492 PEGCSTHQALAAMDELAWKLENTEGVQSAISMVTVSKQVIKGMNEGNLKWETL---SRNQ 548 Query: 543 AALAVEIGRVRGFLSKDCNMLASHLFLADHKAATINGVIQAVKAYRDQHKLAGLEIRLAA 602 L I R G + DC++ +FL DHKA T++ + AV+A+ ++ L+ +LAA Sbjct: 549 DVLNNSIARADGLYNTDCSLAPLLVFLNDHKAETLDRAVAAVQAFAAENDKDDLQFQLAA 608 Query: 603 GNAGVIAAVNDEVEKSELPMMLYVYGAIVLLVFAVYRDWRAIIACCLPLTVATLYTYAFM 662 GNAG+ AA N+ +++SEL +++ VY + + +R + A + LPL + ++ A M Sbjct: 609 GNAGIEAATNEVIKQSELIILVLVYICVAAMCMITFRSFAATLCIVLPLILTSVLGNALM 668 Query: 663 KQLQIGLTVATLPVMVLAVGIGVDYAFYIYNRLQLHLAAGLPIEQALHNAIQEVGIATIF 722 L IG+ VATLPV+ L VGIGVDY YIY RL+ L GLP+++A + ++ G A +F Sbjct: 669 AALGIGVKVATLPVIALGVGIGVDYGIYIYTRLESFLRMGLPLQEAYYETLRSTGKAVLF 728 Query: 723 TAITLAIGVATWSFSDLKFQADMGKLLAFMFLVNLVMAMTALPAFAVVLEKMFPRKSPIK 782 T + LAIGVATW FS +KFQADMG +L FM L N+ A+ LPA A L + P K + Sbjct: 729 TGLCLAIGVATWIFSAIKFQADMGLMLTFMLLWNMFGALWLLPALARFL--INPAKLQAR 786 Query: 783 LNSALAH 789 S AH Sbjct: 787 KASLFAH 793 >MJ1562 [R] COG1033 Predicted exporters of the RND superfamily Mja Methanococcus jannaschii Length = 388 Score = 71.6 bits (174), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 83/334 (24%), Positives = 146/334 (43%), Gaps = 48/334 (14%) Query: 464 IADNYGNGLDWLTVILS-TPSNSCDNVSFGRYQ------DQFDTVMRHVPGVLSVSSFAD 516 + D +G G D +T+ + PS+S D V R + + +R+V G+ SVSS D Sbjct: 65 VRDEFG-GTDVITICIKLKPSDSSDKVVDIRDPRVLKAIKELEDNLRYVDGITSVSSPVD 123 Query: 517 QMKIYNEGYNEGNPAMFTVPLDAANYAALAVEIGRVRGFLSKDCNMLASHLFLADHKAAT 576 + N G VP D I V+ L+K +F +D+ Sbjct: 124 IIIQKNNGI---------VPND----------IDTVKDILNKLPEDKRKRIFNSDYSMTV 164 Query: 577 INGVIQAVKAYRDQHKL-----------------AGLEIRLAAGNAGVIAAVNDEVEKSE 619 +N A DQ KL G+E+ +A G + +++ +++S+ Sbjct: 165 VNAYTDA---GGDQKKLMRVMDDVNERIEETPFPPGVEV-IATGTPPMRKLMDELMKESQ 220 Query: 620 LPMMLYVYGAIVLLVFAVYRDWRAIIACCLPLTVATLYTYAFMKQLQIGLTVATLPVMVL 679 I++++ +R + I LP+ +A ++T M L I L +AT + L Sbjct: 221 SFTTTVGLIGILIILIIYFRKPLSSIMPLLPVLIAVIWTGGAMGLLDIPLDMATAGIGSL 280 Query: 680 AVGIGVDYAFYIYNRLQLHLAAGLPIEQALHNAIQEVGIATIFTAITLAIGVATWSFSDL 739 +G+G+DY ++ +R G+PI++A+ A+ E G A + T T +G + L Sbjct: 281 ILGLGIDYGIHLMHRYDEERRKGMPIDKAIETAVVETGTAVMATTATTVVGFLALVLAPL 340 Query: 740 KFQADMGKLLAFMFLVNLVMAMTALPAFAVVLEK 773 A++GK+ A +V+ +T LPA V+ E+ Sbjct: 341 PMMANLGKVCALGISFCMVVVLTLLPALIVIEER 374 >AF0459 [R] COG1033 Predicted exporters of the RND superfamily Afu Archaeoglobus fulgidus Length = 736 Score = 67.8 bits (164), Expect = 9e-11, Method: Compositional matrix adjust. Identities = 109/539 (20%), Positives = 223/539 (41%), Gaps = 49/539 (9%) Query: 252 CRSLPFTLLPVACSLVSLVWQFGTLRLLGYGLDPL-AVLVPFLVFAIGVSHGVQQINTIV 310 RS L P+ SL+S+ G L LLG + + +P L+ + + + Q N Sbjct: 230 VRSKLTVLFPLIVSLMSVAVMAGLLPLLGLQMTEYNSATIPILI-GLAIDYAAQLQNRYE 288 Query: 311 RGIASGQSCEAAARASFKGLLIPGVLALVTALVSFVTLVMIPIPMVRELAITASIGVGYK 370 G+ + A + P +A+ T ++ F ++ IP + + S+G+ Sbjct: 289 EERRGGREVDEALEEALNHTRFPLFMAMATTVIGFASMCAPGIPSLFWFSFLLSVGLITA 348 Query: 371 IITNLVMLPLAASLLKVGKTYADSAMRAQQ-ARGRWLAVLSRSAQPRVA--RSIVVITL- 426 + + LP SLLK+ +D R + + G +L+ A+ +A R I+ +TL Sbjct: 349 FLLSNTFLP---SLLKL----SDRGGREESISPGILEKLLTTIAKVTIANSRKILALTLI 401 Query: 427 LVLAGSAWYSHDRLVGTLQPGA-PELHADARYNRDARWIADNYGNGLDWLTVILSTPSNS 485 L++ G+ +H L + A P+L A ++ R ++ Y L +LST Sbjct: 402 LIVVGAYASTHVELETNRRKYAPPDLPALVKFEEIERKVSPQYVYAL-----VLSTERID 456 Query: 486 CDNVSFGRYQDQFDTVMRHVPGVLSVSSFADQMKIYNEGYNEGNPAMFTVPLDAANYAAL 545 ++V + + + +++ + + K E Y +P ++ + A Sbjct: 457 AESVV------KAEELAKYISSREEIYDYDSLGKTLEEYYG-------AIPAESFSKAID 503 Query: 546 AVEIGRVRGFLSKDCNMLASHLFLADHKAATINGVIQAVK------AYRDQHKLAGLEIR 599 A+ F+S N LA + + + ++++++ + + + G + Sbjct: 504 ALPKSIYSRFIS--GNQLAVYFYTNTQTEEEVEKMMRSIENDLRFLEWDGDYYITGFPVI 561 Query: 600 LAAGNAGVIAAVNDEVEKSELPMMLYVYGAIVLLVFAVYRDWRAIIACCLPLTVATLYTY 659 L + + +++N M L Y IV + YR I + ++VA Sbjct: 562 LGHLSEVLFSSLN--------LMTLVAYLLIVTFLLLAYRSVVRAIIPLISISVAVASMN 613 Query: 660 AFMKQLQIGLTVATLPVMVLAVGIGVDYAFYIYNRLQLHLAAGLPIEQALHNAIQEVGIA 719 M + I T ++ + + +G+G+DY+ +I R +E+++ ++ G A Sbjct: 614 VCMLLMGIKQTTISIALNSIVLGMGIDYSIHITER-YFEERGKFGVEESVKRTVERTGKA 672 Query: 720 TIFTAITLAIGVATWSFSDLKFQADMGKLLAFMFLVNLVMAMTALPAFAVVLEKMFPRK 778 + +A+T A G FS ++ G L + +L+ A +A+PA ++ EK + R+ Sbjct: 673 VLTSALTTAGGFGALYFSTFPVLSNFGILAFIAIIFSLLAATSAVPALLILYEKNYFRE 731 >Cj1373 [R] COG1033 Predicted exporters of the RND superfamily Cje Campylobacter jejuni Length = 823 Score = 63.2 bits (152), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 170/786 (21%), Positives = 310/786 (39%), Gaps = 134/786 (17%) Query: 35 LSYFALQLRMDAGFEKQMPTHHEYIDTFKQYRDDVLGANRLNIVLRARKGSIWTREGLTR 94 LS+FA +L +DA E + + TF++ N L + + ++ E L + Sbjct: 27 LSFFAFKLSVDASAESLLLEDDADLKTFREISKHYKSDNFLLLAFKPYDEKPFSNENLAK 86 Query: 95 LSEMTQAVMFLPNISRL---------------GVQSLWT--PN---------TFVNEITE 128 L ++ + + P + R+ ++ L PN NEI Sbjct: 87 LKKLHEELEKAPLVERVFSIINAPLLQSSQNTDLKELLKNIPNIESQDINRTKAQNEILN 146 Query: 129 EGFRADPVIP------GTVIPSALTPETIEQIRNTAVNGGFVGTLISRNQDSAMIVAEIN 182 F + +I G +I L P+T+ N + + T ++ I I Sbjct: 147 SPFYKNNIISKDGKVTGLII--YLKPDTV---YNNLIEKRDLAT---DEKEKDQIRLAIK 198 Query: 183 EFDVKGDKVDYLAYNKLLNDLRAKYENADFEVQIIGFAKQIGD--VADGAEGVLKFCAMA 240 E K + + + + + +R +N D +G I D +A ++ + Sbjct: 199 EHQDKQKVITKQSLDTIKSIVRNYEKNKD--TLYLGGVSMIADDMIAYIKSDLVLYGVSL 256 Query: 241 LLLTTIAVYWYCRSLPFTLLPVACSLVSLVWQFGTLRLLGYGLDPLAVLVPFLVFAIGVS 300 + L +A+Y++ RS F LP+ +SL G LL + + ++ LV I +S Sbjct: 257 VFLLGLALYYFFRSWRFVFLPLFICFISLSAASGVFALLNFQITVISSNYVALVLIITLS 316 Query: 301 HGVQQINTIVRGIASGQSCEAAARASFKGLLI---PGVLALVTALVSFVTLVMIPIPMVR 357 V I + + + R + LL P + A+VT ++ F +L++ I + Sbjct: 317 VVVHLITHFIESTQNHPKAKVE-RIVLETLLAKANPSLYAIVTTMIGFFSLILSNIEPII 375 Query: 358 ELAITASIGVGYKIITNLVMLPLAASLLKVGKTYADSAMRAQQARGRWLAVLSRSA-QPR 416 +L I SIG+G +I + + L LLK K Y ++ + LA +++A P+ Sbjct: 376 KLGIMMSIGIGLALIFSYLFLASILVLLK-PKNY-----HKKEFKFNLLAFCAKTALDPK 429 Query: 417 VAR-----SIVVITLLVLAGSAWYSHDRLVGTLQPGAPELHADARYNRDARWIADNYGNG 471 R S++ I L ++ S + V + G+ + I N G Sbjct: 430 KRRMIYEISVLAIILALIGISKLRVENSFVNYFKDGS-------EIKKGLLVIDKNLGGT 482 Query: 472 LDWLTVILSTPSNSCD-NVS--FGRYQDQFDTV-------------------------MR 503 L L VI+ P+N D N S ++ +F+ + Sbjct: 483 LP-LEVIIRFPNNKNDQNASDTLDSFESEFENLATQETYWFDSKKTRIAKKVHEFLENKE 541 Query: 504 HVPGVLSVSSFADQMKIYNEG----------YNEGNPAMFTVPLDAANYAALAVEIGRVR 553 V VLS++S K N+G NE PA F L + + E+ Sbjct: 542 FVGSVLSLNSLLTLGKNINDGKELDDFALAFLNENLPAKFKQDLLSPFVSIENNELRFSM 601 Query: 554 GFLSKDCNMLASHLFLADHKAATINGVIQAVKAYRDQHKLAGLEIRLAAGNAGVIAAVND 613 + D N L + FL D K K + K G+E+++ G++ N+ Sbjct: 602 RIVDSDPN-LRRNEFLIDLK-----------KQLNELVKNDGVEVQIT----GIMVLYNN 645 Query: 614 EVEK---SELPMMLYVYGAIVLLVFAVYRDWR----AIIACCLPLTVATLYTYAFMKQLQ 666 ++ S+ +++V AI +L V+RD + AI+ +PL+V +A M L Sbjct: 646 MLQSLFSSQFDTLIFVILAIFILFIIVFRDLKFSVAAILVNVIPLSVV----FALMGLLG 701 Query: 667 IGLTVATLPVMVLAVGIGVDYAFYIYNRLQLHLAAGLPIEQALHNAIQEVGIATIFTAIT 726 I L + ++ + +A+GIGVD A + R + + +E+A+ + +G A +T I+ Sbjct: 702 IPLDMMSITIAAIAIGIGVDDAIHYIYRFREEIKNK-SLEEAIMISHLSIGSALYYTTIS 760 Query: 727 LAIGVA 732 + +G + Sbjct: 761 IVLGFS 766 >TP0790 [R] COG1033 Predicted exporters of the RND superfamily Tpa Treponema pallidum Length = 888 Score = 62.0 bits (149), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 56/206 (27%), Positives = 89/206 (43%), Gaps = 20/206 (9%) Query: 579 GVIQAVKAY------RDQHKLAGLEIRLAAGNAGVIAAVNDEVEKSELPMMLYVYGAIVL 632 GVI+AVK + +D H G G+ V ++ND V +S+L +++ + + Sbjct: 691 GVIEAVKKFIRENFPQDVHAEFG-------GSVLVEQSLNDLVVQSQLISLVFSLCVVFI 743 Query: 633 LVFAVYRDWRAIIACCLPLTVATLYTYAFMKQLQIGLTVATLPVMVLAVGIGVDYAFYI- 691 ++ YR A I LPL V+ L + M I L + T V + GIGVDY + Sbjct: 744 IIAVHYRSLFAGIIGTLPLGVSVLVNFGVMGFFGIKLNICTTMVAGFSSGIGVDYTIHYL 803 Query: 692 --YNRLQLHLAAGLPIEQALHNAIQEVGIATIFTAITLAIGVATWSFSDLKFQADMGKLL 749 Y R + Q + + G A +F +++ G A S AD G L+ Sbjct: 804 AAYRRAWKECGGKDFLTQTFYGS----GRAILFNVLSVGSGFAVLMLSKFNVLADFGLLM 859 Query: 750 AFMFLVNLVMAMTALPAFAVVLEKMF 775 L + V ++T LP V++ F Sbjct: 860 VLAMLTSSVASLTLLPTLLNVVKPRF 885