BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0008.0155.p (301 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value AF0112 [K] COG0846 NAD-dependent protein deacetylases, SIR2 fami... 144 2e-34 SSO2478 [K] COG0846 NAD-dependent protein deacetylases, SIR2 fam... 143 6e-34 PAE2959 [K] COG0846 NAD-dependent protein deacetylases, SIR2 fam... 140 4e-33 PH0947 [K] COG0846 NAD-dependent protein deacetylases, SIR2 fami... 140 4e-33 TM0490 [K] COG0846 NAD-dependent protein deacetylases, SIR2 fami... 139 1e-32 >AF0112 [K] COG0846 NAD-dependent protein deacetylases, SIR2 family Afu Archaeoglobus fulgidus Length = 253 Score = 144 bits (364), Expect = 2e-34, Method: Compositional matrix adjust. Identities = 86/268 (32%), Positives = 133/268 (49%), Gaps = 29/268 (10%) Query: 26 DLLPALAQLLQRHRQVLVLTGAGISTASGIPDYRDDSGVRRGRLPIQGTEFRQSEAARKR 85 D + A++L + + +V TGAGIS SGIP +R + G+ R P + + + Sbjct: 3 DEIRKAAEILAKSKHAVVFTGAGISAESGIPTFRGEDGLWRKYDPEEVASISGFKRNPRA 62 Query: 86 YWARSMLGWPRLSQAIPNAAHRALAQLQQAGHLGGILTQNVDGLHQQAGSRDVIELHGSI 145 +W SM +L A PN AH A+A+L++ G + ++TQN+D LHQ+AGSR V+ELHGS+ Sbjct: 63 FWEFSMEMKDKLF-AEPNPAHYAIAELERMGIVKAVITQNIDMLHQRAGSRRVLELHGSM 121 Query: 146 HAVRCLACDTVYPRAEIQQELARCNPSFVNLQAEALPDGDARLEPEADAAFHVPSCVACG 205 + CL C Y +E ++ + +P C CG Sbjct: 122 DKLDCLDCHETYDWSEFVEDFNKGE---------------------------IPRCRKCG 154 Query: 206 G-MLQPDVVFFGDGVPPARTAQAEAAAQACDAMLVIGSSLMVLSGFRFPRTVAAAGKPVV 264 ++P VV FG+ +P +A A+ CDA +V+GSSL+V P AG ++ Sbjct: 155 SYYVKPRVVLFGEPLPQRTLFEAIEEAKHCDAFMVVGSSLVVYPAAELPYIAKKAGAKMI 214 Query: 265 AINRGVTRADDLLAFKLREDAESVLPRL 292 +N T AD + K+ A VLP++ Sbjct: 215 IVNAEPTMADPIFDVKIIGKAGEVLPKI 242 >SSO2478 [K] COG0846 NAD-dependent protein deacetylases, SIR2 family Sso Sulfolobus solfataricus Length = 247 Score = 143 bits (360), Expect = 6e-34, Method: Compositional matrix adjust. Identities = 88/263 (33%), Positives = 133/263 (50%), Gaps = 32/263 (12%) Query: 31 LAQLLQRHRQVLVLTGAGISTASGIPDYRDDSGVRRGRLP-IQGTEFRQSEAARKRYWAR 89 +A+ L + TGAGISTASGIPD+R G+ + P + E+ + + K +W Sbjct: 6 VAEELISSSYTIAFTGAGISTASGIPDFRGPQGLWKKYSPELASIEYFEKDP--KNFWGF 63 Query: 90 SMLGWPRLSQAIPNAAHRALAQLQQAGHLGGILTQNVDGLHQQAGSRDVIELHGSIHAVR 149 L L +A PN AH +LA+L++ G + I+TQN+DGLHQ+AGS++VIELHG++ Sbjct: 64 YSLRMRGLFEAQPNKAHYSLAELEKMGIIKVIITQNIDGLHQKAGSKNVIELHGTMRRSY 123 Query: 150 CLACDTVYPRAEIQQELARCNPSFVNLQAEALPDGDARLEPEADAAFHVPSCVACGGMLQ 209 C+ C Y + + + N L P D CGG+++ Sbjct: 124 CVLCLRTYDSLNVLSMIEKGN-----------------LPPRCD----------CGGIIR 156 Query: 210 PDVVFFGDGVPPARTAQAEAAAQACDAMLVIGSSLMVLSGFRFPRTVAAAGKPVVAINRG 269 PDVV FG+ P +A + A D ++ IGSSL V P+TV G ++ +N Sbjct: 157 PDVVLFGE--PVKNIYEALSIAYESDLVISIGSSLTVYPANLIPQTVKERGGKLIILNME 214 Query: 270 VTRADDLLAFKLREDAESVLPRL 292 T D + + +RE E LP++ Sbjct: 215 ETPLDSIADYVVREPVEISLPKI 237 >PAE2959 [K] COG0846 NAD-dependent protein deacetylases, SIR2 family Pya Pyrobaculum aerophilum Length = 254 Score = 140 bits (353), Expect = 4e-33, Method: Compositional matrix adjust. Identities = 93/274 (33%), Positives = 131/274 (47%), Gaps = 29/274 (10%) Query: 19 VSSNVDTDLLPALAQLLQRHRQVLVLTGAGISTASGIPDYRDDSGVRRGRLPIQGTEFRQ 78 ++ + TD L +A L+ R + LTGAG+STASGIPD+R GV R R+ + E Sbjct: 1 MAVDFTTDELDEVASLIARSSCNVALTGAGVSTASGIPDFRGPQGVWR-RVDPEKFEISY 59 Query: 79 SEAARKRYWARSMLGWPRLSQAIPNAAHRALAQLQQAGHLGGILTQNVDGLHQQAGSRDV 138 W + PN AH ALA++++ G L ++TQNVD LHQ AGS++V Sbjct: 60 FYNNPDEVWDLFVKYLLPAFNVKPNPAHYALAEMERLGKLCAVITQNVDRLHQAAGSKNV 119 Query: 139 IELHGSIHAVRCLACDTVYPRAEIQQELARCNPSFVNLQAEALPDGDARLEPEADAAFHV 198 IELHG++ C C + Y AE L+ A Sbjct: 120 IELHGALEYAVCTNCGSKYALAE-------------------------ALKWRKSGA--- 151 Query: 199 PSCVACGGMLQPDVVFFGDGVPPARTAQAEAAAQACDAMLVIGSSLMVLSGFRFPRTVAA 258 P C CGG+++PDVVFFG+ +P +A A+ + + IG+SL V + P Sbjct: 152 PRCPKCGGVIKPDVVFFGEPLPQDALREAFMLAEMAEVFMAIGTSLAVYPANQLPLVAKK 211 Query: 259 AGKPVVAINRGVTRADDLLAFKLREDAESVLPRL 292 G +V IN T D + +R AE VLP+L Sbjct: 212 RGAKLVIINADETYYDFFADYIIRGRAEEVLPKL 245 >PH0947 [K] COG0846 NAD-dependent protein deacetylases, SIR2 family Pho Pyrococcus horikoshii Length = 249 Score = 140 bits (352), Expect = 4e-33, Method: Compositional matrix adjust. Identities = 85/267 (31%), Positives = 135/267 (50%), Gaps = 25/267 (9%) Query: 27 LLPALAQLLQRHRQVLVLTGAGISTASGIPDYRDDSGVRRGRLPIQGTEFRQSEAARKRY 86 ++ +A++L + V+ TGAGIS SGIP +R G+ + P + E K Sbjct: 1 MMAEVARVLASSKNVIAFTGAGISAESGIPTFRGKDGLWKKYRPEELATPEAFERNPKLV 60 Query: 87 WARSMLGWPRLSQAIPNAAHRALAQLQQAGHLGGILTQNVDGLHQQAGSRDVIELHGSIH 146 W ++ +A PN AH AL +L++ G L ++TQNVD LH++AG++++IELHG+I Sbjct: 61 WDFYKWRIKKILKAKPNPAHYALVELEKMGILKAVITQNVDDLHREAGTKNLIELHGNIF 120 Query: 147 AVRCLACDTVYPRAEIQQELARCNPSFVNLQAEALPDGDARLEPEADAAFHVPSCVACGG 206 VRC +C+ E +E R + E L + +P C CG Sbjct: 121 RVRCTSCEF----REHLKESGRID--------EILSE-------------DLPKCPKCGS 155 Query: 207 MLQPDVVFFGDGVPPARTAQAEAAAQACDAMLVIGSSLMVLSGFRFPRTVAAAGKPVVAI 266 +L+PDVV+FG+ +P +A A+ D ++V+G+S +V P V +G V+ I Sbjct: 156 LLRPDVVWFGEPLPSKELNEAFKLAKEADVVIVVGTSGLVYPAAYIPYIVKDSGGVVIEI 215 Query: 267 NRGVTRADDLLAFKLREDAESVLPRLA 293 N + + F LR A +LP+L Sbjct: 216 NVQKSGITPIADFFLRGKAGEILPKLV 242 >TM0490 [K] COG0846 NAD-dependent protein deacetylases, SIR2 family Tma Thermotoga maritima Length = 246 Score = 139 bits (349), Expect = 1e-32, Method: Compositional matrix adjust. Identities = 81/259 (31%), Positives = 128/259 (49%), Gaps = 30/259 (11%) Query: 28 LPALAQLLQRHRQVLVLTGAGISTASGIPDYRDDSGV-RRGRLPIQGTEFRQSEAARKRY 86 + LL R + LTGAGIST SGIPD+R +G+ ++ + +F S Sbjct: 3 MKEFLDLLNESRLTVTLTGAGISTPSGIPDFRGPNGIYKKYSQNVFDIDFFYSHPEEFYR 62 Query: 87 WARSMLGWPRLSQAIPNAAHRALAQLQQAGHLGGILTQNVDGLHQQAGSRDVIELHGSIH 146 +A+ + +P L QA PN AH LA+L++ G + ++TQN+D LHQ+AGS+ VIELHG++ Sbjct: 63 FAKEGI-FPML-QAKPNLAHVLLAKLEEKGLIEAVITQNIDRLHQRAGSKKVIELHGNVE 120 Query: 147 AVRCLACDTVYPRAEIQQELARCNPSFVNLQAEALPDGDARLEPEADAAFHVPSCVACGG 206 C+ C+ Y ++ ++L + VP C C Sbjct: 121 EYYCVRCEKKYTVEDVIKKLESSD---------------------------VPLCDDCNS 153 Query: 207 MLQPDVVFFGDGVPPARTAQAEAAAQACDAMLVIGSSLMVLSGFRFPRTVAAAGKPVVAI 266 +++P++VFFG+ +P +A + M+V+GSSL+V P +G +V + Sbjct: 154 LIRPNIVFFGENLPQDALREAIGLSSRASLMIVLGSSLVVYPAAELPLITVRSGGKLVIV 213 Query: 267 NRGVTRADDLLAFKLREDA 285 N G T DD+ K D Sbjct: 214 NLGETPFDDIATLKYNMDV 232