BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0008.0015.p (306 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSc2187 [GER] COG0697 Permeases of the drug/metabolite transport... 362 e-100 BS_ycbK [GER] COG0697 Permeases of the drug/metabolite transport... 109 6e-24 RSc1002 [GER] COG0697 Permeases of the drug/metabolite transport... 64 5e-10 DR0512 [GER] COG0697 Permeases of the drug/metabolite transporte... 62 1e-09 AF0266 [GER] COG0697 Permeases of the drug/metabolite transporte... 62 2e-09 >RSc2187 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Rso Ralstonia solanacearum Length = 308 Score = 362 bits (928), Expect = e-100, Method: Compositional matrix adjust. Identities = 195/306 (63%), Positives = 238/306 (77%), Gaps = 1/306 (0%) Query: 1 MTAAHTPVHSTPRQAFLGGLLLAIIGAIFFSAKAIVAKLMYRYQVDAVMVITLRMLFSFP 60 MT A + ++ R A GGLLLA +GA+ FSAKAIVAKLMYRYQ+DAVMVITLRML + P Sbjct: 1 MTTASSASPASTRPADAGGLLLASVGAVLFSAKAIVAKLMYRYQIDAVMVITLRMLLAAP 60 Query: 61 MFAAVALWKARTQPPLARADVLRIVVLGLMGYYLSSFLDFLGLQYISAGLERLILFLTPS 120 +F A+ W++R PLA AD RIV LGL+GYYLSSFLDFLGLQYI+AGLERLILFLTPS Sbjct: 61 LFMAMGWWQSRRAAPLAPADRWRIVGLGLIGYYLSSFLDFLGLQYITAGLERLILFLTPS 120 Query: 121 FVMLIAFFFFKRKVGWIEWAALLVSYFGTVLVLQHDLHTGGSNVILGSALVLGSALSYSI 180 FV+LI FKR++ ++W ++ ++Y G V+V HDL GG +V LG LVL SALSY I Sbjct: 121 FVLLITATVFKRRITGLQWLSMAIAYAGIVMVFAHDLGLGGRHVWLGGGLVLASALSYGI 180 Query: 181 YLISSGELVRRVGAVRLVAYAMCVSSVACLIQFFILRAPADLVTQVAPVYQLSLFNAVFC 240 YL++SGELVRRVG++RLVAYAMCVS+VAC++QFF+LR P + VY LS N+VFC Sbjct: 181 YLLASGELVRRVGSMRLVAYAMCVSTVACMVQFFVLR-PVSALVLPWQVYGLSAINSVFC 239 Query: 241 TVLPVFLTMVAVARIGAPTAAQAGLVGPVSTLFMGAVLLDEPITGIQLAGTALVLAGMWL 300 TV PV LTM+AVAR+GAP A+QAG++GPVSTL +G LL EPIT Q+ G+ALVLAGM L Sbjct: 240 TVAPVTLTMMAVARVGAPVASQAGMIGPVSTLLLGWWLLGEPITLWQVGGSALVLAGMAL 299 Query: 301 LSRKKR 306 LSR+ Sbjct: 300 LSRRGN 305 >BS_ycbK [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Bsu Bacillus subtilis Length = 312 Score = 109 bits (273), Expect = 6e-24, Method: Compositional matrix adjust. Identities = 95/308 (30%), Positives = 157/308 (50%), Gaps = 30/308 (9%) Query: 9 HSTPRQAFLGGLLLAIIGAIFFSAKAIVAKLMYRYQVDAVMVITLRMLFSFPMFAAVALW 68 S R+A G + L +IG + F++K+I K Y+ + V+ R L + P+F + L Sbjct: 6 QSKIREAAAGTIFL-LIGTVCFASKSIWIKWAYQMGAEPDAVLLYRQLLAVPLFWLIFL- 63 Query: 69 KARTQPPL----ARADVLRIVVLGLMGYYLSSFLDFLGLQYISAGLERLILFLTPSFVML 124 +PP+ + D+ + G+ ++LS LDF+GL ++SA +ER++L P FV Sbjct: 64 --IYRPPMPDGKKKGDLWKACGAGVFCFFLSPLLDFIGLNHVSAMVERILLMSYPLFVFG 121 Query: 125 IAFFFFKRKVGWIEWAALLVSYFGTVLVLQHDLHTGGSNV------ILGSALVLGSALSY 178 ++ + A+L FG L L GG N ++G+ +L S+ Y Sbjct: 122 FTACRDRKMSSIQDLFAVLAVMFGLFLAL------GGWNAELFQANMIGAVFILLSSAVY 175 Query: 179 SIYLISSGELVRRVGAVRLVAYAMCVSSVACLIQFFILRAPADLVTQVAPVYQLSLFN-- 236 + YL+ SG LV ++G +RL AY M + A ++ + +++ A + T +A Y LS++ Sbjct: 176 AGYLVLSGHLVHQIGGIRLNAYGMTAAGAAMML-YTGIKSAAGMNTPMA-AYPLSMYGLF 233 Query: 237 ---AVFCTVLPVFLTMVAVARIGAPTAAQAGLVGPVSTLFMGAVLLDEPITGIQLAGTA- 292 AV TV+P L + + RIGA AA + GP+ T+F GA+ L E + IQ+ G Sbjct: 234 AVIAVVTTVIPFVLMLEGIKRIGAQRAAAISMAGPILTIFYGALFLGERLGLIQVIGCGG 293 Query: 293 --LVLAGM 298 V+ GM Sbjct: 294 VFFVITGM 301 >RSc1002 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Rso Ralstonia solanacearum Length = 312 Score = 63.9 bits (154), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 88/296 (29%), Positives = 130/296 (43%), Gaps = 21/296 (7%) Query: 19 GLLLAIIGAIFFSAKAIVAKLMYRYQVDAVMVITLRMLFSFPMFAAVALWKART--QPPL 76 G+LL + A F A AI Y D V ++ +R FS A A+ + R PP Sbjct: 20 GVLLIAVSAASFGAMAIFTHYAYASGADTVGLLAVR--FSLAALALTAVMRVRRIGLPPW 77 Query: 77 ARADVLRIVVLGLMGYYLSSFLDFLGLQYISAGLERLILFLTPSFVMLIAFFFFKRKVGW 136 R V + +G +GY SF F L Y A L L+L+L P FV ++A F ++ Sbjct: 78 PR--VAGLAAMGGIGYAGQSFAFFTALHYAPASLVALLLYLYPMFVTVLAAVFLHERLTP 135 Query: 137 IEWAALLVSYFGTVLVLQHDLHTGGSN--VILGSALVLGSALSYSIYLISSGELVRRVGA 194 AL++ G L + GGS V+LG A +A+ YS+Y+ + R V Sbjct: 136 AALLALVLCSVGAGLTVGGAGLAGGSATGVVLGVA----AAVIYSVYITVGARVTRGVDP 191 Query: 195 V---RLVAYAMCVSSVACLIQFFILRAPADLVTQVAPVYQLSLFNAVFCTVLPVFLTMVA 251 + L+ A V + R P + +L A TV+ + Sbjct: 192 IACTTLICTAAAVVYAGAAVAGVPARFPGSVAGWA-----AALAIAGLSTVIAILAFFAG 246 Query: 252 VARIGAPTAAQAGLVGPVSTLFMGAVLLDEPITGIQLAGTALVLAG-MWLLSRKKR 306 + R+GA A+ + PV T+ + A+LL E I Q+AG AL+LAG +WL R Sbjct: 247 LQRLGAAQASMLSTLEPVVTVALAALLLGESIGAAQMAGGALILAGVLWLTRADAR 302 >DR0512 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Dra Deinococcus radiodurans Length = 301 Score = 62.4 bits (150), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 69/267 (25%), Positives = 117/267 (43%), Gaps = 18/267 (6%) Query: 40 MYRYQVDAVMVITLRMLFSFPMFAAVALWKARTQPPLARADVLRIVVLGLMGYYLSSFLD 99 +YR+ V +V ++ + + P+ A LW+ I VL + G L L Sbjct: 51 LYRFLVASVTLLLVMAVTRLPVPAPRDLWQ--------------IGVLSVAGISLYHVLL 96 Query: 100 FLGLQYISAGLERLILFLTPSFVMLIAFFFFKRKVGWIEWAALLVSYFGTVLVLQHDLHT 159 +G + + AG LI+ P L+A F + + W VS G L++ Sbjct: 97 NMGERSVPAGTASLIIAAGPVITALLAARFLGESLNPLGWLGTAVSLGGVALIVLGQGQ- 155 Query: 160 GGSNVILGSALVLGSALSYSIYLISSGELVRRVGAVRLVAYAMCVSSVACLIQFFILRAP 219 G G+ LVLG+A S+Y + ++ RVG++R +++ + +V L+ F+ Sbjct: 156 -GLGFSAGALLVLGAAFFTSLYFVFQKGVLARVGSLRFTVWSLILGTVPLLV--FLPGFG 212 Query: 220 ADLVTQVAPVYQLSLFNAVFCTVLPVFLTMVAVARIGAPTAAQAGLVGPVSTLFMGAVLL 279 +L P + L+ VF + L A++R+GA + V PV L M LL Sbjct: 213 TELRAAPLPAHLAVLYLGVFPSALAYLTWTFAISRVGAGVTSSFLYVSPVFALLMAWALL 272 Query: 280 DEPITGIQLAGTALVLAGMWLLSRKKR 306 E + L G + LAG+ L++ + R Sbjct: 273 GEVPGAVTLLGGVIALAGVLLVNTRGR 299 >AF0266 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Afu Archaeoglobus fulgidus Length = 276 Score = 62.0 bits (149), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 63/269 (23%), Positives = 131/269 (48%), Gaps = 19/269 (7%) Query: 42 RYQV---DAVMVITLRMLFSFPMFAAVALWKARTQPPLARADVLRIVVLGLMGYYLSSFL 98 +Y V + + +LR + +FA + + R + D+ ++ LG+ G + Sbjct: 22 KYSVRFLSPIAIASLRFAIANTLFAVIIILGKRIK----WKDLPKVFALGIFGVSVYHVF 77 Query: 99 DFLGLQYISAGLERLILFLTPSFVMLIAFFFFKRKVGWIEWAALLVSYFGTVLVLQHDLH 158 LG YIS+G+ +++ L P FV++++ F + ++ + + +++++ G V++ + Sbjct: 78 LNLGEVYISSGVASVVISLAPIFVLILSAIFLRERITYSKVVGIIIAFLGVVVISEPSYA 137 Query: 159 TGGSNVILGSALVLGSALSYSIYLISSGELVRRVGAVRLVAYAMCVSSVACLIQFF--IL 216 I G ALV+ S ++ +IY L+ + + L + AM + S+ L F + Sbjct: 138 N-----IYGIALVMVSTVAAAIYTTFGKSLLSKYNPITLTSNAMVLGSIP-LYPFLPDSI 191 Query: 217 RAPADLVTQVAPVYQLSLFNAVFCTVLPVFLTMVAVARIGAPTAAQAGLVGPVSTLFMGA 276 R+ + + + L +F+ F + + + + A A+ L PV +L G Sbjct: 192 RSLGGDLNLIGSIVFLGIFSTFFGYLGWYYF----LEKEEASRASVFLLAIPVVSLLAGN 247 Query: 277 VLLDEPITGIQLAGTALVLAGMWLLSRKK 305 +LL EP+T +AG+ LVL G++++ RK+ Sbjct: 248 ILLAEPLTLRTVAGSGLVLLGIYIVVRKR 276