BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0007.0135.p (395 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSc2490 [C] COG0538 Isocitrate dehydrogenases Rso Ralstonia sola... 422 e-118 PA2623 [C] COG0538 Isocitrate dehydrogenases Pae Pseudomonas aer... 405 e-113 YPO1641 [C] COG0538 Isocitrate dehydrogenases Ype Yersinia pestis 383 e-106 icd [C] COG0538 Isocitrate dehydrogenases Eco Escherichia coli K12 375 e-104 STM1238 [C] COG0538 Isocitrate dehydrogenases Sty Salmonella typ... 375 e-104 >RSc2490 [C] COG0538 Isocitrate dehydrogenases Rso Ralstonia solanacearum Length = 416 Score = 422 bits (1086), Expect = e-118, Method: Compositional matrix adjust. Identities = 200/252 (79%), Positives = 227/252 (90%), Gaps = 1/252 (0%) Query: 3 YQHIQVPAEGRKITANADDTLNVPNNPIIPFIMGDGVGVDVTPVMLKVVDAAVEKAYGGA 62 YQHI+VPA G KIT N D +LNVP+NPIIP+I GDG G D+TPVM+KVVDAAVEKAY G Sbjct: 2 YQHIKVPA-GEKITVNQDFSLNVPDNPIIPYIEGDGTGFDITPVMIKVVDAAVEKAYAGK 60 Query: 63 RKIHWMEIYAGEKSTKLYGADTWLPEETLDVLKEYLVSIKGPLSTPVGGGIRSLNVTMRQ 122 RKI WMEIYAGEKSTK+YG D WLPEETL VLK+Y+VSIKGPL+TPVGGGIRSLNV +RQ Sbjct: 61 RKISWMEIYAGEKSTKVYGPDVWLPEETLQVLKDYVVSIKGPLTTPVGGGIRSLNVALRQ 120 Query: 123 QLDLYVCLRPVRYFKGVPSPLKEPEKTDMVIFRENSEDIYAGIEWQAGTPEVKKLIELLT 182 +LDLYVCLRPVRYFKGVPSP+KEPEKTDMVIFRENSEDIYAGIE++A + + KKLI++L Sbjct: 121 ELDLYVCLRPVRYFKGVPSPVKEPEKTDMVIFRENSEDIYAGIEFEAQSDKAKKLIKILQ 180 Query: 183 REMGVKKLRFPETSALGIKPVSREGTERLVRKAIQYAIDHDKPSVTLVHKGNIMKYTEGA 242 E GVKK+RFPETS +G+KPVS+EGTERLVRKAIQYAID+DKPSVT+VHKGNIMK+TEG Sbjct: 181 DEFGVKKIRFPETSGIGVKPVSKEGTERLVRKAIQYAIDNDKPSVTIVHKGNIMKFTEGG 240 Query: 243 FRDWGYALAGRE 254 FRDW YALA +E Sbjct: 241 FRDWAYALAQKE 252 >PA2623 [C] COG0538 Isocitrate dehydrogenases Pae Pseudomonas aeruginosa Length = 418 Score = 405 bits (1041), Expect = e-113, Method: Compositional matrix adjust. Identities = 186/254 (73%), Positives = 224/254 (88%) Query: 1 MSYQHIQVPAEGRKITANADDTLNVPNNPIIPFIMGDGVGVDVTPVMLKVVDAAVEKAYG 60 M YQ IQVPA G KIT NAD +L+VP NPIIPFI GDG+GVD++PVM+KVVDAAVEKAY Sbjct: 1 MGYQKIQVPATGDKITVNADMSLSVPKNPIIPFIEGDGIGVDISPVMIKVVDAAVEKAYK 60 Query: 61 GARKIHWMEIYAGEKSTKLYGADTWLPEETLDVLKEYLVSIKGPLSTPVGGGIRSLNVTM 120 G RKI WME+YAGEK+T++Y DTWLP+ETLD +++Y+VSIKGPL+TPVGGGIRSLNV + Sbjct: 61 GERKIAWMEVYAGEKATQVYDQDTWLPQETLDAVRDYVVSIKGPLTTPVGGGIRSLNVAL 120 Query: 121 RQQLDLYVCLRPVRYFKGVPSPLKEPEKTDMVIFRENSEDIYAGIEWQAGTPEVKKLIEL 180 RQQLDLYVC RPVR+F+GVPSP+K+P DMVIFRENSEDIYAG+EW+AG+PE +K+I+ Sbjct: 121 RQQLDLYVCQRPVRWFEGVPSPVKKPGDVDMVIFRENSEDIYAGVEWKAGSPEAEKVIKF 180 Query: 181 LTREMGVKKLRFPETSALGIKPVSREGTERLVRKAIQYAIDHDKPSVTLVHKGNIMKYTE 240 LT EMGVKK+RF E +GIKPVS+EGT+RLVRKA+QYA+D+D+ SVTLVHKGNIMK+TE Sbjct: 181 LTEEMGVKKIRFTENCGIGIKPVSQEGTKRLVRKALQYAVDNDRSSVTLVHKGNIMKFTE 240 Query: 241 GAFRDWGYALAGRE 254 GAF+DWGY +A E Sbjct: 241 GAFKDWGYEVARDE 254 >YPO1641 [C] COG0538 Isocitrate dehydrogenases Ype Yersinia pestis Length = 417 Score = 383 bits (983), Expect = e-106, Method: Compositional matrix adjust. Identities = 179/249 (71%), Positives = 213/249 (85%) Query: 6 IQVPAEGRKITANADDTLNVPNNPIIPFIMGDGVGVDVTPVMLKVVDAAVEKAYGGARKI 65 + VPAEG+KIT +A L VP+NPIIPFI GDG+GVDVTP M+ VVDAAV+KAY G RKI Sbjct: 5 VVVPAEGKKITVDAQGKLVVPHNPIIPFIEGDGIGVDVTPAMINVVDAAVKKAYNGERKI 64 Query: 66 HWMEIYAGEKSTKLYGADTWLPEETLDVLKEYLVSIKGPLSTPVGGGIRSLNVTMRQQLD 125 WMEIY GEKST +YG D WLPEETLD++++Y V+IKGPL+TPVGGGIRSLNV +RQQLD Sbjct: 65 SWMEIYTGEKSTHVYGKDVWLPEETLDLIRDYRVAIKGPLTTPVGGGIRSLNVALRQQLD 124 Query: 126 LYVCLRPVRYFKGVPSPLKEPEKTDMVIFRENSEDIYAGIEWQAGTPEVKKLIELLTREM 185 LYVCLRPVRY++G PSP+K PE T+MVIFREN+EDIYAGIEW+AG+PE +K+I+ L EM Sbjct: 125 LYVCLRPVRYYEGTPSPVKHPELTNMVIFRENAEDIYAGIEWKAGSPEAEKVIKFLREEM 184 Query: 186 GVKKLRFPETSALGIKPVSREGTERLVRKAIQYAIDHDKPSVTLVHKGNIMKYTEGAFRD 245 GVKK+RFPE +G+KP S EGT+RLVR AI+YAI +D+ SVTLVHKGNIMK+TEGAF+D Sbjct: 185 GVKKIRFPEQCGIGVKPCSEEGTKRLVRAAIEYAITNDRESVTLVHKGNIMKFTEGAFKD 244 Query: 246 WGYALAGRE 254 WGY LA E Sbjct: 245 WGYQLAREE 253 >icd [C] COG0538 Isocitrate dehydrogenases Eco Escherichia coli K12 Length = 416 Score = 375 bits (964), Expect = e-104, Method: Compositional matrix adjust. Identities = 178/249 (71%), Positives = 211/249 (84%), Gaps = 1/249 (0%) Query: 6 IQVPAEGRKITANADDTLNVPNNPIIPFIMGDGVGVDVTPVMLKVVDAAVEKAYGGARKI 65 + VPA+G+KIT + LNVP NPIIP+I GDG+GVDVTP MLKVVDAAVEKAY G RKI Sbjct: 5 VVVPAQGKKITLQ-NGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKI 63 Query: 66 HWMEIYAGEKSTKLYGADTWLPEETLDVLKEYLVSIKGPLSTPVGGGIRSLNVTMRQQLD 125 WMEIY GEKST++YG D WLP ETLD+++EY V+IKGPL+TPVGGGIRSLNV +RQ+LD Sbjct: 64 SWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELD 123 Query: 126 LYVCLRPVRYFKGVPSPLKEPEKTDMVIFRENSEDIYAGIEWQAGTPEVKKLIELLTREM 185 LY+CLRPVRY++G PSP+K PE TDMVIFRENSEDIYAGIEW+A + + +K+I+ L EM Sbjct: 124 LYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEM 183 Query: 186 GVKKLRFPETSALGIKPVSREGTERLVRKAIQYAIDHDKPSVTLVHKGNIMKYTEGAFRD 245 GVKK+RFPE +GIKP S EGT+RLVR AI+YAI +D+ SVTLVHKGNIMK+TEGAF+D Sbjct: 184 GVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKD 243 Query: 246 WGYALAGRE 254 WGY LA E Sbjct: 244 WGYQLAREE 252 >STM1238 [C] COG0538 Isocitrate dehydrogenases Sty Salmonella typhimurium LT2 Length = 416 Score = 375 bits (964), Expect = e-104, Method: Compositional matrix adjust. Identities = 179/249 (71%), Positives = 210/249 (84%), Gaps = 1/249 (0%) Query: 6 IQVPAEGRKITANADDTLNVPNNPIIPFIMGDGVGVDVTPVMLKVVDAAVEKAYGGARKI 65 + VP EG+KIT + LNVP NPIIPFI GDG+GVDVTP MLKVVDAAVEKAY G RKI Sbjct: 5 VVVPVEGKKITLQ-NGKLNVPENPIIPFIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKI 63 Query: 66 HWMEIYAGEKSTKLYGADTWLPEETLDVLKEYLVSIKGPLSTPVGGGIRSLNVTMRQQLD 125 WMEIY GEKST++YG D WLP ETLD++++Y V+IKGPL+TPVGGGIRSLNV +RQ+LD Sbjct: 64 SWMEIYTGEKSTQVYGQDVWLPAETLDLIRDYRVAIKGPLTTPVGGGIRSLNVALRQELD 123 Query: 126 LYVCLRPVRYFKGVPSPLKEPEKTDMVIFRENSEDIYAGIEWQAGTPEVKKLIELLTREM 185 LYVCLRPVRY++G PSP+K PE TDMVIFRENSEDIYAGIEW+A + + +K+I+ L EM Sbjct: 124 LYVCLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEM 183 Query: 186 GVKKLRFPETSALGIKPVSREGTERLVRKAIQYAIDHDKPSVTLVHKGNIMKYTEGAFRD 245 GVKK+RFPE +GIKP S EGT+RLVR AI+YAI +D+ SVTLVHKGNIMK+TEGAF+D Sbjct: 184 GVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAITNDRDSVTLVHKGNIMKFTEGAFKD 243 Query: 246 WGYALAGRE 254 WGY LA E Sbjct: 244 WGYQLARDE 252