BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0007.0075.p (411 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value lin2949 [GEPR] COG0477 Permeases of the major facilitator superf... 201 3e-51 RSp1614 [GEPR] COG0477 Permeases of the major facilitator superf... 155 2e-37 STM1543 [GEPR] COG0477 Permeases of the major facilitator superf... 150 5e-36 yhaU [GEPR] COG0477 Permeases of the major facilitator superfami... 149 2e-35 ZyhaU [GEPR] COG0477 Permeases of the major facilitator superfam... 149 2e-35 >lin2949 [GEPR] COG0477 Permeases of the major facilitator superfamily Lin Listeria innocua Length = 401 Score = 201 bits (510), Expect = 3e-51, Method: Compositional matrix adjust. Identities = 127/398 (31%), Positives = 217/398 (54%), Gaps = 9/398 (2%) Query: 8 MTKAQGEGRYKYLVLVLLYLGWCVSYIDRAAITFAATQIASEFALKPSDLGILLSSFFLG 67 M + +GE ++ +VL++L++G+ Y+D+ I + ++ + PS G++LS+FFLG Sbjct: 1 MNQVKGE-KHSLMVLLVLFIGYTSVYVDKYTIGISLVTVSQDLGFDPSQKGLILSAFFLG 59 Query: 68 YSLLQLPGGWLADRYGSRPVIVISILLWSVFTGVTGMAWSITSLVVIRFIFG-LGEGAFP 126 Y+L Q+P G+L +R G+RPV+ ISI++ +F + G +S+ LVVIRF+ G G +P Sbjct: 60 YTLFQIPMGYLNNRIGARPVLAISIIIVGLFLIIFGFGYSLLFLVVIRFLSGAFGHAGYP 119 Query: 127 AASVKGVAENFSREERPKMSSLLMSSNYIGSMLAPLLIAPLIMHFGWRAVFHTIGIAGLV 186 + ++ + +R S +++S+ + + PLLIA L++ GWR ++ IGI ++ Sbjct: 120 PSVSNYISLHIPLNKRGFAQSAMLASSGFAAFIGPLLIAQLLLSVGWRNTYYWIGIV-VI 178 Query: 187 FALVYWFCVRPVRPGKDGPKAINKEA----FAALLRMPLMWKIVAVWFGLSIINKGLDSW 242 F + V P P D K+ KE F+ LL+ +W ++ ++ N GL SW Sbjct: 179 FIGLLILLVVPKAPKID--KSTQKEKIKVPFSELLKDKQLWILLLSALFINAANYGLTSW 236 Query: 243 MPTYLMTVRGLNLKAVGLLLPLPYIMAGLSTAIGGWVMVRFFDGREKLLLIASSLLTAVF 302 + +YL RG+++ V + L + ++ IGG+ + RFF G+E +++ S+L A Sbjct: 237 LASYLNEARGISISEVSYISSLAGLCILIAGVIGGYFISRFFKGKEPIVIFTFSVLGAFT 296 Query: 303 VYCMYTAVTVEGVIAWQCLAYFFKSFVLATCIALPTKLLQAQMVGSGVGMVNLGGQLAGF 362 VY +Y + I CL F T + LP KL + + + +N GG L GF Sbjct: 297 VYGVYLFDQLMLSIICLCLCNIFLIMAFTTLMGLPHKLFKQSHIATKYAAINSGGVLGGF 356 Query: 363 ISPLVIGFLVSAFANYDYAFSFLIGAALFSVLVSLFIR 400 +P++IG LV+A +Y AF FL L S ++ L I+ Sbjct: 357 FAPMIIGDLVNATNSYQSAFLFLALTFLVSGIIVLAIK 394 >RSp1614 [GEPR] COG0477 Permeases of the major facilitator superfamily Rso Ralstonia solanacearum Length = 448 Score = 155 bits (391), Expect = 2e-37, Method: Compositional matrix adjust. Identities = 125/421 (29%), Positives = 205/421 (48%), Gaps = 43/421 (10%) Query: 9 TKAQGE-GRYKYLVLVLLYLGWCVSYIDRAAITFAATQIASEFALKPSDLGILLSSFFLG 67 T +G+ + ++LV L++ ++YIDR ++ AA I EF L ++G+++S+FF Sbjct: 4 TPQRGQRSKVRWLVAGLMWAAIAINYIDRTVLSAAAPHIQKEFHLSAVEMGVVMSAFFWS 63 Query: 68 YSLLQLPGGWLADRYGSRPVIVISILLWSVFTGVTGMAWSITSLVVIRFIFGLGE-GAFP 126 Y+LLQLP G LADR+G + V+ ++L WS+ T VTG+A SLV +R G+GE GA+P Sbjct: 64 YALLQLPAGILADRFGQKKVLGFAVLWWSLATAVTGLATGFKSLVGLRVALGVGEAGAYP 123 Query: 127 AASVKGVAEN-FSREERPKMSSLLMSSNYIGSMLAPLLIAPLIMHFGWRAVFHTIGIAGL 185 S G+ F ++ER ++++ S + +GS +A LIA L++ F W+ F G G+ Sbjct: 124 --SNAGITSRWFPKQERATVAAIFDSGSKLGSAIALPLIAWLLVTFDWKITFTVAGSLGI 181 Query: 186 VFALVYWFCVRPVRPGKDG-------------PKAINKEA----FAALLRMPLMWKIVAV 228 V+ +V+ R +G P A +A + LL +W + Sbjct: 182 VWCVVWALVFRDSPAEHEGVNAAELAHIQKGLPPARGADAPAMPWTKLLTHRNVWAMCIG 241 Query: 229 WFGLSIINKGLDSWMPTYLMTVRGLNLKAVGLLLPLPYIMAGLSTAIGGWVMVRFF-DGR 287 +F ++ + +W+PTYL+ RG+ L +G + LP ++ GW R + GR Sbjct: 242 FFMINYNSYFFITWLPTYLVKERGMGLMEMGFMASLPLFVSMFVEVFAGWASDRVYASGR 301 Query: 288 EKL-----------LLIASSLLTAVFVYCMYTAVTVEGVIAWQCLAYFFKSFVLATCIAL 336 L L++ASS+ A F AV + C+A + + AL Sbjct: 302 LSLTATRKLFLVIGLVMASSIGLAAFAQSAVVAVIL------LCIAKSGTTVAASQVWAL 355 Query: 337 PTKLLQAQMVGSGVGMVNLGGQLAGFISPLVIGFLVSAFANYDYAFSF---LIGAALFSV 393 P + V G+ N + G + P+V G +V A ++ A F LIG A+ + Sbjct: 356 PADVAPGNTVSMVAGLQNSVSNMGGVVGPIVTGAIVGATGSFIPALVFSAALIGLAILNY 415 Query: 394 L 394 L Sbjct: 416 L 416 >STM1543 [GEPR] COG0477 Permeases of the major facilitator superfamily Sty Salmonella typhimurium LT2 Length = 428 Score = 150 bits (379), Expect = 5e-36, Method: Compositional matrix adjust. Identities = 110/410 (26%), Positives = 204/410 (49%), Gaps = 27/410 (6%) Query: 19 YLVLVLLYLGWCVSYIDRAAITFAATQIASEFALKPSDLGILLSSFFLGYSLLQLPGGWL 78 +L++ LL++ + ++Y+DR+A++ A I E +++G++ S+FF+GY+L GGW Sbjct: 8 WLIVFLLFIVYMLNYMDRSALSITAPLIEKELGFNAAEMGMIFSAFFIGYALFNFIGGWA 67 Query: 79 ADRYGSRPVIVISILLWSVFTGVTGMAWSITSLVVIRFIFGLGEGAFPAASVKGVAENFS 138 +D+ G + V +I+ LLWSVF G+TG+ + +++++R +FG+ EG AA K + S Sbjct: 68 SDKVGPKTVFLIAALLWSVFCGLTGLVTGLWTMLIVRVLFGMAEGPVSAAGNKIINNWIS 127 Query: 139 REERPKMSSLLMSSNYIGSMLAPLLIAPLIMHFGWRAVFHTIGIAGLVFALVYWFCV--R 196 R+E + + + +G ++ ++ L + GWR F I + GLV+ L+++F V + Sbjct: 128 RKESATAIGIFSAGSPLGGAVSGPIVGLLALSLGWRPAFGIIFLFGLVWVLLWYFIVSDK 187 Query: 197 PVRPGKDGPKA----INKE------------AFAALLRMPLMWKIVAVWFGLSIINKGLD 240 P + P+ N E + ++ P++W +F + I Sbjct: 188 PTMSKRLAPEERIDFENHEDVILSDDGRATPSLGYYMKQPMVWATTLAFFSYNYILFFFL 247 Query: 241 SWMPTYLMTVRGLNLKAVGLLLPLPYIMAGLSTAIGGW---VMVRFFDG---REKLLLIA 294 +W P+YL L++K + + +P+++ + +GG V+ R +L+L Sbjct: 248 TWFPSYLNHSLHLDIKEISIATVIPWVIGAIGMVLGGVCSDVIYRITGNALLSRRLILGV 307 Query: 295 SSLLTAVFVYCMYTAVTVEGVIAWQCLAYFFKSFVLATCIALPTKLLQAQMVGSGVGMVN 354 AV V T T+ I ++ F A+ ++ VGS G ++ Sbjct: 308 CLAGAAVCVAVSGTVSTIGSAITLMSVSLFLLYLTGPIYWAVIQDVVHKDKVGSVGGAMH 367 Query: 355 LGGQLAGFISPLVIGFLVSAFANYDYAFSFLIG--AALFSVLVSLFIRTS 402 ++G I PLV GF+V YDYAF +L G A + S+LV +F+++ Sbjct: 368 GLANISGIIGPLVTGFIVQFSGKYDYAF-YLAGAIAIVSSLLVFVFVKSK 416 >yhaU [GEPR] COG0477 Permeases of the major facilitator superfamily Eco Escherichia coli K12 Length = 444 Score = 149 bits (375), Expect = 2e-35, Method: Compositional matrix adjust. Identities = 120/426 (28%), Positives = 207/426 (48%), Gaps = 52/426 (12%) Query: 18 KYLVLVLLYLGWCVSYIDRAAITFAATQIASEFALKPSDLGILLSSFFLGYSLLQLPGGW 77 +YL+L+++++ V+Y DRA ++ A T++A E L +G + S+F Y L+Q+PGGW Sbjct: 16 RYLILLIIFIVTAVNYADRATLSIAGTEVAKELQLSAVSMGYIFSAFGWAYLLMQIPGGW 75 Query: 78 LADRYGSRPVIVISILLWSVFTGVTG------MAWSITSLVVIRFIFGLGEGAFPAASVK 131 L D++GS+ V S+ WS+FT + G +AW+ S+ +RF+ G E A+ + Sbjct: 76 LLDKFGSKKVYTYSLFFWSLFTFLQGFVDMFPLAWAGISMFFMRFMLGFSEAPSFPANAR 135 Query: 132 GVAENFSREERPKMSSLLMSSNYIGSMLAPLLIAPLIMHFGWRAVFHTIGIAGLVFALVY 191 VA F +ER S++ S+ Y L L+ L +GW VF +G+ G V ++ Sbjct: 136 IVAAWFPTKERGTASAIFNSAQYFSLALFSPLLGWLTFAWGWEHVFTVMGVIGFVLTALW 195 Query: 192 WFCVRPVRPGKDGPKAINKE-----AFAALLRM------------PLMWKI--------- 225 ++ + D P+ +E A++ M P + I Sbjct: 196 ---IKLIHNPTDHPRMSAEELKFISENGAVVDMDHKKPGSAAASGPKLHYIKQLLSNRMM 252 Query: 226 VAVWFGLSIINK---GLDSWMPTYLMTVRGLNLKAVGLLLPLPYIMAGLSTAIGGWVMVR 282 + V+FG IN +W P YL+ +G+++ VGL+ +P + G + + G V Sbjct: 253 LGVFFGQYFINTITWFFLTWFPIYLVQEKGMSILKVGLVASIP-ALCGFAGGVLGGVFSD 311 Query: 283 FFDGR-------EKLLLIASSLLTAVFVYCMYTAVTVEGVIAWQCLAYFFKSFVLATCIA 335 + R KL ++ LL + + C YT T V+ LA+F K F + Sbjct: 312 YLIKRGLSLTLARKLPIVLGMLLASTIILCNYTNNTTL-VVMLMALAFFGKGF---GALG 367 Query: 336 LP--TKLLQAQMVGSGVGMVNLGGQLAGFISPLVIGFLVSAFANYDYAFSFLIGAALFSV 393 P + ++VG G+ N+ G +A ++PLVIG+LVS +++ A F+ +AL ++ Sbjct: 368 WPVISDTAPKEIVGLCGGVFNVFGNVASIVTPLVIGYLVSELHSFNAALVFVGCSALMAM 427 Query: 394 LVSLFI 399 + LF+ Sbjct: 428 VCYLFV 433 >ZyhaU [GEPR] COG0477 Permeases of the major facilitator superfamily EcZ Escherichia coli O157:H7 EDL933 Length = 444 Score = 149 bits (375), Expect = 2e-35, Method: Compositional matrix adjust. Identities = 120/426 (28%), Positives = 207/426 (48%), Gaps = 52/426 (12%) Query: 18 KYLVLVLLYLGWCVSYIDRAAITFAATQIASEFALKPSDLGILLSSFFLGYSLLQLPGGW 77 +YL+L+++++ V+Y DRA ++ A T++A E L +G + S+F Y L+Q+PGGW Sbjct: 16 RYLILLIIFIVTAVNYADRATLSIAGTEVAKELQLSAVSMGYIFSAFGWAYLLMQIPGGW 75 Query: 78 LADRYGSRPVIVISILLWSVFTGVTG------MAWSITSLVVIRFIFGLGEGAFPAASVK 131 L D++GS+ V S+ WS+FT + G +AW+ S+ +RF+ G E A+ + Sbjct: 76 LLDKFGSKKVYTYSLFFWSLFTFLQGFVDMFPLAWAGISMFFMRFMLGFSEAPSFPANAR 135 Query: 132 GVAENFSREERPKMSSLLMSSNYIGSMLAPLLIAPLIMHFGWRAVFHTIGIAGLVFALVY 191 VA F +ER S++ S+ Y L L+ L +GW VF +G+ G V ++ Sbjct: 136 IVAAWFPTKERGTASAIFNSAQYFSLALFSPLLGWLTFAWGWEHVFTVMGVIGFVLTALW 195 Query: 192 WFCVRPVRPGKDGPKAINKE-----AFAALLRM------------PLMWKI--------- 225 ++ + D P+ +E A++ M P + I Sbjct: 196 ---IKLIHNPTDHPRMSAEELKFISENGAVVDMDHKKPGSAAASGPKLHYIKQLLSNRMM 252 Query: 226 VAVWFGLSIINK---GLDSWMPTYLMTVRGLNLKAVGLLLPLPYIMAGLSTAIGGWVMVR 282 + V+FG IN +W P YL+ +G+++ VGL+ +P + G + + G V Sbjct: 253 LGVFFGQYFINTITWFFLTWFPIYLVQEKGMSILKVGLVASIP-ALCGFAGGVLGGVFSD 311 Query: 283 FFDGR-------EKLLLIASSLLTAVFVYCMYTAVTVEGVIAWQCLAYFFKSFVLATCIA 335 + R KL ++ LL + + C YT T V+ LA+F K F + Sbjct: 312 YLIKRGLSLTLARKLPIVLGMLLASTIILCNYTNNTTL-VVMLMALAFFGKGF---GALG 367 Query: 336 LP--TKLLQAQMVGSGVGMVNLGGQLAGFISPLVIGFLVSAFANYDYAFSFLIGAALFSV 393 P + ++VG G+ N+ G +A ++PLVIG+LVS +++ A F+ +AL ++ Sbjct: 368 WPVISDTAPKEIVGLCGGVFNVFGNVASIVTPLVIGYLVSELHSFNAALVFVGCSALMAM 427 Query: 394 LVSLFI 399 + LF+ Sbjct: 428 VCYLFV 433