BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0007.0071.p (1049 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSp0818 [V] COG0841 Cation/multidrug efflux pump Rso Ralstonia s... 1782 0.0 STM0475 [V] COG0841 Cation/multidrug efflux pump Sty Salmonella ... 1378 0.0 acrB [V] COG0841 Cation/multidrug efflux pump Eco Escherichia co... 1373 0.0 ZacrB [V] COG0841 Cation/multidrug efflux pump EcZ Escherichia c... 1372 0.0 ECs0515 [V] COG0841 Cation/multidrug efflux pump Ecs Escherichia... 1372 0.0 >RSp0818 [V] COG0841 Cation/multidrug efflux pump Rso Ralstonia solanacearum Length = 1053 Score = 1782 bits (4615), Expect = 0.0, Method: Compositional matrix adjust. Identities = 875/1031 (84%), Positives = 958/1031 (92%) Query: 1 MARFFIDRPIFAWVLAIIVMLAGAISVLTLPIAQYPAIAPPAIAITANYPGASAKTLEDT 60 MAR+FIDRPIFAWVLAIIVMLAGA+S+ TLPIAQYP+IAPPA+AITA YPGASAKTLEDT Sbjct: 1 MARYFIDRPIFAWVLAIIVMLAGALSIATLPIAQYPSIAPPAVAITATYPGASAKTLEDT 60 Query: 61 VTQIIEQKMKGLDRLSYMASTSESSGSVTITLTFENGTNPDTAQVQVQNKLSLATPLLPS 120 VTQIIEQKMKGLD LSYMASTSESSG+VTITLTF+NGT+PDTAQVQVQNKL+LATPLLP Sbjct: 61 VTQIIEQKMKGLDHLSYMASTSESSGTVTITLTFDNGTDPDTAQVQVQNKLALATPLLPQ 120 Query: 121 EVQQQGITVTKSATNFLNVLAFTSEDGSMSGSDLSDYVAANIQDAISRVEGVGDTTLFGS 180 EVQQQG+ VTKSATNFLNVLAFTSEDGSM+GSDLSDYVAAN+QDA+SRVEGVGDTTLFGS Sbjct: 121 EVQQQGVQVTKSATNFLNVLAFTSEDGSMNGSDLSDYVAANVQDALSRVEGVGDTTLFGS 180 Query: 181 QYAMRIWLDPNKLNSYSLTPLDVKNAIQAQNVQVSSGQLGGLPAAENQQINATITAQTRL 240 QYAMRIWLDP+KL+++SLTPLDVK AIQAQN QVS+GQLGG+PAA+NQQINATIT+QTRL Sbjct: 181 QYAMRIWLDPHKLSNFSLTPLDVKTAIQAQNAQVSAGQLGGMPAADNQQINATITSQTRL 240 Query: 241 RTADQFQNIVLRTLSDGARVKLRDVARIELGSESYTSVGRYNGKPAAGLAIKLATGANAL 300 +TA+ F NI+LRT +DGA+V+LRDVARIELGSESY++VGRYNGKPAAGLAIKLATGANAL Sbjct: 241 KTAEAFGNILLRTQADGAQVRLRDVARIELGSESYSTVGRYNGKPAAGLAIKLATGANAL 300 Query: 301 DTVKAIDARVAQLEKFFPAGMKVQKPYDTTPFVRISIEEVVRTLIEAVVLVFLVMYLFLQ 360 DTVKAIDARVA+LE FFP GMKVQKPYDTTPFVRISIEEVVRTL+EA+ LVFLVMYLFLQ Sbjct: 301 DTVKAIDARVAELEPFFPPGMKVQKPYDTTPFVRISIEEVVRTLVEAIALVFLVMYLFLQ 360 Query: 361 NFRATLIPTIAVPVVLLGTFGVLAAFGFTINTLTMFAMVLAIGLLVDDAIVVVENVERVM 420 NFRATLIPTIAVPVVLLGTFGVLAA GFTINTLTMFAMVLAIGLLVDDAIVVVENVERVM Sbjct: 361 NFRATLIPTIAVPVVLLGTFGVLAACGFTINTLTMFAMVLAIGLLVDDAIVVVENVERVM 420 Query: 421 SEEGLPPKEATRKSMGQISGALVGVALVLAAVFVPMAFFSGSTGVIYRQFSITIVSAMTL 480 SEEGLPP+EATRKSMGQI+GAL+GVALVLAAVFVPMAFF GSTGVIYRQFSITIVSAMTL Sbjct: 421 SEEGLPPREATRKSMGQITGALIGVALVLAAVFVPMAFFKGSTGVIYRQFSITIVSAMTL 480 Query: 481 SVLVALVLTPALCATLLKPAAKGHALATTGFFGWFNRQFDRGNLRYQGIVRHMLGRGWRY 540 SVLVA+VLTPALCATLLKP KGHA ATTGFFGWFNR FDRGN RYQGIVRHMLG+ RY Sbjct: 481 SVLVAMVLTPALCATLLKPVRKGHAQATTGFFGWFNRTFDRGNHRYQGIVRHMLGKQRRY 540 Query: 541 MAAYAVLLALVVTGFMKLPVGFLPDEDQGTLFAILQLPSGATKARTDEVIQQVEHHFLVD 600 MA Y VL A+VV GFMKLPVGFLPDEDQGTLF + QLP GAT ART++V++QVEHHFLVD Sbjct: 541 MAMYGVLFAMVVVGFMKLPVGFLPDEDQGTLFVLAQLPPGATNARTEDVLRQVEHHFLVD 600 Query: 601 QKDAVSGVFAVSGFSFAGSGQNMGFAFIKLKPWDERKGPGLSVTDVAAKAGAAFAQIRDA 660 QK+AVSGVF+V+GFSFAGSGQNMGFAF+KL+PW+ERKG LSV+ V A+A FA IRDA Sbjct: 601 QKEAVSGVFSVAGFSFAGSGQNMGFAFVKLRPWNERKGEALSVSGVVARAFGFFATIRDA 660 Query: 661 RVFAFAPPAVSELGNATGFDLMLKDEANLGHAALMQARNQLLGTLMQDKRLVAVRPNGLE 720 RVFAFAPPAV+ELGNATGFDLML+D ANLGHAALMQARNQLLGTL QD RLVAVRPNG E Sbjct: 661 RVFAFAPPAVAELGNATGFDLMLQDRANLGHAALMQARNQLLGTLSQDPRLVAVRPNGQE 720 Query: 721 DTPEFRLNVDTDKAGALGVAMSDINDTIATAWGSSYVNDFIDKGRVKKVMLQADAQYRML 780 DTPEF+L +D KA LG+++SDIN T+ATAWGSSYVNDFID+GRVKKVMLQADA +RM Sbjct: 721 DTPEFQLQIDAHKAETLGLSISDINSTLATAWGSSYVNDFIDRGRVKKVMLQADAPFRMN 780 Query: 781 PSDLDRWYVRNSAGTMVPFSALSTASWTSGSPRLERYNGVPSMEILGMALPGAASSGEAM 840 P D+D+WYVRNSAGTMVPF+A + W+SGSPRLERYNGVPSMEILGMA PG+ASSGEA+ Sbjct: 781 PEDIDKWYVRNSAGTMVPFTAFARVDWSSGSPRLERYNGVPSMEILGMAKPGSASSGEAL 840 Query: 841 AIVEAALAKMPPGIGYEWTGLSLQEKASSGKTGLLYSISILIVFLALAALYESWAVPFSV 900 AIVEAA+ K+P GIGY WTGLSLQEKASSG+T LLY++SILIVFL LAALYESWA+PFSV Sbjct: 841 AIVEAAVTKLPAGIGYAWTGLSLQEKASSGQTTLLYTLSILIVFLCLAALYESWAIPFSV 900 Query: 901 ILVVPLGVFGALLGAILTWKMNDVYFQVGLLTTIGLACKNAILIVEFAKDLHEHGKSLVE 960 I+VVPLGV GALLGAILTWKMNDVYFQVGLLTTIGLA KNAILIVEFAK+L+ G +VE Sbjct: 901 IMVVPLGVLGALLGAILTWKMNDVYFQVGLLTTIGLASKNAILIVEFAKELNAQGMRVVE 960 Query: 961 ATMDAVRMRLRPILMTSLAFILGVLPLVLGSGAGAGAQHALGTAVIGGMLSGTVLAVFFV 1020 A M A RMRLRPILMTSLAFILGV+P+V GSGAGAGAQHALGTAVIGGMLSGTVLA+FFV Sbjct: 961 AAMTAARMRLRPILMTSLAFILGVVPMVTGSGAGAGAQHALGTAVIGGMLSGTVLAIFFV 1020 Query: 1021 PLFFVIIMKLF 1031 PLFFV++ LF Sbjct: 1021 PLFFVLVRGLF 1031 >STM0475 [V] COG0841 Cation/multidrug efflux pump Sty Salmonella typhimurium LT2 Length = 1049 Score = 1378 bits (3567), Expect = 0.0, Method: Compositional matrix adjust. Identities = 667/1020 (65%), Positives = 818/1020 (80%), Gaps = 4/1020 (0%) Query: 1 MARFFIDRPIFAWVLAIIVMLAGAISVLTLPIAQYPAIAPPAIAITANYPGASAKTLEDT 60 M FFIDRPIFAWV+AII+MLAG +++L LP+AQYP IAPPA+ I+A YPGA AKT++DT Sbjct: 1 MPNFFIDRPIFAWVIAIIIMLAGGLAILKLPVAQYPTIAPPAVTISATYPGADAKTVQDT 60 Query: 61 VTQIIEQKMKGLDRLSYMASTSESSGSVTITLTFENGTNPDTAQVQVQNKLSLATPLLPS 120 VTQ+IEQ M G+D L YM+S S+S+G+V ITLTFE+GT+ D AQVQVQNKL LA PLLP Sbjct: 61 VTQVIEQNMNGIDNLMYMSSNSDSTGTVQITLTFESGTDADIAQVQVQNKLQLAMPLLPQ 120 Query: 121 EVQQQGITVTKSATNFLNVLAFTSEDGSMSGSDLSDYVAANIQDAISRVEGVGDTTLFGS 180 EVQQQG++V KS+++FL V+ + DG+M+ D+SDYVAAN++D ISR GVGD LFGS Sbjct: 121 EVQQQGVSVEKSSSSFLMVVGVINTDGTMTQEDISDYVAANMKDPISRTSGVGDVQLFGS 180 Query: 181 QYAMRIWLDPNKLNSYSLTPLDVKNAIQAQNVQVSSGQLGGLPAAENQQINATITAQTRL 240 QYAMRIW++P +L Y LTP+DV NAI+AQN QV++GQLGG P + QQ+NA+I AQTRL Sbjct: 181 QYAMRIWMNPTELTKYQLTPVDVINAIKAQNAQVAAGQLGGTPPVKGQQLNASIIAQTRL 240 Query: 241 RTADQFQNIVLRTLSDGARVKLRDVARIELGSESYTSVGRYNGKPAAGLAIKLATGANAL 300 + D+F I+L+ DG++V+LRDVA+IELG E+Y + ++NG+PA+GL IKLATGANAL Sbjct: 241 TSTDEFGKILLKVNQDGSQVRLRDVAKIELGGENYDVIAKFNGQPASGLGIKLATGANAL 300 Query: 301 DTVKAIDARVAQLEKFFPAGMKVQKPYDTTPFVRISIEEVVRTLIEAVVLVFLVMYLFLQ 360 DT AI A + ++E FFP GMK+ PYDTTPFV+ISI EVV+TL+EA++LVFLVMYLFLQ Sbjct: 301 DTATAIRAELKKMEPFFPPGMKIVYPYDTTPFVKISIHEVVKTLVEAIILVFLVMYLFLQ 360 Query: 361 NFRATLIPTIAVPVVLLGTFGVLAAFGFTINTLTMFAMVLAIGLLVDDAIVVVENVERVM 420 NFRATLIPTIAVPVVLLGTF VLAAFGF+INTLTMF MVLAIGLLVDDAIVVVENVERVM Sbjct: 361 NFRATLIPTIAVPVVLLGTFAVLAAFGFSINTLTMFGMVLAIGLLVDDAIVVVENVERVM 420 Query: 421 SEEGLPPKEATRKSMGQISGALVGVALVLAAVFVPMAFFSGSTGVIYRQFSITIVSAMTL 480 +EEGLPPKEATRKSMGQI GALVG+A+VL+AVF+PMAFF GSTG IYRQFSITIVSAM L Sbjct: 421 TEEGLPPKEATRKSMGQIQGALVGIAMVLSAVFIPMAFFGGSTGAIYRQFSITIVSAMAL 480 Query: 481 SVLVALVLTPALCATLLKPAAKG-HALATTGFFGWFNRQFDRGNLRYQGIVRHMLGRGWR 539 SVLVAL+LTPALCAT+LKP AKG H GFFGWFNR FD+ Y V ++L R Sbjct: 481 SVLVALILTPALCATMLKPVAKGDHGEGKKGFFGWFNRLFDKSTHHYTDSVGNILRSTGR 540 Query: 540 YMAAYAVLLALVVTGFMKLPVGFLPDEDQGTLFAILQLPSGATKARTDEVIQQVEHHFLV 599 Y+ Y +++ + F++LP FLPDEDQG ++QLP+GAT+ RT +V+ +V ++L Sbjct: 541 YLLLYLIIVVGMAYLFVRLPSSFLPDEDQGVFLTMVQLPAGATQERTQKVLDEVTDYYLN 600 Query: 600 DQKDAVSGVFAVSGFSFAGSGQNMGFAFIKLKPWDERKGPGLSVTDVAAKAGAAFAQIRD 659 +K V VFAV+GF FAG GQN G AF+ LK W +R G V + +A AAF+QI+D Sbjct: 601 KEKANVESVFAVNGFGFAGRGQNTGIAFVSLKDWADRPGEKNKVEAITQRATAAFSQIKD 660 Query: 660 ARVFAFAPPAVSELGNATGFDLMLKDEANLGHAALMQARNQLLGTLMQ-DKRLVAVRPNG 718 A VFAF PA+ ELG ATGFD L D+A LGH L QARNQL G + + LV VRPNG Sbjct: 661 AMVFAFNLPAIVELGTATGFDFELIDQAGLGHEKLTQARNQLFGEVAKYPDLLVGVRPNG 720 Query: 719 LEDTPEFRLNVDTDKAGALGVAMSDINDTIATAWGSSYVNDFIDKGRVKKVMLQADAQYR 778 LEDTP+F++++D +KA ALGV++SDIN T+ AWG SYVNDFID+GRVKKV + ++A+YR Sbjct: 721 LEDTPQFKIDIDQEKAQALGVSISDINTTLGAAWGGSYVNDFIDRGRVKKVYVMSEAKYR 780 Query: 779 MLPSDLDRWYVRNSAGTMVPFSALSTASWTSGSPRLERYNGVPSMEILGMALPGAASSGE 838 MLP D++ WYVR S G MVPFSA S++ W GSPRLERYNG+PSMEILG A PG S+GE Sbjct: 781 MLPDDINDWYVRGSDGQMVPFSAFSSSRWEYGSPRLERYNGLPSMEILGQAAPG-KSTGE 839 Query: 839 AMAIVEAALAKMPPGIGYEWTGLSLQEKASSGKTGLLYSISILIVFLALAALYESWAVPF 898 AMA++E +K+P GIGY+WTG+S QE+ S + LY+IS+++VFL LAALYESW++PF Sbjct: 840 AMAMMEELASKLPSGIGYDWTGMSYQERLSGNQAPALYAISLIVVFLCLAALYESWSIPF 899 Query: 899 SVILVVPLGVFGALLGAILTWKMNDVYFQVGLLTTIGLACKNAILIVEFAKDL-HEHGKS 957 SV+LVVPLGV GALL A NDVYFQVGLLTTIGL+ KNAILIVEFAKDL + GK Sbjct: 900 SVMLVVPLGVIGALLAATFRGLTNDVYFQVGLLTTIGLSAKNAILIVEFAKDLMDKEGKG 959 Query: 958 LVEATMDAVRMRLRPILMTSLAFILGVLPLVLGSGAGAGAQHALGTAVIGGMLSGTVLAV 1017 LVEAT++AVRMRLRPILMTSLAF+LGV+PLV+ SGAG+GAQ+A+GT V+GGM++ TVLA+ Sbjct: 960 LVEATLEAVRMRLRPILMTSLAFMLGVMPLVISSGAGSGAQNAVGTGVLGGMVTATVLAI 1019 >acrB [V] COG0841 Cation/multidrug efflux pump Eco Escherichia coli K12 Length = 1049 Score = 1373 bits (3554), Expect = 0.0, Method: Compositional matrix adjust. Identities = 663/1020 (65%), Positives = 818/1020 (80%), Gaps = 4/1020 (0%) Query: 1 MARFFIDRPIFAWVLAIIVMLAGAISVLTLPIAQYPAIAPPAIAITANYPGASAKTLEDT 60 M FFIDRPIFAWV+AII+MLAG +++L LP+AQYP IAPPA+ I+A+YPGA AKT++DT Sbjct: 1 MPNFFIDRPIFAWVIAIIIMLAGGLAILKLPVAQYPTIAPPAVTISASYPGADAKTVQDT 60 Query: 61 VTQIIEQKMKGLDRLSYMASTSESSGSVTITLTFENGTNPDTAQVQVQNKLSLATPLLPS 120 VTQ+IEQ M G+D L YM+S S+S+G+V ITLTFE+GT+ D AQVQVQNKL LA PLLP Sbjct: 61 VTQVIEQNMNGIDNLMYMSSNSDSTGTVQITLTFESGTDADIAQVQVQNKLQLAMPLLPQ 120 Query: 121 EVQQQGITVTKSATNFLNVLAFTSEDGSMSGSDLSDYVAANIQDAISRVEGVGDTTLFGS 180 EVQQQG++V KS+++FL V+ + DG+M+ D+SDYVAAN++DAISR GVGD LFGS Sbjct: 121 EVQQQGVSVEKSSSSFLMVVGVINTDGTMTQEDISDYVAANMKDAISRTSGVGDVQLFGS 180 Query: 181 QYAMRIWLDPNKLNSYSLTPLDVKNAIQAQNVQVSSGQLGGLPAAENQQINATITAQTRL 240 QYAMRIW++PN+LN + LTP+DV AI+AQN QV++GQLGG P + QQ+NA+I AQTRL Sbjct: 181 QYAMRIWMNPNELNKFQLTPVDVITAIKAQNAQVAAGQLGGTPPVKGQQLNASIIAQTRL 240 Query: 241 RTADQFQNIVLRTLSDGARVKLRDVARIELGSESYTSVGRYNGKPAAGLAIKLATGANAL 300 + ++F I+L+ DG+RV LRDVA+IELG E+Y + +NG+PA+GL IKLATGANAL Sbjct: 241 TSTEEFGKILLKVNQDGSRVLLRDVAKIELGGENYDIIAEFNGQPASGLGIKLATGANAL 300 Query: 301 DTVKAIDARVAQLEKFFPAGMKVQKPYDTTPFVRISIEEVVRTLIEAVVLVFLVMYLFLQ 360 DT AI A +A++E FFP+G+K+ PYDTTPFV+ISI EVV+TL+EA++LVFLVMYLFLQ Sbjct: 301 DTAAAIRAELAKMEPFFPSGLKIVYPYDTTPFVKISIHEVVKTLVEAIILVFLVMYLFLQ 360 Query: 361 NFRATLIPTIAVPVVLLGTFGVLAAFGFTINTLTMFAMVLAIGLLVDDAIVVVENVERVM 420 NFRATLIPTIAVPVVLLGTF VLAAFGF+INTLTMF MVLAIGLLVDDAIVVVENVERVM Sbjct: 361 NFRATLIPTIAVPVVLLGTFAVLAAFGFSINTLTMFGMVLAIGLLVDDAIVVVENVERVM 420 Query: 421 SEEGLPPKEATRKSMGQISGALVGVALVLAAVFVPMAFFSGSTGVIYRQFSITIVSAMTL 480 +EEGLPPKEATRKSMGQI GALVG+A+VL+AVFVPMAFF GSTG IYRQFSITIVSAM L Sbjct: 421 AEEGLPPKEATRKSMGQIQGALVGIAMVLSAVFVPMAFFGGSTGAIYRQFSITIVSAMAL 480 Query: 481 SVLVALVLTPALCATLLKPAAKG-HALATTGFFGWFNRQFDRGNLRYQGIVRHMLGRGWR 539 SVLVAL+LTPALCAT+LKP AKG H GFFGWFNR F++ Y V +L R Sbjct: 481 SVLVALILTPALCATMLKPIAKGDHGEGKKGFFGWFNRMFEKSTHHYTDSVGGILRSTGR 540 Query: 540 YMAAYAVLLALVVTGFMKLPVGFLPDEDQGTLFAILQLPSGATKARTDEVIQQVEHHFLV 599 Y+ Y +++ + F++LP FLPDEDQG ++QLP+GAT+ RT +V+ +V H++L Sbjct: 541 YLVLYLIIVVGMAYLFVRLPSSFLPDEDQGVFMTMVQLPAGATQERTQKVLNEVTHYYLT 600 Query: 600 DQKDAVSGVFAVSGFSFAGSGQNMGFAFIKLKPWDERKGPGLSVTDVAAKAGAAFAQIRD 659 +K+ V VFAV+GF FAG GQN G AF+ LK W +R G V + +A AF+QI+D Sbjct: 601 KEKNNVESVFAVNGFGFAGRGQNTGIAFVSLKDWADRPGEENKVEAITMRATRAFSQIKD 660 Query: 660 ARVFAFAPPAVSELGNATGFDLMLKDEANLGHAALMQARNQLLGTLMQD-KRLVAVRPNG 718 A VFAF PA+ ELG ATGFD L D+A LGH L QARNQLL + L +VRPNG Sbjct: 661 AMVFAFNLPAIVELGTATGFDFELIDQAGLGHEKLTQARNQLLAEAAKHPDMLTSVRPNG 720 Query: 719 LEDTPEFRLNVDTDKAGALGVAMSDINDTIATAWGSSYVNDFIDKGRVKKVMLQADAQYR 778 LEDTP+F++++D +KA ALGV+++DIN T+ AWG SYVNDFID+GRVKKV + ++A+YR Sbjct: 721 LEDTPQFKIDIDQEKAQALGVSINDINTTLGAAWGGSYVNDFIDRGRVKKVYVMSEAKYR 780 Query: 779 MLPSDLDRWYVRNSAGTMVPFSALSTASWTSGSPRLERYNGVPSMEILGMALPGAASSGE 838 MLP D+ WYVR + G MVPFSA S++ W GSPRLERYNG+PSMEILG A PG S+GE Sbjct: 781 MLPDDIGDWYVRAADGQMVPFSAFSSSRWEYGSPRLERYNGLPSMEILGQAAPG-KSTGE 839 Query: 839 AMAIVEAALAKMPPGIGYEWTGLSLQEKASSGKTGLLYSISILIVFLALAALYESWAVPF 898 AM ++E +K+P G+GY+WTG+S QE+ S + LY+IS+++VFL LAALYESW++PF Sbjct: 840 AMELMEQLASKLPTGVGYDWTGMSYQERLSGNQAPSLYAISLIVVFLCLAALYESWSIPF 899 Query: 899 SVILVVPLGVFGALLGAILTWKMNDVYFQVGLLTTIGLACKNAILIVEFAKDL-HEHGKS 957 SV+LVVPLGV GALL A NDVYFQVGLLTTIGL+ KNAILIVEFAKDL + GK Sbjct: 900 SVMLVVPLGVIGALLAATFRGLTNDVYFQVGLLTTIGLSAKNAILIVEFAKDLMDKEGKG 959 Query: 958 LVEATMDAVRMRLRPILMTSLAFILGVLPLVLGSGAGAGAQHALGTAVIGGMLSGTVLAV 1017 L+EAT+DAVRMRLRPILMTSLAFILGV+PLV+ +GAG+GAQ+A+GT V+GGM++ TVLA+ Sbjct: 960 LIEATLDAVRMRLRPILMTSLAFILGVMPLVISTGAGSGAQNAVGTGVMGGMVTATVLAI 1019 >ZacrB [V] COG0841 Cation/multidrug efflux pump EcZ Escherichia coli O157:H7 EDL933 Length = 1049 Score = 1372 bits (3552), Expect = 0.0, Method: Compositional matrix adjust. Identities = 662/1020 (64%), Positives = 818/1020 (80%), Gaps = 4/1020 (0%) Query: 1 MARFFIDRPIFAWVLAIIVMLAGAISVLTLPIAQYPAIAPPAIAITANYPGASAKTLEDT 60 M FFIDRPIFAWV+AII+MLAG +++L LP+AQYP IAPPA+ I+A+YPGA AKT++DT Sbjct: 1 MPNFFIDRPIFAWVIAIIIMLAGGLAILKLPVAQYPTIAPPAVTISASYPGADAKTVQDT 60 Query: 61 VTQIIEQKMKGLDRLSYMASTSESSGSVTITLTFENGTNPDTAQVQVQNKLSLATPLLPS 120 VTQ+IEQ M G+D L YM+S S+S+G+V ITLTFE+GT+ D AQVQVQNKL LA PLLP Sbjct: 61 VTQVIEQNMNGIDNLMYMSSNSDSTGTVQITLTFESGTDADIAQVQVQNKLQLAMPLLPQ 120 Query: 121 EVQQQGITVTKSATNFLNVLAFTSEDGSMSGSDLSDYVAANIQDAISRVEGVGDTTLFGS 180 EVQQQG+++ KS+++FL V+ + DG+M+ D+SDYVAAN++DAISR GVGD LFGS Sbjct: 121 EVQQQGVSIEKSSSSFLMVVGVINTDGTMTQEDISDYVAANMKDAISRTSGVGDVQLFGS 180 Query: 181 QYAMRIWLDPNKLNSYSLTPLDVKNAIQAQNVQVSSGQLGGLPAAENQQINATITAQTRL 240 QYAMRIW++PN+LN + LTP+DV AI+AQN QV++GQLGG P + QQ+NA+I AQTRL Sbjct: 181 QYAMRIWMNPNELNKFQLTPVDVITAIKAQNAQVAAGQLGGTPPVKGQQLNASIIAQTRL 240 Query: 241 RTADQFQNIVLRTLSDGARVKLRDVARIELGSESYTSVGRYNGKPAAGLAIKLATGANAL 300 + ++F I+L+ DG+RV LRDVA+IELG E+Y + +NG+PA+GL IKLATGANAL Sbjct: 241 TSTEEFGKILLKVNQDGSRVLLRDVAKIELGGENYDIIAEFNGQPASGLGIKLATGANAL 300 Query: 301 DTVKAIDARVAQLEKFFPAGMKVQKPYDTTPFVRISIEEVVRTLIEAVVLVFLVMYLFLQ 360 DT AI A +A++E FFP+G+K+ PYDTTPFV+ISI EVV+TL+EA++LVFLVMYLFLQ Sbjct: 301 DTAAAIRAELAKMEPFFPSGLKIVYPYDTTPFVKISIHEVVKTLVEAIILVFLVMYLFLQ 360 Query: 361 NFRATLIPTIAVPVVLLGTFGVLAAFGFTINTLTMFAMVLAIGLLVDDAIVVVENVERVM 420 NFRATLIPTIAVPVVLLGTF VLAAFGF+INTLTMF MVLAIGLLVDDAIVVVENVERVM Sbjct: 361 NFRATLIPTIAVPVVLLGTFAVLAAFGFSINTLTMFGMVLAIGLLVDDAIVVVENVERVM 420 Query: 421 SEEGLPPKEATRKSMGQISGALVGVALVLAAVFVPMAFFSGSTGVIYRQFSITIVSAMTL 480 +EEGLPPKEATRKSMGQI GALVG+A+VL+AVFVPMAFF GSTG IYRQFSITIVSAM L Sbjct: 421 AEEGLPPKEATRKSMGQIQGALVGIAMVLSAVFVPMAFFGGSTGAIYRQFSITIVSAMAL 480 Query: 481 SVLVALVLTPALCATLLKPAAKG-HALATTGFFGWFNRQFDRGNLRYQGIVRHMLGRGWR 539 SVLVAL+LTPALCAT+LKP AKG H GFFGWFNR F++ Y V +L R Sbjct: 481 SVLVALILTPALCATMLKPIAKGDHGEGKKGFFGWFNRMFEKSTHHYTDSVGGILRSTGR 540 Query: 540 YMAAYAVLLALVVTGFMKLPVGFLPDEDQGTLFAILQLPSGATKARTDEVIQQVEHHFLV 599 Y+ Y +++ + F++LP FLPDEDQG ++QLP+GAT+ RT +V+ +V H++L Sbjct: 541 YLVLYLIIVVGMAYLFVRLPSSFLPDEDQGVFMTMVQLPAGATQERTQKVLNEVTHYYLT 600 Query: 600 DQKDAVSGVFAVSGFSFAGSGQNMGFAFIKLKPWDERKGPGLSVTDVAAKAGAAFAQIRD 659 +K+ V VFAV+GF FAG GQN G AF+ LK W +R G V + +A AF+QI+D Sbjct: 601 KEKNNVESVFAVNGFGFAGRGQNTGIAFVSLKDWADRPGEENKVEAITMRATRAFSQIKD 660 Query: 660 ARVFAFAPPAVSELGNATGFDLMLKDEANLGHAALMQARNQLLGTLMQD-KRLVAVRPNG 718 A VFAF PA+ ELG ATGFD L D+A LGH L QARNQLL + L +VRPNG Sbjct: 661 AMVFAFNLPAIVELGTATGFDFELIDQAGLGHEKLTQARNQLLAEAAKHPDMLTSVRPNG 720 Query: 719 LEDTPEFRLNVDTDKAGALGVAMSDINDTIATAWGSSYVNDFIDKGRVKKVMLQADAQYR 778 LEDTP+F++++D +KA ALGV+++DIN T+ AWG SYVNDFID+GRVKKV + ++A+YR Sbjct: 721 LEDTPQFKIDIDQEKAQALGVSINDINTTLGAAWGGSYVNDFIDRGRVKKVYVMSEAKYR 780 Query: 779 MLPSDLDRWYVRNSAGTMVPFSALSTASWTSGSPRLERYNGVPSMEILGMALPGAASSGE 838 MLP D+ WYVR + G MVPFSA S++ W GSPRLERYNG+PSMEILG A PG S+GE Sbjct: 781 MLPDDIGDWYVRAADGQMVPFSAFSSSRWEYGSPRLERYNGLPSMEILGQAAPG-KSTGE 839 Query: 839 AMAIVEAALAKMPPGIGYEWTGLSLQEKASSGKTGLLYSISILIVFLALAALYESWAVPF 898 AM ++E +K+P G+GY+WTG+S QE+ S + LY+IS+++VFL LAALYESW++PF Sbjct: 840 AMELMEQLASKLPTGVGYDWTGMSYQERLSGNQAPSLYAISLIVVFLCLAALYESWSIPF 899 Query: 899 SVILVVPLGVFGALLGAILTWKMNDVYFQVGLLTTIGLACKNAILIVEFAKDL-HEHGKS 957 SV+LVVPLGV GALL A NDVYFQVGLLTTIGL+ KNAILIVEFAKDL + GK Sbjct: 900 SVMLVVPLGVIGALLAATFRGLTNDVYFQVGLLTTIGLSAKNAILIVEFAKDLMDKEGKG 959 Query: 958 LVEATMDAVRMRLRPILMTSLAFILGVLPLVLGSGAGAGAQHALGTAVIGGMLSGTVLAV 1017 L+EAT+DAVRMRLRPILMTSLAFILGV+PLV+ +GAG+GAQ+A+GT V+GGM++ TVLA+ Sbjct: 960 LIEATLDAVRMRLRPILMTSLAFILGVMPLVISTGAGSGAQNAVGTGVMGGMVTATVLAI 1019 >ECs0515 [V] COG0841 Cation/multidrug efflux pump Ecs Escherichia coli O157:H7 Length = 1049 Score = 1372 bits (3552), Expect = 0.0, Method: Compositional matrix adjust. Identities = 662/1020 (64%), Positives = 818/1020 (80%), Gaps = 4/1020 (0%) Query: 1 MARFFIDRPIFAWVLAIIVMLAGAISVLTLPIAQYPAIAPPAIAITANYPGASAKTLEDT 60 M FFIDRPIFAWV+AII+MLAG +++L LP+AQYP IAPPA+ I+A+YPGA AKT++DT Sbjct: 1 MPNFFIDRPIFAWVIAIIIMLAGGLAILKLPVAQYPTIAPPAVTISASYPGADAKTVQDT 60 Query: 61 VTQIIEQKMKGLDRLSYMASTSESSGSVTITLTFENGTNPDTAQVQVQNKLSLATPLLPS 120 VTQ+IEQ M G+D L YM+S S+S+G+V ITLTFE+GT+ D AQVQVQNKL LA PLLP Sbjct: 61 VTQVIEQNMNGIDNLMYMSSNSDSTGTVQITLTFESGTDADIAQVQVQNKLQLAMPLLPQ 120 Query: 121 EVQQQGITVTKSATNFLNVLAFTSEDGSMSGSDLSDYVAANIQDAISRVEGVGDTTLFGS 180 EVQQQG+++ KS+++FL V+ + DG+M+ D+SDYVAAN++DAISR GVGD LFGS Sbjct: 121 EVQQQGVSIEKSSSSFLMVVGVINTDGTMTQEDISDYVAANMKDAISRTSGVGDVQLFGS 180 Query: 181 QYAMRIWLDPNKLNSYSLTPLDVKNAIQAQNVQVSSGQLGGLPAAENQQINATITAQTRL 240 QYAMRIW++PN+LN + LTP+DV AI+AQN QV++GQLGG P + QQ+NA+I AQTRL Sbjct: 181 QYAMRIWMNPNELNKFQLTPVDVITAIKAQNAQVAAGQLGGTPPVKGQQLNASIIAQTRL 240 Query: 241 RTADQFQNIVLRTLSDGARVKLRDVARIELGSESYTSVGRYNGKPAAGLAIKLATGANAL 300 + ++F I+L+ DG+RV LRDVA+IELG E+Y + +NG+PA+GL IKLATGANAL Sbjct: 241 TSTEEFGKILLKVNQDGSRVLLRDVAKIELGGENYDIIAEFNGQPASGLGIKLATGANAL 300 Query: 301 DTVKAIDARVAQLEKFFPAGMKVQKPYDTTPFVRISIEEVVRTLIEAVVLVFLVMYLFLQ 360 DT AI A +A++E FFP+G+K+ PYDTTPFV+ISI EVV+TL+EA++LVFLVMYLFLQ Sbjct: 301 DTAAAIRAELAKMEPFFPSGLKIVYPYDTTPFVKISIHEVVKTLVEAIILVFLVMYLFLQ 360 Query: 361 NFRATLIPTIAVPVVLLGTFGVLAAFGFTINTLTMFAMVLAIGLLVDDAIVVVENVERVM 420 NFRATLIPTIAVPVVLLGTF VLAAFGF+INTLTMF MVLAIGLLVDDAIVVVENVERVM Sbjct: 361 NFRATLIPTIAVPVVLLGTFAVLAAFGFSINTLTMFGMVLAIGLLVDDAIVVVENVERVM 420 Query: 421 SEEGLPPKEATRKSMGQISGALVGVALVLAAVFVPMAFFSGSTGVIYRQFSITIVSAMTL 480 +EEGLPPKEATRKSMGQI GALVG+A+VL+AVFVPMAFF GSTG IYRQFSITIVSAM L Sbjct: 421 AEEGLPPKEATRKSMGQIQGALVGIAMVLSAVFVPMAFFGGSTGAIYRQFSITIVSAMAL 480 Query: 481 SVLVALVLTPALCATLLKPAAKG-HALATTGFFGWFNRQFDRGNLRYQGIVRHMLGRGWR 539 SVLVAL+LTPALCAT+LKP AKG H GFFGWFNR F++ Y V +L R Sbjct: 481 SVLVALILTPALCATMLKPIAKGDHGEGKKGFFGWFNRMFEKSTHHYTDSVGGILRSTGR 540 Query: 540 YMAAYAVLLALVVTGFMKLPVGFLPDEDQGTLFAILQLPSGATKARTDEVIQQVEHHFLV 599 Y+ Y +++ + F++LP FLPDEDQG ++QLP+GAT+ RT +V+ +V H++L Sbjct: 541 YLVLYLIIVVGMAYLFVRLPSSFLPDEDQGVFMTMVQLPAGATQERTQKVLNEVTHYYLT 600 Query: 600 DQKDAVSGVFAVSGFSFAGSGQNMGFAFIKLKPWDERKGPGLSVTDVAAKAGAAFAQIRD 659 +K+ V VFAV+GF FAG GQN G AF+ LK W +R G V + +A AF+QI+D Sbjct: 601 KEKNNVESVFAVNGFGFAGRGQNTGIAFVSLKDWADRPGEENKVEAITMRATRAFSQIKD 660 Query: 660 ARVFAFAPPAVSELGNATGFDLMLKDEANLGHAALMQARNQLLGTLMQD-KRLVAVRPNG 718 A VFAF PA+ ELG ATGFD L D+A LGH L QARNQLL + L +VRPNG Sbjct: 661 AMVFAFNLPAIVELGTATGFDFELIDQAGLGHEKLTQARNQLLAEAAKHPDMLTSVRPNG 720 Query: 719 LEDTPEFRLNVDTDKAGALGVAMSDINDTIATAWGSSYVNDFIDKGRVKKVMLQADAQYR 778 LEDTP+F++++D +KA ALGV+++DIN T+ AWG SYVNDFID+GRVKKV + ++A+YR Sbjct: 721 LEDTPQFKIDIDQEKAQALGVSINDINTTLGAAWGGSYVNDFIDRGRVKKVYVMSEAKYR 780 Query: 779 MLPSDLDRWYVRNSAGTMVPFSALSTASWTSGSPRLERYNGVPSMEILGMALPGAASSGE 838 MLP D+ WYVR + G MVPFSA S++ W GSPRLERYNG+PSMEILG A PG S+GE Sbjct: 781 MLPDDIGDWYVRAADGQMVPFSAFSSSRWEYGSPRLERYNGLPSMEILGQAAPG-KSTGE 839 Query: 839 AMAIVEAALAKMPPGIGYEWTGLSLQEKASSGKTGLLYSISILIVFLALAALYESWAVPF 898 AM ++E +K+P G+GY+WTG+S QE+ S + LY+IS+++VFL LAALYESW++PF Sbjct: 840 AMELMEQLASKLPTGVGYDWTGMSYQERLSGNQAPSLYAISLIVVFLCLAALYESWSIPF 899 Query: 899 SVILVVPLGVFGALLGAILTWKMNDVYFQVGLLTTIGLACKNAILIVEFAKDL-HEHGKS 957 SV+LVVPLGV GALL A NDVYFQVGLLTTIGL+ KNAILIVEFAKDL + GK Sbjct: 900 SVMLVVPLGVIGALLAATFRGLTNDVYFQVGLLTTIGLSAKNAILIVEFAKDLMDKEGKG 959 Query: 958 LVEATMDAVRMRLRPILMTSLAFILGVLPLVLGSGAGAGAQHALGTAVIGGMLSGTVLAV 1017 L+EAT+DAVRMRLRPILMTSLAFILGV+PLV+ +GAG+GAQ+A+GT V+GGM++ TVLA+ Sbjct: 960 LIEATLDAVRMRLRPILMTSLAFILGVMPLVISTGAGSGAQNAVGTGVMGGMVTATVLAI 1019