BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0007.0063.p (443 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSc1093 [GEPR] COG0477 Permeases of the major facilitator superf... 377 e-104 PA0235 [GEPR] COG0477 Permeases of the major facilitator superfa... 372 e-103 ECs3031 [GEPR] COG0477 Permeases of the major facilitator superf... 319 7e-87 Z3394 [GEPR] COG0477 Permeases of the major facilitator superfam... 319 8e-87 STM2179 [GEPR] COG0477 Permeases of the major facilitator superf... 301 2e-81 >RSc1093 [GEPR] COG0477 Permeases of the major facilitator superfamily Rso Ralstonia solanacearum Length = 454 Score = 377 bits (969), Expect = e-104, Method: Compositional matrix adjust. Identities = 202/426 (47%), Positives = 273/426 (64%), Gaps = 4/426 (0%) Query: 7 LDVRSHINGRKMSGYQWLLLILCFLIVATDGMDVAIMGFLAPAITKEWGISRAAFGVVMS 66 +DVR+ ++ ++ S +QW +++LCF +VA DG D A +GF+APA+ ++W I A G V S Sbjct: 8 IDVRAWLDRQRFSAFQWSVVLLCFFVVAIDGFDTACVGFIAPALAQDWHIGPAVLGTVFS 67 Query: 67 AAPIGLAVGALLVGPLSDRYGRKKLLMTAVAWFGACSLACAFAQDVVTLSALRFLTGLGL 126 A GL VGAL+ GPL+DR GRK+ L+ V FG S+ AFA V L ALRFLTGLGL Sbjct: 68 AGLAGLMVGALIFGPLADRIGRKQTLLFTVGAFGLASVLSAFAPSVGALVALRFLTGLGL 127 Query: 127 GAAMPNATTLLSEYVPERSRSTLLAIMFTGFNLGSGLVGFLAAALLPDYGWRTVLMVGGA 186 G AMPNA L SEY PER R+ L +MF GF LGSG G +AA L+P++GWR+VL+ GG Sbjct: 128 GGAMPNAIALTSEYCPERRRAFLTTVMFCGFTLGSGFGGIVAAQLVPEFGWRSVLLFGGV 187 Query: 187 IPLLCLPFYLWLVPESARFMVVRHYPADRIARTLARVCGGHFAAGQTFSVSEPPVKG--G 244 IPLL LP ++ +PES R++V + + + R L R+ F + E KG G Sbjct: 188 IPLLLLPVMVFALPESVRYLVAKGGQSAAVGRLLNRIAPVQVTPDTRFVLHETAAKGAPG 247 Query: 245 QPAKVLLSETYRKTTLSLWGTYFMGLLVIYLLSGWLPTLIKDAGLPIEKAASITALFQLG 304 P + L +R TL LW +FM LL++YL++ WLPTLI G+ + A+ I ++QLG Sbjct: 248 SPVRQLFLPAFRTGTLLLWSVFFMSLLIVYLMTNWLPTLIHSGGVALALASRIAVMYQLG 307 Query: 305 GTVGALVVGFLMDRWSPSRAIACAYIAGAVFILLLASGSVQSGMFAAYVLLAGFCMSGAQ 364 GTVGALV+G +MDR+ + + C Y GA F++L +G Q M A V GFC+SG+Q Sbjct: 308 GTVGALVIGRMMDRYPATVVLCCTYGLGAGFLVL--TGVSQGTMLAIAVTGVGFCISGSQ 365 Query: 365 TGLNAFAPSCYPTVVRATGVSWMLGVGRFGSILGSFAGGVLLSMGWGFGAVIAILAVPAT 424 G NAFA YPT R TG+SW LG+GR GS+ G+ GGVLL+ GF + ++AVPA Sbjct: 366 IGANAFAAQFYPTASRVTGISWALGIGRLGSVCGALIGGVLLAANIGFQLLFLLVAVPAA 425 Query: 425 LAALII 430 +A+L I Sbjct: 426 IASLAI 431 >PA0235 [GEPR] COG0477 Permeases of the major facilitator superfamily Pae Pseudomonas aeruginosa Length = 448 Score = 372 bits (955), Expect = e-103, Method: Compositional matrix adjust. Identities = 211/412 (51%), Positives = 286/412 (69%), Gaps = 1/412 (0%) Query: 5 QSLDVRSHINGRKMSGYQWLLLILCFLIVATDGMDVAIMGFLAPAITKEWGISRAAFGVV 64 + LDV++ IN + +S YQW +++LCFLIV DG+D A MGF+APA+T++WGI RA+ G V Sbjct: 10 ERLDVQAFINAQPLSPYQWRIVLLCFLIVFLDGLDTAAMGFIAPALTQDWGIDRASLGPV 69 Query: 65 MSAAPIGLAVGALLVGPLSDRYGRKKLLMTAVAWFGACSLACAFAQDVVTLSALRFLTGL 124 MSAA IG+ GAL GPL+DRYGRK +L+ AV FG SLA A++ +V L ALRFLTGL Sbjct: 70 MSAALIGMVFGALGSGPLADRYGRKLVLVAAVFLFGLFSLASAYSTNVEQLLALRFLTGL 129 Query: 125 GLGAAMPNATTLLSEYVPERSRSTLLAIMFTGFNLGSGLVGFLAAALLPDYGWRTVLMVG 184 GLGAAMPNATTLLSEY PER +S L+ MF GFNLG GF++A L+P +GW ++L++G Sbjct: 130 GLGAAMPNATTLLSEYTPERLKSLLVTSMFCGFNLGMACGGFVSAKLIPLFGWHSLLLLG 189 Query: 185 GAIPLLCLPFYLWLVPESARFMVVRHYPADRIARTLARVCGGHFAAGQTFSVSEPP-VKG 243 G +PL+ L+ +PESAR++VVR+ ++R+ + LA + A ++F V E V+ Sbjct: 190 GLLPLVLAVVLLFRLPESARYLVVRNRGSERVRQVLAPIAPAQVALARSFHVPEQQTVQA 249 Query: 244 GQPAKVLLSETYRKTTLSLWGTYFMGLLVIYLLSGWLPTLIKDAGLPIEKAASITALFQL 303 V+ S TY TL LW TYFMGL+++YLL+ WLPTL++D+G +E+AA I ALFQ Sbjct: 250 RNVFAVIFSGTYSAGTLLLWLTYFMGLVIVYLLTSWLPTLMRDSGASLEQAAFIGALFQF 309 Query: 304 GGTVGALVVGFLMDRWSPSRAIACAYIAGAVFILLLASGSVQSGMFAAYVLLAGFCMSGA 363 GG + A+ VG+ MDR++P + I Y+ VF + Q + A VLLAG C++GA Sbjct: 310 GGVLSAVAVGWAMDRFNPHKVIGLFYLLAGVFAWCVGQSLGQVTLLATLVLLAGMCINGA 369 Query: 364 QTGLNAFAPSCYPTVVRATGVSWMLGVGRFGSILGSFAGGVLLSMGWGFGAV 415 Q+ + + A YPT RATGVSWMLG+GRFG+ILG++ G LL +GW F V Sbjct: 370 QSAMPSLAARFYPTQGRATGVSWMLGIGRFGAILGAWIGATLLGLGWNFEQV 421 >ECs3031 [GEPR] COG0477 Permeases of the major facilitator superfamily Ecs Escherichia coli O157:H7 Length = 452 Score = 319 bits (818), Expect = 7e-87, Method: Compositional matrix adjust. Identities = 181/441 (41%), Positives = 271/441 (61%), Gaps = 5/441 (1%) Query: 5 QSLDVRSHINGRKMSGYQWLLLILCFLIVATDGMDVAIMGFLAPAITKEWGISRAAFGVV 64 Q D+++ I+ + QW ++I CFL+V DG D A +GF+AP I W ++ + Sbjct: 3 QRRDLQALIDAAPVGKMQWRVIICCFLVVMLDGFDTAAIGFIAPDIRTHWQLTAGDLAPL 62 Query: 65 MSAAPIGLAVGALLVGPLSDRYGRKKLLMTAVAWFGACSLACAFAQDVVTLSALRFLTGL 124 A +GL GALL GPLSDR+GRK+++ V FGA SLA AF+ D+ TL LRFLTGL Sbjct: 63 FGAGLLGLTAGALLCGPLSDRFGRKRVIELCVFLFGALSLASAFSPDLQTLVFLRFLTGL 122 Query: 125 GLGAAMPNATTLLSEYVPERSRSTLLAIMFTGFNLGSGLVGFLAAALLPDYGWRTVLMVG 184 GLG AMPN T+ SEY+P R R L+ +MF GF LGS G ++A L+P GW +L++G Sbjct: 123 GLGGAMPNTITMTSEYLPARRRGALVTLMFCGFTLGSAFGGIVSAQLVPVIGWHGILVLG 182 Query: 185 GAIPLLCLPFYLWLVPESARFMVVRHYPADRIARTLARVCGGHFAAGQTFSVSEPPVKGG 244 G +PL+ L ++PES R+ V R P IA+T++ + + + + V G Sbjct: 183 GVLPLMLFVALLVVLPESPRWQVRRQLPQAVIAKTVSAITRERYVDTHFYLIESASVTKG 242 Query: 245 QPAKVLLSETYRKTTLSLWGTYFMGLLVIYLLSGWLPTLIKDAGLPIEKAASITALFQLG 304 ++ + TL LW +FM LL+IYLLS W+PTL+ G+ ++ A+ +TA FQ+G Sbjct: 243 SIRQLFMGRQL-PITLMLWVVFFMSLLIIYLLSSWMPTLLNHRGIDLQHASWVTAAFQIG 301 Query: 305 GTVGALVVGFLMDRWSPSRAIACAYIAGAVFILLLASGSVQSGMF--AAYVLLAGFCMSG 362 GT+GAL +G LMD+++P R + +Y GA+ I+++ G Q G++ A + G +SG Sbjct: 302 GTLGALALGVLMDKFNPFRVLTLSYAIGAICIVMI--GLSQDGLWLMALAIFGTGIGISG 359 Query: 363 AQTGLNAFAPSCYPTVVRATGVSWMLGVGRFGSILGSFAGGVLLSMGWGFGAVIAILAVP 422 +Q GLNA + YPT RATGVSW +GR G+I+GS +GGV+++M + F + I+AVP Sbjct: 360 SQVGLNALTATLYPTQSRATGVSWSNAIGRCGAIVGSLSGGVMMAMNFSFDTLFFIIAVP 419 Query: 423 ATLAALIIVFIQMGQRPAAAV 443 A ++A+++ + R + +V Sbjct: 420 AAISAVMLTLLITVVRQSTSV 440 >Z3394 [GEPR] COG0477 Permeases of the major facilitator superfamily EcZ Escherichia coli O157:H7 EDL933 Length = 452 Score = 319 bits (818), Expect = 8e-87, Method: Compositional matrix adjust. Identities = 180/441 (40%), Positives = 270/441 (61%), Gaps = 5/441 (1%) Query: 5 QSLDVRSHINGRKMSGYQWLLLILCFLIVATDGMDVAIMGFLAPAITKEWGISRAAFGVV 64 Q D+++ I+ + QW ++I CFL+V DG D A +GF+AP I W ++ + Sbjct: 3 QRRDLQALIDAAPVGKMQWRVIICCFLVVMLDGFDTAAIGFIAPDIRTHWQLTAGDLSPL 62 Query: 65 MSAAPIGLAVGALLVGPLSDRYGRKKLLMTAVAWFGACSLACAFAQDVVTLSALRFLTGL 124 A + L GALL GPLSDR+GRK+++ V FGA SLA AF+ D+ TL LRFLTGL Sbjct: 63 FGAGLLXLTAGALLCGPLSDRFGRKRVIELCVFLFGALSLASAFSPDLQTLVFLRFLTGL 122 Query: 125 GLGAAMPNATTLLSEYVPERSRSTLLAIMFTGFNLGSGLVGFLAAALLPDYGWRTVLMVG 184 GLG AMPN T+ SEY+P R R L+ +MF GF LGS G ++A L+P GW +L++G Sbjct: 123 GLGGAMPNTITMTSEYLPARRRGALVTLMFCGFTLGSAFGGIVSAQLVPVIGWHGILVLG 182 Query: 185 GAIPLLCLPFYLWLVPESARFMVVRHYPADRIARTLARVCGGHFAAGQTFSVSEPPVKGG 244 G +PL+ L ++PES R+ V R P IA+T++ + + + + V G Sbjct: 183 GVLPLMLFVALLVVLPESPRWQVRRQLPQAVIAKTVSAITRERYVDTHFYLIESASVTKG 242 Query: 245 QPAKVLLSETYRKTTLSLWGTYFMGLLVIYLLSGWLPTLIKDAGLPIEKAASITALFQLG 304 ++ + TL LW +FM LL+IYLLS W+PTL+ G+ ++ A+ +TA FQ+G Sbjct: 243 SIRQLFMGRQL-PITLMLWVVFFMSLLIIYLLSSWMPTLLNHRGIDLQHASWVTAAFQIG 301 Query: 305 GTVGALVVGFLMDRWSPSRAIACAYIAGAVFILLLASGSVQSGMF--AAYVLLAGFCMSG 362 GT+GAL +G LMD+++P R + +Y GA+ I+++ G Q G++ A + G +SG Sbjct: 302 GTLGALALGVLMDKFNPFRVLTLSYAIGAICIVMI--GLSQDGLWLMALAIFGTGIGISG 359 Query: 363 AQTGLNAFAPSCYPTVVRATGVSWMLGVGRFGSILGSFAGGVLLSMGWGFGAVIAILAVP 422 +Q GLNA + YPT RATGVSW +GR G+I+GS +GGV+++M + F + I+AVP Sbjct: 360 SQVGLNALTATLYPTQSRATGVSWSNAIGRCGAIVGSLSGGVMMAMNFSFDTLFFIIAVP 419 Query: 423 ATLAALIIVFIQMGQRPAAAV 443 A ++A+++ + R + +V Sbjct: 420 AAISAVMLTLLITVVRQSTSV 440 >STM2179 [GEPR] COG0477 Permeases of the major facilitator superfamily Sty Salmonella typhimurium LT2 Length = 452 Score = 301 bits (772), Expect = 2e-81, Method: Compositional matrix adjust. Identities = 181/439 (41%), Positives = 272/439 (61%), Gaps = 1/439 (0%) Query: 5 QSLDVRSHINGRKMSGYQWLLLILCFLIVATDGMDVAIMGFLAPAITKEWGISRAAFGVV 64 Q D+++ I+ + QW ++I CFL+V DG D A +GF+AP I W +S + + Sbjct: 3 QRRDLQALIDAAPVGKMQWRVIICCFLVVMLDGFDTAAIGFIAPDIRTHWQLSASELAPL 62 Query: 65 MSAAPIGLAVGALLVGPLSDRYGRKKLLMTAVAWFGACSLACAFAQDVVTLSALRFLTGL 124 A +GL GALL GPL+DR+GRK+++ VA FGA SL AF+ D+ TL LRFLTGL Sbjct: 63 FGAGLLGLTAGALLCGPLADRFGRKRVIELCVALFGALSLLSAFSPDIETLVLLRFLTGL 122 Query: 125 GLGAAMPNATTLLSEYVPERSRSTLLAIMFTGFNLGSGLVGFLAAALLPDYGWRTVLMVG 184 GLG AMPN T+ SEY+P R R L+ +MF GF LGS + G ++A L+P GW +L +G Sbjct: 123 GLGGAMPNTITMTSEYLPARRRGALVTLMFCGFTLGSAMGGIVSAQLVPLIGWHGILALG 182 Query: 185 GAIPLLCLPFYLWLVPESARFMVVRHYPADRIARTLARVCGGHFAAGQTFSVSEPPVKGG 244 G +PL+ L+ +PES R+ V R P +ART++ + G + Q F V G Sbjct: 183 GILPLMLFFGLLFALPESPRWQVRRQLPQAVVARTVSAITGERYHDTQFFLHETAAVAKG 242 Query: 245 QPAKVLLSETYRKTTLSLWGTYFMGLLVIYLLSGWLPTLIKDAGLPIEKAASITALFQLG 304 + L + TL LW +FM LL+IYLLS W+PTL+ G+ +++A+ +TA FQ+G Sbjct: 243 S-IRQLFAGRQLVITLMLWVVFFMSLLIIYLLSSWMPTLLNHRGIDLQQASWVTAAFQVG 301 Query: 305 GTVGALVVGFLMDRWSPSRAIACAYIAGAVFILLLASGSVQSGMFAAYVLLAGFCMSGAQ 364 GT+GAL++G LMDR +P R +A +Y GAV I+++ + A + G +SG+Q Sbjct: 302 GTLGALLLGVLMDRLNPFRVLAVSYALGAVCIVMIGLSENGLWLMALAIFGTGIGISGSQ 361 Query: 365 TGLNAFAPSCYPTVVRATGVSWMLGVGRFGSILGSFAGGVLLSMGWGFGAVIAILAVPAT 424 GLNA + YPT RATGVSW +GR G+I+GS +GG+++++ + F + ++A+PA Sbjct: 362 VGLNALTATLYPTQSRATGVSWSNAIGRCGAIVGSLSGGMMMALNFSFDTLFFVIAIPAA 421 Query: 425 LAALIIVFIQMGQRPAAAV 443 ++A+++ + + R + +V Sbjct: 422 ISAVMLTLLTVVVRLSISV 440