BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0007.0051.p (247 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value VC2021 [IQR] COG1028 Dehydrogenases with different specificities... 149 4e-36 SMc03878 [IQR] COG1028 Dehydrogenases with different specificiti... 147 2e-35 BH2491 [IQR] COG1028 Dehydrogenases with different specificities... 145 1e-34 SSO3114 [IQR] COG1028 Dehydrogenases with different specificitie... 141 1e-33 CC0511 [IQR] COG1028 Dehydrogenases with different specificities... 140 2e-33 >VC2021 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Vch Vibrio cholerae Length = 248 Score = 149 bits (377), Expect = 4e-36, Method: Compositional matrix adjust. Identities = 93/246 (37%), Positives = 135/246 (54%), Gaps = 5/246 (2%) Query: 1 MDKKIALVTGAARGLGESIARKMHAAGYKVALADIDLEQVSAVAASLDASGATAMPLALD 60 ++ K+ALVTGA+RG+G++IA + G KV A++ D G +AL+ Sbjct: 7 LEGKVALVTGASRGIGKAIAELLAERGAKVIGTATSESGAQAIS---DYLGDNGKGMALN 63 Query: 61 VRRKPDFIAACDAIELRWGGAAVLVNNAGRSRVAALMEITPEEWDEVTAINMKGTFLACQ 120 V A AI +GG +LVNNAG +R LM + EEW ++ N+ F + Sbjct: 64 VTNPESIEAVLKAITDEFGGVDILVNNAGITRDNLLMRMKEEEWSDIMETNLTSIFRLSK 123 Query: 121 VFGKRFADRGYGRIINIASLAGQNGGTATGAHYAAAKGAVLTLTKVFARELAGAGVTVNA 180 + + GRIIN+ S+ G G A A+YAAAK V+ TK ARE+A GVTVN Sbjct: 124 AVLRGMMKKRQGRIINVGSVVGTM-GNAGQANYAAAKAGVIGFTKSMAREVASRGVTVNT 182 Query: 181 ISPGPLDLPIVREIVPADKLAATIASIPVKTLGEPDFIADAVLLLASPDAGSATGACLDI 240 ++PG ++ + + + ++ AT+A +P LG+P IA AV LASP+A TG L + Sbjct: 183 VAPGFIETDMTKAL-NDEQRTATLAQVPAGRLGDPREIASAVAFLASPEAAYITGETLHV 241 Query: 241 NGGLYM 246 NGG+YM Sbjct: 242 NGGMYM 247 >SMc03878 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Sme Sinorhizobium meliloti Length = 241 Score = 147 bits (371), Expect = 2e-35, Method: Compositional matrix adjust. Identities = 96/244 (39%), Positives = 131/244 (53%), Gaps = 7/244 (2%) Query: 4 KIALVTGAARGLGESIARKMHAAGYKVALADIDLEQVSAVAASLDASGATAMPL-ALDVR 62 ++ALVTG +RG+G +I + AAGYKVA A+ A A + + +P+ DV Sbjct: 3 RVALVTGGSRGIGAAICVALKAAGYKVA-ANYAGNDERAKAFEQE----SGIPVYKWDVS 57 Query: 63 RKPDFIAACDAIELRWGGAAVLVNNAGRSRVAALMEITPEEWDEVTAINMKGTFLACQVF 122 + +E G +LVNNAG +R A ++TPE+W EV N+ G F Sbjct: 58 SYQACVDGIARVEADLGPVDILVNNAGITRDAMFHKMTPEQWGEVIGTNLTGVFNMTHPL 117 Query: 123 GKRFADRGYGRIINIASLAGQNGGTATGAHYAAAKGAVLTLTKVFARELAGAGVTVNAIS 182 DRG+GRI+NI+S+ GQ G +Y+AAK L LTK A+E A G+TVNAI Sbjct: 118 WSGMRDRGFGRIVNISSINGQKGQMGQ-VNYSAAKAGDLGLTKALAQEGAAKGITVNAIC 176 Query: 183 PGPLDLPIVREIVPADKLAATIASIPVKTLGEPDFIADAVLLLASPDAGSATGACLDING 242 PG + +VR + I IPV LGEP+ +A V+ LAS DAG TG+ + NG Sbjct: 177 PGYIGTEMVRAVPEKVLNERIIPQIPVGRLGEPEEVARCVVFLASDDAGFITGSTISANG 236 Query: 243 GLYM 246 G Y Sbjct: 237 GQYF 240 >BH2491 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Bha Bacillus halodurans Length = 246 Score = 145 bits (365), Expect = 1e-34, Method: Compositional matrix adjust. Identities = 91/245 (37%), Positives = 132/245 (53%), Gaps = 5/245 (2%) Query: 4 KIALVTGAARGLGESIARKM--HAAGYKVALADIDLEQVSAVAASLDASGATAMPLALDV 61 K A+VTGA+RG+G + A ++ H A V A + E+ V A + G A+ + DV Sbjct: 5 KTAIVTGASRGIGRATAMELARHGANVVVNYAG-NKEKAEKVVAEIKELGVEAIAIQADV 63 Query: 62 RRKPDFIAACDAIELRWGGAAVLVNNAGRSRVAALMEITPEEWDEVTAINMKGTFLACQV 121 A +G +LVNNAG +R M + E+WD V N+KG F + Sbjct: 64 ADSESVQAMVKETIDTFGAVDILVNNAGITRDNLFMRMKEEDWDAVIDTNLKGVFHCSKA 123 Query: 122 FGKRFADRGYGRIINIASLAGQNGGTATGAHYAAAKGAVLTLTKVFARELAGAGVTVNAI 181 + + +GRIIN++S+ G G A A+Y AAK V+ LTK ARELA +TVNA+ Sbjct: 124 VTRPMMKQRFGRIINVSSVVGAI-GNAGQANYVAAKAGVIGLTKTLARELANRNITVNAV 182 Query: 182 SPGPLDLPIVREIVPADKLAATIASIPVKTLGEPDFIADAVLLLASPDAGSATGACLDIN 241 +PG ++ + E+ P D A + IP+ LG+P+ +A AV LAS DA TG + +N Sbjct: 183 APGFIETDMTGEL-PEDVKAQMLGQIPLARLGQPEEVAKAVRFLASDDASYLTGQTIHVN 241 Query: 242 GGLYM 246 GG+ M Sbjct: 242 GGMVM 246 >SSO3114 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Sso Sulfolobus solfataricus Length = 252 Score = 141 bits (355), Expect = 1e-33, Method: Compositional matrix adjust. Identities = 88/249 (35%), Positives = 138/249 (55%), Gaps = 12/249 (4%) Query: 4 KIALVTGAARGLGESIARKMHAAGYKVALADIDLEQVSAVAASL-DASGATAMPLALDVR 62 +IA+VTG A G+G +IA K+ + G V L D+ LE++ V + + + +PL ++V Sbjct: 10 RIAIVTGGASGIGRAIAFKLASLGATVVLGDVKLEELKNVVNEITQQTSSKVLPLYVNV- 68 Query: 63 RKPDFIAACDAIE-----LRWGGAAVLVNNAGRSRVAALMEITPEEWDEVTAINMKGTFL 117 DF +A + + L +LVNNAG +R A +++T E+WDEV +++ F Sbjct: 69 --GDFNSAKEFYQKATEILGIDYVDILVNNAGINRDALFVKMTFEQWDEVMKVDLYSMFN 126 Query: 118 ACQVFGKRFADRGYGRIINIASLAGQNGGTATGAHYAAAKGAVLTLTKVFARELAGAGVT 177 + R YGRIIN++S++ G A+Y+AAK V+ TK ARELA +T Sbjct: 127 MTKQVVDGMIRRNYGRIINMSSMSWL--GNIGQANYSAAKAGVIGFTKTLARELAKYNIT 184 Query: 178 VNAISPGPLDLPIVREIVPADKLAATIASIPVKTLGEPDFIADAVLLLASPDAGSATGAC 237 VNAI+PG +D P+ R VP I IP+ +G P+ +A+ + L+S +A TG Sbjct: 185 VNAITPGFIDTPMTRA-VPEKVRQKIIERIPMGRVGSPEEVANLIAFLSSEEASYITGEV 243 Query: 238 LDINGGLYM 246 + + GGL + Sbjct: 244 IGVTGGLVL 252 >CC0511 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Ccr Caulobacter vibrioides Length = 240 Score = 140 bits (354), Expect = 2e-33, Method: Compositional matrix adjust. Identities = 97/243 (39%), Positives = 129/243 (53%), Gaps = 6/243 (2%) Query: 4 KIALVTGAARGLGESIARKMHAAGYKVALADIDLEQVSAVAASLDASGATAMPLALDVRR 63 ++A VTG RG+G +I ++ A G+KVA + AA A M + +V Sbjct: 3 RVAFVTGGTRGIGRAICERLIADGHKVAAG----YSGNEAAAEACAKELGVMVVKGNVGV 58 Query: 64 KPDFIAACDAIELRWGGAAVLVNNAGRSRVAALMEITPEEWDEVTAINMKGTFLACQVFG 123 D AA +E G +LVNNAG +R L ++T E+W EV +NM F + Sbjct: 59 FEDCQAAVKKVEAELGPIDILVNNAGITRDGMLHKMTYEQWSEVIRVNMDSAFNMTRPVI 118 Query: 124 KRFADRGYGRIINIASLAGQNGGTATGAHYAAAKGAVLTLTKVFARELAGAGVTVNAISP 183 + DR +GRIINI+S+ GQ G +Y+AAK ++ TK A E A GVTVN I P Sbjct: 119 EGMRDRSWGRIINISSINGQKGQMGQ-TNYSAAKAGLIGFTKALALENAKKGVTVNVICP 177 Query: 184 GPLDLPIVREIVPADKLAATIASIPVKTLGEPDFIADAVLLLASPDAGSATGACLDINGG 243 G +D +V VP + LA +A IPV LG + IAD V LA AG TGA L +NGG Sbjct: 178 GYIDTEMV-AAVPENVLAQIVAGIPVGRLGRGEEIADMVSFLAGERAGFVTGATLTLNGG 236 Query: 244 LYM 246 YM Sbjct: 237 QYM 239