BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0006.0024.p (310 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSc1953 [GER] COG0697 Permeases of the drug/metabolite transport... 189 6e-48 BH0390 [GER] COG0697 Permeases of the drug/metabolite transporte... 149 1e-35 BS_yetK [GER] COG0697 Permeases of the drug/metabolite transport... 129 7e-30 RSp0685 [GER] COG0697 Permeases of the drug/metabolite transport... 95 2e-19 SMc00428 [GER] COG0697 Permeases of the drug/metabolite transpor... 83 7e-16 >RSc1953 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Rso Ralstonia solanacearum Length = 336 Score = 189 bits (481), Expect = 6e-48, Method: Compositional matrix adjust. Identities = 124/290 (42%), Positives = 178/290 (61%), Gaps = 4/290 (1%) Query: 14 LILSMSLVGAYVALTKPLAALLPVFLLAWLRFAIGAVAMLRWLKKPTDEKPLSTQSRWL- 72 LI +M+LVG+ V K + A++PV L A LRF I M W + + T+ W Sbjct: 25 LIAAMALVGSNVGFGKSIVAVMPVMLFALLRFVIAVACMAPWYRPSRMRR--VTRGEWTN 82 Query: 73 VFLESFLGNFLFTLCMITGVSMTNAVSAGVIMSSIPAVVAVMSWVFLKEKISLRVWGAVA 132 +FL++ G F FTL M+ GV +T+A++AG+I S+IPA VA++SW+ L+EK S R +V Sbjct: 83 LFLQALFGTFGFTLLMLNGVRLTSALAAGIITSTIPATVALLSWLVLREKPSGRTLVSVT 142 Query: 133 CGAIGIGLLSLAKDSH-GAAAATGGQSAWLGNVLVFCAVLCEAAYAVIGKKLTTVLTPKR 191 G+ LL+ + AA A LGN LV AVLCE+ Y V+ ++LT L Sbjct: 143 LAVAGVALLNADRGGEFAGAAPADAARALLGNALVMGAVLCESVYVVLSRRLTQTLPAIE 202 Query: 192 ISAVINLWGLLLMTPMGLYTALQFNFSTVPVNIWLLLVFYALAASVWTVWLWMTGLKVVP 251 I A +L G LLM P+GL L F+ S+VP +IW L+V+YAL+AS+++ WLWM G++ VP Sbjct: 203 ICAYTHLIGALLMLPLGLAPLLTFDLSSVPPHIWGLVVWYALSASLFSFWLWMKGIRHVP 262 Query: 252 AARAGVFTVMLPVSAAVVGVLALGESLSALQAGAFAVALAGMFLATLPGR 301 A AGVFT +LP++AA G++ALGE+ A A +AG+ +A+ P R Sbjct: 263 AHLAGVFTSVLPIAAAAYGIIALGEAPGWAHGAALACVVAGILVASWPAR 312 >BH0390 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Bha Bacillus halodurans Length = 311 Score = 149 bits (375), Expect = 1e-35, Method: Compositional matrix adjust. Identities = 96/296 (32%), Positives = 168/296 (56%), Gaps = 10/296 (3%) Query: 14 LILSMSLVGAYVALTKPLAALLPVFLLAWLRFAIGAVAMLRWLKKPTDEKPLSTQSRWLV 73 ++ +M +VG+ V K L PVFL + LRF I A+ ++ L K S + ++ Sbjct: 11 IMFAMVIVGSSVVAGKMLVESFPVFLASELRFLIAALILVPMLLKKEGIPTFSKKEVGIL 70 Query: 74 FLESFLGNFLFTLCMITGVSMTNAVSAGVIMSSIPAVVAVMSWVFLKEKIS-LRVWGAV- 131 FL++ G FLF++ M+ G+ T A+ G+IMS++PAVVA+M+++ LKEK++ L + G + Sbjct: 71 FLQALSGVFLFSIFMLYGLMYTTAMEGGIIMSTLPAVVALMAFITLKEKLTRLTIIGILL 130 Query: 132 ACGAIGIGLLSLAKDSHGA-AAATGGQSAWLGNVLVFCAVLCEAAYAVIGKKLTTVLTPK 190 A G +LA ++ G + G + LGN+L+ AV+ EA + + GK ++ ++P Sbjct: 131 AVGG------TLAINTSGTLSDVERGVAPLLGNLLIIGAVISEALFIIFGKSISQRVSPL 184 Query: 191 RISAVINLWGLLLMTPMGLYTALQFNFSTVPVNIWLLLVFYALAASVWTVWLWMTGLKVV 250 IS +++++G++L P +Y A +F + V +N WL++ ++ + +V L G++ V Sbjct: 185 AISTMVSVFGVVLFLPFAIYEATRFPLTDVSLNDWLIIFYFGVVVTVIAFVLMYQGIEKV 244 Query: 251 PAARAGVFTVMLPVSAAVVGVLALGESLSALQAGAFAVALAGMFLATLPGRNTADK 306 PA+ GV T +LP+SA ++ L L ES S + LA + L ++ N K Sbjct: 245 PASTVGVLTGVLPISAVLLSALILKESFSTFHVAGMGLVLAAILLISID-SNVEKK 299 >BS_yetK [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Bsu Bacillus subtilis Length = 330 Score = 129 bits (325), Expect = 7e-30, Method: Compositional matrix adjust. Identities = 95/308 (30%), Positives = 165/308 (53%), Gaps = 13/308 (4%) Query: 6 SRPMG-YGCLILSMSLVGAYVALTKPLAALLPVFLLAWLRFAIGAVAMLRWLKKPTDEKP 64 + MG Y L +M++VG+ V + K + +PVFL + LRF I +V +L L P Sbjct: 24 KKQMGAYVSLAAAMAIVGSSVVVGKLMVERIPVFLSSGLRFLIASVVLLMLLFCIEKGFP 83 Query: 65 -LSTQSRWLVFLESFLGNFLFTLCMITGVSMTNAVSAGVIMSSIPAVVAVMSWVFLKEKI 123 L+ + +++ ++SF G FLF++C++ GV T +G++ S+ P ++ ++S+ L+EKI Sbjct: 84 ALTKKDVFVLLVQSFTGVFLFSICLLYGVQYTTGTESGILTSTTPMLIGILSFFLLREKI 143 Query: 124 SLRVWGAV---ACGAIGIGLLSLAKDSHGAAAATGGQSAWLGNVLVFCAVLCEAAYAVIG 180 + + CG + I L GA + G A GN+L+ AV+ EA + ++ Sbjct: 144 EKKTLIGILLAVCGVMAINLF-------GAGSQDGTPHALFGNMLIIAAVIGEALFTLMA 196 Query: 181 KKLTTVLTPKRISAVINLWGLLLMTPMGLYTALQFNFSTVPVNIWLLLVFYALAASVWTV 240 K L+ ++ IS ++L+G L P L+ A F++S V W +++YAL +V Sbjct: 197 KLLSPHISALAISTFVSLFGFLFFLPFALFEASSFDYSVPTVLDWSYVLYYALFVTVLAF 256 Query: 241 WLWMTGLKVVPAARAGVFTVMLPVSAAVVGVLALGESLSALQAGAFAVALAGMFLATLPG 300 +LW +G+ VPA +G+FT +LPVSA ++ + L E + A + G+F+ T+ Sbjct: 257 YLWYSGVTKVPAGVSGIFTSVLPVSAVILSGVILKEPFEFVHFIGIACVIGGIFV-TVIK 315 Query: 301 RNTADKLP 308 + D P Sbjct: 316 KKQPDAYP 323 >RSp0685 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Rso Ralstonia solanacearum Length = 300 Score = 94.7 bits (234), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 97/294 (32%), Positives = 152/294 (51%), Gaps = 26/294 (8%) Query: 6 SRPMGYGCLILSMSLVGAYVALTKPLAALLPVFLLAWLRFAIG-----AVAMLRWLKKPT 60 +R +GY L L+M VG+ V +K +A LP F LRFA+ A+ +LR + P Sbjct: 3 NRTIGYLLLSLAMMTVGSTVIASKLIAGNLPPFPATALRFAVALPFLFALVLLRGQRWPR 62 Query: 61 DEKPLSTQSRWLVFLESFLGNFLFTLCMITGVSMTNAVSAGVIMSSIPAVVAVMSWVFLK 120 LS ++ L+ L++ G+ +T +I+G++ A AGV++ ++PAV A+ S + L Sbjct: 63 ----LSGRAWGLLVLQAGAGSVGYTTLLISGLAHLPAADAGVVIGTLPAVSALFSVIVLG 118 Query: 121 EKISLRVWGAVACGAIGIGLLSLAKDSHGAAAATGGQSAWLGNVL-VFCAVLCEAAYAVI 179 E+ LR+ +V IG+ A A TG SA L VL + AV+CE+A+ ++ Sbjct: 119 ERPKLRLMVSVLLATIGV----------MAVAWTGSGSAPLTGVLFILGAVVCESAFILL 168 Query: 180 GKKLTTVLTPKRISAVINLWGLLLMTPMGLYTALQFNFSTVPVNIWL-LLVFYALAASVW 238 K++ L P + + GLL+ P + L+F +TVP + +V+YAL +V Sbjct: 169 NKRMPVPLPPLLQATAMTALGLLVSLP---FAVLEFP-ATVPSTAAIAAVVWYALVPTVG 224 Query: 239 TVWLWMTGLKVVPAARAGVFTVMLPVSAAVVGVLALGESLSALQA-GAFAVALA 291 LW G V + A FT + P++A + L L E + A QA G AV LA Sbjct: 225 GFLLWYAGAARVSGSEAATFTAVAPLTAVALAALFLNERIGATQAFGVVAVILA 278 >SMc00428 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Sme Sinorhizobium meliloti Length = 298 Score = 83.2 bits (204), Expect = 7e-16, Method: Compositional matrix adjust. Identities = 90/281 (32%), Positives = 141/281 (50%), Gaps = 22/281 (7%) Query: 9 MGYGCLILSMSLVGAYVALTKPLAALLPVFLLAWLRFAIGAVAMLRWLKKPTDEKPLSTQ 68 GY L L+M LVG+ V +K +AA LP F LRFAI L ++ P + Sbjct: 6 QGYVFLSLAMVLVGSTVIASKIIAAGLPPFTATALRFAIAFPLFLGLMRATGASWPKLPK 65 Query: 69 SRWLVFL-ESFLGNFLFTLCMITGVSMTNAVSAGVIMSSIPAVVAVMSWVFLKEKISLRV 127 S WLV L ++ G+ +T +I+G+ +T+A AGVI+ ++P V A ++ + L E+ V Sbjct: 66 SDWLVLLFQAGAGSVGYTTLLISGLKLTSAADAGVIIGTLPVVSAAIAIMVLGERPHRSV 125 Query: 128 WGAVACGAIGIGLLSLAKDSHGAAAATGGQSAWLGNVLVFCAVLCEAAYAVIGKKLTTVL 187 A A G+ + D++ A + G+ L+F AV+CE + ++ K+++ + Sbjct: 126 LAAACLAAAGVLAIVFRPDANAA-------HSLAGSALIFGAVICEGLFILLNKRVSVAI 178 Query: 188 TPKRISAVINLWGLLLMTPMGLYTALQFNFSTVP------VNIWLLLVFYALAASVWTVW 241 P +SA LMT G AL F + +P V + +YAL +V Sbjct: 179 PPLGLSA--------LMTGFGGAIALPFALAELPSMGATGVPALAAVAYYALVPTVGGFV 230 Query: 242 LWMTGLKVVPAARAGVFTVMLPVSAAVVGVLALGESLSALQ 282 LW GL+ V A VFT + PVSA ++ LGE+++A Q Sbjct: 231 LWYAGLQKVSGTEASVFTALAPVSALLLAAAVLGETITANQ 271