BLASTP 2.2.21 [Jun-14-2009]

Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Reference for compositional score matrix adjustment: Altschul, Stephen F., 
John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis,
Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches
using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109.

Query= 0006.0006.p         (247 letters)

Database: COGmodified 
           192,987 sequences; 59,019,183 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

BH1646 [H] COG0302 GTP cyclohydrolase I Bha Bacillus halodurans       130   3e-30
HI1447 [H] COG0302 GTP cyclohydrolase I Hin Haemophilus influenzae    123   5e-28
lin2047 [H] COG0302 GTP cyclohydrolase I Lin Listeria innocua         122   1e-27
PM0693 [H] COG0302 GTP cyclohydrolase I Pmu Pasteurella multocida     121   2e-27
Cgl2639 [H] COG0302 GTP cyclohydrolase I Cgl Corynebacterium glu...   119   8e-27

>BH1646 [H] COG0302 GTP cyclohydrolase I Bha Bacillus halodurans
          Length = 188

 Score =  130 bits (327), Expect = 3e-30,   Method: Compositional matrix adjust.
 Identities = 77/184 (41%), Positives = 104/184 (56%), Gaps = 7/184 (3%)

Query: 60  EVQSKLAAVLESLVIDVESDHNTQDTAKRVAKMYLNEVFKGRYQAAPPVTEFPNI--ERL 117
           ++Q  +  +LE++  D  +    +DT KRVAKMY  EVF G  Q   P   F  I  E  
Sbjct: 8   KIQQAVVMILEAIGED-PAREGLEDTPKRVAKMY-EEVFAGLNQ--DPKEHFATIFGEDH 63

Query: 118 NELMIVGPITVRSACSHHLCPIMGKVWVGVMPNEHSNLIGLSKYARLLEWIMSRPQIQEE 177
            EL++V  I   S C HHL P  GK  VG +P     + GLSK AR +E +  RPQ+QE 
Sbjct: 64  EELVLVKDIPFFSMCEHHLVPFFGKAHVGYIPK-GGKVTGLSKLARAVEAVARRPQLQER 122

Query: 178 AVSQAADLLMQKLQPDGLAIVMEADHFCMHWRGVKDVESKMINSVMRGSFLRDANLRREF 237
             S  AD L++ L+P G+ +V+EA+H CM  RGVK   +  + S +RG+F  DA  R E 
Sbjct: 123 ITSTVADALVETLEPHGVIVVVEAEHMCMTMRGVKKPGAATVTSAVRGTFANDAAARAEV 182

Query: 238 LALI 241
           L+LI
Sbjct: 183 LSLI 186


>HI1447 [H] COG0302 GTP cyclohydrolase I Hin Haemophilus influenzae
          Length = 218

 Score =  123 bits (308), Expect = 5e-28,   Method: Compositional matrix adjust.
 Identities = 60/166 (36%), Positives = 95/166 (57%), Gaps = 3/166 (1%)

Query: 79  DHNTQDTAKRVAKMYLNEVFKG-RYQAAPPVTEFPNIERLNELMIVGPITVRSACSHHLC 137
           D + ++T  R+AKM+++E+F G  Y   P +T+  N  +++E++ V  IT+ S C HH  
Sbjct: 55  DDSLEETPNRLAKMFIDEIFSGMDYANFPKMTKIKNQMKVSEMVQVNDITLTSTCEHHFV 114

Query: 138 PIMGKVWVGVMPNEHSNLIGLSKYARLLEWIMSRPQIQEEAVSQAADLLMQKLQPDGLAI 197
            I GKV V   P +   +IGLSK  R++ +   RPQ+QE    Q        L+ D +A+
Sbjct: 115 TIDGKVCVAYYPKDW--VIGLSKINRIVSFFAQRPQVQERLTEQLLTAFQTILETDDVAV 172

Query: 198 VMEADHFCMHWRGVKDVESKMINSVMRGSFLRDANLRREFLALISQ 243
            ++A HFC+  RG++D  S  + S   G FL D + R+EFLA + +
Sbjct: 173 YVKATHFCVKARGIRDTNSYTVTSAYGGVFLEDRDTRKEFLATVQK 218


>lin2047 [H] COG0302 GTP cyclohydrolase I Lin Listeria innocua
          Length = 189

 Score =  122 bits (305), Expect = 1e-27,   Method: Compositional matrix adjust.
 Identities = 68/162 (41%), Positives = 94/162 (58%), Gaps = 6/162 (3%)

Query: 84  DTAKRVAKMYLNEVFKGRYQAAPPVTEFPNI--ERLNELMIVGPITVRSACSHHLCPIMG 141
           DT  RVA+MY  EVF G  +   P   F  I  E+  EL++V  I   S C HHL P  G
Sbjct: 31  DTPMRVARMY-EEVFAGLKKD--PSVHFDTIFEEQHEELVLVKDIRFSSMCEHHLVPFFG 87

Query: 142 KVWVGVMPNEHSNLIGLSKYARLLEWIMSRPQIQEEAVSQAADLLMQKLQPDGLAIVMEA 201
              V  +P ++  + GLSK AR+++ +  RPQ+QE   +  A+++M KL+P G+ ++MEA
Sbjct: 88  VAHVAYLP-QNGRVAGLSKLARVVDDVSRRPQLQERITTTVAEIMMDKLKPLGVMVIMEA 146

Query: 202 DHFCMHWRGVKDVESKMINSVMRGSFLRDANLRREFLALISQ 243
           +H CM  RGV    +K I S +RG+F  D  LR E LALI  
Sbjct: 147 EHMCMTIRGVNKPGTKTITSAVRGAFKNDDKLRSEVLALIKH 188


>PM0693 [H] COG0302 GTP cyclohydrolase I Pmu Pasteurella multocida
          Length = 218

 Score =  121 bits (303), Expect = 2e-27,   Method: Compositional matrix adjust.
 Identities = 64/194 (32%), Positives = 109/194 (56%), Gaps = 4/194 (2%)

Query: 51  EGELEQLQAEVQSKLAAVLESLVIDVESDHNTQDTAKRVAKMYLNEVFKG-RYQAAPPVT 109
           E + +  +A ++  +  V++ + +D+  D + ++T  R+AKM+++E+F G  Y   P +T
Sbjct: 28  EQDRDTRRAGIEQHMREVMKLIGLDLRDD-SLEETPVRLAKMFVDEIFSGLDYANFPKIT 86

Query: 110 EFPNIERLNELMIVGPITVRSACSHHLCPIMGKVWVGVMPNEHSNLIGLSKYARLLEWIM 169
              N  +++E+++V  +T+ S C HH   I G V V   P +   +IGLSK  R++ +  
Sbjct: 87  NIENRMKVSEMVLVNDVTLTSTCEHHFVTIDGMVSVAYYPKKW--VIGLSKINRIVAFFA 144

Query: 170 SRPQIQEEAVSQAADLLMQKLQPDGLAIVMEADHFCMHWRGVKDVESKMINSVMRGSFLR 229
            RPQ+QE    Q        L+ D +A+ ++A HFC+  RG+KD  S  + S   G FL 
Sbjct: 145 QRPQVQERLTEQILLAFQTILETDDVAVYVKATHFCVKCRGIKDTNSYTVTSAFGGVFLD 204

Query: 230 DANLRREFLALISQ 243
           D   R+EFL LI++
Sbjct: 205 DRETRKEFLTLINK 218


>Cgl2639 [H] COG0302 GTP cyclohydrolase I Cgl Corynebacterium glutamicum
          Length = 201

 Score =  119 bits (297), Expect = 8e-27,   Method: Compositional matrix adjust.
 Identities = 73/199 (36%), Positives = 103/199 (51%), Gaps = 7/199 (3%)

Query: 43  DNIAAFIREGELEQLQAEVQSKLAAVLESLVIDVESDHNTQDTAKRVAKMYLNEVFKGRY 102
           DN AA +RE + E+  A ++  L AV E             +T  RVA+ Y  E F G +
Sbjct: 7   DNHAA-VREFDEERATAAIRELLIAVGED-----PDREGLLETPARVARAY-KETFAGLH 59

Query: 103 QAAPPVTEFPNIERLNELMIVGPITVRSACSHHLCPIMGKVWVGVMPNEHSNLIGLSKYA 162
           +    V E    E   EL++V  I + S C HHL P  G   +G +P +   + GLSK A
Sbjct: 60  EDPTTVLEKTFSEGHEELVLVREIPIYSMCEHHLVPFFGVAHIGYIPGKSGKVTGLSKLA 119

Query: 163 RLLEWIMSRPQIQEEAVSQAADLLMQKLQPDGLAIVMEADHFCMHWRGVKDVESKMINSV 222
           RL +    RPQ+QE   SQ AD L++KL    +A+V+EA+H CM  RG++   +    S 
Sbjct: 120 RLADMFAKRPQVQERLTSQIADALVEKLDAQAVAVVIEAEHLCMAMRGIRKPGAVTTTSA 179

Query: 223 MRGSFLRDANLRREFLALI 241
           +RG F  +A  R E  +LI
Sbjct: 180 VRGGFKNNAASRAEVFSLI 198