BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0006.0001.p (492 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value YPO2916 [T] COG0642 Signal transduction histidine kinase Ype Yer... 206 9e-53 ZyfhK [T] COG0642 Signal transduction histidine kinase EcZ Esche... 199 9e-51 ECs3422 [T] COG0642 Signal transduction histidine kinase Ecs Esc... 199 9e-51 yfhK [T] COG0642 Signal transduction histidine kinase Eco Escher... 199 1e-50 STM2564 [T] COG0642 Signal transduction histidine kinase Sty Sal... 193 8e-49 >YPO2916 [T] COG0642 Signal transduction histidine kinase Ype Yersinia pestis Length = 483 Score = 206 bits (524), Expect = 9e-53, Method: Compositional matrix adjust. Identities = 156/467 (33%), Positives = 241/467 (51%), Gaps = 9/467 (1%) Query: 25 SFRQLLLAAFLLIAALLSGTSIHALFTLDRMSANSRETARQAVQLTESAQRLAERTVAME 84 S RQL+L AFLL+ L + A +LD +S + + R + ++ + + ME Sbjct: 18 SLRQLVLMAFLLVLLPLLVLAYQAYQSLDHLSTQAADINRTTLADARRSEAMTSVALEME 77 Query: 85 RSARQYLVLDDRAFHDRFNEAREQARQALGELSDSLPMAPRDLFSQWGVYVDEAAGVLEA 144 RS RQY VLDD + R+Q Q L + LP A + +++ + Sbjct: 78 RSYRQYCVLDDATLATLYQHQRKQYTQMLVAHAPILPDA--RYYQTLQGLLNQLTDIKCK 135 Query: 145 ESRKDKGEQAKLFQDFARLPALNERIALESRREVDRRNNALSAALEQQRQLLTAQVVGAI 204 S DK E + L + F+R N + +R + R L + ++ Q Q + Sbjct: 136 NSGPDK-EASILLEQFSRS---NAEMVQATRDVIFSRGQQLQKDIAERGQFFGWQSLLLF 191 Query: 205 VLAVLLAFCFGLWLSRPMARLEQAIGRLGDNR-FDQPIDVRGPADIRRLGQQLDWLRQRL 263 +++VLL F + P+ +E+ I RLG+ R +GP ++R L Q++ WL +RL Sbjct: 192 LVSVLLVVLFTRMIIGPVKGIERMINRLGEGRSLGNTALFKGPRELRSLAQRIIWLSERL 251 Query: 264 ADLEAEKSRFLRHVSHELKTPLAALCEGAALLDDGVAGQLTENQREIARILRQNTQSLQT 323 A LE+++ FLRH+SHELKTPLA++ EG LL D VAG LT++Q+E+ IL +++ LQ Sbjct: 252 AWLESQRHEFLRHISHELKTPLASMREGTELLADEVAGPLTQDQQEVVAILDHSSRHLQQ 311 Query: 324 QIEDLLRYNEVSFDAQRIHPVPVDLRALLHKVIDDQRLQWLARELKVEIEGVARTVVVDP 383 IE LL YN D P VDL ++ VI L A+ ++ E E AR +P Sbjct: 312 LIEQLLDYNRKLADGPG-EPEHVDLAEMVGNVISAHSLPARAKMIRTETELDARICWAEP 370 Query: 384 EKMAIVLANLLSNAVRFSPQGGFIRFLLSEAPGMVRVECLDQGPGVAPTDAARIFEPFYQ 443 + VL NL SNAV + + G I + V+++ + G + ++ IFEPF+Q Sbjct: 371 TLLMRVLDNLYSNAVHYGEESGTIWICSRQVNDRVQIDVANTGAPIPTSEEIMIFEPFFQ 430 Query: 444 GLHQPSGARRGNGIGLSVVREYVQAHSGKVYLVPREGGA-HFRIELP 489 G HQ GA +G+G+GLS+ ++ ++ G + LV + A FRIELP Sbjct: 431 GSHQRKGAVKGSGLGLSIAQDCIRRMQGDLQLVTVDYAAVCFRIELP 477 >ZyfhK [T] COG0642 Signal transduction histidine kinase EcZ Escherichia coli O157:H7 EDL933 Length = 496 Score = 199 bits (507), Expect = 9e-51, Method: Compositional matrix adjust. Identities = 146/470 (31%), Positives = 237/470 (50%), Gaps = 9/470 (1%) Query: 25 SFRQLLLAAFLLIAALLSGTSIHALFTLDRMSANSRETARQAVQLTESAQRLAERTVAME 84 S RQL++ AFLLI L + A +L+ +S + R + ++ + + ME Sbjct: 31 SLRQLVMLAFLLILLPLLVLAWQAWQSLNALSDQAALVNRTTLIDARRSEAMTNAALEME 90 Query: 85 RSARQYLVLDDRAFHDRFNEAREQARQALGELSDSLPMAPRDLFSQWGVYVDEAAGVLEA 144 RS RQY VLDD + R++ + L + LP D Q + + L Sbjct: 91 RSYRQYCVLDDPTLAKVYQSQRKRYSEMLDAHAGVLP---DDKLYQ---ALRQDLNNLAQ 144 Query: 145 ESRKDKGEQAKLFQDFARLPALNERIALESRREVDRRNNALSAALEQQRQLLTAQVVGAI 204 + G A + N + +R V R L + ++ Q Q + Sbjct: 145 LQCNNSGPDAAAAARLEAFASANTEMVQATRTVVFSRGQQLQREIAERGQYFGWQSLVLF 204 Query: 205 VLAVLLAFCFGLWLSRPMARLEQAIGRLGDNR-FDQPIDVRGPADIRRLGQQLDWLRQRL 263 ++++++ F + P+ +E+ I RLG+ R + GP+++R +GQ++ WL +RL Sbjct: 205 LVSLVMVLLFTRMIIGPVKNIERMINRLGEGRSLGNSVSFSGPSELRSVGQRILWLSERL 264 Query: 264 ADLEAEKSRFLRHVSHELKTPLAALCEGAALLDDGVAGQLTENQREIARILRQNTQSLQT 323 + LE+++ +FLRH+SHELKTPLA++ EG LL D V G LT Q+E+ IL ++++LQ Sbjct: 265 SWLESQRHQFLRHLSHELKTPLASMREGTELLADQVVGPLTPEQKEVVSILDSSSRNLQK 324 Query: 324 QIEDLLRYNEVSFDAQRIHPVPVDLRALLHKVIDDQRLQWLARELKVEIEGVARTVVVDP 383 IE LL YN D+ + V+L L+ V+ L A+ + +++ A + +P Sbjct: 325 LIEQLLDYNRKQADSA-VELDNVELAPLVETVVSAHSLPARAKMMHTDVDLKATACLAEP 383 Query: 384 EKMAIVLANLLSNAVRFSPQGGFIRFLLSEAPGMVRVECLDQGPGVAPTDAARIFEPFYQ 443 + VL NL SNAV + + G I S V ++ ++ G + + A IFEPF+Q Sbjct: 384 MLLMSVLDNLYSNAVHYGAESGNICLRSSLHGARVYIDVINTGTPIPQEERAMIFEPFFQ 443 Query: 444 GLHQPSGARRGNGIGLSVVREYVQAHSGKVYLVPREG-GAHFRIELPDEK 492 G HQ GA +G+G+GLS+ R+ ++ G++YLV G FRIELP K Sbjct: 444 GSHQRKGAVKGSGLGLSIARDCIRRMQGELYLVDESGQDVCFRIELPSSK 493 >ECs3422 [T] COG0642 Signal transduction histidine kinase Ecs Escherichia coli O157:H7 Length = 496 Score = 199 bits (507), Expect = 9e-51, Method: Compositional matrix adjust. Identities = 146/470 (31%), Positives = 237/470 (50%), Gaps = 9/470 (1%) Query: 25 SFRQLLLAAFLLIAALLSGTSIHALFTLDRMSANSRETARQAVQLTESAQRLAERTVAME 84 S RQL++ AFLLI L + A +L+ +S + R + ++ + + ME Sbjct: 31 SLRQLVMLAFLLILLPLLVLAWQAWQSLNALSDQAALVNRTTLIDARRSEAMTNAALEME 90 Query: 85 RSARQYLVLDDRAFHDRFNEAREQARQALGELSDSLPMAPRDLFSQWGVYVDEAAGVLEA 144 RS RQY VLDD + R++ + L + LP D Q + + L Sbjct: 91 RSYRQYCVLDDPTLAKVYQSQRKRYSEMLDAHAGVLP---DDKLYQ---ALRQDLNNLAQ 144 Query: 145 ESRKDKGEQAKLFQDFARLPALNERIALESRREVDRRNNALSAALEQQRQLLTAQVVGAI 204 + G A + N + +R V R L + ++ Q Q + Sbjct: 145 LQCNNSGPDAAAAARLEAFASANTEMVQATRTVVFSRGQQLQREIAERGQYFGWQSLVLF 204 Query: 205 VLAVLLAFCFGLWLSRPMARLEQAIGRLGDNR-FDQPIDVRGPADIRRLGQQLDWLRQRL 263 ++++++ F + P+ +E+ I RLG+ R + GP+++R +GQ++ WL +RL Sbjct: 205 LVSLVMVLLFTRMIIGPVKNIERMINRLGEGRSLGNSVSFSGPSELRSVGQRILWLSERL 264 Query: 264 ADLEAEKSRFLRHVSHELKTPLAALCEGAALLDDGVAGQLTENQREIARILRQNTQSLQT 323 + LE+++ +FLRH+SHELKTPLA++ EG LL D V G LT Q+E+ IL ++++LQ Sbjct: 265 SWLESQRHQFLRHLSHELKTPLASMREGTELLADQVVGPLTPEQKEVVSILDSSSRNLQK 324 Query: 324 QIEDLLRYNEVSFDAQRIHPVPVDLRALLHKVIDDQRLQWLARELKVEIEGVARTVVVDP 383 IE LL YN D+ + V+L L+ V+ L A+ + +++ A + +P Sbjct: 325 LIEQLLDYNRKQADSA-VELDNVELAPLVETVVSAHSLPARAKMMHTDVDLKATACLAEP 383 Query: 384 EKMAIVLANLLSNAVRFSPQGGFIRFLLSEAPGMVRVECLDQGPGVAPTDAARIFEPFYQ 443 + VL NL SNAV + + G I S V ++ ++ G + + A IFEPF+Q Sbjct: 384 MLLMSVLDNLYSNAVHYGAESGNICLRSSLHGARVYIDVINTGTPIPQEERAMIFEPFFQ 443 Query: 444 GLHQPSGARRGNGIGLSVVREYVQAHSGKVYLVPREG-GAHFRIELPDEK 492 G HQ GA +G+G+GLS+ R+ ++ G++YLV G FRIELP K Sbjct: 444 GSHQRKGAVKGSGLGLSIARDCIRRMQGELYLVDESGQDVCFRIELPSSK 493 >yfhK [T] COG0642 Signal transduction histidine kinase Eco Escherichia coli K12 Length = 496 Score = 199 bits (506), Expect = 1e-50, Method: Compositional matrix adjust. Identities = 146/470 (31%), Positives = 237/470 (50%), Gaps = 9/470 (1%) Query: 25 SFRQLLLAAFLLIAALLSGTSIHALFTLDRMSANSRETARQAVQLTESAQRLAERTVAME 84 S RQL++ AFLLI L + A +L+ +S + R + ++ + + ME Sbjct: 31 SLRQLVMLAFLLILLPLLVLAWQAWQSLNALSDQAALVNRTTLIDARRSEAMTNAALEME 90 Query: 85 RSARQYLVLDDRAFHDRFNEAREQARQALGELSDSLPMAPRDLFSQWGVYVDEAAGVLEA 144 RS RQY VLDD + R++ + L + LP D Q + + L Sbjct: 91 RSYRQYCVLDDPTLAKVYQSQRKRYSEMLDAHAGVLP---DDKLYQ---ALRQDLHNLAQ 144 Query: 145 ESRKDKGEQAKLFQDFARLPALNERIALESRREVDRRNNALSAALEQQRQLLTAQVVGAI 204 + G A + N + +R V R L + ++ Q Q + Sbjct: 145 LQCNNSGPDAAAAARLEAFASANTEMVQATRTVVFSRGQQLQREIAERGQYFGWQSLVLF 204 Query: 205 VLAVLLAFCFGLWLSRPMARLEQAIGRLGDNR-FDQPIDVRGPADIRRLGQQLDWLRQRL 263 ++++++ F + P+ +E+ I RLG+ R + GP+++R +GQ++ WL +RL Sbjct: 205 LVSLVMVLLFTRMIIGPVKNIERMINRLGEGRSLGNSVSFSGPSELRSVGQRILWLSERL 264 Query: 264 ADLEAEKSRFLRHVSHELKTPLAALCEGAALLDDGVAGQLTENQREIARILRQNTQSLQT 323 + LE+++ +FLRH+SHELKTPLA++ EG LL D V G LT Q+E+ IL ++++LQ Sbjct: 265 SWLESQRHQFLRHLSHELKTPLASMREGTELLADQVVGPLTPEQKEVVSILDSSSRNLQK 324 Query: 324 QIEDLLRYNEVSFDAQRIHPVPVDLRALLHKVIDDQRLQWLARELKVEIEGVARTVVVDP 383 IE LL YN D+ + V+L L+ V+ L A+ + +++ A + +P Sbjct: 325 LIEQLLDYNRKQADSA-VELENVELAPLVETVVSAHSLPARAKMMHTDVDLKATACLAEP 383 Query: 384 EKMAIVLANLLSNAVRFSPQGGFIRFLLSEAPGMVRVECLDQGPGVAPTDAARIFEPFYQ 443 + VL NL SNAV + + G I S V ++ ++ G + + A IFEPF+Q Sbjct: 384 MLLMSVLDNLYSNAVHYGAESGNICLRSSLHGARVYIDVINTGTPIPQEERAMIFEPFFQ 443 Query: 444 GLHQPSGARRGNGIGLSVVREYVQAHSGKVYLVPREG-GAHFRIELPDEK 492 G HQ GA +G+G+GLS+ R+ ++ G++YLV G FRIELP K Sbjct: 444 GSHQRKGAVKGSGLGLSIARDCIRRMQGELYLVDESGQDVCFRIELPSSK 493 >STM2564 [T] COG0642 Signal transduction histidine kinase Sty Salmonella typhimurium LT2 Length = 480 Score = 193 bits (490), Expect = 8e-49, Method: Compositional matrix adjust. Identities = 145/467 (31%), Positives = 230/467 (49%), Gaps = 9/467 (1%) Query: 25 SFRQLLLAAFLLIAALLSGTSIHALFTLDRMSANSRETARQAVQLTESAQRLAERTVAME 84 S RQL++ AFLLI L + A +L+ +S + T R + ++ + + ME Sbjct: 14 SLRQLVMLAFLLILLPLLVLAWQAWQSLNALSDQAAVTNRSTLIDARRSEAMTNVALEME 73 Query: 85 RSARQYLVLDDRAFHDRFNEAREQARQALGELSDSLPMAPRDLFSQWGVYVDEAAGVLEA 144 RS RQY VLDD + R++ L + LP D Q + + L Sbjct: 74 RSYRQYCVLDDPTLAKVYQSQRKRYSDMLDAHAGVLP---DDKLYQ---ALRQDLNALAQ 127 Query: 145 ESRKDKGEQAKLFQDFARLPALNERIALESRREVDRRNNALSAALEQQRQLLTAQVVGAI 204 KD G +A N + +R V R L + ++ Q Q + Sbjct: 128 LQCKDSGPEAAAAARLEAFANANTEMVQATRTVVYSRGQQLQQEIAERGQFFGWQALVLF 187 Query: 205 VLAVLLAFCFGLWLSRPMARLEQAIGRLGDNR-FDQPIDVRGPADIRRLGQQLDWLRQRL 263 ++++ + F + P+ +E+ I RLG+ R + GP ++R +GQ++ WL +RL Sbjct: 188 LVSLAMVLLFTRMIIGPVKGIERMINRLGEGRSLGNTVTFTGPRELRSVGQRIIWLSERL 247 Query: 264 ADLEAEKSRFLRHVSHELKTPLAALCEGAALLDDGVAGQLTENQREIARILRQNTQSLQT 323 A LE+++ +FLRH+SHELKTPLA++ EG LL D V G LT Q+E+ IL ++++LQ Sbjct: 248 AWLESQRHQFLRHLSHELKTPLASMREGTELLADQVVGPLTPEQKEVVDILDDSSRNLQK 307 Query: 324 QIEDLLRYNEVSFDAQRIHPVPVDLRALLHKVIDDQRLQWLARELKVEIEGVARTVVVDP 383 IE LL YN D+ VD+ L+ V+ L A+ + +++ A + +P Sbjct: 308 LIEQLLDYNRKLVDSA-TELEAVDIAPLVDMVVSAHSLPARAKMMHTDVDLEAERCIAEP 366 Query: 384 EKMAIVLANLLSNAVRFSPQGGFIRFLLSEAPGMVRVECLDQGPGVAPTDAARIFEPFYQ 443 + VL NL SNAV + + G I V ++ ++ G + T+ IFEPF+Q Sbjct: 367 MLLMSVLDNLYSNAVHYGAESGNICIRSRSQGSTVYIDVVNSGEPIPQTEREMIFEPFFQ 426 Query: 444 GLHQPSGARRGNGIGLSVVREYVQAHSGKVYLVPREGG-AHFRIELP 489 G HQ GA +G+G+GLS+ R+ ++ G++ LV FRI LP Sbjct: 427 GSHQRKGAVKGSGLGLSIARDCIRRMQGEIQLVDDNAQEVCFRISLP 473