BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0004.0176.p (356 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value BS_ycbE [GEPR] COG0477 Permeases of the major facilitator superf... 481 e-135 RSp0828 [GEPR] COG0477 Permeases of the major facilitator superf... 469 e-132 ygcZ [GEPR] COG0477 Permeases of the major facilitator superfami... 462 e-130 Z4105 [GEPR] COG0477 Permeases of the major facilitator superfam... 462 e-130 ECs3649 [GEPR] COG0477 Permeases of the major facilitator superf... 462 e-130 >BS_ycbE [GEPR] COG0477 Permeases of the major facilitator superfamily Bsu Bacillus subtilis Length = 455 Score = 481 bits (1237), Expect = e-135, Method: Compositional matrix adjust. Identities = 225/342 (65%), Positives = 274/342 (80%) Query: 1 MSTGAAVIALFLLRFMVGLAEAPSFPANGRIVAAWFPTKERGTASAIFNSAQYFAAVIFT 60 S G A+I LF LRF+VGL+EAPSFP NGR+VA+WFP+ ERGTASA FNSAQYFA VIF Sbjct: 108 FSAGTAIILLFALRFLVGLSEAPSFPGNGRVVASWFPSSERGTASAFFNSAQYFAIVIFP 167 Query: 61 PLMAWIVHTYSWHHVFTVMGVVGILLAMVWGKIIYSPKDHPRINPAELEHIESGGGLVDM 120 PLM W+ H++ WH VF VMG+ GILLA++W K +Y PK HP++N AEL +IE GGGL+ M Sbjct: 168 PLMGWLTHSFGWHSVFVVMGIAGILLAVIWLKTVYEPKKHPKVNEAELAYIEQGGGLISM 227 Query: 121 DNKKVAAPSTKGKGYIRQLLSNRMLLGVYIGQYCINVITYFFLTWFPVYLVQERGMSILK 180 D+ K + YI+QLL+NRML+GVYI QYCI +TYFFLTWFPVYLVQ RGMSIL+ Sbjct: 228 DDSKSKQETESKWPYIKQLLTNRMLIGVYIAQYCITTLTYFFLTWFPVYLVQARGMSILE 287 Query: 181 AGFVASIPAVCGFIGGVVGGLISDRLIKSGMSVTWARKIPIVGGMLLSMTMILCNYVDAQ 240 AGFVAS+PA+CGF GGV+GG++SD L+K G S+T+ARK+PI+ GMLLS +MI+CNY D+ Sbjct: 288 AGFVASLPALCGFAGGVLGGIVSDILLKKGRSLTFARKVPIIAGMLLSCSMIVCNYTDSA 347 Query: 241 WMVVGIMALAFFGKGVGALGWAVVADTAPKQIVGLSGGLFNMFGNVAGITTPIVIGYIVK 300 W+VV IM+LAFFGKG GALGWAVV+DT+PK+ GLSGGLFN FGN+A ITTPI+IGYIV Sbjct: 348 WLVVVIMSLAFFGKGFGALGWAVVSDTSPKECAGLSGGLFNTFGNIASITTPIIIGYIVN 407 Query: 301 ETGSFAGALVFVGINALVTVISYLVIVKEIKRVXPPPPPPPP 342 TGSF GALVFVG NA+ ++SYL++V IKRV P Sbjct: 408 ATGSFNGALVFVGANAIAAILSYLLLVGPIKRVVLKKQEQDP 449 >RSp0828 [GEPR] COG0477 Permeases of the major facilitator superfamily Rso Ralstonia solanacearum Length = 450 Score = 469 bits (1208), Expect = e-132, Method: Compositional matrix adjust. Identities = 233/333 (69%), Positives = 278/333 (83%) Query: 5 AAVIALFLLRFMVGLAEAPSFPANGRIVAAWFPTKERGTASAIFNSAQYFAAVIFTPLMA 64 AA++ +F LRFMVG+AEAPSFPAN RIVAAWFP ERGTASAIFNSAQY A VIF PLMA Sbjct: 117 AAIVLVFFLRFMVGVAEAPSFPANSRIVAAWFPANERGTASAIFNSAQYAATVIFAPLMA 176 Query: 65 WIVHTYSWHHVFTVMGVVGILLAMVWGKIIYSPKDHPRINPAELEHIESGGGLVDMDNKK 124 W+VH + WH+VF VMGV+GI++A+ W + ++ PKDHPRI AE+E+IE+GGGLV+MD Sbjct: 177 WLVHAFGWHYVFIVMGVIGIVMALAWKRFMHDPKDHPRITRAEIEYIEAGGGLVNMDRAG 236 Query: 125 VAAPSTKGKGYIRQLLSNRMLLGVYIGQYCINVITYFFLTWFPVYLVQERGMSILKAGFV 184 VA GYI+QLL NRML+GVYI QYCIN +TYFF+TWFPVYLVQ RGMSILKAGFV Sbjct: 237 VAKTEGPDMGYIKQLLRNRMLMGVYIAQYCINALTYFFITWFPVYLVQARGMSILKAGFV 296 Query: 185 ASIPAVCGFIGGVVGGLISDRLIKSGMSVTWARKIPIVGGMLLSMTMILCNYVDAQWMVV 244 ASIPAVCGF+GG++GGL+SD L++ G S++ ARK+PIV GMLLSM+M++CNYVDAQ +VV Sbjct: 297 ASIPAVCGFLGGILGGLVSDALLRRGASLSVARKVPIVLGMLLSMSMVICNYVDAQGIVV 356 Query: 245 GIMALAFFGKGVGALGWAVVADTAPKQIVGLSGGLFNMFGNVAGITTPIVIGYIVKETGS 304 +MAL+FFGKG+GALGWAV +DTAPKQI GLSG L N FGN++ ITTPI IGYIV TGS Sbjct: 357 ALMALSFFGKGLGALGWAVNSDTAPKQIAGLSGALMNTFGNLSSITTPIAIGYIVNTTGS 416 Query: 305 FAGALVFVGINALVTVISYLVIVKEIKRVXPPP 337 F GALV+VGI+ALV + YLV+V EIKRV P Sbjct: 417 FNGALVYVGIHALVACLCYLVMVGEIKRVELKP 449 >ygcZ [GEPR] COG0477 Permeases of the major facilitator superfamily Eco Escherichia coli K12 Length = 450 Score = 462 bits (1190), Expect = e-130, Method: Compositional matrix adjust. Identities = 220/333 (66%), Positives = 271/333 (81%), Gaps = 2/333 (0%) Query: 7 VIALFLLRFMVGLAEAPSFPANGRIVAAWFPTKERGTASAIFNSAQYFAAVIFTPLMAWI 66 ++ALF LRF+VGLAEAPSFP N RIVAAWFP +ERGTA +IFNSAQYFA VIF P+M W+ Sbjct: 114 IVALFTLRFLVGLAEAPSFPGNSRIVAAWFPAQERGTAVSIFNSAQYFATVIFAPIMGWL 173 Query: 67 VHTYSWHHVFTVMGVVGILLAMVWGKIIYSPKDHPRINPAELEHIESGGGLVDMD--NKK 124 H W HVF MG +GI+++ +W K+I+ P HP +N ELE+I +GG L++MD N K Sbjct: 174 THEVGWSHVFFFMGGLGIVISFIWLKVIHEPNQHPGVNKKELEYIAAGGALINMDQQNTK 233 Query: 125 VAAPSTKGKGYIRQLLSNRMLLGVYIGQYCINVITYFFLTWFPVYLVQERGMSILKAGFV 184 V P + G I+QLL +RM++GVYIGQYCIN +TYFF+TWFPVYLVQ RGMSILKAGFV Sbjct: 234 VKVPFSVKWGQIKQLLGSRMMIGVYIGQYCINALTYFFITWFPVYLVQARGMSILKAGFV 293 Query: 185 ASIPAVCGFIGGVVGGLISDRLIKSGMSVTWARKIPIVGGMLLSMTMILCNYVDAQWMVV 244 AS+PAVCGFIGGV+GG+ISD L++ S+ ARK PIV GMLLSM M+ CNYV+ +WM++ Sbjct: 294 ASVPAVCGFIGGVLGGIISDWLMRRTGSLNIARKTPIVMGMLLSMVMVFCNYVNVEWMII 353 Query: 245 GIMALAFFGKGVGALGWAVVADTAPKQIVGLSGGLFNMFGNVAGITTPIVIGYIVKETGS 304 G MALAFFGKG+GALGWAV+ADTAPK+I GLSGGLFNMFGN++GI TPI IGYIV TGS Sbjct: 354 GFMALAFFGKGIGALGWAVMADTAPKEISGLSGGLFNMFGNISGIVTPIAIGYIVGTTGS 413 Query: 305 FAGALVFVGINALVTVISYLVIVKEIKRVXPPP 337 F GAL++VG++AL+ V+SYLV+V +IKR+ P Sbjct: 414 FNGALIYVGVHALIAVLSYLVLVGDIKRIELKP 446 >Z4105 [GEPR] COG0477 Permeases of the major facilitator superfamily EcZ Escherichia coli O157:H7 EDL933 Length = 450 Score = 462 bits (1188), Expect = e-130, Method: Compositional matrix adjust. Identities = 220/333 (66%), Positives = 270/333 (81%), Gaps = 2/333 (0%) Query: 7 VIALFLLRFMVGLAEAPSFPANGRIVAAWFPTKERGTASAIFNSAQYFAAVIFTPLMAWI 66 ++ALF LRF+VGLAEAPSFP N RIVAAWFP +ERGTA +IFNSAQYFA VIF P+M W+ Sbjct: 114 IVALFTLRFLVGLAEAPSFPGNSRIVAAWFPAQERGTAVSIFNSAQYFATVIFAPIMGWL 173 Query: 67 VHTYSWHHVFTVMGVVGILLAMVWGKIIYSPKDHPRINPAELEHIESGGGLVDMD--NKK 124 H W HVF MG +GI ++ +W K+I+ P HP +N ELE+I +GG L++MD N K Sbjct: 174 THEVGWSHVFFFMGGLGIAISFIWLKVIHEPNQHPGVNQKELEYIAAGGALINMDQQNTK 233 Query: 125 VAAPSTKGKGYIRQLLSNRMLLGVYIGQYCINVITYFFLTWFPVYLVQERGMSILKAGFV 184 V P + G I+QLL +RM++GVYIGQYCIN +TYFF+TWFPVYLVQ RGMSILKAGFV Sbjct: 234 VKVPFSVKWGQIKQLLGSRMMIGVYIGQYCINALTYFFITWFPVYLVQARGMSILKAGFV 293 Query: 185 ASIPAVCGFIGGVVGGLISDRLIKSGMSVTWARKIPIVGGMLLSMTMILCNYVDAQWMVV 244 AS+PAVCGFIGGV+GG+ISD L++ S+ ARK PIV GMLLSM M+ CNYV+ +WM++ Sbjct: 294 ASVPAVCGFIGGVLGGIISDWLMRRTGSLNIARKTPIVMGMLLSMVMVFCNYVNVEWMII 353 Query: 245 GIMALAFFGKGVGALGWAVVADTAPKQIVGLSGGLFNMFGNVAGITTPIVIGYIVKETGS 304 G MALAFFGKG+GALGWAV+ADTAPK+I GLSGGLFNMFGN++GI TPI IGYIV TGS Sbjct: 354 GFMALAFFGKGIGALGWAVMADTAPKEISGLSGGLFNMFGNISGIVTPIAIGYIVGTTGS 413 Query: 305 FAGALVFVGINALVTVISYLVIVKEIKRVXPPP 337 F GAL++VG++AL+ V+SYLV+V +IKR+ P Sbjct: 414 FNGALIYVGVHALIAVLSYLVLVGDIKRIELKP 446 >ECs3649 [GEPR] COG0477 Permeases of the major facilitator superfamily Ecs Escherichia coli O157:H7 Length = 450 Score = 462 bits (1188), Expect = e-130, Method: Compositional matrix adjust. Identities = 220/333 (66%), Positives = 270/333 (81%), Gaps = 2/333 (0%) Query: 7 VIALFLLRFMVGLAEAPSFPANGRIVAAWFPTKERGTASAIFNSAQYFAAVIFTPLMAWI 66 ++ALF LRF+VGLAEAPSFP N RIVAAWFP +ERGTA +IFNSAQYFA VIF P+M W+ Sbjct: 114 IVALFTLRFLVGLAEAPSFPGNSRIVAAWFPAQERGTAVSIFNSAQYFATVIFAPIMGWL 173 Query: 67 VHTYSWHHVFTVMGVVGILLAMVWGKIIYSPKDHPRINPAELEHIESGGGLVDMD--NKK 124 H W HVF MG +GI ++ +W K+I+ P HP +N ELE+I +GG L++MD N K Sbjct: 174 THEVGWSHVFFFMGGLGIAISFIWLKVIHEPNQHPGVNQKELEYIAAGGALINMDQQNTK 233 Query: 125 VAAPSTKGKGYIRQLLSNRMLLGVYIGQYCINVITYFFLTWFPVYLVQERGMSILKAGFV 184 V P + G I+QLL +RM++GVYIGQYCIN +TYFF+TWFPVYLVQ RGMSILKAGFV Sbjct: 234 VKVPFSVKWGQIKQLLGSRMMIGVYIGQYCINALTYFFITWFPVYLVQARGMSILKAGFV 293 Query: 185 ASIPAVCGFIGGVVGGLISDRLIKSGMSVTWARKIPIVGGMLLSMTMILCNYVDAQWMVV 244 AS+PAVCGFIGGV+GG+ISD L++ S+ ARK PIV GMLLSM M+ CNYV+ +WM++ Sbjct: 294 ASVPAVCGFIGGVLGGIISDWLMRRTGSLNIARKTPIVMGMLLSMVMVFCNYVNVEWMII 353 Query: 245 GIMALAFFGKGVGALGWAVVADTAPKQIVGLSGGLFNMFGNVAGITTPIVIGYIVKETGS 304 G MALAFFGKG+GALGWAV+ADTAPK+I GLSGGLFNMFGN++GI TPI IGYIV TGS Sbjct: 354 GFMALAFFGKGIGALGWAVMADTAPKEISGLSGGLFNMFGNISGIVTPIAIGYIVGTTGS 413 Query: 305 FAGALVFVGINALVTVISYLVIVKEIKRVXPPP 337 F GAL++VG++AL+ V+SYLV+V +IKR+ P Sbjct: 414 FNGALIYVGVHALIAVLSYLVLVGDIKRIELKP 446