BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0004.0122.p (565 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value Cj0284c_1 [NT] COG0643 Chemotaxis protein histidine kinase and r... 322 2e-87 HP0392_1 [NT] COG0643 Chemotaxis protein histidine kinase and re... 306 7e-83 CC0594 [NT] COG0643 Chemotaxis protein histidine kinase and rela... 281 2e-75 jhp0989_1 [NT] COG0643 Chemotaxis protein histidine kinase and r... 262 2e-69 VC2063 [NT] COG0643 Chemotaxis protein histidine kinase and rela... 253 8e-67 >Cj0284c_1 [NT] COG0643 Chemotaxis protein histidine kinase and related kinases Cje Campylobacter jejuni Length = 622 Score = 322 bits (825), Expect = 2e-87, Method: Compositional matrix adjust. Identities = 196/620 (31%), Positives = 333/620 (53%), Gaps = 74/620 (11%) Query: 4 EMLKDFVVEALDLATNVEEHLLTLERHPDDLEILNAVFRAFHTIKGGAGFVNLPAMVSAC 63 E+L+DF+VEA +L ++ L+ LE +P+DLE+LN +FR HT+KG + F+N + Sbjct: 6 EILEDFLVEAFELVEQIDHDLVELESNPEDLELLNRIFRVAHTVKGSSSFLNFDVLTKLT 65 Query: 64 HLTENLFDALRTGKAPVTPLAIEAALQ-------------------ASGF----VADQLT 100 H E++ + R G+ +TP ++ L+ A G + +LT Sbjct: 66 HHMEDVLNKARHGELKITPDIMDVVLESIDRMKTLLNSIRDNGNDTAIGMDIEPICARLT 125 Query: 101 ELSNGAAPDSLASMPAELKDILTQAIEGKSESAPAPAPAAAAPPIAAPAADGE------- 153 +S G +P + + + K I +E + P P ++ + E Sbjct: 126 AISEGESP--VVATDSNEKSIPQAELEAPKQEIATPEPEVDVNQLSDSEVEAEIERLLKV 183 Query: 154 -------------------PK-----AAAPAQQNRR---ATDSPGGAKEESIRIDAVKLD 186 PK A P + + A+ S + +++IR++ +LD Sbjct: 184 RKAEDQARRAQKKQTTNAAPKPTNNTANKPTESGEKKVPASGSNASSMDQTIRVEVKRLD 243 Query: 187 ALLEVAGESVQAANQAAVLLEKLQQFKFEGTAAALMSTLAETLGRASRYSSELQRATLST 246 L+ + GE V N+ + + +++ ++EG + L + + + S +++Q A + T Sbjct: 244 HLMNLIGELVLGKNRLLKIYDDVEE-RYEG--EKFLEELNQVVSQLSIIITDVQLAVMKT 300 Query: 247 RMQPVGRLFQKFPRLVRELAKDLGKDVDLVITGAETEVDRVVVDSLYDPLVHMLRNSLDH 306 RMQP+ ++F KFPR+VR+L+++LGK ++L ITG ETE+D+ +V+ + DP++HM+RNS DH Sbjct: 301 RMQPIAKVFNKFPRVVRDLSRELGKQIELEITGEETELDKSIVEEIGDPIMHMIRNSCDH 360 Query: 307 GIE--VDRAAAGKPNKATISLNAWQAGSSVMIEVFDDGKGMDPDMLRNKALAKGLINEHQ 364 G+E RAA GKP K + L A+ G+ +++E+ DDGKG+DP+ L+ KA+ K LI E + Sbjct: 361 GVEDPATRAANGKPEKGIVQLKAYNEGNHIVVEITDDGKGLDPNGLKAKAIEKNLITERE 420 Query: 365 A--LTSDEALQLVFLPGFSTKEVASSVSGRGVGMDVVKTAVEKHRGTIRIESTIGKGTKF 422 A +T EA L+F PGFST ++VSGRGVGMDVVKT +EK G I I+S +GKG+ F Sbjct: 421 ADQMTDKEAFALIFKPGFSTAAKVTNVSGRGVGMDVVKTNIEKLNGVIEIDSELGKGSSF 480 Query: 423 SIRLPIELSIIPTMLVRCAGAPLALPMAVVERVVELP-ETFDEVGGAPVLRDQGRPLPVN 481 +++P+ L+II ++LV A+P+A V V +P + + G VLR + L + Sbjct: 481 KLKIPLTLAIIQSLLVGTQEEFYAIPLASVLETVRVPIDDIYTIEGKNVLRLRDEVLSLV 540 Query: 482 SLAGVLG----YEPGNERVGIVMAVPHPYI-LGVESVEGTADLVIKPLTAI--HTAGITG 534 L+ V G E G++ +V+ V + + V+++ G ++VIK + + GI G Sbjct: 541 RLSDVFGVKQVLESGDQTYVVVIGVAESKLGIIVDTLVGQEEIVIKSMGDYLQNIQGIAG 600 Query: 535 TARSAEGELVLVVGLSFLLD 554 +G + L++ + ++D Sbjct: 601 ATIRGDGRVTLIIDVGAMMD 620 >HP0392_1 [NT] COG0643 Chemotaxis protein histidine kinase and related kinases Hpy Helicobacter pylori 26695 Length = 651 Score = 306 bits (785), Expect = 7e-83, Method: Compositional matrix adjust. Identities = 201/654 (30%), Positives = 336/654 (51%), Gaps = 105/654 (16%) Query: 1 MDD--EMLKDFVVEALDLATNVEEHLLTLERHPDDLEILNAVFRAFHTIKGGAGFVNLPA 58 MDD E+++DF++EA ++ +++ L+ LE +P+DL++LN +FR HTIKG + F+NL Sbjct: 1 MDDLQEIMEDFLIEAFEMNEQLDQDLVELEHNPEDLDLLNRIFRVAHTIKGSSSFLNLNI 60 Query: 59 MVSACHLTENLFDALRTGKAPVTPLAIEAALQASGFVADQLTEL------SNGAAPDSLA 112 + H E++ + R G+ +TP ++ L++ + L + +N + + Sbjct: 61 LTHLTHNMEDVLNRARKGEIKITPDIMDVVLRSIDLMKTLLVTIRDTGSDTNNGKENEIE 120 Query: 113 SMPAELKDILTQAIEG-KSESAPAPA--------------------------------PA 139 +L+ I +Q +E K + AP P Sbjct: 121 EAVKQLQAITSQNLESAKERTTEAPQKENKEETKEEAKEENKENKAKAPTAENTSSDNPL 180 Query: 140 AAAPPI-------------------AAPAADGEPKA-----AAPAQQNRRATDSPGGAKE 175 A P + AD E +A A P Q+ ++P K Sbjct: 181 ADEPDLDYANMSAEEVEAEIERLLNKRQEADKERRAQKKQEAKPKQEVTPTKETPKAPKT 240 Query: 176 ES---------------------IRIDAVKLDALLEVAGESVQAANQAAVLLEKLQQFKF 214 E+ +R+D +LD L+ + GE V N+ + +++ ++ Sbjct: 241 ETKAKAKADTEENKAPSIGVEQTVRVDVRRLDHLMNLIGELVLGKNRLIRIYSDVEE-RY 299 Query: 215 EGTAAALMSTLAETLGRASRYSSELQRATLSTRMQPVGRLFQKFPRLVRELAKDLGKDVD 274 +G + L + + S +++LQ A + TRMQPVG++F KFPR+VR+L+++LGK ++ Sbjct: 300 DG--EKFLEELNQVVSSISAVTTDLQLAVMKTRMQPVGKVFNKFPRMVRDLSRELGKSIE 357 Query: 275 LVITGAETEVDRVVVDSLYDPLVHMLRNSLDHGIE--VDRAAAGKPNKATISLNAWQAGS 332 L+I G ETE+D+ +V+ + DPL+H++RNS DHGIE +R KP + L+A+ G+ Sbjct: 358 LIIEGEETELDKSIVEEIGDPLIHIIRNSCDHGIEPLEERRKLNKPETGKVQLSAYNEGN 417 Query: 333 SVMIEVFDDGKGMDPDMLRNKALAKGLINEHQA--LTSDEALQLVFLPGFSTKEVASSVS 390 ++I++ DDGKG+DP ML+ KA+ KG+I+E A ++ EA L+F PGFST +V S+VS Sbjct: 418 HIVIKISDDGKGLDPVMLKEKAIEKGVISERDAEGMSDREAFNLIFKPGFSTAKVVSNVS 477 Query: 391 GRGVGMDVVKTAVEKHRGTIRIESTIGKGTKFSIRLPIELSIIPTMLVRCAGAPLALPMA 450 GRGVGMDVVKT +EK G I I+S +G GT +++P+ L+II +LV A+P++ Sbjct: 478 GRGVGMDVVKTNIEKLNGIIEIDSEVGVGTTQKLKIPLTLAIIQALLVGVQEEYYAIPLS 537 Query: 451 VVERVVELPETFDE---VGGAPVLRDQGRPLPVNSLAGVLGYE---PGNERVGIVMAVPH 504 V V + + DE V G VLR + L + L+ + + N V +V+ Sbjct: 538 SVLETVRISQ--DEIYTVDGKSVLRLRDEVLSLVRLSDIFKVDAILESNSDVYVVIIGLA 595 Query: 505 PYILG--VESVEGTADLVIKPLTAI--HTAGITGTARSAEGELVLVVGLSFLLD 554 +G V+ + G ++VIK L +T GI G +G++ L+V + ++D Sbjct: 596 DQKIGVIVDYLIGQEEVVIKSLGYYLKNTRGIAGATVRGDGKITLIVDVGAMMD 649 >CC0594 [NT] COG0643 Chemotaxis protein histidine kinase and related kinases Ccr Caulobacter vibrioides Length = 764 Score = 281 bits (720), Expect = 2e-75, Method: Compositional matrix adjust. Identities = 198/611 (32%), Positives = 323/611 (52%), Gaps = 69/611 (11%) Query: 3 DEMLKDFVVEALDLATNVEEHLLTLERHPDDLEILNAVFRAFHTIKGGAGFVNLPAMVSA 62 D+++ DF+VEA + ++ L+ E P+D L+ +FR HT+KG GF+ L + + Sbjct: 2 DDLIADFLVEAHEGLEVIDVELVRFEARPEDRAALDKIFRLVHTLKGACGFLGLGRLEAI 61 Query: 63 CHLTENLFDALRTGKAPVTPLAIEAALQASG---FVADQLTEL----------------- 102 H E L R G+ V+ A+ A L A + D L +L Sbjct: 62 AHAGETLLGRFRDGRLEVSSQAVTAVLSAIDRIKMILDGLGDLGREPEGDDTALIQALEA 121 Query: 103 -SNGAAPDSLASMPAE---------------------LKDILTQAIEGKSESAPAPAPAA 140 S+GAAP + + AE L+++ + + APAP Sbjct: 122 FSDGAAPSEQSPVAAEPEPLAADVAAPERTLRPGEVSLEELEAAFLAAEGPVFDAPAPPV 181 Query: 141 AAPPIAAPAADGEPKAAAPAQQNRRATDSPGGAKEESIRIDAVKLDALLEVAGESVQAAN 200 P A+PAA EP A + ++S G ++IR+ L+ ++ + E V N Sbjct: 182 ETPSAASPAATFEPDQTDSAPEAL-VSESLG---PQTIRVGVDVLEDMMTLVSELVLTRN 237 Query: 201 QAAVLLEKLQQFKFEGTAAALMSTLAETLGRASRYSSELQRATLSTRMQPVGRLFQKFPR 260 Q LQ + G T L R S + ELQ + + TRMQP+G+ ++K PR Sbjct: 238 QL------LQLNRGRGD-----ETFTPPLQRLSSITGELQDSVMKTRMQPIGQAWKKLPR 286 Query: 261 LVRELAKDLGKDVDLVITGAETEVDRVVVDSLYDPLVHMLRNSLDHGIE--VDRAAAGKP 318 LVR+L+ +LGK ++LV+ G TE+DR V++ + DPL HM+RNS DHG+E R AAGKP Sbjct: 287 LVRDLSGELGKPIELVMEGEATELDRQVLEQIRDPLTHMVRNSADHGLEGPEARRAAGKP 346 Query: 319 NKATISLNAWQAGSSVMIEVFDDGKGMDPDMLRNKALAKGLINEHQALTSDEAL--QLVF 376 I L+A+ G +++I + DDG+G+D +R KA+ KG++ +A T EA +L+F Sbjct: 347 EAGLIHLSAYHEGGAIVIRLRDDGRGLDTARIREKAIEKGIVGRAEAETMTEAQVHRLIF 406 Query: 377 LPGFSTKEVASSVSGRGVGMDVVKTAVEKHRGTIRIESTIGKGTKFSIRLPIELSIIPTM 436 PGFST V ++VSGRGVGMDVV++ +E+ G I ++ST+G+G ++++P+ L+I+ + Sbjct: 407 APGFSTAAVVTNVSGRGVGMDVVRSNIEQIGGQIELQSTLGQGCVVTVKIPLTLAIVSAL 466 Query: 437 LVRCAGAPLALPMAVVERVVELP----ETFDEVGGAPVLRDQGRPLPVNSLAGVLGYEPG 492 ++R AG A+P A V+ +V++ F+E+ +LR + + +P+ L+ LG E Sbjct: 467 IIRAAGERFAVPQASVQELVKVSADSDHRFEEIEHVRMLRLREQLIPLIDLSEELGRERR 526 Query: 493 NE-RVGIVMAV-PHPYILGVESVEGTADLVIKPLTAI--HTAGITGTARSAEGELVLVVG 548 +E + ++M V H + + VE V T ++V+KPL ++ +G +G +VL++ Sbjct: 527 HEAKFVLIMRVGAHRFGVLVEEVIDTEEIVVKPLASVLRTIPVFSGATLLGDGSVVLIID 586 Query: 549 LSFLLDGCRDL 559 + L D D+ Sbjct: 587 PNGLSDRAGDM 597 >jhp0989_1 [NT] COG0643 Chemotaxis protein histidine kinase and related kinases jHp Helicobacter pylori J99 Length = 663 Score = 262 bits (670), Expect = 2e-69, Method: Compositional matrix adjust. Identities = 162/476 (34%), Positives = 266/476 (55%), Gaps = 37/476 (7%) Query: 110 SLASMPAELKDILTQAIEGKSESAPAPAPAAAAPPI--AAPAADGEPKAAAPAQQNRRA- 166 S + AE++ +L + E E A P APA + PK P + R+ Sbjct: 192 SAEEVEAEIERLLNKRQEADKERRAQKKQEDQAKPKQEVAPAKET-PKTETPKTETRKVP 250 Query: 167 --------------TDSPGGAKEESIRIDAVKLDALLEVAGESVQAANQAAVLLEKLQQF 212 +P E+++R+D +LD L+ + GE V N+ + +++ Sbjct: 251 KAETKAKAKADTEENKAPSIGVEQTVRVDVRRLDHLMNLIGELVLGKNRLIRIYSDVEE- 309 Query: 213 KFEGTAAALMSTLAETLGRASRYSSELQRATLSTRMQPVGRLFQKFPRLVRELAKDLGKD 272 +++G + L + + S +++LQ A + TRMQPVG++F KFPR+VR+L+++LGK Sbjct: 310 RYDG--EKFLEELNQVVSSISAVTTDLQLAVMKTRMQPVGKVFNKFPRMVRDLSRELGKS 367 Query: 273 VDLVITGAETEVDRVVVDSLYDPLVHMLRNSLDHGIE--VDRAAAGKPNKATISLNAWQA 330 ++L+I G ETE+D+ +V+ + DPL+H++RNS DHGIE +R KP + L+A+ Sbjct: 368 IELIIEGEETELDKSIVEEIGDPLIHIIRNSCDHGIEPLEERRRLNKPETGKVQLSAYNE 427 Query: 331 GSSVMIEVFDDGKGMDPDMLRNKALAKGLINEHQA--LTSDEALQLVFLPGFSTKEVASS 388 G+ ++I++ DDGKG+DP ML+ KA+ KG+I+E A ++ EA L+F PGFST++V S+ Sbjct: 428 GNHIVIKISDDGKGLDPVMLKEKAIEKGVISERDAESMSDREAFNLIFKPGFSTRKVVSN 487 Query: 389 VSGRGVGMDVVKTAVEKHRGTIRIESTIGKGTKFSIRLPIELSIIPTMLVRCAGAPLALP 448 VSGRGVGMDVVKT +EK G I I+S +G GT +++P+ L+II +LV A+P Sbjct: 488 VSGRGVGMDVVKTNIEKLNGIIEIDSEVGVGTTQKLKIPLTLAIIQALLVGVQEEYYAIP 547 Query: 449 MAVVERVVELPETFDE---VGGAPVLRDQGRPLPVNSLAGVLGYE---PGNERVGIVMAV 502 ++ V V + + DE V G VLR + L + L+ + + N V +V+ Sbjct: 548 LSSVLETVRISQ--DEIYTVDGKSVLRLRDEVLSLVRLSDIFKVDAILESNSDVYVVIIG 605 Query: 503 PHPYILG--VESVEGTADLVIKPLTAI--HTAGITGTARSAEGELVLVVGLSFLLD 554 +G V+ + G ++VIK L +T GI G +G++ L+V + +++ Sbjct: 606 LADQKIGVIVDYLIGQEEVVIKSLGYYLKNTRGIAGATVRGDGKITLIVDVGAMME 661 Score = 84.7 bits (208), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 41/141 (29%), Positives = 81/141 (57%), Gaps = 8/141 (5%) Query: 1 MDD--EMLKDFVVEALDLATNVEEHLLTLERHPDDLEILNAVFRAFHTIKGGAGFVNLPA 58 MDD E+++DF++EA ++ +++ L+ LE +P+DL++LN +FR HTIKG + F+NL Sbjct: 1 MDDLQEIMEDFLIEAFEMNEQLDQDLVELEHNPEDLDLLNRIFRVAHTIKGSSSFLNLNI 60 Query: 59 MVSACHLTENLFDALRTGKAPVTPLAIEAALQASGFVADQLTEL------SNGAAPDSLA 112 + H E++ + R G+ +TP ++ L++ + L + +N + + Sbjct: 61 LTHLTHNMEDVLNRARKGEIKITPDIMDVVLRSIDLMKTLLVTIRDTGSDTNNGKENEIE 120 Query: 113 SMPAELKDILTQAIEGKSESA 133 + +L+ I +Q +EG E++ Sbjct: 121 EVVKKLQAITSQNLEGAKETS 141 >VC2063 [NT] COG0643 Chemotaxis protein histidine kinase and related kinases Vch Vibrio cholerae Length = 785 Score = 253 bits (646), Expect = 8e-67, Method: Compositional matrix adjust. Identities = 150/393 (38%), Positives = 239/393 (60%), Gaps = 25/393 (6%) Query: 175 EESIRIDAVKLDALLEVAGESVQAANQAAVLLEKLQQFKFEGTAAALMSTLAETLGRASR 234 E ++R+D LD ++ + GE V N+ L L E +++ + Sbjct: 395 ESTVRVDTSTLDTIMNMVGELVLVRNRLLSL--GLNSNDEE---------MSKAVANLDV 443 Query: 235 YSSELQRATLSTRMQPVGRLFQKFPRLVRELAKDLGKDVDLVITGAETEVDRVVVDSLYD 294 +++LQ A + TRMQP+ ++F +FPR+VR+LA+ L K++DL + G ET++D+ +V++L D Sbjct: 444 VTADLQGAVMKTRMQPIKKVFGRFPRVVRDLARSLNKEIDLELRGEETDLDKNLVEALAD 503 Query: 295 PLVHMLRNSLDHGIEV--DRAAAGKPNKATISLNAWQAGSSVMIEVFDDGKGMDPDMLRN 352 PL+H++RNS+DHGIE+ +RA GK + L+A Q G + + + DDG GMDPD LR Sbjct: 504 PLIHLVRNSVDHGIEMPDERAKNGKSRTGKVILSASQEGDHIQLAIVDDGAGMDPDKLRG 563 Query: 353 KALAKGLINEHQA--LTSDEALQLVFLPGFSTKEVASSVSGRGVGMDVVKTAVEKHRGTI 410 A+ +G+++E A LT+ E L+F+PGFS+KE + +SGRGVGMDVVKTA+ G+I Sbjct: 564 IAVKRGIMDEDAANRLTNKECFNLIFMPGFSSKEKITDISGRGVGMDVVKTAINTLNGSI 623 Query: 411 RIESTIGKGTKFSIRLPIELSIIPTMLVRCAGAPLALPMAVVERVVELP-ETFDEVGG-- 467 I+ST+GKGTK +I++P+ L+I+PT++V AG P ALP+A V + L + V G Sbjct: 624 DIDSTMGKGTKITIKVPLTLAILPTLMVGVAGHPFALPLASVNEIFHLDLRRTNVVDGQL 683 Query: 468 APVLRDQGRPLPV--NSLA---GVLGYEPGNERVGIVMAVPHPYILGVESVEGTADLVIK 522 ++R++ PL N LA G + G+ V IV L V+++ G ++VIK Sbjct: 684 TIIVREKSIPLFYLQNWLAPKKGKVQLRQGHGHVVIVQIGSQRVGLVVDTLIGQEEVVIK 743 Query: 523 PLTAI--HTAGITGTARSAEGELVLVVGLSFLL 553 PL + T G++G +++G + L++ + LL Sbjct: 744 PLDKLLQGTPGMSGATITSDGHIALILDVPDLL 776 Score = 99.0 bits (245), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 44/99 (44%), Positives = 69/99 (69%) Query: 1 MDDEMLKDFVVEALDLATNVEEHLLTLERHPDDLEILNAVFRAFHTIKGGAGFVNLPAMV 60 +D+++L+DF+VEA ++ + E L+ LE +P+D ++LNA+FR FHT+KGGAGF+ L +V Sbjct: 5 LDEDILQDFLVEAGEILELLSEQLVELENNPEDRDLLNAIFRGFHTVKGGAGFLALSELV 64 Query: 61 SACHLTENLFDALRTGKAPVTPLAIEAALQASGFVADQL 99 CH EN+FD LR G+ V+P ++ L+A V +Q Sbjct: 65 ETCHGAENVFDILRNGQRHVSPSLMDTMLKALDTVNEQF 103