BLASTP 2.2.21 [Jun-14-2009]

Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Reference for compositional score matrix adjustment: Altschul, Stephen F., 
John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis,
Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches
using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109.

Query= 0004.0088.p         (143 letters)

Database: COGmodified 
           192,987 sequences; 59,019,183 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

PA3569 [I] COG2084 3-hydroxyisobutyrate dehydrogenase and relate...   171   3e-43
RSp0649 [I] COG2084 3-hydroxyisobutyrate dehydrogenase and relat...   157   5e-39
PA0743 [I] COG2084 3-hydroxyisobutyrate dehydrogenase and relate...   147   5e-36
AGl1448 [I] COG2084 3-hydroxyisobutyrate dehydrogenase and relat...   123   1e-28
CC1354 Non COG                                                        120   9e-28

>PA3569 [I] COG2084 3-hydroxyisobutyrate dehydrogenase and related
           beta-hydroxyacid dehydrogenases Pae Pseudomonas
           aeruginosa
          Length = 298

 Score =  171 bits (434), Expect = 3e-43,   Method: Compositional matrix adjust.
 Identities = 84/137 (61%), Positives = 102/137 (74%), Gaps = 2/137 (1%)

Query: 1   MGKAIYHAGESGSGQTVKVCNNMLLGTLMIGTSEAIRLGMANGMDPKVLSEIMSKSSGRN 60
           MG+ I+HAG+ G+GQ  K+CNNMLLG LM GT+EA+ LG+ NG+DP VLSE+M +SSG N
Sbjct: 154 MGRNIFHAGDHGAGQVAKICNNMLLGILMAGTAEALALGVKNGLDPAVLSEVMKQSSGGN 213

Query: 61  WTLEVYNPCPGVMETAPASKGYAGGFGVDLMLKDLGLAVENALATNCAIPLGSTARNLYD 120
           W L +YNP PGVM  APAS GYAGGF V LM KDLGLA+ NA A   + PLG+ ARNL+ 
Sbjct: 214 WALNLYNPWPGVMPQAPASNGYAGGFQVRLMNKDLGLALANAQAVQASTPLGALARNLFS 273

Query: 121 IHSMNGAGK--LDFSSI 135
           +H+   A    LDFSSI
Sbjct: 274 LHAQADAEHEGLDFSSI 290


>RSp0649 [I] COG2084 3-hydroxyisobutyrate dehydrogenase and related
           beta-hydroxyacid dehydrogenases Rso Ralstonia
           solanacearum
          Length = 298

 Score =  157 bits (398), Expect = 5e-39,   Method: Compositional matrix adjust.
 Identities = 75/138 (54%), Positives = 100/138 (72%)

Query: 1   MGKAIYHAGESGSGQTVKVCNNMLLGTLMIGTSEAIRLGMANGMDPKVLSEIMSKSSGRN 60
           MGK + H GE+G+GQ  K+CNN++LG  M G +EA+ LG A G+DPKVL  I++ S+GR 
Sbjct: 153 MGKNLVHCGEAGAGQGAKICNNLVLGITMAGVAEAMSLGEALGIDPKVLGGIINTSTGRC 212

Query: 61  WTLEVYNPCPGVMETAPASKGYAGGFGVDLMLKDLGLAVENALATNCAIPLGSTARNLYD 120
           W+ + YNP PGV+ETAP+S+GY GGFG DLMLKDLGLA + A +    + LG+ A+ LY 
Sbjct: 213 WSSDTYNPFPGVIETAPSSRGYTGGFGTDLMLKDLGLAGDAAKSVRQPVYLGALAQQLYQ 272

Query: 121 IHSMNGAGKLDFSSIFNM 138
             S  GAGKLDFS++  +
Sbjct: 273 ASSSQGAGKLDFSAVIRL 290


>PA0743 [I] COG2084 3-hydroxyisobutyrate dehydrogenase and related
           beta-hydroxyacid dehydrogenases Pae Pseudomonas
           aeruginosa
          Length = 298

 Score =  147 bits (372), Expect = 5e-36,   Method: Compositional matrix adjust.
 Identities = 80/143 (55%), Positives = 100/143 (69%)

Query: 1   MGKAIYHAGESGSGQTVKVCNNMLLGTLMIGTSEAIRLGMANGMDPKVLSEIMSKSSGRN 60
           MG+ I+HAG  G+GQ  KVCNN LL  LMIGT+EA+ LG+ANG++ KVL+EIM +SSG N
Sbjct: 154 MGRNIFHAGPDGAGQVAKVCNNQLLAVLMIGTAEAMALGVANGLEAKVLAEIMRRSSGGN 213

Query: 61  WTLEVYNPCPGVMETAPASKGYAGGFGVDLMLKDLGLAVENALATNCAIPLGSTARNLYD 120
           W LEVYNP PGVME APAS+ Y+GGF   LM KDLGLA E A A+  + P+GS A +LY 
Sbjct: 214 WALEVYNPWPGVMENAPASRDYSGGFMAQLMAKDLGLAQEAAQASASSTPMGSLALSLYR 273

Query: 121 IHSMNGAGKLDFSSIFNMLGKAQ 143
           +    G  + DFS +  +    Q
Sbjct: 274 LLLKQGYAERDFSVVQKLFDPTQ 296


>AGl1448 [I] COG2084 3-hydroxyisobutyrate dehydrogenase and related
           beta-hydroxyacid dehydrogenases Atu Agrobacterium
           tumefaciens strain C58 (Cereon)
          Length = 304

 Score =  123 bits (308), Expect = 1e-28,   Method: Compositional matrix adjust.
 Identities = 65/139 (46%), Positives = 83/139 (59%)

Query: 1   MGKAIYHAGESGSGQTVKVCNNMLLGTLMIGTSEAIRLGMANGMDPKVLSEIMSKSSGRN 60
           MGK I H G+ G+GQ  K+CNNM+LG  MI  SEA  LG   G+  + L ++ S SSG+ 
Sbjct: 161 MGKKIVHCGKGGNGQAAKICNNMILGISMIAVSEAFVLGEKLGLSHQALFDVASTSSGQC 220

Query: 61  WTLEVYNPCPGVMETAPASKGYAGGFGVDLMLKDLGLAVENALATNCAIPLGSTARNLYD 120
           W+L  Y P PG + T+PA+K Y  GF   LMLKDL L+   A  T  + PLG+ A  LY+
Sbjct: 221 WSLTTYCPVPGPVPTSPANKDYQPGFAAALMLKDLKLSQAAANGTGVSTPLGAAASALYE 280

Query: 121 IHSMNGAGKLDFSSIFNML 139
                G G  DFS+I  ML
Sbjct: 281 SFVGEGGGGRDFSAIVEML 299


>CC1354 Non COG
          Length = 298

 Score =  120 bits (301), Expect = 9e-28,   Method: Compositional matrix adjust.
 Identities = 63/139 (45%), Positives = 81/139 (58%)

Query: 1   MGKAIYHAGESGSGQTVKVCNNMLLGTLMIGTSEAIRLGMANGMDPKVLSEIMSKSSGRN 60
           M +   HAG+ G+GQ  K+CNNMLLG  M+GT EA  L    G+      EI SKSSG+ 
Sbjct: 152 MSRVTIHAGDHGAGQAAKICNNMLLGVSMLGTCEAFALAEKLGLAADRFFEIASKSSGQC 211

Query: 61  WTLEVYNPCPGVMETAPASKGYAGGFGVDLMLKDLGLAVENALATNCAIPLGSTARNLYD 120
           W++  Y P PGV    PA +GY GGF   +MLKDL LA E A     + P+G+ A  LY 
Sbjct: 212 WSITSYCPVPGVGPQTPADRGYEGGFASAMMLKDLKLAQEAAAKAGASTPMGAQAEALYA 271

Query: 121 IHSMNGAGKLDFSSIFNML 139
           +   NG G  DFS++  +L
Sbjct: 272 LFDANGFGGKDFSAVIELL 290