BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0004.0064.p (699 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value STM2691 [V] COG2274 ABC-type bacteriocin/lantibiotic exporters, ... 359 1e-98 Z0634 [V] COG2274 ABC-type bacteriocin/lantibiotic exporters, co... 340 6e-93 ECs0543 [V] COG2274 ABC-type bacteriocin/lantibiotic exporters, ... 340 6e-93 RSp1182 [V] COG2274 ABC-type bacteriocin/lantibiotic exporters, ... 331 5e-90 VCA1084 [V] COG2274 ABC-type bacteriocin/lantibiotic exporters, ... 326 1e-88 >STM2691 [V] COG2274 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain Sty Salmonella typhimurium LT2 Length = 726 Score = 359 bits (922), Expect = 1e-98, Method: Compositional matrix adjust. Identities = 222/554 (40%), Positives = 329/554 (59%), Gaps = 15/554 (2%) Query: 137 LGEYRPIILEVVIASVVMSVIALGASVFSMQVYDRVIPTHGVATLIVLAIGVSLAIVFEL 196 L + RP L V++A+ +++V++L VFSMQVYDRVIP TL VL+ GV +A++F Sbjct: 162 LQDIRPY-LPVMVAAFLINVLSLAGIVFSMQVYDRVIPAQSYPTLYVLSFGVLVAVLFGF 220 Query: 197 GMKFARSHIMDSVVSGLDAKLSQALFERLLSVRVDQLPGSVGSLAGQLRGYEQIRSFYTS 256 ++ AR+HIMD + D ++S +F L +R +P S GS QLR EQIR TS Sbjct: 221 LLREARTHIMDVLGKRADMRISDRVFGHALRLRNSAIPRSTGSFISQLRELEQIREMITS 280 Query: 257 QTLFTLVDLPLGLLFVLVIAFIASPWMALVPTVFGLAAIGIGYLSNRKVVRLADKSAAAS 316 TL T+VDLP LF++V+A IA P +A + V L I G +K+ LA+++A + Sbjct: 281 STLATIVDLPFFFLFMIVLAIIAPP-LAWIAPVAALLMILPGVALQKKLAVLANQAAHEA 339 Query: 317 NLKTGLLVETVEGVETIKSGSGGWKFLSRW---IDVSAESIRSDMAMRAIGDHAGYIA-- 371 L+ +LVE+V+G+E IK +FL +W I ++ ES +R G I+ Sbjct: 340 TLRNAVLVESVQGLEDIKLMQAENRFLQQWNSYIRITGES-----GLRTRKLTQGLISWG 394 Query: 372 AMLQQLSYSTTVIVGSFLVINGQITMGALIACSILGGRILAPVAMIPGLMVQRAHTKATL 431 +Q L Y+ ++ G+ +VI G +T GA++A S+LG R++AP+A + G++ + KA Sbjct: 395 MSVQSLVYAAVIMFGAPMVIEGSMTTGAVVAASMLGSRMIAPMANLCGVLARWQQVKAAK 454 Query: 432 AGLEKIYALQTD-QGNERQLTPDTLRGEFRVEEVKFTYAGSMLN-AMSIDQLGIRAGERV 489 GL+ I L T+ Q ++ + D L G + E +F Y + + +L I GER+ Sbjct: 455 MGLDNIMQLPTETQHDDSLIHRDILHGHYLFENAQFRYHNDDQRIPLRLVRLEIMPGERI 514 Query: 490 AILGPIGAGKSTILRLLSGLYRPQQGRILIDGLDMANINRLTLNQHIGYLQQDHRLFVGT 549 AILG GAGKST+L+ ++G QG +D L +++I+ L ++IG+L Q+ RLF GT Sbjct: 515 AILGRNGAGKSTLLQAMAGGLEMIQGDARLDNLSLSHIDMADLRRNIGFLSQNARLFFGT 574 Query: 550 LRENLLIGLPDPGDEVLRQVMERTGLLRLVSAHPKGLDLPIQEGGRGLSGGQRQLVAFTR 609 LRENL +G P DE + +E +G V KGLD PI EGG GLSGGQRQ + R Sbjct: 575 LRENLTLGAPHANDEQIFDALEVSGGAVFVRRLAKGLDHPIMEGGNGLSGGQRQSLLLAR 634 Query: 610 LLLCRPDIFLLDEPTASMDEDLERHCLGVLNEEISGGRTLVVVTHKPAFLPMVERVIVVV 669 +LL P+I LLDEP+AS+DE ER + L++ + G RTLVV TH+ L +VERV+V+ Sbjct: 635 MLLRSPNIVLLDEPSASLDEHTEREFIQRLHQWL-GNRTLVVATHRVPILELVERVVVLK 693 Query: 670 GNRIVLDGPRDAVL 683 ++V+D P+ L Sbjct: 694 EGQLVMDAPKAQAL 707 >Z0634 [V] COG2274 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain EcZ Escherichia coli O157:H7 EDL933 Length = 720 Score = 340 bits (872), Expect = 6e-93, Method: Compositional matrix adjust. Identities = 198/540 (36%), Positives = 312/540 (57%), Gaps = 4/540 (0%) Query: 146 EVVIASVVMSVIALGASVFSMQVYDRVIPTHGVATLIVLAIGVSLAIVFELGMKFARSHI 205 ++++AS+V +V+AL A +FSMQVYDRV+P TL VL GV +AI+FE M+ R+H+ Sbjct: 161 DIMLASLVANVLALAAMIFSMQVYDRVVPAQSYPTLWVLFAGVMMAILFEFCMRMVRTHL 220 Query: 206 MDSVVSGLDAKLSQALFERLLSVRVDQLPGSVGSLAGQLRGYEQIRSFYTSQTLFTLVDL 265 D + D ++S +F L ++ + S GS Q+R E +R TS T+ + DL Sbjct: 221 SDVIGKRADLRISDRVFGHALRLKNNVRSKSTGSFISQIRELESVRELITSTTIGAVADL 280 Query: 266 PLGLLFVLVIAFIASPWMALVPTVFGLAAIGIGYLSNRKVVRLADKSAAASNLKTGLLVE 325 P LLFV ++ I W+ LV + + G L R + RLA++ S ++ LVE Sbjct: 281 PFFLLFVFILWMIGG-WLVLVVLLALPLLVIPGLLVQRPLARLANEGMRESAVRNATLVE 339 Query: 326 TVEGVETIKSGSGGWKFLSRWIDVSAESIRSDMAMRAIGDHAGYIAAMLQQLSYSTTVIV 385 V+ +E IK +F ++W + + M R + +Q + Y ++V Sbjct: 340 AVQSIEDIKLLRAEQRFQNQWNHTNDVASSISMKQRFLTGLLLTWTQEVQSIVYVVVLLV 399 Query: 386 GSFLVINGQITMGALIACSILGGRILAPVAMIPGLMVQRAHTKATLAGLEKIYALQTDQG 445 G F+V+NG +T GAL+ +IL R +AP++ I G++ + K GL+++ DQ Sbjct: 400 GCFMVMNGDMTTGALVGTTILASRTIAPLSQISGVLSRWQQAKVARNGLDELMKRPVDQP 459 Query: 446 NERQLTPDT-LRGEFRVEEVKFTY-AGSMLNAMSIDQLGIRAGERVAILGPIGAGKSTIL 503 +L L G ++ F Y + ++I +L I+AGE++AILG GAGKST+L Sbjct: 460 EHGKLVHKAVLHGNYQFSNAVFYYDEEEKIADVAIGKLNIQAGEKIAILGRNGAGKSTLL 519 Query: 504 RLLSGLYRPQQGRILIDGLDMANINRLTLNQHIGYLQQDHRLFVGTLRENLLIGLPDPGD 563 ++L+G+ QQG++L+D + + ++ L + +G L Q RLF G+LRENL +G+P+ D Sbjct: 520 QMLAGMRIAQQGQVLLDNISIGQLDPADLRRDMGLLSQTGRLFFGSLRENLTMGMPEASD 579 Query: 564 EVLRQVMERTGLLRLVSAHPKGLDLPIQEGGRGLSGGQRQLVAFTRLLLCRPDIFLLDEP 623 E + + + +G L V GL+ IQEGG GLSGGQRQ + RLL+ +P+I LLDEP Sbjct: 580 EDIERALTLSGALPFVQKQKNGLNYMIQEGGFGLSGGQRQTLLLARLLISQPNIVLLDEP 639 Query: 624 TASMDEDLERHCLGVLNEEISGGRTLVVVTHKPAFLPMVERVIVVVGNRIVLDGPRDAVL 683 +AS+DE E + + L + I G RTL++ TH+ A L +V+R+IV+ RIV+DG ++A+L Sbjct: 640 SASLDEMAEAYLIEQLKQWI-GHRTLIIATHRTAMLQLVDRIIVMDQGRIVMDGAKEAIL 698 >ECs0543 [V] COG2274 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain Ecs Escherichia coli O157:H7 Length = 706 Score = 340 bits (872), Expect = 6e-93, Method: Compositional matrix adjust. Identities = 198/540 (36%), Positives = 312/540 (57%), Gaps = 4/540 (0%) Query: 146 EVVIASVVMSVIALGASVFSMQVYDRVIPTHGVATLIVLAIGVSLAIVFELGMKFARSHI 205 ++++AS+V +V+AL A +FSMQVYDRV+P TL VL GV +AI+FE M+ R+H+ Sbjct: 147 DIMLASLVANVLALAAMIFSMQVYDRVVPAQSYPTLWVLFAGVMMAILFEFCMRMVRTHL 206 Query: 206 MDSVVSGLDAKLSQALFERLLSVRVDQLPGSVGSLAGQLRGYEQIRSFYTSQTLFTLVDL 265 D + D ++S +F L ++ + S GS Q+R E +R TS T+ + DL Sbjct: 207 SDVIGKRADLRISDRVFGHALRLKNNVRSKSTGSFISQIRELESVRELITSTTIGAVADL 266 Query: 266 PLGLLFVLVIAFIASPWMALVPTVFGLAAIGIGYLSNRKVVRLADKSAAASNLKTGLLVE 325 P LLFV ++ I W+ LV + + G L R + RLA++ S ++ LVE Sbjct: 267 PFFLLFVFILWMIGG-WLVLVVLLALPLLVIPGLLVQRPLARLANEGMRESAVRNATLVE 325 Query: 326 TVEGVETIKSGSGGWKFLSRWIDVSAESIRSDMAMRAIGDHAGYIAAMLQQLSYSTTVIV 385 V+ +E IK +F ++W + + M R + +Q + Y ++V Sbjct: 326 AVQSIEDIKLLRAEQRFQNQWNHTNDVASSISMKQRFLTGLLLTWTQEVQSIVYVVVLLV 385 Query: 386 GSFLVINGQITMGALIACSILGGRILAPVAMIPGLMVQRAHTKATLAGLEKIYALQTDQG 445 G F+V+NG +T GAL+ +IL R +AP++ I G++ + K GL+++ DQ Sbjct: 386 GCFMVMNGDMTTGALVGTTILASRTIAPLSQISGVLSRWQQAKVARNGLDELMKRPVDQP 445 Query: 446 NERQLTPD-TLRGEFRVEEVKFTY-AGSMLNAMSIDQLGIRAGERVAILGPIGAGKSTIL 503 +L L G ++ F Y + ++I +L I+AGE++AILG GAGKST+L Sbjct: 446 EHGKLVHKAVLHGNYQFSNAVFYYDEEEKIADVAIGKLNIQAGEKIAILGRNGAGKSTLL 505 Query: 504 RLLSGLYRPQQGRILIDGLDMANINRLTLNQHIGYLQQDHRLFVGTLRENLLIGLPDPGD 563 ++L+G+ QQG++L+D + + ++ L + +G L Q RLF G+LRENL +G+P+ D Sbjct: 506 QMLAGMRIAQQGQVLLDNISIGQLDPADLRRDMGLLSQTGRLFFGSLRENLTMGMPEASD 565 Query: 564 EVLRQVMERTGLLRLVSAHPKGLDLPIQEGGRGLSGGQRQLVAFTRLLLCRPDIFLLDEP 623 E + + + +G L V GL+ IQEGG GLSGGQRQ + RLL+ +P+I LLDEP Sbjct: 566 EDIERALTLSGALPFVQKQKNGLNYMIQEGGFGLSGGQRQTLLLARLLISQPNIVLLDEP 625 Query: 624 TASMDEDLERHCLGVLNEEISGGRTLVVVTHKPAFLPMVERVIVVVGNRIVLDGPRDAVL 683 +AS+DE E + + L + I G RTL++ TH+ A L +V+R+IV+ RIV+DG ++A+L Sbjct: 626 SASLDEMAEAYLIEQLKQWI-GHRTLIIATHRTAMLQLVDRIIVMDQGRIVMDGAKEAIL 684 >RSp1182 [V] COG2274 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain Rso Ralstonia solanacearum Length = 739 Score = 331 bits (848), Expect = 5e-90, Method: Compositional matrix adjust. Identities = 206/558 (36%), Positives = 319/558 (57%), Gaps = 11/558 (1%) Query: 140 YRPIILEVVIASVVMSVIALGASVFSMQVYDRVIPTHGVATLIVLAIGVSLAIVFELGMK 199 + P++LE+ S+ +++A+G S+F+MQV+DRV+P TL VLA GV+LA++ EL ++ Sbjct: 171 HWPLLLELGAGSLFGNLLAVGTSLFAMQVWDRVVPARSTHTLWVLASGVALALLLELLLR 230 Query: 200 FARSHIMDSVVSGLDAKLSQALFERLLSVRVDQLPGSVGSLAGQLRGYEQIRSFYTSQTL 259 AR I D D KLS F R+L +R D P S G+L QLR EQ+R TS TL Sbjct: 231 TARVAIADHFGKAADLKLSAMFFARVLDIRNDARPRSPGTLIAQLRDLEQLRELLTSSTL 290 Query: 260 FTLVDLPLGLLFVLVIAFIASPWMALVPTVFGLAAIGI----GYLSNRKVVRLADKSAAA 315 L+DLP F+ +I + P +A VP LAAI + G L+ + +L++ A Sbjct: 291 GVLIDLPFVAAFLCIIWLLGGP-LAFVP----LAAIPLLIMPGVLAQIPLAKLSNAGLAE 345 Query: 316 SNLKTGLLVETVEGVETIKSGSGGWKFLSRWIDVSAESIRSDMAMRAIGDHAGYIAAMLQ 375 + ++ +L+E++ VE IK+ +F W + + + R +G +A+ +Q Sbjct: 346 AAVRNAILMESIYRVEDIKTLQAEPRFRHLWNHTNRVNADIGLKQRHLGGLLVNLASTVQ 405 Query: 376 QLSYSTTVIVGSFLVINGQITMGALIACSILGGRILAPVAMIPGLMVQRAHTKATLAGLE 435 Q +Y ++ G + +++ ++ GA++ACSIL R +AP+ IP ++ + + + GL+ Sbjct: 406 QFAYVGVLVTGVYGMLDASLSFGAVLACSILTSRTIAPLGQIPAVLARVQNVRVGKKGLD 465 Query: 436 KIYALQTDQGNERQ-LTPDTLRGEFRVEEVKFTYAGSMLNAMSIDQLGIRAGERVAILGP 494 + +L D + L G +R + V + + +++ +L I AGERVAILG Sbjct: 466 SLLSLPVDHDPAKDAYHKPALIGRYRFDNVAYGFDPEEKPVLTLPRLSIEAGERVAILGR 525 Query: 495 IGAGKSTILRLLSGLYRPQQGRILIDGLDMANINRLTLNQHIGYLQQDHRLFVGTLRENL 554 +GAGKST+LRLL GL P QGRIL++ + I+ + + +G + Q+ LF GTLREN+ Sbjct: 526 VGAGKSTLLRLLGGLATPVQGRILLNDTPLPLIDVADVRRDVGMVLQESSLFFGTLRENM 585 Query: 555 LIGLPDPGDEVLRQVMERTGLLRLVSAHPKGLDLPIQEGGRGLSGGQRQLVAFTRLLLCR 614 I P DE + M + +L+ P GLDL ++E G GLSGGQ+Q + R L Sbjct: 586 RIASPLASDEAILAAMRLSCADQLLLNQPHGLDLQLRESGLGLSGGQKQALILARTFLRS 645 Query: 615 PDIFLLDEPTASMDEDLERHCLGVLNEEISGGRTLVVVTHKPAFLPMVERVIVVVGNRIV 674 P + LLDEPTAS+DE E + + + G RTL+V TH+ L +V+R+IV+ G RIV Sbjct: 646 PSVLLLDEPTASLDEATEAAIIERMKPWL-GQRTLIVATHRYPVLSLVDRIIVIDGGRIV 704 Query: 675 LDGPRDAVLARLRGDTAS 692 DGP+D +LA LRG A+ Sbjct: 705 RDGPKDEILAGLRGTAAN 722 >VCA1084 [V] COG2274 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain Vch Vibrio cholerae Length = 704 Score = 326 bits (836), Expect = 1e-88, Method: Compositional matrix adjust. Identities = 189/567 (33%), Positives = 322/567 (56%), Gaps = 8/567 (1%) Query: 123 KP-DQHGFERVFKEALGEYRPIILEVVIASVVMSVIALGASVFSMQVYDRVIPTHGVATL 181 KP D H F ++ YR +V+IAS+++++ A+ A +FS VYD+V+P TL Sbjct: 136 KPRDGHWFWSTIYKSKHIYR----DVLIASLLINLFAVAAPMFSRIVYDKVVPNLAFETL 191 Query: 182 IVLAIGVSLAIVFELGMKFARSHIMDSVVSGLDAKLSQALFERLLSVRVDQLPGSVGSLA 241 VL+ G+ + +F+ K RS+ +D D +S LF +++ +R++ P SVG+ A Sbjct: 192 WVLSSGILVIFLFDFVFKMLRSYFIDVAGKKSDILISSKLFSKVMGIRMEARPPSVGAFA 251 Query: 242 GQLRGYEQIRSFYTSQTLFTLVDLPLGLLFVLVIAFIASPWMALVPTVFGLAAIGIGYLS 301 L+ +E IR F+TS T+ +L+DLP LLF+++I +A + VP + L + +L Sbjct: 252 RHLQEFESIREFFTSATISSLIDLPFALLFLVLIWLMAG-HLVWVPVIGVLILVIYSFLI 310 Query: 302 NRKVVRLADKSAAASNLKTGLLVETVEGVETIKSGSGGWKFLSRWIDVSAESIRSDMAMR 361 ++ R ++ + ++ K L+E++ G+ET+K +F RW + A ++ R Sbjct: 311 QSRLKRAIEEGSRLASQKYANLIESLAGLETVKLFGAQGQFQYRWEEAVAHMANWNIKSR 370 Query: 362 AIGDHAGYIAAMLQQLSYSTTVIVGSFLVINGQITMGALIACSILGGRILAPVAMIPGLM 421 I D A +QQ + +IVG +L+ NG +TMG LIA ++L GR + P+ + L Sbjct: 371 RITDSIQNTAGFVQQAANIGMIIVGVYLISNGDLTMGGLIAATMLSGRAIGPLVQLSLLS 430 Query: 422 VQRAHTKATLAGLEKIYALQTDQGN-ERQLTPDTLRGEFRVEEVKFTYAGSMLNAMSIDQ 480 + K+++ +E++ ++ +Q +R + ++G+ ++ V F Y S + ++ Sbjct: 431 TRYNQAKSSMTIIEQVMSMPDEQEEGKRYIHRPIIQGKIELDRVTFHYPNSPIASVRDLS 490 Query: 481 LGIRAGERVAILGPIGAGKSTILRLLSGLYRPQQGRILIDGLDMANINRLTLNQHIGYLQ 540 L I GE+VAI+G IG+GK+T+ RL+ GLY+P +G + ID D++ ++ + + ++IG + Sbjct: 491 LTIHPGEKVAIIGRIGSGKTTLERLIMGLYKPTEGHVRIDDTDISQLHHIDIRRNIGCVP 550 Query: 541 QDHRLFVGTLRENLLIGLPDPGDEVLRQVMERTGLLRLVSAHPKGLDLPIQEGGRGLSGG 600 QD LF G++R+N+ +G P D + R G+ P GL+ + EGG LSGG Sbjct: 551 QDSVLFYGSIRDNITLGRPLSDDREVMDAANRAGVTVFTQQDPAGLERQVGEGGMLLSGG 610 Query: 601 QRQLVAFTRLLLCRPDIFLLDEPTASMDEDLERHCLGVLNEEISGGRTLVVVTHKPAFLP 660 QRQ V+ R L RP + L+DEPT++MD E H L+ ++ TL+++THK + L Sbjct: 611 QRQSVSIARAFLGRPPVLLMDEPTSAMDNRSEMHIKQQLS-QLKPSETLILITHKTSMLD 669 Query: 661 MVERVIVVVGNRIVLDGPRDAVLARLR 687 +V+RVIV+ I+ DGP+ VL LR Sbjct: 670 VVDRVIVMEKGCIIADGPKHEVLNDLR 696