BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0004.0024.p (451 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value PA2214 [GEPR] COG0477 Permeases of the major facilitator superfa... 318 1e-86 BMEII1096 [GEPR] COG0477 Permeases of the major facilitator supe... 308 1e-83 RSc2352 [GEPR] COG0477 Permeases of the major facilitator superf... 306 7e-83 YPO2237 [GEPR] COG0477 Permeases of the major facilitator superf... 302 1e-81 CC2354 [GEPR] COG0477 Permeases of the major facilitator superfa... 293 8e-79 >PA2214 [GEPR] COG0477 Permeases of the major facilitator superfamily Pae Pseudomonas aeruginosa Length = 440 Score = 318 bits (816), Expect = 1e-86, Method: Compositional matrix adjust. Identities = 181/426 (42%), Positives = 254/426 (59%), Gaps = 13/426 (3%) Query: 12 QVLTSAVSKIKWRILPLFVAMFIINYIDRVNIGFVRSHLATDLGIGAAAFGLGAGLFFVG 71 ++L+SA++ + R+LP V M+++ +IDR N+G+ R+ L D G+G AAF GA +FF+G Sbjct: 9 RLLSSAIATSRLRLLPFLVLMYVLAFIDRANVGYARAFLQADTGLGDAAFAFGASIFFIG 68 Query: 72 YAIFEVPSNMLLQRYGARAWLTRIMFTWGLVAACMAFVHSETSFYFMRFLLGVTEAGFFP 131 YA FEVPSN++L R GAR WL RIM TWGLV+A M F +FY +RFLLGV EAGFFP Sbjct: 69 YACFEVPSNLMLHRLGARVWLCRIMVTWGLVSAAMMFADDAMTFYVLRFLLGVAEAGFFP 128 Query: 132 GVVYYFTQWLPNHERGRAMAVFLSGSAIASILSGPITGALLLIEG-GGLHGWQWMFIIEG 190 G++ Y T W P R +A+ +F G +A +L GP++G LL G GL WQW+F+ EG Sbjct: 129 GIILYLTYWFPQRSRAQALGLFYFGLPLALVLGGPLSGWLLEFHGIFGLANWQWLFVTEG 188 Query: 191 GASMLFCVVVWKVLDSTPRDAKWLSPEQREALATVIAAEQEQRAANRPAHVSALTLLRDP 250 + L + + L PRDA WLS EQ+ AL +A E ++ A P L+ LR Sbjct: 189 LLASLVGIAAYFYLVDRPRDAGWLSDEQKRALEGELAEEDTRKQARGPHGF--LSALRSG 246 Query: 251 QIVLFCLIYFAIQLTIYGATFWLPTIIKKMGHFNDFQ----VGLFNSIPWIVAIAAMYVF 306 Q++ FCL+YF IQ+++YG F+LPT ++ F D Q VGL +IPW+ A+ + Sbjct: 247 QVLKFCLVYFTIQMSVYGVVFYLPT---RIASFLDGQVGLNVGLITAIPWVCALVVTRLV 303 Query: 307 AVLAARY-KKPQFWVATTLVISAIGMAVSASAGPVIGFVAVCFAGIGFKAASSLFWPIPQ 365 A R + Q VA + +A A + + + +A CFA GF + LFW +P Sbjct: 304 TRQADRSGQHRQLAVAMLGMAAAGIAASALAGNLGLAVIAFCFAASGFVSVQPLFWTLPT 363 Query: 366 AYLDARIAAAVLALINSLGNLGGFFAPATFGYLEQKTGSIQGGLYALSGASLVAAVLVFL 425 YL AA+ +ALINSLGNLGGF AP +E + + G++AL+ L+ A L L Sbjct: 364 GYLSGAAAASGIALINSLGNLGGFVAPNLKTLMESQFADPRAGMFALAAVGLLGACL--L 421 Query: 426 ARTRPS 431 AR + S Sbjct: 422 ARLKTS 427 >BMEII1096 [GEPR] COG0477 Permeases of the major facilitator superfamily Bme Brucella melitensis Length = 451 Score = 308 bits (790), Expect = 1e-83, Method: Compositional matrix adjust. Identities = 167/426 (39%), Positives = 263/426 (61%), Gaps = 9/426 (2%) Query: 2 NPSQSSPATNQVLTSAVSKIKWRILPLFVAMFIINYIDRVNIGFVRSHLATDLGIGAAAF 61 N + +SP + +T K+ +RI+PL + +II Y+DRVN+GF + ++ +LG A + Sbjct: 23 NTAITSPEVVENMT--YRKVAFRIIPLLMICYIIAYLDRVNVGFAKLQMSEELGFSEAIY 80 Query: 62 GLGAGLFFVGYAIFEVPSNMLLQRYGARAWLTRIMFTWGLVAACMAFVHSETSFYFMRFL 121 GLGAGLFF+GY FE+PSN+LL + GAR W+ RIM TWGL++A AFV +E FY +RFL Sbjct: 81 GLGAGLFFIGYFFFEIPSNILLHKLGARLWIARIMITWGLLSALFAFVQTEWQFYILRFL 140 Query: 122 LGVTEAGFFPGVVYYFTQWLPNHERGRAMAVFLSGSAIASILSGPITGALL--LIEGGGL 179 LG EAGF+PGV+ Y T W P+H RG A+F +GS A I P++G ++ + G Sbjct: 141 LGAAEAGFYPGVILYLTYWFPSHRRGNMFALFQAGSPAAGIFGNPLSGWIMDQFHDTAGW 200 Query: 180 HGWQWMFIIEGGASMLFCVVVWKVLDSTPRDAKWLSPEQREALATVIAAEQEQRAANRPA 239 GWQWMF++E +++ VV+ LD++ + AKWL+ E++ ++ I A+ + +AA+ Sbjct: 201 QGWQWMFVLEAIPAVVLGVVILLYLDNSVKAAKWLTEEEKAIISRDIEADSKGKAASH-- 258 Query: 240 HVSALTLLRDPQIVLFCLIYFAIQLTIYGATFWLPTIIKKMGHFNDFQVGLFNSIPWIVA 299 S ++L+++P + + LIYF + +G T W+PT+I+ G ++ +GL +IP+I A Sbjct: 259 --SLMSLVKNPMLWVMMLIYFCFVMGQHGLTLWMPTLIRASGVTSNVTIGLLGAIPFICA 316 Query: 300 IAAMYVFAVLAARYKKPQFWVATTLVISAIGMAVSASA-GPVIGFVAVCFAGIGFKAASS 358 I AM +F+ A Y++ ++ + ++ A+G V+ASA + + + A G A + Sbjct: 317 IIAMVIFSRSADHYRERRWHLVVPALLGAVGFVVAASATNTTVSIIFLSMAAAGVLACAP 376 Query: 359 LFWPIPQAYLDARIAAAVLALINSLGNLGGFFAPATFGYLEQKTGSIQGGLYALSGASLV 418 LFW +P A L AAA +ALINS+ NL GF +P G + T S + G+Y L+G ++ Sbjct: 377 LFWSLPTAILSGAAAAAGIALINSVANLAGFISPYMVGIIRDATHSSELGMYVLAGFLIL 436 Query: 419 AAVLVF 424 A +V Sbjct: 437 GAAIVL 442 >RSc2352 [GEPR] COG0477 Permeases of the major facilitator superfamily Rso Ralstonia solanacearum Length = 442 Score = 306 bits (784), Expect = 7e-83, Method: Compositional matrix adjust. Identities = 170/426 (39%), Positives = 256/426 (60%), Gaps = 12/426 (2%) Query: 3 PSQSSPATNQVLTSAVSKIKWRILPLFVAMFIINYIDRVNIGFVRSHLATDLGIGAAAFG 62 P QS+ + + K+ WR++P + +++ Y+DRVN+GF + + DL +G Sbjct: 16 PPQSASGFEE---ATYRKVSWRLIPFLLLCYVVAYLDRVNVGFAKLQMLNDLKFSETVYG 72 Query: 63 LGAGLFFVGYAIFEVPSNMLLQRYGARAWLTRIMFTWGLVAACMAFVHSETSFYFMRFLL 122 LGAG+FF+GY +FEVPSN++L R GAR W+ RIM +WGL++A M FV + FY MRFLL Sbjct: 73 LGAGIFFIGYFLFEVPSNVILHRVGARMWIARIMISWGLISAAMMFVTTPAMFYVMRFLL 132 Query: 123 GVTEAGFFPGVVYYFTQWLPNHERGRAMAVFLSGSAIASILSGPITGALLLIEGG--GLH 180 G+ EAGFFPG++ Y T W P RGR F++ A++ ++ GPI+G L GG GL Sbjct: 133 GLAEAGFFPGIILYLTYWYPAERRGRTTTFFMTAVALSGVIGGPISGWALKTFGGVYGLA 192 Query: 181 GWQWMFIIEGGASMLFCVVVWKVLDSTPRDAKWLSPEQREALATVIAAEQEQRAANRPAH 240 GWQWMF+IEG S++ + V LD+ A+WL+ E++ L IAAE+ Q+ A Sbjct: 193 GWQWMFLIEGIPSVVIGLCVLAYLDNRISHARWLTDEEKALLTRNIAAEEAQK---EDAP 249 Query: 241 VSALTLLRDPQIVLFCLIYFAIQLTIYGATFWLPTIIKKMGHFNDFQVGLFNSIPWIVAI 300 ++A ++ P++ L LIYF+ + +YG +FWLPT+IK+ G + VGL +IP+ A+ Sbjct: 250 IAA--IMASPRVWLMSLIYFSFVMGLYGVSFWLPTLIKQTGVADPLSVGLLTAIPYGAAV 307 Query: 301 AAMYVFAVLAARYKKPQFWVATTLVISAIGMAVSA--SAGPVIGFVAVCFAGIGFKAASS 358 AM + A A R ++ ++ +A + AIG+ +SA + A+ +G Sbjct: 308 VAMVLVARSADRTRERRWHIAIPALAGAIGLVLSAVWHTNTTLAMAALTLGTMGILTTLP 367 Query: 359 LFWPIPQAYLDARIAAAVLALINSLGNLGGFFAPATFGYLEQKTGSIQGGLYALSGASLV 418 LFW +P A+L AAA +ALINSLGNL GF +P G+L+ T S G+Y L+ + ++ Sbjct: 368 LFWSLPTAFLAGTGAAAGIALINSLGNLAGFLSPYAVGWLKDTTRSTDSGMYLLAASMVL 427 Query: 419 AAVLVF 424 A+L Sbjct: 428 GALLTL 433 >YPO2237 [GEPR] COG0477 Permeases of the major facilitator superfamily Ype Yersinia pestis Length = 436 Score = 302 bits (773), Expect = 1e-81, Method: Compositional matrix adjust. Identities = 171/432 (39%), Positives = 245/432 (56%), Gaps = 17/432 (3%) Query: 2 NPSQSSPATNQVLTSAVSKIKWRILPLFVAMFIINYIDRVNIGFVRSHLATDLGIGAAAF 61 S S P Q +A K W +LPL + +++NY+DRVN+GF + +A DL + Sbjct: 6 TESLSQPTQLQEENNAYRKTVWHLLPLLMLCYVLNYLDRVNVGFAKLQMADDLQFSDTVY 65 Query: 62 GLGAGLFFVGYAIFEVPSNMLLQRYGARAWLTRIMFTWGLVAACMAFVHSETSFYFMRFL 121 GLGAG+FF+GY E+PSN++L R GAR W+ RIM TWG+++ACMAFV + SFY MRFL Sbjct: 66 GLGAGMFFIGYFFLEIPSNLILHRVGARLWIARIMITWGIISACMAFVTTPMSFYVMRFL 125 Query: 122 LGVTEAGFFPGVVYYFTQWLPNHERGRAMAVFLSGSAIASILSGPITGALLLIEGG--GL 179 LGV EAGFFPG++ Y + W P+H RGR +F+ ++ I+ P++G ++ G G Sbjct: 126 LGVAEAGFFPGIILYISYWFPSHRRGRVYGLFVISVPLSGIIGAPLSGWIMQYFNGFQGY 185 Query: 180 HGWQWMFIIEGGASMLFCVVVWKVLDSTPRDAKWLSPEQREALATVIAAEQEQRAANRPA 239 GWQWMFI+EG S+L +++ L A WL+ ++++ L T I E A +R Sbjct: 186 AGWQWMFILEGIPSVLVGILIIYKLKDRITHATWLTDKEKDILQTNIENEAAHYAHSR-- 243 Query: 240 HVSALTLLRD----PQIVLFCLIYFAIQLTIYGATFWLPTIIKKMGHFNDFQVGLFNSIP 295 LRD P++ L LIYF + Y FWLPT+I+ G + +G +IP Sbjct: 244 -------LRDAFLQPRVWLLTLIYFCLISGFYTIGFWLPTLIRDSGVKDILSIGFLTAIP 296 Query: 296 WIVAIAAMYVFAVLAARYKKPQFWVATTLVISAIGMAVSA--SAGPVIGFVAVCFAGIGF 353 A M V + A R ++ ++ +A T V+ A+G+ +S S V+ V + +G Sbjct: 297 SAAAAVTMIVVSRSADRLRERRWHLALTAVLGAVGIILSTYFSDNIVVAMVCLTIGAMGA 356 Query: 354 KAASSLFWPIPQAYLDARIAAAVLALINSLGNLGGFFAPATFGYLEQKTGSIQGGLYALS 413 + LFW +P A+L AAA +A INS GNLGGF AP GYL+ T S G+ +S Sbjct: 357 LSTIPLFWSLPTAFLGGSAAAAGIAFINSWGNLGGFVAPYMMGYLKDLTQSTTTGMLIIS 416 Query: 414 GASLVAAVLVFL 425 + A LVFL Sbjct: 417 TTLFIGAALVFL 428 >CC2354 [GEPR] COG0477 Permeases of the major facilitator superfamily Ccr Caulobacter vibrioides Length = 430 Score = 293 bits (749), Expect = 8e-79, Method: Compositional matrix adjust. Identities = 161/426 (37%), Positives = 249/426 (58%), Gaps = 8/426 (1%) Query: 7 SPATNQVLTSAVSKIKWRILPLFVAMFIINYIDRVNIGFVRSHLATDLGIGAAAFGLGAG 66 S ++ + + V ++ R++PLF M++I YIDR N+ + + + + LG+ AA+GLGA Sbjct: 2 SDPSSALERATVGRVTRRLMPLFCLMYLIAYIDRQNVSYAKLDMVSALGLSEAAYGLGAS 61 Query: 67 LFFVGYAIFEVPSNMLLQRYGARAWLTRIMFTWGLVAACMAFVHSETSFYFMRFLLGVTE 126 LFF+GY +FE P+N++L R GAR W RIMF+WGLV + F + FY +RFLLGV E Sbjct: 62 LFFIGYFLFEAPANLILARVGARVWFARIMFSWGLVTLALGFTQNAAMFYVLRFLLGVAE 121 Query: 127 AGFFPGVVYYFTQWLPNHERGRAMAVFLSGSAIASILSGPITGALLLIEGG-GLHGWQWM 185 AGFFPGV+Y T W P R R + +F+ SA A+ + I G LL ++G GL GWQW+ Sbjct: 122 AGFFPGVLYVLTLWYPQAHRARMVGLFMIASAFANAVGAAIGGLLLGMDGFLGLAGWQWV 181 Query: 186 FIIEGGASMLFC-VVVWKVLDSTPRDAKWLSPEQREALATVIAAEQEQRAANRPAHVSAL 244 F++ G ++L V+W+ L S P DA+WL ++ LA+ +AAE R H A Sbjct: 182 FLVTGAPAVLLAPYVLWR-LPSGPSDARWLPDVEKSWLASTLAAE---RGGEVDDHRGAW 237 Query: 245 TLLRDPQIVLFCLIYFAIQLTIYGATFWLPTIIKKMGHFNDFQVGLFNSIPWIVAIAAMY 304 + DP++++ +Y + L+ YG ++WLPTI+K G N G N IPW++ A++ Sbjct: 238 KAIFDPRVLMLAGLYIGMPLSAYGLSYWLPTIVKSFGVSNTVN-GFINVIPWLLVAVALW 296 Query: 305 VFAVLAARYKKPQFWVATTLVISAIGMAVSA-SAGPVIGFVAVCFAGIGFKAASSLFWPI 363 AAR+ + +A ++++A+ +++S G + F +C A AA +FW + Sbjct: 297 FVPRHAARHGASAWHIAGPVLLAAVALSLSVILPGAALKFTMLCIAAPAIFAAQPVFWSL 356 Query: 364 PQAYLDARIAAAVLALINSLGNLGGFFAPATFGYLEQKTGSIQGGLYALSGASLVAAVLV 423 P ++L AAA +A IN++GNLGGF A + TGS + AL+ LV ++L+ Sbjct: 357 PPSFLSGPRAAAGIATINAVGNLGGFIAQNLVPVVRDATGSELAPMLALAAVLLVTSLLI 416 Query: 424 FLARTR 429 F+ R Sbjct: 417 FIVMGR 422