BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0003.0117.p (282 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value PA3975 [H] COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidi... 158 1e-38 PH1155_1 [H] COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimi... 99 8e-21 lin0667 [H] COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimid... 97 4e-20 thiD [H] COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidine... 96 1e-19 PAB1646_1 [H] COG0351 Hydroxymethylpyrimidine/phosphomethylpyrim... 95 1e-19 >PA3975 [H] COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase Pae Pseudomonas aeruginosa Length = 265 Score = 158 bits (400), Expect = 1e-38, Method: Compositional matrix adjust. Identities = 95/263 (36%), Positives = 145/263 (55%), Gaps = 10/263 (3%) Query: 4 QTP---PLILSFGAADPVGATGVQADLATFAAMGCHGLSVVTALLIGDTARVEDVQVVDV 60 +TP P++L DP G G+QAD+ A GCH VTAL + DT V D +V+D Sbjct: 2 KTPTSRPVVLCLSGHDPSGGAGLQADIEALLAQGCHAAPAVTALTVQDTVNVSDFRVLDR 61 Query: 61 DWVADQARVILEDMAVAAFKVGALGSIENISVIAEIVSDYPDVPLILDPFIS-ALANQED 119 +WV QA +L D+ VAA K+G LGS+E + +AEI++ +P +P++ DP + Sbjct: 62 EWVLAQANAVLADLPVAAVKLGMLGSLEMVDTVAEILAAHPHLPVVCDPVLRAGGGGALG 121 Query: 120 EDDRLIAIRELLIPQATVLICSAGELTRLAETWREPVPGDALELDAMRIIEMGCEYLLVT 179 + D A+RE L+P+AT+ + E LA+ +P + + A R++E CE+LL+T Sbjct: 122 KGDVGFAMRERLLPRATIATPNLPEARLLAD-----LPEGSADQCAERLLEH-CEHLLIT 175 Query: 180 NTQTDLQEVANSLFDESGLVRQDAWPRLPGSFVGAGSTLSAAMAAMLANDLEVPLAASEA 239 D EV N L+ G R RLPGS+ G+G TL++A+A +A + A A Sbjct: 176 GGHGDESEVHNRLYSRDGSRRTFTCQRLPGSYHGSGCTLASALAGRIALGEALHGAVQSA 235 Query: 240 QEFTLAALANAQRIGMGKLLPDR 262 ++T L +A+ G G+ +P R Sbjct: 236 LDYTWRTLRDAESPGHGQYVPRR 258 >PH1155_1 [H] COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase Pho Pyrococcus horikoshii Length = 260 Score = 99.4 bits (246), Expect = 8e-21, Method: Compositional matrix adjust. Identities = 75/240 (31%), Positives = 125/240 (52%), Gaps = 12/240 (5%) Query: 23 VQADLATFAAMGCHGLSVVTALLIGDTARVEDVQVVDVDWVADQARVILEDMAVAAFKVG 82 ++ADL TF A G HGL +T++ +T V + + + V++Q RV+ ED+ V A K G Sbjct: 21 IEADLKTFTAFGVHGLVAITSVTAQNTQTVTAIHDIPPEVVSEQIRVVAEDIGVDAAKTG 80 Query: 83 ALGSIENISVIAEIVSDYPDVPLILDPFISALAN----QEDEDDRLIAIRELLIPQATVL 138 L + E I +A+ V +Y D PL++DP + A + +ED D LI + ++P AT++ Sbjct: 81 MLSNAEIIKAVAKTVKNY-DFPLVVDPVMIAKSGAPLLREDAVDALI---KYILPLATLV 136 Query: 139 ICSAGELTRLAETWREPVPGDALELDAMRII-EMGCEYLLVTNTQTDLQEVANSLFDESG 197 + E +L T E + +L A +I E G + ++V + +E + L+ +G Sbjct: 137 TPNRFEAEKL--TGMEIRNVNDAKLAAKKIAEETGAKAVIVKGGHLEGKEAIDVLY-HNG 193 Query: 198 LVRQDAWPRLPGSFVGAGSTLSAAMAAMLANDLEVPLAASEAQEFTLAALANAQRIGMGK 257 + P++ G G G + SAA+ A LA L + A S A+EF ++ +IG G Sbjct: 194 AYKLYRAPKVDGCTHGTGCSFSAAITANLAKGLSLEDAVSVAKEFITLGISTGHKIGHGH 253 >lin0667 [H] COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase Lin Listeria innocua Length = 271 Score = 97.1 bits (240), Expect = 4e-20, Method: Compositional matrix adjust. Identities = 75/247 (30%), Positives = 122/247 (49%), Gaps = 15/247 (6%) Query: 10 LSFGAADPVGATGVQADLATFAAMGCHGLSVVTALLIGD--TARVEDVQVVDVDWVADQA 67 L+ +D G G+QADL TF G +G S +T ++ D V +D V +Q Sbjct: 7 LTIAGSDSSGGAGLQADLKTFEEYGTYGFSAITTIVTMDPDNNWAHGVTPIDAQLVREQL 66 Query: 68 RVILEDMAVAAFKVGALGSIENISVIAEIVSDYPDVPLILDPFISALANQEDE---DDRL 124 + IL V A K G LGSI+ I E + Y +++DP + + EDE + Sbjct: 67 KTILSGGPVDAMKTGMLGSIDIIKATREAIDKYDLKNVVIDPVM--VCKGEDELIQPENA 124 Query: 125 IAIRELLIPQATVL---ICSAGELTRLAETWREPVPGDALELDAMRIIEMGCEYLLVTNT 181 AIR+LL+P+AT+ + AG+L+ L + D ++ A +IIE+G +Y+++ Sbjct: 125 EAIRDLLLPKATITTPNLFEAGQLSGLGKL----TTLDDMKKAAKKIIELGAKYVVIKGG 180 Query: 182 QT-DLQEVANSLFDESGLVRQDAWPRLPGSFVGAGSTLSAAMAAMLANDLEVPLAASEAQ 240 + + + + L+D + P GAG T +AA+ A LA L V A ++A+ Sbjct: 181 KALESDKAIDLLYDGKEFTVYEVEKISPSHNHGAGCTFAAAITAGLAKGLTVEEAVAKAK 240 Query: 241 EFTLAAL 247 +F AA+ Sbjct: 241 DFVTAAI 247 >thiD [H] COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase Eco Escherichia coli K12 Length = 266 Score = 95.5 bits (236), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 77/262 (29%), Positives = 127/262 (48%), Gaps = 9/262 (3%) Query: 10 LSFGAADPVGATGVQADLATFAAMGCHGLSVVTALLIGDTARVEDVQVVDVDWVADQARV 69 L+ DP G G+QADL TF+A+G +G SV+TAL+ +T V+ V ++ D+VA Q Sbjct: 7 LTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDS 66 Query: 70 ILEDMAVAAFKVGALGSIENISVIAEIVSDYPDVPLILDPFISALANQED---EDDRLIA 126 + D+ + K+G L + + +AE + Y ++LD + LA D + Sbjct: 67 VFSDVRIDTTKIGMLAETDIVEAVAERLQRYQIQNVVLDTVM--LAKSGDPLLSPSAVAT 124 Query: 127 IRELLIPQATVLICSAGELTRLAETWREPVPGDALELDAMRIIEMGCEYLLVTNTQTDLQ 186 +R L+PQ +++ + E L + + LE ++ MGC +L+ D + Sbjct: 125 LRSRLLPQVSLITPNLPEAAALLDAPHARTEQEMLE-QGRSLLAMGCGAVLMKGGHLDDE 183 Query: 187 EVANSLFDESGLVRQDAWPR-LPGSFVGAGSTLSAAMAAMLANDLEVPLAASEAQEFTLA 245 + + LF G R A PR + + G G TLSAA+AA+ EA+ + + Sbjct: 184 QSPDWLFTREGEQRFTA-PRIMTKNTHGTGCTLSAALAALRPRHTNWADTVQEAKSWLSS 242 Query: 246 ALANAQRIGMGK-LLPDRYFWA 266 ALA A + +G + P +F A Sbjct: 243 ALAQADTLEVGHGIGPVHHFHA 264 >PAB1646_1 [H] COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase Pab Pyrococcus abyssi Length = 260 Score = 95.1 bits (235), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 75/240 (31%), Positives = 123/240 (51%), Gaps = 12/240 (5%) Query: 23 VQADLATFAAMGCHGLSVVTALLIGDTARVEDVQVVDVDWVADQARVILEDMAVAAFKVG 82 ++ADL TF A G HGL +T++ +T V + + D V++Q R + ED+ V A K G Sbjct: 21 IEADLKTFTAFGVHGLVAITSVTAQNTQAVTAIHDIPPDVVSEQIRAVAEDIGVDAAKTG 80 Query: 83 ALGSIENISVIAEIVSDYPDVPLILDPFISALAN----QEDEDDRLIAIRELLIPQATVL 138 L + E I +A+ V +Y D PL++DP + A + +ED D LI + ++P AT++ Sbjct: 81 MLSNAEIIKAVAKTVKNY-DFPLVVDPVMIAKSGAPLLREDAVDALI---KYILPLATLV 136 Query: 139 ICSAGELTRLAETWREPVPGDALELDAMRII-EMGCEYLLVTNTQTDLQEVANSLFDESG 197 + E +L+ V DA ++ A +I E G + ++V + +E + L+ +G Sbjct: 137 TPNRFEAEKLSGMKIRTVE-DA-KIAAKKIAEETGAKAVIVKGGHIEGEEAIDVLY-HNG 193 Query: 198 LVRQDAWPRLPGSFVGAGSTLSAAMAAMLANDLEVPLAASEAQEFTLAALANAQRIGMGK 257 R P++ G G G + SAA+ A LA + A A++F +A RIG G Sbjct: 194 SYRLYRAPKVEGCTHGTGCSFSAAITANLAKGFGLEDAIEVAKKFITLGIAMGHRIGHGH 253